KR900017581A - α-아미노보론산 유도체를 함유하는 펩티드-약제 조성물 - Google Patents
α-아미노보론산 유도체를 함유하는 펩티드-약제 조성물 Download PDFInfo
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- KR900017581A KR900017581A KR1019890006223A KR890006223A KR900017581A KR 900017581 A KR900017581 A KR 900017581A KR 1019890006223 A KR1019890006223 A KR 1019890006223A KR 890006223 A KR890006223 A KR 890006223A KR 900017581 A KR900017581 A KR 900017581A
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- Prior art keywords
- peptide
- pharmaceutical composition
- protein
- tyr
- phe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 필수적으로, 약제학적으로 허용되는 담체, 단백질 또는 펩티드, 임의로는 흡수 증진제, 및 하기 일반식의 α-아미노보론산 유도체로 이루어진 약제학적 조성물.상기식에서, HW는 무기산, 설폰산, 알카노산 또는퍼플루오로알카노산이고, Y는 탄소원자 및, 임의로는 N,S 또는 O일수 있는 헤테로 원자를 함유하는 쇄 또는 환에서 두개 이상의 결합원자에 의해 분리된 하이드록시 그룹을 두개이상 함유하는 디하이드록시 화합물로부터 유도된 잔기이며, R은 알킬 또는 -CH2R1이고, R1은 -XR2,아릴 또는 하나이상의 알킬그룹으로 치환된 아릴이며, X는 O또는 S이고, R2는 -H,알킬 또는 -SiR3R4R5이며, R3,R4및 R5는 각각 알킬, 아릴, 또는 하나 이상의 알콕시그룹으로 치환된 아릴이다.
- 제1항에 있어서, 단백질 또는 펩티드 프로테아제에 의해 가수분될 수 있는 약제학적 조성물.
- 제2항에 있어서,단백질 또는 펩티드가 로이신 엔케팔린,LH-RH,Tyr-PHe-Met-Arg-Phe-NH2,Tyr-브레디키닌 및 티모포이에틴 Ⅱ로 이루어진 그룹중에서 선택되는 약제학적 조성물.
- 제1항에 있어서, Y가또는 -(CH2)2NH2(CH)2-인 약제학적 조성물.
- 제1항에 있어서, R이 -CH3, -CH(CH3)2, -CH2CH2(CH|3)2, CH(CH3)C2H5또는인 약제학적 조성물.
- 제1항에 있어서, HW가 CF3CO2H, CH3CO2H, Hcl 또는 HBr인 약제학적 조성물.
- 제1항에 있어서, α-아미노보론산 유도체가 3-메틸-1-(4,4,5,5-테트라메틸-1,3,2-디옥사보롤란-2-일-1-부타민, 트리플루오로아세트산염인 약제학적 조성물.
- 제1항에 있어서,경구투여에 적합한 투여형태인 약제학적 조성물.
- 제1항에 있어서, 경구투여에 적합한 투여형태인 약제학적 조성물
- 하기 일반식의 α-아미노보론산 유도체의 존재하에 약제를 투여함을 특징으로 하여, 프로테아제에 의해 가수분해될 수 있는 펩티드 또는 단백질 약제를 투여하는방법.상기식에서 HW,Y 및R은 제1항에서 정의한 바와 같다.
- 제10항에 있어서,단백질 또는 펩티드가 로이신 엔케팔린, LH-RH, Tyr-PHe-Met-Arg-Phe-NH2,Tyr-브레디키닌 및 티모포이에틴 Ⅱ로 이루어진 그룹 중 에서 선택되는 방법.
- 제10항에 있어서, 펩티드 또는 단백질이 흡수 점막을 통해 투여되는 방법.※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19269088A | 1988-05-11 | 1988-05-11 | |
US192,690 | 1988-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900017581A true KR900017581A (ko) | 1990-12-19 |
Family
ID=22710674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890006223A KR900017581A (ko) | 1988-05-11 | 1989-05-10 | α-아미노보론산 유도체를 함유하는 펩티드-약제 조성물 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0341661A3 (ko) |
JP (1) | JPH01319428A (ko) |
KR (1) | KR900017581A (ko) |
AU (1) | AU616968B2 (ko) |
DK (1) | DK229089A (ko) |
FI (1) | FI892254A (ko) |
HU (1) | HUT51144A (ko) |
IL (1) | IL90244A (ko) |
MY (1) | MY104088A (ko) |
NO (1) | NO891926L (ko) |
NZ (1) | NZ229053A (ko) |
PT (1) | PT90519B (ko) |
ZA (1) | ZA893517B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2673376A1 (fr) * | 1991-03-01 | 1992-09-04 | Lefesvre Andre | Composition pharmaceutique pour le traitement des tumeurs de kaposi. |
CA2125400A1 (en) * | 1991-12-18 | 1993-06-24 | Gordon L. Amidon | Soybean protein or hydrolyzates in pharmaceutical compositions to protect bioactive peptides from enzymatic inactivation |
US6153592A (en) * | 1992-11-09 | 2000-11-28 | Port Systems, Llc | Enhancing the bioavailability of proteolytically labile therapeutic agents |
US7097839B1 (en) | 1993-10-26 | 2006-08-29 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
MXPA05002662A (es) | 2002-09-09 | 2005-09-20 | Trigen Ltd | Sales de metal multivalente de acidos boronicos para el tratamiento de trombosis. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4537773A (en) * | 1983-12-05 | 1985-08-27 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid derivatives |
US4499082A (en) * | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
DE3840452A1 (de) * | 1988-12-01 | 1990-06-07 | Hoechst Ag | (beta)-amino-boronsaeure-derivate |
-
1989
- 1989-05-09 NZ NZ229053A patent/NZ229053A/en unknown
- 1989-05-09 IL IL90244A patent/IL90244A/xx unknown
- 1989-05-09 EP EP19890108324 patent/EP0341661A3/en not_active Withdrawn
- 1989-05-10 JP JP1115238A patent/JPH01319428A/ja active Pending
- 1989-05-10 DK DK229089A patent/DK229089A/da not_active Application Discontinuation
- 1989-05-10 FI FI892254A patent/FI892254A/fi not_active Application Discontinuation
- 1989-05-10 PT PT90519A patent/PT90519B/pt not_active IP Right Cessation
- 1989-05-10 KR KR1019890006223A patent/KR900017581A/ko not_active Application Discontinuation
- 1989-05-11 ZA ZA893517A patent/ZA893517B/xx unknown
- 1989-05-11 AU AU34682/89A patent/AU616968B2/en not_active Ceased
- 1989-05-11 MY MYPI89000629A patent/MY104088A/en unknown
- 1989-05-11 HU HU892373A patent/HUT51144A/hu unknown
- 1989-05-11 NO NO89891926A patent/NO891926L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HUT51144A (en) | 1990-04-28 |
NZ229053A (en) | 1990-12-21 |
NO891926D0 (no) | 1989-05-11 |
MY104088A (en) | 1993-11-30 |
IL90244A0 (en) | 1989-12-15 |
DK229089A (da) | 1989-11-12 |
IL90244A (en) | 1993-05-13 |
FI892254A0 (fi) | 1989-05-10 |
EP0341661A3 (en) | 1991-05-02 |
AU3468289A (en) | 1989-11-16 |
ZA893517B (en) | 1991-01-30 |
PT90519A (pt) | 1989-11-30 |
JPH01319428A (ja) | 1989-12-25 |
DK229089D0 (da) | 1989-05-10 |
NO891926L (no) | 1989-11-13 |
AU616968B2 (en) | 1991-11-14 |
FI892254A (fi) | 1989-11-12 |
EP0341661A2 (en) | 1989-11-15 |
PT90519B (pt) | 1994-10-31 |
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