ATE2318T1 - Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide. - Google Patents
Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide.Info
- Publication number
- ATE2318T1 ATE2318T1 AT80101112T AT80101112T ATE2318T1 AT E2318 T1 ATE2318 T1 AT E2318T1 AT 80101112 T AT80101112 T AT 80101112T AT 80101112 T AT80101112 T AT 80101112T AT E2318 T1 ATE2318 T1 AT E2318T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- image
- tyr
- somatostatin
- inhibiting
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 102000005157 Somatostatin Human genes 0.000 title abstract 2
- 108010056088 Somatostatin Proteins 0.000 title abstract 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
- 229960000553 somatostatin Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical group OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- 125000001711 D-phenylalanine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical compound C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 abstract 1
- 102400000321 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/020,148 US4190648A (en) | 1979-03-13 | 1979-03-13 | Peptides having somatostatin activity |
| EP80101112A EP0017746B1 (de) | 1979-03-13 | 1980-03-05 | Peptide mit Somatostatin-Wirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung der Peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE2318T1 true ATE2318T1 (de) | 1983-02-15 |
Family
ID=21797013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80101112T ATE2318T1 (de) | 1979-03-13 | 1980-03-05 | Peptide mit somatostatin-wirkung, sie enthaltende zusammensetzungen und verfahren zur herstellung der peptide. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4190648A (de) |
| EP (1) | EP0017746B1 (de) |
| JP (1) | JPS55124747A (de) |
| AT (1) | ATE2318T1 (de) |
| DE (1) | DE3061721D1 (de) |
| DK (1) | DK105680A (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| CY1327A (en) * | 1979-11-27 | 1986-06-27 | Sandoz Ag | Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use |
| DD155985A5 (de) * | 1979-12-21 | 1982-07-21 | Ciba Geigy Ag | Verfahren zur herstellung cyclischr octapeptide |
| US4360516A (en) * | 1981-04-13 | 1982-11-23 | Merck & Co., Inc. | Modified D-retro cyclic hexapeptide somatostatin analogs |
| EP0113029B1 (de) * | 1982-12-06 | 1989-04-19 | Merck & Co. Inc. | Dicyclische Hexapeptiden, deren Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| US4871717A (en) * | 1987-01-07 | 1989-10-03 | Administrators Of The Tulane Educational Fund | Peptides |
| US4994554A (en) * | 1988-05-11 | 1991-02-19 | Immunobiology Research Institute, Inc. | Probursin |
| US5504069A (en) * | 1993-02-11 | 1996-04-02 | Biomeasure, Inc. | Inhibition of trauma-induced tumor growth |
| US5597894A (en) * | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
| AU7655098A (en) * | 1997-05-13 | 1998-12-08 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Somatostatin and somatostatin agonists for decreasing body weight |
| EP0981364B1 (de) * | 1997-05-13 | 2006-03-01 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Methoden und zusammensetzungen zur behandlung der hyperlipidämie |
| US6004928A (en) * | 1997-05-13 | 1999-12-21 | Biomeasure, Incorporated | Method of treating hyperlipidemia |
| PT980253E (pt) * | 1997-05-13 | 2004-08-31 | Conseils De Rec Appl Scient S | Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x |
| US5968903A (en) * | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
| AU2002305845B2 (en) | 2001-06-08 | 2006-03-30 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
| US8709998B2 (en) | 2003-04-22 | 2014-04-29 | Ipsen Pharma S.A.S. | Peptide vectors |
| BRPI0915142A8 (pt) | 2008-06-12 | 2018-01-02 | Syntaxin Ltd | Polipeptídeos, ácido nucleico e usos dos mesmos |
| JP5728380B2 (ja) | 2008-06-12 | 2015-06-03 | シンタクシン リミテッドＳｙｎｔａｘｉｎ Ｌｉｍｉｔｅｄ | 神経内分泌疾患の抑制 |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2860734D1 (en) * | 1977-06-08 | 1981-09-03 | Merck & Co Inc | Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them |
| US4140767A (en) * | 1977-12-01 | 1979-02-20 | Merck & Co., Inc. | Somatostatin analogs |
| US4139526A (en) * | 1977-12-01 | 1979-02-13 | Merck & Co., Inc. | Somatostatin analogs |
-
1979
- 1979-03-13 US US06/020,148 patent/US4190648A/en not_active Expired - Lifetime
-
1980
- 1980-03-05 AT AT80101112T patent/ATE2318T1/de not_active IP Right Cessation
- 1980-03-05 DE DE8080101112T patent/DE3061721D1/de not_active Expired
- 1980-03-05 EP EP80101112A patent/EP0017746B1/de not_active Expired
- 1980-03-12 DK DK105680A patent/DK105680A/da unknown
- 1980-03-13 JP JP3214580A patent/JPS55124747A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4190648A (en) | 1980-02-26 |
| EP0017746A1 (de) | 1980-10-29 |
| DK105680A (da) | 1980-09-14 |
| JPS55124747A (en) | 1980-09-26 |
| DE3061721D1 (en) | 1983-03-03 |
| EP0017746B1 (de) | 1983-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK105680A (da) | Fremgangsmaade til fremstilling af peptider | |
| IE781151L (en) | Somatostatin analogs | |
| US4563352A (en) | Human pancreatic GRF | |
| ES531585A0 (es) | Un procedimiento para preparar peptidos analogos al factor de liberacion de corticotropina | |
| US4435385A (en) | N-Acyl-polypeptides and processes for the production thereof | |
| EP0301087B1 (de) | Peptid | |
| YU46023B (sh) | Postupak za dobijanje novih analoga insulina | |
| IL102848A0 (en) | Polypeptides having growth hormone releasing activity,their use and pharmaceutical compositions containing them | |
| KR920002164A (ko) | 연속 방출성 약학 조성물 | |
| DK162103B (da) | Syntetiske grf-analoge peptider og farmaceutisk acceptable salte heraf samt farmaceutisk middel indeholdende peptidet eller et ikke-toksisk salt deraf | |
| KR920014828A (ko) | 신규한 종양 성장-억제 소마토스타틴 동족체, 이 동족체를 함유하는 제약 조성물 및 그 제조방법 | |
| JPH0133118B2 (de) | ||
| KR927002373A (ko) | 성장 호르몬 분비 활성을 갖는 폴리펩타이드 화합물 | |
| HUP0001431A2 (hu) | Módosított tandem peptid, ezt tartalmazó immunogén gyógyászati készítmény és vakcina az LHRH hormon termelés ellen, és eljárás a sertéshús minőségének javítására | |
| KR880013974A (ko) | 합성펩티드와 이를 포함하는 제약학적 조성물 | |
| IE802224L (en) | Cyclic hexapeptide somatostatin | |
| ATE2622T1 (de) | 2-niedrigalkyl-7-substituierte-2 oder 3-cephem-4- carbonsaeuren, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
| US4428942A (en) | Analogs of somatostatin | |
| AU646451B2 (en) | Hybrid calcitonin | |
| KR0163033B1 (ko) | Grf 유사체 viia | |
| IE800168L (en) | Cyclic hexapeptide and dipeptide composition | |
| KR900006711B1 (ko) | 펩티드의 제조방법 | |
| GB1059854A (en) | Improvements in or relating to a cyclic nonapeptide | |
| KR890005149A (ko) | 합성 펩타이드 및 이를 포함한 제약학적 조성물 | |
| KR900017581A (ko) | α-아미노보론산 유도체를 함유하는 펩티드-약제 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |