ATE244574T1 - Verfahren zur verbesserten funktionelle erholung der motorische koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns - Google Patents
Verfahren zur verbesserten funktionelle erholung der motorische koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des znsInfo
- Publication number
- ATE244574T1 ATE244574T1 AT97917532T AT97917532T ATE244574T1 AT E244574 T1 ATE244574 T1 AT E244574T1 AT 97917532 T AT97917532 T AT 97917532T AT 97917532 T AT97917532 T AT 97917532T AT E244574 T1 ATE244574 T1 AT E244574T1
- Authority
- AT
- Austria
- Prior art keywords
- morphogens
- nervous system
- central nervous
- morphogen
- ischemia
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Control Of Electric Motors In General (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Protection Of Generators And Motors (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62044496A | 1996-03-22 | 1996-03-22 | |
| PCT/US1997/004177 WO1997034626A1 (en) | 1996-03-22 | 1997-03-21 | Methods for enhancing functional recovery following central nervous system ischemia or trauma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244574T1 true ATE244574T1 (de) | 2003-07-15 |
Family
ID=24485972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97917532T ATE244574T1 (de) | 1996-03-22 | 1997-03-21 | Verfahren zur verbesserten funktionelle erholung der motorische koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns |
| AT03010945T ATE493141T1 (de) | 1996-03-22 | 1997-03-21 | Verfahren zur verbesserten funktionellen erholung der motorischen koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03010945T ATE493141T1 (de) | 1996-03-22 | 1997-03-21 | Verfahren zur verbesserten funktionellen erholung der motorischen koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6214796B1 (OSRAM) |
| EP (3) | EP1364655B1 (OSRAM) |
| JP (2) | JP4847634B2 (OSRAM) |
| KR (1) | KR20000064752A (OSRAM) |
| CN (1) | CN1181885C (OSRAM) |
| AT (2) | ATE244574T1 (OSRAM) |
| AU (2) | AU725341B2 (OSRAM) |
| CA (2) | CA2249368A1 (OSRAM) |
| DE (2) | DE69740089D1 (OSRAM) |
| ES (1) | ES2201287T5 (OSRAM) |
| WO (2) | WO1997034618A1 (OSRAM) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| EP0698094B1 (en) | 1993-05-12 | 2004-02-04 | Genetics Institute, LLC | Bmp-11 compositions |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| JP3717930B2 (ja) | 1993-12-07 | 2005-11-16 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | Bmp−12、bmp−13およびそれらの腱誘導組成物 |
| US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| AU5244998A (en) * | 1996-11-15 | 1998-06-03 | Creative Biomolecules, Inc. | Morphogen-induced regeneration of sense perceptory tissues |
| DK0980252T3 (da) * | 1997-05-05 | 2005-01-31 | Curis Inc | Terapier til akut nyresvigt |
| JP2001526788A (ja) * | 1997-05-30 | 2001-12-18 | クリエイティブ バイオモレキュールズ,インコーポレイテッド | 組織形態形成および活性を評価するための方法 |
| WO1999028341A2 (en) * | 1997-12-04 | 1999-06-10 | Creative Biomolecules, Inc. | Maintenance of smooth muscle integrity by morphogenic proteins |
| US20030170213A1 (en) * | 1998-01-23 | 2003-09-11 | Marc F. Charette | Methods and compositions for enhancing cognitive function using morphogenic proteins |
| US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| DE19837230A1 (de) * | 1998-08-17 | 2000-03-09 | Jean Krutmann | Neurotrophin-4 zur Behandlung von Tumoren neuroektodermalen Ursprungs |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| US6749850B1 (en) | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| JP2003507349A (ja) * | 1999-08-18 | 2003-02-25 | ザ ゼネラル ホスピタル コーポレーション | 中枢神経系への損傷からの回復を促進する方法、組成物およびキット |
| ATE271886T1 (de) | 1999-10-15 | 2004-08-15 | Inst Genetics Llc | Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine |
| US7060676B2 (en) * | 1999-12-20 | 2006-06-13 | Trustees Of Tufts College | T. cruzi-derived neurotrophic agents and methods of use therefor |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| AU2001268147B2 (en) * | 2000-06-01 | 2006-05-04 | Children's Medical Center Corporation | Methods and compositions for producing a neurosalutary effect in a subject |
| US6855690B2 (en) | 2000-06-01 | 2005-02-15 | Children's Medical Center Corporation | Methods and compositions for treating ocular disorders |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| EP1399023B1 (en) | 2001-06-01 | 2008-04-30 | Wyeth | COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9; |
| KR20040048379A (ko) * | 2001-06-01 | 2004-06-09 | 싸이트 테라피스 인코포레이티드 | T 세포 유도된 조직 복구 및 재생 |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US20060259014A1 (en) | 2002-05-22 | 2006-11-16 | Surgimark, Inc. | Aspirator sleeve and suction handle |
| US20040229292A1 (en) * | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
| DE60331584D1 (de) | 2002-11-26 | 2010-04-15 | Biocon Ltd | Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen |
| EP1623017B1 (en) | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| CA2897218A1 (en) | 2004-06-17 | 2006-01-26 | Thrasos Innovation, Inc. | Tdf-related compounds and analogs thereof |
| EP1766077B1 (en) * | 2004-06-21 | 2012-03-28 | The Board Of Trustees Of The Leland Stanford Junior University | Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder |
| WO2006012365A2 (en) * | 2004-07-20 | 2006-02-02 | University Of Maryland | Protease inhibitor |
| EP1782821A4 (en) * | 2004-07-29 | 2009-11-11 | Anges Mg Inc | MEDICAMENT AND METHOD FOR IMPROVING BRAIN FUNCTION |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| GB0425625D0 (en) * | 2004-11-22 | 2004-12-22 | Royal College Of Surgeons Ie | Treatment of disease |
| SI2497780T1 (sl) | 2005-09-20 | 2015-08-31 | Thrasos Innovation, Inc. | Spojine, povezane s TDF, in njihovi analogi |
| US20090233842A1 (en) | 2005-11-12 | 2009-09-17 | Prtzker Neuropsychiatric Research Fund Llc | Fgf2-related methods for diagnosing and treating depression |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| EP2121142B1 (en) * | 2007-01-25 | 2013-04-03 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Use of gdf-5 for the improvement or maintenance of dermal appearance |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| US7947649B2 (en) * | 2008-04-14 | 2011-05-24 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered GDF-5 formulations |
| AU2010213591B2 (en) * | 2009-02-12 | 2013-11-21 | Stryker Corporation | Compositions and methods for minimally-invasive systemic delivery of proteins including TGF-beta superfamily members |
| CN102369016A (zh) * | 2009-02-12 | 2012-03-07 | 史赛克公司 | 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用 |
| WO2010103070A2 (en) | 2009-03-12 | 2010-09-16 | Charité - Universitätsmedizin Berlin | Bone morphogenetic protein 2 (bmp2) variants with reduced bmp antagonist sensitivity |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| WO2011035094A1 (en) | 2009-09-17 | 2011-03-24 | Stryker Corporation | Buffers for controlling the ph of bone morphogenetic proteins |
| CA2785038A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
| CN101822815A (zh) * | 2010-04-29 | 2010-09-08 | 广东八加一医药有限公司 | 系列多肽小分子在制备防治缺血性脑血管疾病药物中的应用 |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| AU2011292810B2 (en) | 2010-08-20 | 2015-04-30 | Wyeth Llc | Designer osteogenic proteins |
| US9700596B2 (en) | 2011-03-04 | 2017-07-11 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
| KR101274930B1 (ko) * | 2011-06-03 | 2013-06-17 | 전남대학교산학협력단 | 골 형성 또는 혈관신생 촉진용 펩타이드 bfp 4 및 이의 용도 |
| HK1198333A1 (zh) * | 2011-07-19 | 2015-04-02 | Thrasos Innovation, Inc. | 抗纤维化肽及其在用於治疗以纤维化为特徵的疾病和病症的方法中的用途 |
| EP2784083A1 (en) | 2013-03-28 | 2014-10-01 | Charité - Universitätsmedizin Berlin | Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity |
| EP2981822B1 (en) | 2013-05-06 | 2020-09-02 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
| US20160220640A1 (en) * | 2013-06-11 | 2016-08-04 | The Brigham And Women's Hospital, Inc. | Methods and compositions for increasing neurogenesis and angiogenesis |
| US11241505B2 (en) | 2015-02-13 | 2022-02-08 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| US10576167B2 (en) | 2016-08-17 | 2020-03-03 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| WO2020010180A1 (en) * | 2018-07-03 | 2020-01-09 | Cardio Vascular Bio Therapeutics, Inc. | Compositions and methods for treating stroke |
| US20230095167A1 (en) * | 2020-02-20 | 2023-03-30 | Universiteit Maastricht | Detection method of circulating bmp10 (bone morphogenetic protein 10) |
| EP4154001A4 (en) * | 2020-05-19 | 2024-06-05 | Elevian, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF STROKE |
| WO2024259004A1 (en) * | 2023-06-13 | 2024-12-19 | Bedford Research Foundation | Systems and methods of cell transport at ambient temperature |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440860A (en) | 1980-01-18 | 1984-04-03 | The Children's Medical Center Corporation | Stimulating cell growth |
| US4296100A (en) | 1980-06-30 | 1981-10-20 | Franco Wayne P | Method of treating the heart for myocardial infarction |
| US4378347A (en) * | 1980-06-30 | 1983-03-29 | Franco Wayne P | Composition for treating the heart for myocardial infarction |
| DE3110560A1 (de) | 1981-03-18 | 1982-10-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben" |
| EP0105014B1 (en) | 1982-09-24 | 1992-05-20 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Repair of tissue in animals |
| US4971952A (en) | 1986-03-06 | 1990-11-20 | Collagen Corporation | Method of treating inflammation with cartilage inducing factor |
| US4806523A (en) | 1985-08-06 | 1989-02-21 | Collagen Corporation | Method of treating inflammation |
| US4994559A (en) * | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
| IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US4801575A (en) | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| CA1322714C (en) | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
| EP0269408A3 (en) | 1986-11-26 | 1989-08-30 | Genentech, Inc. | Tgf-beta in the treatment of inflammatory disorders |
| US4797277A (en) | 1987-09-22 | 1989-01-10 | Pharmacia Ab | Method for reperfusion therapy |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5108753A (en) | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
| JPH0262829A (ja) | 1988-05-18 | 1990-03-02 | Nippon Kayaku Co Ltd | 虚血に基づく傷害の予防及び治療剤 |
| US4983581A (en) | 1988-05-20 | 1991-01-08 | Institute Of Molecular Biology, Inc. | Wound healing composition of IGF-I and TGF-β |
| HU201095B (en) | 1988-06-14 | 1990-09-28 | Richter Gedeon Vegyeszet | New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions |
| WO1990000619A1 (en) | 1988-07-08 | 1990-01-25 | University College London | Analysis of cell modifying substances |
| WO1990000900A1 (en) | 1988-07-20 | 1990-02-08 | Amgen Inc. | Method of treating inflammatory disorders by reducing phagocyte activation |
| US5057494A (en) | 1988-08-03 | 1991-10-15 | Ethicon, Inc. | Method for preventing tissue damage after an ischemic episode |
| US5106626A (en) | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
| US5135915A (en) | 1988-10-14 | 1992-08-04 | Genentech, Inc. | Method for the treatment of grafts prior to transplantation using TGF-.beta. |
| US5011914A (en) | 1989-01-05 | 1991-04-30 | Collins Franklin D | Purified ciliary neurotrophic factor |
| US5002965A (en) | 1989-05-09 | 1991-03-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Use of ginkgolides to prevent reperfusion injury in organ transplantation |
| US5118791A (en) | 1989-05-25 | 1992-06-02 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
| IL97365A0 (en) * | 1991-02-27 | 1992-05-25 | Yeda Res & Dev | Pharmaceutical compositions comprising a lymphokine |
| US5158934A (en) | 1989-09-01 | 1992-10-27 | Genentech, Inc. | Method of inducing bone growth using TGF-β |
| DK0448704T3 (da) | 1989-10-17 | 1999-04-06 | Stryker Corp | Osteogene anordninger |
| US5108989A (en) | 1990-04-04 | 1992-04-28 | Genentech, Inc. | Method of predisposing mammals to accelerated tissue repair |
| ATE184052T1 (de) | 1990-06-15 | 1999-09-15 | Carnegie Inst Of Washington | Gdf-1 und uog1 proteine |
| DE69133338T2 (de) | 1990-09-26 | 2004-04-15 | Genetics Institute, LLC, Cambridge | Bmp-5-derivate |
| AU663689B2 (en) | 1990-10-18 | 1995-10-19 | Stryker Corporation | Osteogenic peptides |
| AU660635B2 (en) | 1990-11-16 | 1995-07-06 | Celtrix Pharmaceuticals, Inc. | A beta-type transforming growth factor |
| WO1992009301A1 (en) | 1990-11-27 | 1992-06-11 | The American National Red Cross | Tissue sealant and growth factor containing compositions that promote accelerated wound healing |
| JP3356775B2 (ja) | 1990-11-30 | 2002-12-16 | セルトリックス ファーマシューティカルズ, インコーポレイテッド | TGF―βとの共同的組合せによる骨修復のための骨形成タンパク質の使用 |
| JP3627985B2 (ja) * | 1991-03-11 | 2005-03-09 | キュリス インコーポレイテッド | タンパク質により誘導される形態形成 |
| US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
| CA2102808A1 (en) | 1991-05-10 | 1992-11-11 | Hanne Bentz | Targeted delivery of bone growth factors |
| EP0542971A1 (en) | 1991-05-10 | 1993-05-26 | The Salk Institute For Biological Studies | CLONING AND RECOMBINANT PRODUCTION OF RECEPTOR(S) OF THE ACTIVIN/TGF-$g(b) SUPERFAMILY |
| US5597897A (en) | 1991-06-21 | 1997-01-28 | Genetics Institute, Inc. | Pharmaceutical formulations of osteogenic proteins |
| CA2108770C (en) | 1991-06-25 | 2007-04-03 | John M. Wozney | Bmp-9 compositions |
| ES2149776T5 (es) | 1991-08-30 | 2004-07-01 | Curis, Inc. | Modulacion, inducida por un morfogeno, de la respuesta inflamatoria. |
| JP3616089B2 (ja) | 1991-08-30 | 2005-02-02 | キュリス インコーポレイテッド | 形態形成誘導蛋白のスクリーニング方法 |
| ATE308336T1 (de) | 1991-08-30 | 2005-11-15 | Curis Inc | Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten |
| DE69233022T2 (de) | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US5733871A (en) * | 1991-11-08 | 1998-03-31 | The General Hospital Corporation | Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration |
| JP4101284B2 (ja) | 1991-11-22 | 2008-06-18 | ジェネンテック・インコーポレーテッド | 神経損傷を改善するtgf−beta |
| DE19525416A1 (de) † | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
| AU681594B2 (en) * | 1992-07-31 | 1997-09-04 | Stryker Corporation | Morphogen-induced nerve regeneration and repair |
| ES2061380B1 (es) * | 1992-11-23 | 1995-07-01 | Boehringer Ingelheim Espana | Empleo del factor de crecimiento fibroblastico y sus derivados como neuroprotectores y neuromoduladores. |
| JPH09501932A (ja) † | 1993-08-26 | 1997-02-25 | ジェネティックス・インスティテュート・インコーポレイテッド | ヒト・骨形態形成蛋白を用いる神経再生 |
| AU7605394A (en) | 1993-09-03 | 1995-03-22 | Regents Of The University Of California, The | Neural tissue affecting factor and compositions |
| CA2174098C (en) | 1993-10-14 | 2011-01-25 | Douglas A. Melton | Method of inducing and maintaining neuronal cells |
| WO1995024474A1 (en) | 1994-03-10 | 1995-09-14 | Human Genome Sciences, Inc. | Bone morphogenic protein-10 |
| AU5244998A (en) * | 1996-11-15 | 1998-06-03 | Creative Biomolecules, Inc. | Morphogen-induced regeneration of sense perceptory tissues |
-
1997
- 1997-03-21 US US08/822,455 patent/US6214796B1/en not_active Expired - Fee Related
- 1997-03-21 WO PCT/US1997/005071 patent/WO1997034618A1/en not_active Ceased
- 1997-03-21 JP JP53358397A patent/JP4847634B2/ja not_active Expired - Fee Related
- 1997-03-21 DE DE69740089T patent/DE69740089D1/de not_active Expired - Lifetime
- 1997-03-21 WO PCT/US1997/004177 patent/WO1997034626A1/en not_active Ceased
- 1997-03-21 US US08/828,281 patent/US6407060B1/en not_active Expired - Lifetime
- 1997-03-21 AT AT97917532T patent/ATE244574T1/de not_active IP Right Cessation
- 1997-03-21 JP JP9533791A patent/JP2000507939A/ja not_active Withdrawn
- 1997-03-21 EP EP03010945A patent/EP1364655B1/en not_active Expired - Lifetime
- 1997-03-21 CA CA002249368A patent/CA2249368A1/en not_active Abandoned
- 1997-03-21 CA CA2249596A patent/CA2249596C/en not_active Expired - Fee Related
- 1997-03-21 EP EP97917532A patent/EP0894004B2/en not_active Expired - Lifetime
- 1997-03-21 EP EP97917091A patent/EP0904093A4/en not_active Withdrawn
- 1997-03-21 AU AU25823/97A patent/AU725341B2/en not_active Ceased
- 1997-03-21 ES ES97917532T patent/ES2201287T5/es not_active Expired - Lifetime
- 1997-03-21 KR KR1019980707507A patent/KR20000064752A/ko not_active Ceased
- 1997-03-21 CN CNB97194749XA patent/CN1181885C/zh not_active Expired - Fee Related
- 1997-03-21 AU AU25529/97A patent/AU734312B2/en not_active Ceased
- 1997-03-21 DE DE69723429T patent/DE69723429T3/de not_active Expired - Lifetime
- 1997-03-21 AT AT03010945T patent/ATE493141T1/de not_active IP Right Cessation
-
2001
- 2001-04-10 US US09/833,096 patent/US20010039261A1/en not_active Abandoned
-
2002
- 2002-02-01 US US10/062,370 patent/US20030022830A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000507939A (ja) | 2000-06-27 |
| US20010039261A1 (en) | 2001-11-08 |
| AU2552997A (en) | 1997-10-10 |
| EP1364655A1 (en) | 2003-11-26 |
| US6407060B1 (en) | 2002-06-18 |
| DE69723429T2 (de) | 2004-04-22 |
| WO1997034626A1 (en) | 1997-09-25 |
| CN1219133A (zh) | 1999-06-09 |
| DE69723429T3 (de) | 2007-09-20 |
| JP4847634B2 (ja) | 2011-12-28 |
| ES2201287T3 (es) | 2004-03-16 |
| EP0904093A1 (en) | 1999-03-31 |
| EP0894004A1 (en) | 1999-02-03 |
| ATE493141T1 (de) | 2011-01-15 |
| JP2000506894A (ja) | 2000-06-06 |
| DE69740089D1 (de) | 2011-02-10 |
| CA2249596C (en) | 2011-11-08 |
| ES2201287T5 (es) | 2007-10-16 |
| EP0904093A4 (en) | 2004-11-17 |
| CA2249368A1 (en) | 1997-09-25 |
| WO1997034618A1 (en) | 1997-09-25 |
| KR20000064752A (ko) | 2000-11-06 |
| CN1181885C (zh) | 2004-12-29 |
| AU725341B2 (en) | 2000-10-12 |
| US20030022830A1 (en) | 2003-01-30 |
| EP0894004B1 (en) | 2003-07-09 |
| CA2249596A1 (en) | 1997-09-25 |
| AU2582397A (en) | 1997-10-10 |
| DE69723429D1 (de) | 2003-08-14 |
| AU734312B2 (en) | 2001-06-07 |
| US6214796B1 (en) | 2001-04-10 |
| EP1364655B1 (en) | 2010-12-29 |
| EP0894004B2 (en) | 2007-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE244574T1 (de) | Verfahren zur verbesserten funktionelle erholung der motorische koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns | |
| DE3587266D1 (de) | Verfahren und system zur entfernung von immunosuppressiven bestandteilen aus saeugetierblut. | |
| DE69532482D1 (de) | Kombinationspräparat zur behandlung der parkinsonschen krankheit, das selektive nmda-antagonisten enthält | |
| ATE140388T1 (de) | Zusammensetzungen enthaltend omega conotoxin peptide derivate und deren verwendung zur behandlung von ischämie-artigen neuronalen schädigungen | |
| EP0464932A3 (en) | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines | |
| IL91322A0 (en) | Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract | |
| DE69731652D1 (de) | Verfahren zur behandlung von endothelialen verletzungen | |
| DE69232287D1 (de) | Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards | |
| DE3878627D1 (de) | Zusammensetzung zur oberflaechenbehandlung von kautschuk. | |
| DE69316013D1 (de) | Verwendung von phosphinate zur behandlung der osteoporose | |
| DE69638281D1 (de) | Anti-Interleukin-9 Antikörper oder Anti-Interleukin-9 Rezeptor Antikörper zur Behandlung von bronchialem Hyperreaktionsvermögen | |
| DE69625682D1 (de) | Verfahren zur behandlung von entzündungen und zusammensetzungen dafür | |
| MX9701187A (es) | Nuevas lactamas naftofusionadas n-substituidas. | |
| ATE526980T1 (de) | Zusammensetzungen und verfahren zur heilung von nervengeweben | |
| EP0577025A3 (de) | Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen | |
| ATE118350T1 (de) | Zusammensetzungen und verfahren zur behandlung von hautkrankheiten und zur aktivierung der wundheilung. | |
| ATE291918T1 (de) | Kombinationstherapie zur behandlung von tumoren | |
| ATE238793T1 (de) | Verfahren zur förderung von ovulation und geburt bei säugetieren | |
| EP0435177A3 (en) | 4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-ones and their use as anticonvulsants | |
| BG102716A (en) | Method for the treatment of cardiac insufficiency by means of formulations opposing the endotheline | |
| GR3017358T3 (en) | 5-Aryl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants. | |
| Baines et al. | Selective activity of a proctolin analogue reveals the existence of two receptor subtypes | |
| UA39179C2 (uk) | Фармацевтична композиція для лікування порушень серцевого ритму у великих ссавців та людей, спосіб її одержання та антиаритмічний лікарський засіб | |
| EP0116628A4 (en) | 1-ACYL-3-PYRIDYLMETHYLGUANIDINE AND THEIR USE AS AN ANI-HYPERTENSIVE. | |
| ZA873928B (en) | Topical methotrexate preparation for the treatment of hyperproliferative epithelial disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |