ATE253906T1 - Neue starke induktoren der terminalen differenzierung und verfahren für ihre verwendung - Google Patents

Neue starke induktoren der terminalen differenzierung und verfahren für ihre verwendung

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Publication number
ATE253906T1
ATE253906T1 AT95921378T AT95921378T ATE253906T1 AT E253906 T1 ATE253906 T1 AT E253906T1 AT 95921378 T AT95921378 T AT 95921378T AT 95921378 T AT95921378 T AT 95921378T AT E253906 T1 ATE253906 T1 AT E253906T1
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Austria
Prior art keywords
terminal differentiation
methods
compounds
different
new powerful
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AT95921378T
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English (en)
Inventor
Ronald Breslow
Paul A Marks
Richard A Rifkind
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Sloan Kettering Inst Cancer
Univ Columbia
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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AT95921378T 1994-05-19 1995-05-19 Neue starke induktoren der terminalen differenzierung und verfahren für ihre verwendung ATE253906T1 (de)

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US08/246,363 US5700811A (en) 1991-10-04 1994-05-19 Potent inducers of terminal differentiation and method of use thereof
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EP0760657B9 (de) 2004-08-11
WO1995031977A1 (en) 1995-11-30
ES2210293T3 (es) 2004-07-01
EP0760657B1 (de) 2003-11-12
DE69532118D1 (de) 2003-12-18
AU2647495A (en) 1995-12-18
EP0760657A1 (de) 1997-03-12
CA2190765C (en) 2007-04-17
AU692561B2 (en) 1998-06-11
DE69532118T2 (de) 2004-07-22
US5700811A (en) 1997-12-23
CA2190765A1 (en) 1995-11-30

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