ATE271395T1 - Konjugate von gallensäure derivaten und metallionenchelatkomplexen und ihre verwendung zur beurteilung der microvaskulären permeabilität - Google Patents

Konjugate von gallensäure derivaten und metallionenchelatkomplexen und ihre verwendung zur beurteilung der microvaskulären permeabilität

Info

Publication number
ATE271395T1
ATE271395T1 AT01940333T AT01940333T ATE271395T1 AT E271395 T1 ATE271395 T1 AT E271395T1 AT 01940333 T AT01940333 T AT 01940333T AT 01940333 T AT01940333 T AT 01940333T AT E271395 T1 ATE271395 T1 AT E271395T1
Authority
AT
Austria
Prior art keywords
bale
conjugates
metal ion
acid derivatives
microvascular permeability
Prior art date
Application number
AT01940333T
Other languages
English (en)
Inventor
Friedrich Cavagna
Timothy P L Roberts
Original Assignee
Bracco Imaging Spa
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa, Univ California filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE271395T1 publication Critical patent/ATE271395T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Steroid Compounds (AREA)
AT01940333T 2000-04-21 2001-04-17 Konjugate von gallensäure derivaten und metallionenchelatkomplexen und ihre verwendung zur beurteilung der microvaskulären permeabilität ATE271395T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000899A IT1318485B1 (it) 2000-04-21 2000-04-21 Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
PCT/EP2001/004324 WO2001082974A2 (en) 2000-04-21 2001-04-17 Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability

Publications (1)

Publication Number Publication Date
ATE271395T1 true ATE271395T1 (de) 2004-08-15

Family

ID=11444911

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01940333T ATE271395T1 (de) 2000-04-21 2001-04-17 Konjugate von gallensäure derivaten und metallionenchelatkomplexen und ihre verwendung zur beurteilung der microvaskulären permeabilität

Country Status (12)

Country Link
US (2) US7128895B2 (de)
EP (1) EP1274465B1 (de)
JP (1) JP4786112B2 (de)
KR (1) KR100847912B1 (de)
AT (1) ATE271395T1 (de)
AU (2) AU7394601A (de)
CA (1) CA2406629C (de)
DE (1) DE60104409T2 (de)
HU (1) HU228437B1 (de)
IL (2) IL152344A0 (de)
IT (1) IT1318485B1 (de)
WO (1) WO2001082974A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
US7303741B2 (en) * 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
ATE411819T1 (de) * 2003-02-17 2008-11-15 Upperton Ltd Konjugate für medizinische abbildungen umfassend träger, targeting-anteile und kontrastmittel
CN102526103B (zh) * 2010-12-07 2013-11-13 西藏海思科药业集团股份有限公司 一种多种微量元素注射液药物组合物及其制备方法
EP2822605A1 (de) * 2012-03-05 2015-01-14 Bracco Imaging S.p.A Dynamisches kontrastverstärktes mrt-verfahren und mittel zur beurteilung des makromolekularen transports in pathologischen geweben
US10294265B1 (en) 2017-11-17 2019-05-21 International Business Machines Corporation Functionalized bile acids for therapeutic and material applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL91933A (en) 1988-10-11 1994-12-29 Univ Southern California Their immuno-bracelet and isophiles which are beneficial in increasing vascular permeability or blood supply to tumor or otherwise damaged tissue
NO940115D0 (no) * 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
IT1269839B (it) * 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
IT1304501B1 (it) 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
IT1317862B1 (it) * 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari

Also Published As

Publication number Publication date
EP1274465A2 (de) 2003-01-15
JP2003531870A (ja) 2003-10-28
US20070059246A1 (en) 2007-03-15
US7128895B2 (en) 2006-10-31
IT1318485B1 (it) 2003-08-25
WO2001082974A2 (en) 2001-11-08
IL152344A0 (en) 2003-05-29
EP1274465B1 (de) 2004-07-21
JP4786112B2 (ja) 2011-10-05
DE60104409T2 (de) 2005-08-11
ITMI20000899A0 (it) 2000-04-21
ITMI20000899A1 (it) 2001-10-21
CA2406629A1 (en) 2001-11-08
CA2406629C (en) 2009-10-13
IL152344A (en) 2007-10-31
US20030103904A1 (en) 2003-06-05
HU228437B1 (en) 2013-03-28
KR20020089494A (ko) 2002-11-29
HUP0300601A3 (en) 2010-03-29
DE60104409D1 (de) 2004-08-26
WO2001082974A3 (en) 2002-01-17
AU7394601A (en) 2001-11-12
KR100847912B1 (ko) 2008-07-22
HUP0300601A2 (hu) 2003-06-28
AU2001273946B2 (en) 2004-11-04

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