ATE26263T1 - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel. - Google Patents

1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.

Info

Publication number
ATE26263T1
ATE26263T1 AT83105610T AT83105610T ATE26263T1 AT E26263 T1 ATE26263 T1 AT E26263T1 AT 83105610 T AT83105610 T AT 83105610T AT 83105610 T AT83105610 T AT 83105610T AT E26263 T1 ATE26263 T1 AT E26263T1
Authority
AT
Austria
Prior art keywords
sub
hydrogen
lower alkyl
same
tetrahydro
Prior art date
Application number
AT83105610T
Other languages
German (de)
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Larry Davis
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE26263T1 publication Critical patent/ATE26263T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT83105610T 1982-06-14 1983-06-08 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel. ATE26263T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof
EP83105610A EP0096838B1 (en) 1982-06-14 1983-06-08 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments

Publications (1)

Publication Number Publication Date
ATE26263T1 true ATE26263T1 (de) 1987-04-15

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83105610T ATE26263T1 (de) 1982-06-14 1983-06-08 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.

Country Status (17)

Country Link
US (1) US4988690A (forum.php)
EP (1) EP0096838B1 (forum.php)
JP (1) JPS595165A (forum.php)
KR (1) KR900001214B1 (forum.php)
AT (1) ATE26263T1 (forum.php)
AU (1) AU570920B2 (forum.php)
CA (1) CA1214460A (forum.php)
DE (1) DE3370621D1 (forum.php)
DK (1) DK270983A (forum.php)
ES (1) ES8503666A1 (forum.php)
FI (1) FI78473C (forum.php)
GR (1) GR78291B (forum.php)
HU (1) HU190902B (forum.php)
IE (1) IE55404B1 (forum.php)
IL (1) IL68964A (forum.php)
PT (1) PT76864B (forum.php)
ZA (1) ZA834309B (forum.php)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27337A (en) * 1987-03-27 1993-06-08 Schering Corp Substituted benzazepines their preparation and pharmaceutical compositions containing them
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
CA1327795C (en) * 1987-08-14 1994-03-15 Jules Freedman Antidepressants which are aryloxy inadanamines
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
AU2002228725A1 (en) * 2000-11-30 2002-06-11 Advanced Research And Technology Institute, Inc. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
SI2332921T1 (sl) * 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
CN1805939B (zh) * 2003-06-17 2010-10-13 艾尼纳制药公司 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
RS50996B (sr) 2004-12-21 2010-10-31 Arena Pharmaceuticals Inc. Kristalni oblici (r)-8-hloro-1-metil-2,3,4,5-tetrahidro-1h-benzazepin hlorhidrat
CA2588941A1 (en) 2004-12-23 2006-07-06 Arena Pharmaceuticals, Inc. 5ht2c receptor modulator compositions and methods of use
EP2518053A1 (en) 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
ES2522587T3 (es) * 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
MX2009011922A (es) 2007-05-10 2009-11-18 Amr Technology Inc Tetrahidrobenzazepinas ariloxi- y heteroariloxi-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.
CN102015591B (zh) 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
SG10201506896RA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
JP6272695B2 (ja) 2010-09-01 2018-01-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
RU2674670C1 (ru) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Способ коррекции массы тела

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
GR78291B (forum.php) 1984-09-26
PT76864B (en) 1986-02-27
JPS595165A (ja) 1984-01-12
FI832092L (fi) 1983-12-15
ZA834309B (en) 1984-03-28
EP0096838B1 (en) 1987-04-01
DK270983A (da) 1983-12-15
IE55404B1 (en) 1990-09-12
IL68964A (en) 1988-03-31
PT76864A (en) 1983-07-01
KR900001214B1 (ko) 1990-02-28
FI78473B (fi) 1989-04-28
IL68964A0 (en) 1983-10-31
DE3370621D1 (en) 1987-05-07
CA1214460A (en) 1986-11-25
AU1576483A (en) 1983-12-22
US4988690A (en) 1991-01-29
JPH0365342B2 (forum.php) 1991-10-11
IE831384L (en) 1983-12-14
KR840005103A (ko) 1984-11-03
FI832092A0 (fi) 1983-06-10
EP0096838A1 (en) 1983-12-28
DK270983D0 (da) 1983-06-13
AU570920B2 (en) 1988-03-31
FI78473C (fi) 1989-08-10
ES523191A0 (es) 1985-03-01
HU190902B (en) 1986-12-28
ES8503666A1 (es) 1985-03-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee