PT1347963E - Derivados de benzofurano e de benzotiofeno como inibidores selectivos da cox-2 - Google Patents

Derivados de benzofurano e de benzotiofeno como inibidores selectivos da cox-2

Info

Publication number
PT1347963E
PT1347963E PT01994723T PT01994723T PT1347963E PT 1347963 E PT1347963 E PT 1347963E PT 01994723 T PT01994723 T PT 01994723T PT 01994723 T PT01994723 T PT 01994723T PT 1347963 E PT1347963 E PT 1347963E
Authority
PT
Portugal
Prior art keywords
benzofuran
cox
selective inhibitors
benzotiophene
derivatives
Prior art date
Application number
PT01994723T
Other languages
English (en)
Inventor
David Bernard Smith
Kevin Lee Mc Laren
Jahari Laurant Tracy
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT1347963E publication Critical patent/PT1347963E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
PT01994723T 2000-12-05 2001-11-26 Derivados de benzofurano e de benzotiofeno como inibidores selectivos da cox-2 PT1347963E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25128300P 2000-12-05 2000-12-05

Publications (1)

Publication Number Publication Date
PT1347963E true PT1347963E (pt) 2004-12-31

Family

ID=22951260

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01994723T PT1347963E (pt) 2000-12-05 2001-11-26 Derivados de benzofurano e de benzotiofeno como inibidores selectivos da cox-2

Country Status (16)

Country Link
US (1) US6433005B1 (pt)
EP (1) EP1347963B1 (pt)
JP (1) JP4212892B2 (pt)
KR (1) KR20030070054A (pt)
CN (1) CN1273460C (pt)
AR (1) AR035719A1 (pt)
AT (1) ATE274507T1 (pt)
AU (2) AU2002224890B2 (pt)
BR (1) BR0115963A (pt)
CA (1) CA2437048A1 (pt)
DE (1) DE60105195T2 (pt)
ES (1) ES2225641T3 (pt)
MX (1) MXPA03004398A (pt)
PT (1) PT1347963E (pt)
WO (1) WO2002046178A2 (pt)
ZA (1) ZA200303641B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051587A1 (fr) * 1998-04-01 1999-10-14 Ono Pharmaceutical Co., Ltd. Derives de thiophene condenses et medicaments contenant ceux-ci comme principe actif
JP2001261674A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
HUP0302473A2 (hu) * 2000-05-18 2003-11-28 Daiichi Pharmaceutical Co., Ltd. Új benzotiofénszármazékok
AU2001268051A1 (en) * 2000-06-28 2002-01-08 Eli Lilly And Company Spla2 inhibitors
US7071220B2 (en) * 2000-09-18 2006-07-04 Toa Eiyo Ltd. N-substituted benzothiophenesulfonamide derivatives
EP1673373A2 (en) * 2003-10-02 2006-06-28 Salmedix, Inc. Indole derivatives
ATE555091T1 (de) 2006-02-03 2012-05-15 Bionomics Ltd Substituierte benzofurane, benzothiophene, benzoselenophene und indole und ihre verwendung als tubulinpolymerisationsinhibitoren
WO2008055808A1 (en) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Indole and benzofuran 2-carboxamide derivatives
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
CN103819371B (zh) * 2012-11-16 2016-05-04 中国科学院大连化学物理研究所 一种对甲砜基苯甲醛的合成方法
CN103058988B (zh) * 2012-12-31 2015-09-02 中国人民大学 苯并噻吩及其衍生物及其制备方法与应用
CN110903225B (zh) * 2019-12-11 2021-11-09 苏州开元民生科技股份有限公司 一种对甲砜基苯甲醛的合成方法
KR102542698B1 (ko) * 2022-04-05 2023-06-14 주식회사 베노바이오 신규한 벤조사이오펜 유도체 및 bet 억제제로서의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3331854A (en) * 1964-12-14 1967-07-18 American Cyanamid Co Novel furan and thiophene compounds
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
US4745127A (en) * 1983-10-31 1988-05-17 Merck Frosst Canada, Inc. Benzyl esters of benzofuran-2-carboxylic acids useful as inhibitors of leukotriene biosynthesis
DE3342624A1 (de) 1983-11-25 1984-03-29 Heinfried Dr. 4019 Monheim Grote Benzaronderivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
US4621091A (en) 1984-10-09 1986-11-04 Merck & Co., Inc. 3-hydroxybenzo[b]thiophene-2-sulfide derivatives compositions, and method of use therefor
US5208253A (en) * 1992-02-24 1993-05-04 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion
JPH09500130A (ja) 1993-07-15 1997-01-07 ワーナー−ランバート・コンパニー 炎症性腸疾患の治療において用いる薬剤としてのベンゾチオフェンおよびベンゾフランおよび炎症をアッセイする方法
US5426113A (en) 1994-04-08 1995-06-20 Warner-Lambert Company Method of preventing ulcer formation caused by nonsteroidal antiinflammatory drugs employing tetrazol-benzothiophene carboxamide compounds
US5521213A (en) * 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5731342A (en) 1996-02-22 1998-03-24 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods
JP2000505455A (ja) * 1996-02-22 2000-05-09 イーライ・リリー・アンド・カンパニー ベンゾチオフエン類、それらを含む製剤、および方法

Also Published As

Publication number Publication date
AU2489002A (en) 2002-06-18
BR0115963A (pt) 2003-10-28
WO2002046178A3 (en) 2002-10-10
US20020107280A1 (en) 2002-08-08
AR035719A1 (es) 2004-07-07
EP1347963A2 (en) 2003-10-01
ZA200303641B (en) 2004-08-12
KR20030070054A (ko) 2003-08-27
ES2225641T3 (es) 2005-03-16
CA2437048A1 (en) 2002-06-13
CN1273460C (zh) 2006-09-06
JP2004517088A (ja) 2004-06-10
AU2002224890B2 (en) 2007-03-22
EP1347963B1 (en) 2004-08-25
WO2002046178A2 (en) 2002-06-13
JP4212892B2 (ja) 2009-01-21
ATE274507T1 (de) 2004-09-15
DE60105195D1 (de) 2004-09-30
CN1479736A (zh) 2004-03-03
MXPA03004398A (es) 2003-09-05
DE60105195T2 (de) 2005-09-08
US6433005B1 (en) 2002-08-13

Similar Documents

Publication Publication Date Title
AR028576A1 (es) Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa
AR028575A1 (es) Derivados de pirrolopiridinona utiles como inhibidores de fosfodiesterasa
PT1268480E (pt) Derivados de 8-quinolinil-xantina e 8-isoquinolinil-xantina como inibidores da pde 5
PT1287001E (pt) Derivados de tiofeno uteis como agentes anticancerigenos
MA26060A1 (fr) Nouveaux derives de pyrazolopyridine
FR12C0007I2 (fr) Nouveaux derives de phenyle-propargylether
DZ3439A1 (fr) Derives de 2-aminocarbonyl-9h-purine
PT1244647E (pt) Derivados de quinazolina como inibidores de vegf
PT1303521E (pt) Derivados de tetra-hidro-heterocicloazepinil-pirimidina
AR028596A1 (es) Nuevos derivados de fenilglicina
PT1178986E (pt) Derivados da furanona como inibidores da catepsina s
AR027967A1 (es) Derivados de esteres de pirazol como agentes antinflamatorios/analgesicos
PT1097127E (pt) Derivados de diacil-hidrazina como inibidores da integrina
MXPA03001848A (es) Derivados de fenoxibencilamina como inhibidores de la reabsorcion de serotonina.
PT1212320E (pt) Fenilpiperazinas como inibidores de reabsorcao de serotonina
PT1347963E (pt) Derivados de benzofurano e de benzotiofeno como inibidores selectivos da cox-2
ATE428695T1 (de) Spirocyclische 3-phenyl-3-substituierte-4- ketolaktame und -laktone
PT1189907E (pt) Tienopirimidinas como inibidores da fosfodiesterase
FR2810318B1 (fr) Derives de diamano-phenothiazine
DE50114491D1 (de) Substituierte C-Cyclohexylmethylamin-Derivative
AR028282A1 (es) Derivados de aminofenil pirimidona
PT1377550E (pt) Derivados eter fenil-heterociclilico como inibidores da recaptacao de serotonina.
PT1322592E (pt) Derivados substituidos de 1-aminobutan-3-ol
PT1351959E (pt) Novos derivados de pleuromutilina
PT1167260E (pt) Derivados de vitamina d3