AR035719A1 - Compuestos derivados de benzofurano y benzotiofeno, su uso, un procedimiento para prepararlos y composiciones farmaceuticas que los comprenden - Google Patents

Compuestos derivados de benzofurano y benzotiofeno, su uso, un procedimiento para prepararlos y composiciones farmaceuticas que los comprenden

Info

Publication number
AR035719A1
AR035719A1 ARP010105603A ARP010105603A AR035719A1 AR 035719 A1 AR035719 A1 AR 035719A1 AR P010105603 A ARP010105603 A AR P010105603A AR P010105603 A ARP010105603 A AR P010105603A AR 035719 A1 AR035719 A1 AR 035719A1
Authority
AR
Argentina
Prior art keywords
disease
alkyl
nr4r5
hydrogen
benzofuran
Prior art date
Application number
ARP010105603A
Other languages
English (en)
Inventor
Kevin Lee Mclaren
Jahari Laurant Tracy
David Bernard Smith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR035719A1 publication Critical patent/AR035719A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Compuestos derivados de benzofurano y benzotiofeno representados por la fórmula (1) en la cual: Y es O ó S; A es -CH2-, -C(O)-, -O-, -S-, -S(O)- ó S(O)2-; Ar es un fenilo opcionalmente sustituido; R1 es hidrógeno, alquilo, alcoxi, hidroxi, halo, ciano, -C(O)NR4R5, -COOR4, ó -NR4R5; R4 y R5 son cada uno independientemente en cada caso hidrógeno o alquilo; R2 es hidrógeno, alquilo, alcoxi, hidroxi, halo, haloalquilo, nitro, ciano ó -NR4R5; R3 es -SR6, -SOR6, -SO2R6 ó -SO2NR4R5, en donde R6 es alquilo, hidroxialquilo, alcoxialquilo, carboxialquilo o alcoxicarbonilalquilo; o prodrogas, isómeros individuales, mezclas de isómeros y sales farmacéuticamente aceptables de los mismos. Su uso, un procedimiento para prepararlos y composiciones farmacéuticas que los comprenden. Los compuestos de fórmula (1) son útiles para el tratamiento de una enfermedad de un mamífero que se puede tratar mediante la administración de un inhibidor selectivo de la COX II, especialmente en donde la enfermedad es una enfermedad inflamatoria seleccionada entre miositis, sinovitis, artritis (artritis reumatoide y osteoartritis), gota, dolor de espalda, dolor dental, lesiones por deportes, esguinces, distensiones, cefaleas, tendinitis, espondilitis anquilosante y bursitis, o en donde la enfermedad es dismenorrea o parto prematuro, o en donde la enfermedad es enfermedad de Alzheimer.
ARP010105603A 2000-12-05 2001-12-03 Compuestos derivados de benzofurano y benzotiofeno, su uso, un procedimiento para prepararlos y composiciones farmaceuticas que los comprenden AR035719A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25128300P 2000-12-05 2000-12-05

Publications (1)

Publication Number Publication Date
AR035719A1 true AR035719A1 (es) 2004-07-07

Family

ID=22951260

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105603A AR035719A1 (es) 2000-12-05 2001-12-03 Compuestos derivados de benzofurano y benzotiofeno, su uso, un procedimiento para prepararlos y composiciones farmaceuticas que los comprenden

Country Status (16)

Country Link
US (1) US6433005B1 (es)
EP (1) EP1347963B1 (es)
JP (1) JP4212892B2 (es)
KR (1) KR20030070054A (es)
CN (1) CN1273460C (es)
AR (1) AR035719A1 (es)
AT (1) ATE274507T1 (es)
AU (2) AU2489002A (es)
BR (1) BR0115963A (es)
CA (1) CA2437048A1 (es)
DE (1) DE60105195T2 (es)
ES (1) ES2225641T3 (es)
MX (1) MXPA03004398A (es)
PT (1) PT1347963E (es)
WO (1) WO2002046178A2 (es)
ZA (1) ZA200303641B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020009383A (ko) * 1998-04-01 2002-02-01 우에노 도시오 축합 티오펜 유도체 및 이의 유도체를 유효 성분으로 하는약제
JP2001261674A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
HUP0302473A2 (hu) * 2000-05-18 2003-11-28 Daiichi Pharmaceutical Co., Ltd. Új benzotiofénszármazékok
US6713505B2 (en) * 2000-06-28 2004-03-30 Eli Lilly And Company spla2 inhibitors
US7071220B2 (en) * 2000-09-18 2006-07-04 Toa Eiyo Ltd. N-substituted benzothiophenesulfonamide derivatives
TW200526668A (en) * 2003-10-02 2005-08-16 Salmedix Inc Substituted indole derivatives
NZ570014A (en) 2006-02-03 2011-04-29 Bionomics Ltd Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
JP2010509259A (ja) 2006-11-09 2010-03-25 エフ．ホフマン−ラ ロシュ アーゲー インドール及びベンゾフラン２−カルボキサミド誘導体
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
CN103819371B (zh) * 2012-11-16 2016-05-04 中国科学院大连化学物理研究所 一种对甲砜基苯甲醛的合成方法
CN103058988B (zh) * 2012-12-31 2015-09-02 中国人民大学 苯并噻吩及其衍生物及其制备方法与应用
CN110903225B (zh) * 2019-12-11 2021-11-09 苏州开元民生科技股份有限公司 一种对甲砜基苯甲醛的合成方法
CN114456136B (zh) * 2022-01-27 2024-06-07 广西中医药大学 双靶点非甾体抗炎化合物及其制备方法与用途
KR102542698B1 (ko) * 2022-04-05 2023-06-14 주식회사 베노바이오 신규한 벤조사이오펜 유도체 및 bet 억제제로서의 용도

Family Cites Families (13)

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US3331854A (en) * 1964-12-14 1967-07-18 American Cyanamid Co Novel furan and thiophene compounds
US4745127A (en) * 1983-10-31 1988-05-17 Merck Frosst Canada, Inc. Benzyl esters of benzofuran-2-carboxylic acids useful as inhibitors of leukotriene biosynthesis
US4933351A (en) 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
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DE3342624A1 (de) 1983-11-25 1984-03-29 Heinfried Dr. 4019 Monheim Grote Benzaronderivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
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Also Published As

Publication number Publication date
JP4212892B2 (ja) 2009-01-21
DE60105195D1 (de) 2004-09-30
JP2004517088A (ja) 2004-06-10
EP1347963B1 (en) 2004-08-25
CN1479736A (zh) 2004-03-03
PT1347963E (pt) 2004-12-31
CN1273460C (zh) 2006-09-06
ATE274507T1 (de) 2004-09-15
ES2225641T3 (es) 2005-03-16
DE60105195T2 (de) 2005-09-08
AU2489002A (en) 2002-06-18
EP1347963A2 (en) 2003-10-01
BR0115963A (pt) 2003-10-28
US20020107280A1 (en) 2002-08-08
WO2002046178A3 (en) 2002-10-10
AU2002224890B2 (en) 2007-03-22
KR20030070054A (ko) 2003-08-27
CA2437048A1 (en) 2002-06-13
WO2002046178A2 (en) 2002-06-13
MXPA03004398A (es) 2003-09-05
ZA200303641B (en) 2004-08-12
US6433005B1 (en) 2002-08-13

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