ATE267586T1 - An phosphocholin gebundene prodrug-derivate - Google Patents
An phosphocholin gebundene prodrug-derivateInfo
- Publication number
- ATE267586T1 ATE267586T1 AT00908713T AT00908713T ATE267586T1 AT E267586 T1 ATE267586 T1 AT E267586T1 AT 00908713 T AT00908713 T AT 00908713T AT 00908713 T AT00908713 T AT 00908713T AT E267586 T1 ATE267586 T1 AT E267586T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- unsubstituted
- compounds
- phosphocholine
- substituent
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical group C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Anesthesiology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12048399P | 1999-02-18 | 1999-02-18 | |
| PCT/US2000/004140 WO2000048572A1 (en) | 1999-02-18 | 2000-02-16 | Phosphocholine linked prodrug derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267586T1 true ATE267586T1 (de) | 2004-06-15 |
Family
ID=22390592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00908713T ATE267586T1 (de) | 1999-02-18 | 2000-02-16 | An phosphocholin gebundene prodrug-derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7060290B1 (de) |
| EP (1) | EP1161226B1 (de) |
| JP (1) | JP2002537243A (de) |
| AT (1) | ATE267586T1 (de) |
| AU (1) | AU3000800A (de) |
| DE (1) | DE60011053T2 (de) |
| WO (1) | WO2000048572A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003026632A2 (en) | 2001-09-26 | 2003-04-03 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
| PL373850A1 (en) * | 2002-04-08 | 2005-09-19 | Guilford Pharmaceuticals, Inc. | Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same |
| EP1587818A4 (de) | 2003-01-21 | 2010-10-13 | Merck Sharp & Dohme | 17-carbomoyloxycortisolderivate als selektive modulatoren des glucocorticoidrezeptors |
| ZA200504940B (en) * | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| US7230003B2 (en) | 2003-09-09 | 2007-06-12 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
| EP1744785A1 (de) * | 2004-04-30 | 2007-01-24 | Kopran Research Laboratories Limited | Hydroxyalkylderivate von biologischen wirkstoffen |
| DE602005010270D1 (de) | 2004-07-12 | 2008-11-20 | Xenoport Inc | Von aminosäuren abgeleitete prodrugs von propofolzusammensetzungen und anwendungen davon |
| WO2006017351A1 (en) * | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
| JP2008525501A (ja) | 2004-12-23 | 2008-07-17 | ゼノポート，インコーポレイティド | セリンアミノ酸誘導のプロポフォールのプロドラッグ、その使用及び結晶体 |
| US7208611B2 (en) | 2005-02-23 | 2007-04-24 | Xenoport, Inc. | Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use |
| AU2006327892B2 (en) * | 2005-12-19 | 2011-12-22 | Methylgene Inc. | Histone deacetylase inhibitors for enhancing activity of antifungal agents |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| JP2010513326A (ja) | 2006-12-19 | 2010-04-30 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ |
| NZ580752A (en) | 2007-05-09 | 2012-03-30 | Pharmacofore Inc | Stereoisomers propofol therapeutic compounds |
| CA2685813A1 (en) | 2007-05-09 | 2008-11-20 | Pharmacofore, Inc. | Therapeutic compounds |
| AU2009305563C1 (en) | 2008-10-17 | 2015-09-03 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| US9493477B2 (en) | 2009-09-08 | 2016-11-15 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
| US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| EP2560486B1 (de) | 2010-04-21 | 2018-11-21 | Signature Therapeutics, Inc. | Zusammensetzungen aus enzymspaltbaren amphetamin-prodrugs und hemmern dafür |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| CN101906039B (zh) * | 2010-06-23 | 2013-05-08 | 四川大学华西医院 | 取代苯酚的羟基酸酯化合物、制备方法及在药物中的应用 |
| CN101885735B (zh) * | 2010-06-23 | 2012-09-12 | 四川大学华西医院 | 取代苯酚羟基酸酯的磷酸酯化合物、制备方法及在药物中的应用 |
| WO2012096886A1 (en) | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| ES2584634T3 (es) | 2011-01-11 | 2016-09-28 | Signature Therapeutics, Inc. | Composiciones que comprenden un profármaco de oxicodona escindible enzimáticamente |
| AU2012225337B2 (en) | 2011-03-09 | 2016-04-28 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| JP6049712B2 (ja) | 2011-07-08 | 2016-12-21 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ | 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子 |
| JP6547755B2 (ja) * | 2014-10-15 | 2019-07-24 | 日油株式会社 | ホスホリルコリン基含有化合物およびホスホリルコリン複合体 |
| SI3229810T1 (sl) * | 2014-11-17 | 2021-01-29 | Cellestar Biosciences, Inc. | Analogi fosfolipidnega etra kot vehikli zdravil, usmerjenih proti raku |
| US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
| US9808452B2 (en) | 2015-10-01 | 2017-11-07 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| EP3439666A4 (de) * | 2016-05-20 | 2019-12-11 | The University of Chicago | Nanopartikel zur chemotherapie, gezielte therapie, photodynamische therapie, immuntherapie und alle kombinationen davon |
| WO2018170465A1 (en) | 2017-03-17 | 2018-09-20 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US11826426B2 (en) | 2017-08-02 | 2023-11-28 | The University Of Chicago | Nanoscale metal-organic layers and metal-organic nanoplates for x-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| US11547714B2 (en) | 2020-02-05 | 2023-01-10 | Epalex Corporation | Fospropofol salts, methods and compositions |
| US11478490B1 (en) | 2021-03-30 | 2022-10-25 | Epalex Corporation | Fospropofol formulations |
| US11628178B2 (en) | 2019-03-26 | 2023-04-18 | Epalex Corporation | Fospropofol methods and compositions |
| US11439653B1 (en) | 2021-03-30 | 2022-09-13 | Epalex Corporation | Fospropofol formulations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534499A (en) * | 1994-05-19 | 1996-07-09 | The University Of British Columbia | Lipophilic drug derivatives for use in liposomes |
| HUT77514A (hu) * | 1994-11-30 | 1998-05-28 | Amur Research Corp. | Gyógyszerhatóanyagok foszfokolinszármazékai |
| JP2002514183A (ja) | 1996-09-17 | 2002-05-14 | スーパージェン・インコーポレーテッド | リン脂質薬剤誘導体 |
| US5830432A (en) * | 1997-03-31 | 1998-11-03 | Amur Pharmacuticals, Inc. | Phospholipid drug derivatives |
| US5776915A (en) * | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
| EP1150685A4 (de) * | 1999-02-03 | 2005-06-15 | Supergen Inc | Oberflächenaktive phosphocholine und deren verwendung |
-
2000
- 2000-02-16 WO PCT/US2000/004140 patent/WO2000048572A1/en active IP Right Grant
- 2000-02-16 AU AU30008/00A patent/AU3000800A/en not_active Abandoned
- 2000-02-16 DE DE60011053T patent/DE60011053T2/de not_active Expired - Fee Related
- 2000-02-16 US US09/890,006 patent/US7060290B1/en not_active Expired - Fee Related
- 2000-02-16 EP EP00908713A patent/EP1161226B1/de not_active Expired - Lifetime
- 2000-02-16 AT AT00908713T patent/ATE267586T1/de not_active IP Right Cessation
- 2000-02-16 JP JP2000599364A patent/JP2002537243A/ja active Pending
-
2006
- 2006-03-21 US US11/386,991 patent/US20060166903A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60011053T2 (de) | 2005-05-25 |
| US7060290B1 (en) | 2006-06-13 |
| EP1161226A4 (de) | 2002-04-10 |
| US20060166903A1 (en) | 2006-07-27 |
| EP1161226A1 (de) | 2001-12-12 |
| JP2002537243A (ja) | 2002-11-05 |
| EP1161226B1 (de) | 2004-05-26 |
| DE60011053D1 (de) | 2004-07-01 |
| AU3000800A (en) | 2000-09-04 |
| WO2000048572A1 (en) | 2000-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |