ATE272049T1 - Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker - Google Patents

Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker

Info

Publication number
ATE272049T1
ATE272049T1 AT00914643T AT00914643T ATE272049T1 AT E272049 T1 ATE272049 T1 AT E272049T1 AT 00914643 T AT00914643 T AT 00914643T AT 00914643 T AT00914643 T AT 00914643T AT E272049 T1 ATE272049 T1 AT E272049T1
Authority
AT
Austria
Prior art keywords
salicylamide
lanthanide complexes
ligands
luminescence markers
salicylamidyl
Prior art date
Application number
AT00914643T
Other languages
English (en)
Inventor
Kenneth N Raymond
Stephane Petoud
Seth Cohen
Jide Xu
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE272049T1 publication Critical patent/ATE272049T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1007—Non-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/18—Metal complexes
    • C09K2211/182—Metal complexes of the rare earth metals, i.e. Sc, Y or lanthanide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
AT00914643T 1999-02-18 2000-02-18 Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker ATE272049T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12060099P 1999-02-18 1999-02-18
PCT/US2000/004284 WO2000048991A1 (en) 1999-02-18 2000-02-18 Salicylamide-lanthanide complexes for use as luminescent markers
US09/507,599 US6406297B1 (en) 1999-02-18 2000-02-18 Salicylamide-lanthanide complexes for use as luminescent markers

Publications (1)

Publication Number Publication Date
ATE272049T1 true ATE272049T1 (de) 2004-08-15

Family

ID=26818543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00914643T ATE272049T1 (de) 1999-02-18 2000-02-18 Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker

Country Status (9)

Country Link
US (4) US6406297B1 (de)
EP (1) EP1154991B1 (de)
JP (1) JP4943585B2 (de)
AT (1) ATE272049T1 (de)
AU (1) AU762754B2 (de)
CA (1) CA2371818C (de)
DE (1) DE60012485T2 (de)
DK (1) DK1154991T3 (de)
WO (1) WO2000048991A1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749811B2 (en) 1998-04-28 2004-06-15 The Johns Hopkins University Molecularly imprinted polymer solution anion sensor
DE69922052T2 (de) * 1999-02-17 2005-06-16 Bracco International B.V. Immobilisierte marker-verbindungen und verfahren
WO2000048991A1 (en) * 1999-02-18 2000-08-24 The Regents Of The University Of California Salicylamide-lanthanide complexes for use as luminescent markers
JP4819223B2 (ja) * 1999-02-18 2011-11-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 発光マーカーとして使用するためのフタルアミド−ランタニド錯体
DE19936997B4 (de) * 1999-08-02 2007-06-14 Biolitec Ag Verfahren zur Applikation von Photosensibilisatoren (PS) mittels Multiplikatoren in der photodymamischen Therapie
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7067148B2 (en) * 2001-02-15 2006-06-27 King Pharmaceutical Research & Development, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
WO2003067210A2 (en) 2001-07-10 2003-08-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting the activation state of the multiple proteins in single cells
US7381535B2 (en) 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030198671A1 (en) * 2001-08-10 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique plasma AUC properties
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US6846915B2 (en) * 2001-08-13 2005-01-25 The Regents Of The University Of California Hydroxypyridonate and hydroxypyrimidinone chelating agents
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20040043066A1 (en) * 2001-10-29 2004-03-04 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
EP1517684B1 (de) 2002-06-27 2009-07-22 Health Research, Inc. Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie
EP2036908A3 (de) * 2002-07-02 2009-05-13 Health Research, INC. Effiziente Synthese von Pyropheophorbid-A-Derivaten
JP2006507841A (ja) * 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
US20040161737A1 (en) * 2003-02-14 2004-08-19 Yang Dan-Hui D. Novel luminescent metal chelates and methods for their detection
BRPI0408967B8 (pt) 2003-03-31 2021-07-27 Hoffmann La Roche kit e métodos para detecção de um ácido nucléico de vários membros do sorogrupo do vírus da encefalite japonesa em uma amostra biológica sob condições de hibridização rigorosas
WO2005001415A2 (en) * 2003-05-23 2005-01-06 Epix Pharmaceuticals, Inc. Optically pure and enriched isomers of chelating ligands and contrast agents
WO2004106907A1 (en) * 2003-05-27 2004-12-09 Alexander Menzel Method for detecting trace explosives using photoluminescence
DK1706452T3 (da) * 2003-12-30 2009-01-19 Univ California Office Of The Aromatiske triamid-lanthanidkomplekser
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
US20070009980A1 (en) * 2004-06-01 2007-01-11 Applera Corporation Continuous fluorogenic analyte assays with dendritic amplification of signal
CN1707244B (zh) * 2004-06-11 2010-04-07 中国科学院大连化学物理研究所 一种二氧化钛纳米铕荧光探针
JP5243684B2 (ja) * 2004-11-04 2013-07-24 ユー・ディー・シー アイルランド リミテッド 有機金属錯体、発光性固体、有機ｅｌ素子及び有機ｅｌディスプレイ
WO2006055883A2 (en) * 2004-11-19 2006-05-26 The Scripps Research Institute Subnanomolar precipitator of thiophilic metals
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
WO2007109465A2 (en) * 2006-03-21 2007-09-27 Board Of Supervisors Of Louisiana State University & Agricultural And Mechanical College Lanthanide complexes as fluorescent indicators for neutral sugars and cancer diagnosis
CA2659251C (en) 2006-07-10 2016-06-14 The Regents Of The University Of California Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
ES2655082T3 (es) * 2006-08-15 2018-02-16 The Regents Of The University Of California Complejos luminiscentes de lantánidos macrocíclicos
US8507199B2 (en) * 2007-01-25 2013-08-13 Lumiphore, Inc. Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes
EP2179037A4 (de) 2007-08-21 2010-12-22 Nodality Inc Diagnose-, prognose- und behandlungsverfahren
FR2934684B1 (fr) 2008-07-31 2012-11-16 Cis Bio Int Methode de detection de l'internalisation de proteines membranaires.
WO2010051544A2 (en) * 2008-10-31 2010-05-06 Lumiphore, Inc. Rapid homogeneous diagnostic testing platform based on lanthanide fluorescent resonance energy transfer
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
US20120070378A1 (en) * 2008-12-16 2012-03-22 The University Of Akron Lanthanide ion complexes and imaging method
US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
WO2011025790A1 (en) 2009-08-24 2011-03-03 Lumiphore, Inc. Macrocyclic hopo chelators
US9459246B2 (en) 2009-09-08 2016-10-04 Nodality, Inc. Induced intercellular communication
EP2516407A4 (de) 2009-12-24 2013-06-12 Lumiphore Inc Radiopharmazeutische komplexe
JP5958339B2 (ja) 2010-06-07 2016-07-27 コニカミノルタ株式会社 近接場増強蛍光センサチップ
WO2012023391A1 (ja) 2010-08-17 2012-02-23 コニカミノルタホールディングス株式会社 非特異吸着の精製機構を備えたｓｐｆｓ用センサ
JP6043288B2 (ja) 2010-09-15 2016-12-14 エンダセア， インコーポレイテッド 時間分解蛍光ベースのアッセイによるリポ多糖の測定のための使用方法およびキット
DE102011001368B4 (de) * 2011-03-17 2013-01-31 Bundesanstalt für Materialforschung und -Prüfung (BAM) Lanthanoid-Chelate enthaltende Partikel, deren Herstellung sowie deren Verwendung in der Bioanalytik
FR2977674B1 (fr) 2011-07-06 2015-08-14 Cisbio Bioassays Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule
EP2738556B1 (de) 2011-07-28 2019-11-06 Konica Minolta, Inc. Verfahren zum messen der menge eines analyten und vorrichtung für spfs
US9944657B2 (en) 2011-08-19 2018-04-17 Radiometer Turku Oy Luminescent lanthanide chelates having three chromophores an their use
JP5818990B2 (ja) * 2011-08-19 2015-11-18 デーホーアェル・フィンランド・オサケユキチュア ３つの発色団を有する発光ランタニドキレート及びそれらの使用
FR2980271B1 (fr) 2011-09-16 2013-10-11 Cisbio Bioassays Procede de determination de la glycosylation d'un anticorps
US9518186B2 (en) 2011-12-22 2016-12-13 Radiometer Turku Oy Luminescent lanthanide chelates with enhanced excitation properties
EP2607884A1 (de) * 2011-12-23 2013-06-26 Essilor International (Compagnie Générale d'Optique) Brillenglasbewertung hinsichtlich des Schutzes gegen UV-Gefahren
US20150185150A1 (en) 2012-02-22 2015-07-02 Cisbio Bioassays Method for normalizing the luminescence emitted by a measuring medium
FR2988174B1 (fr) 2012-03-19 2014-04-25 Cisbio Bioassays Procede de determination de la capacite d'un anticorps a maintenir des cellules a proximite l'une de l'autre
WO2013187971A2 (en) 2012-05-31 2013-12-19 The Regents Of The University Of California Macrocycles
AU2013344514B2 (en) 2012-11-16 2017-09-14 Lumiphore, Inc. Di-Macrocycles
WO2014147288A1 (en) 2013-01-31 2014-09-25 Kaivogen Oy Luminescent triazacyclononane-based lanthanide chelate complexes as labelling reagents
US11453652B2 (en) 2013-03-15 2022-09-27 Lumiphore, Inc. Di-macrocycles
US9388110B2 (en) * 2013-12-12 2016-07-12 Saudi Arabian Oil Company Liquid phase oxidation of aromatic feedstocks with manganate recycling to produce carboxylic acids
DE102014203266B4 (de) 2014-02-24 2018-07-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Zusammensetzung mit FRET-Paar in definierter Geometrie
US11691997B2 (en) 2014-04-09 2023-07-04 Lumiphore, Inc. Macrocycles
US10434186B2 (en) 2014-12-22 2019-10-08 Lumiphore, Inc. Functionalized linear ligands and complexes thereof
FR3032797B1 (fr) 2015-02-13 2017-03-03 Cisbio Bioassays Procede de quantification d'une proteine d'interet presente dans un echantillon biologique
US11248269B2 (en) 2015-03-05 2022-02-15 University Of New Hampshire Methods and compositions for identifying pathogenic vibrio parahaemolyticus
WO2017027834A1 (en) 2015-08-13 2017-02-16 The General Hospital Corporation Manganese-based chelate conjugates for molecular mr imaging
CN106010502B (zh) * 2015-11-24 2019-03-01 河北科技大学 一种具有氟离子传感性能的稀土介孔杂化发光材料的制备方法
JP6924780B2 (ja) 2016-06-09 2021-08-25 ラジオメーター・トゥルク・オサケユキチュア 結合アッセイのバックグラウンド遮断剤
CN106317096B (zh) * 2016-08-19 2019-05-28 华南师范大学 一种邻菲罗啉并咪唑型稀土配位分子基探针及其制备方法和应用
CA3035526A1 (en) 2016-09-02 2018-03-08 Lumiphore, Inc. Macrocyclic ligands with pendant chelating moieties and complexes thereof
EP3568398A1 (de) 2017-01-12 2019-11-20 Société des Produits Nestlé S.A. Cryptatderivate und deren verwendung als lumineszente lanthanidkomplexe
JP2020521440A (ja) * 2017-05-31 2020-07-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｌｋ、ｒｅｔ、およびｒｏｓ融合の多重ｐｃｒ検出
FR3069644A1 (fr) 2017-07-28 2019-02-01 Cisbio Bioassays Methode pour mesurer la modulation de l'activation d'un recepteur couple a une proteine g
WO2019069885A1 (ja) 2017-10-02 2019-04-11 コニカミノルタ株式会社 アナライトの検出方法
WO2019159109A1 (en) 2018-02-15 2019-08-22 Societe Des Produits Nestle S.A. Analyzer
JP2021514052A (ja) 2018-02-15 2021-06-03 プロサイズディーエックス インコーポレーテッド アッセイキュベット
CA3093247A1 (en) 2018-03-07 2019-09-12 Lumiphore, Inc. Macrocyclic ligands with pendant chelating moieties and complexes thereof
ES2859775T3 (es) 2018-07-05 2021-10-04 Univ Strasbourg Nanopartículas de lantánido luminiscentes ultrabrillantes que comprenden terbio, con una mayor vida útil de estado excitado
FR3084365B1 (fr) 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
EP3880838A4 (de) 2018-11-15 2022-11-02 The Board of Trustees of the Leland Stanford Junior University Zusammensetzungen und verfahren zur prognose und klassifizierung von präeklampsie
FR3092172B1 (fr) 2019-01-30 2021-02-12 Cisbio Bioassays Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP
WO2020232262A1 (en) 2019-05-16 2020-11-19 Procisedx Inc. Assay detection methods for vcam-1 and calprotectin
WO2020232295A1 (en) 2019-05-16 2020-11-19 Procisedx Inc. An assay method for the detection of vcam-1 and alpha-2-macroglobulin in blood
WO2020236528A1 (en) 2019-05-23 2020-11-26 Procisedx Inc. Assay methods for the detection of human serum albumin, vitamin d, c-reactive protein, and anti-transglutaminase autoantibody
US20230021481A1 (en) 2019-12-06 2023-01-26 Otsuka Pharmaceutical Co., Ltd. Standard substance for psa quantification, preparation method therefor, standard solution for psa quantification, and psa quantification method
EP4073066A4 (de) * 2019-12-13 2023-12-27 University of Pittsburgh - of the Commonwealth System of Higher Education Lanthanidverbindungen für die lumineszenz-einschalt-detektion
WO2021242725A1 (en) 2020-05-28 2021-12-02 Procisedx Inc. Predetermined calibration curve
EP4343775A1 (de) 2022-09-22 2024-03-27 SurgeCare Verfahren zur bestimmung eines medizinischen ergebnisses für eine person, zugehöriges elektronisches system und computerprogramm

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2588265B3 (fr) * 1985-10-04 1988-01-15 Inst Francais Du Petrole Procede d'adoucissement d'une charge d'hydrocarbures contenant des produits soufres
SE8703682L (sv) * 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
AU9163491A (en) 1990-12-17 1992-07-22 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Derivatized tris-catechol chelating agents
DE4222255A1 (de) * 1992-07-07 1994-01-13 Bayer Ag Fotochemische Markierung von Nukleinsäuren mit Europiumchelat-Reagenzien und ihre Verwendung in Gensondentestsystemen
DE19525924A1 (de) 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19728021A1 (de) * 1997-07-01 1999-01-07 Clariant Gmbh Metall-Komplexe als Bleichaktivatoren
WO2000048991A1 (en) * 1999-02-18 2000-08-24 The Regents Of The University Of California Salicylamide-lanthanide complexes for use as luminescent markers
JP4819223B2 (ja) * 1999-02-18 2011-11-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 発光マーカーとして使用するためのフタルアミド−ランタニド錯体

Also Published As

Publication number Publication date
DE60012485D1 (de) 2004-09-02
US20080293155A1 (en) 2008-11-27
AU762754B2 (en) 2003-07-03
EP1154991B1 (de) 2004-07-28
DK1154991T3 (da) 2004-11-22
US20060286567A1 (en) 2006-12-21
AU3600600A (en) 2000-09-04
US7404912B2 (en) 2008-07-29
US6406297B1 (en) 2002-06-18
JP4943585B2 (ja) 2012-05-30
WO2000048991A1 (en) 2000-08-24
EP1154991A1 (de) 2001-11-21
US20030027189A1 (en) 2003-02-06
CA2371818A1 (en) 2000-08-24
CA2371818C (en) 2009-01-06
JP2003535812A (ja) 2003-12-02
DE60012485T2 (de) 2005-08-18
US7018850B2 (en) 2006-03-28

Similar Documents

Publication Publication Date Title
ATE272049T1 (de) Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker
ATE285394T1 (de) Phthalamid-lanthanid komplexe zur verwendung als lumineszenzmarker
ATE277058T1 (de) Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel
MXPA03006055A (es) Nuevos compuestos de n-fenilpirrolbisfosfano y sus complejos de metal.
DK1706452T3 (da) Aromatiske triamid-lanthanidkomplekser
CA2457584A1 (en) Enhancing solubility of iron amino acid chelates and iron proteinates
ATE227297T1 (de) 2-pyridylmethylen-polyazamacrocyclophosphonsäur n,ihre komplexe und derivate zur verwendung als kontrastmittel
CY1105386T1 (el) Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου
MX2007003470A (es) Compuestos de carbonilo los cuales pueden utilizarse como inhibidores del factor de coagulacion xa.
DE69807558D1 (de) Chelatkomplexe paramagnetischer Metalle mit niedriger Toxizität
ATE342896T1 (de) Fluoreszierende proben zur quantitativen bestimmung von zink
DE60110558D1 (de) Konjugate von gallensäure mit metallbindenden chelatverbdingungen und die verwendung davon
DE69822162D1 (de) Neue tetrazolderivate
BR0008761A (pt) Material eletroluminescente e dispositivoeletroluminescente
DE60014267D1 (de) Magnet aus seltenen erdmetallen für mri abtaster hergestellt aus aufbereitetem, pr-nd enthaltendem erzresiduum
BRPI0410635A (pt) isÈmeros enriquecidos e opticamente puros de ligantes de quelação e agentes de contraste
EP0943620A3 (de) Betulinsauer Derivate zur Hemmung von Krebswachstum
EP1226153A4 (de) Fluoreszierende cobalamine und deren verwendung
ATE287403T1 (de) 6-phenylbenzonaphthyidine
DE59709024D1 (de) Pseudopolyrotaxane
PT920413E (pt) Reagentes complexantes e complexos com compostos boronicos
YU36104A (sh) Kristalna struktura fosfodiesteraza 5 i njihova upotreba
ATE271395T1 (de) Konjugate von gallensäure derivaten und metallionenchelatkomplexen und ihre verwendung zur beurteilung der microvaskulären permeabilität
DE60313331D1 (de) Neue benzonaphthyridine

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1154991

Country of ref document: EP