ATE223904T1 - Nitronderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Nitronderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE223904T1
ATE223904T1 AT99401565T AT99401565T ATE223904T1 AT E223904 T1 ATE223904 T1 AT E223904T1 AT 99401565 T AT99401565 T AT 99401565T AT 99401565 T AT99401565 T AT 99401565T AT E223904 T1 ATE223904 T1 AT E223904T1
Authority
AT
Austria
Prior art keywords
production
pharmaceutical compositions
compositions containing
nitrone
arylalkyl
Prior art date
Application number
AT99401565T
Other languages
English (en)
Inventor
Solo Goldstein
Alain Dhainaut
Andre Tizot
Brian Lockhart
Pierre Lestage
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of ATE223904T1 publication Critical patent/ATE223904T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99401565T 1998-06-26 1999-06-24 Nitronderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen ATE223904T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9808116A FR2780404B1 (fr) 1998-06-26 1998-06-26 Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE223904T1 true ATE223904T1 (de) 2002-09-15

Family

ID=9527896

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99401565T ATE223904T1 (de) 1998-06-26 1999-06-24 Nitronderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen

Country Status (17)

Country Link
US (1) US6034250A (de)
EP (1) EP0967207B1 (de)
JP (1) JP2000026428A (de)
CN (1) CN1153766C (de)
AT (1) ATE223904T1 (de)
AU (1) AU747203B2 (de)
BR (1) BR9903282A (de)
CA (1) CA2274621C (de)
DE (1) DE69902851T2 (de)
DK (1) DK0967207T3 (de)
ES (1) ES2183492T3 (de)
FR (1) FR2780404B1 (de)
HU (1) HUP9902199A1 (de)
NO (1) NO312722B1 (de)
NZ (1) NZ336460A (de)
PT (1) PT967207E (de)
ZA (1) ZA994201B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096899A (en) * 1998-04-14 2000-08-01 The Regents Of The University Of Michigan Cylic imidazole compounds having relatively low hydrogen content and relatively high nitrogen content and polymers formed therefrom
KR100986225B1 (ko) * 2001-02-16 2010-10-07 아스비오파마 가부시키가이샤 Ａｏｐ－１ 유전자 또는 ａｏｐ－１의 발현 감소를수반하는 질환의 치료 방법 및 상기 질환의 치료약
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
EP1482931B1 (de) * 2002-03-05 2011-10-19 TransTech Pharma, Inc. Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
AU2003230770A1 (en) * 2002-03-28 2003-10-13 Oxis International, Inc. Neuroprotectant methods, compositions, and screening methods thereof
EP1635823A1 (de) * 2003-05-20 2006-03-22 TransTech Pharma Inc. Rage antagonisten in der behandlung amyloidosis und anderer assoziierten krankheiten
CN101468970B (zh) 2008-04-25 2011-05-11 暨南大学 一种硝酮类化合物及其制备方法和在制药中的应用
EP2470510B1 (de) 2009-09-30 2014-05-14 TransTech Pharma, LLC Substituierte imidazol-derivate für die behandlung von alzheimers krankheit.
JP5885620B2 (ja) * 2012-08-22 2016-03-15 四国化成工業株式会社 ２−（２−フリル）イミダゾール化合物及び酸化防止剤
FR3012460B1 (fr) 2013-10-25 2015-12-11 Michelin & Cie Composition de caoutchouc comprenant un elastomere dienique portant des fonctions imidazole reparties de facon aleatoire le long de la chaine
FR3012451B1 (fr) 2013-10-25 2016-11-11 Michelin & Cie Compose 1,3-dipolaire portant une fonction imidazole
FR3012458B1 (fr) * 2013-10-25 2015-10-30 Michelin & Cie Composition de caoutchouc comprenant un additif compose 1,3-dipolaire portant une fonction imidazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0643403B2 (ja) * 1986-01-25 1994-06-08 四国化成工業株式会社 イミダゾール―アルドキシム化合物の合成方法
US4803282A (en) * 1986-08-27 1989-02-07 Pennwalt Corporation Alpha-substituted ketonitrone derivatives
ATE209908T1 (de) * 1991-06-18 2001-12-15 Oklahoma Med Res Found RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
WO1997019054A1 (en) * 1995-11-17 1997-05-29 Florida International University Azulenyl nitrone spin trapping agents, methods of making and using same

Also Published As

Publication number Publication date
EP0967207B1 (de) 2002-09-11
AU3680099A (en) 2000-01-13
PT967207E (pt) 2002-12-31
NZ336460A (en) 2000-05-26
CN1153766C (zh) 2004-06-16
US6034250A (en) 2000-03-07
DE69902851T2 (de) 2003-05-28
HUP9902199A1 (hu) 2000-06-28
NO993122D0 (no) 1999-06-23
CA2274621A1 (fr) 1999-12-26
CA2274621C (fr) 2004-01-20
BR9903282A (pt) 2000-04-18
ZA994201B (en) 2000-01-11
JP2000026428A (ja) 2000-01-25
FR2780404B1 (fr) 2001-04-13
CN1245169A (zh) 2000-02-23
FR2780404A1 (fr) 1999-12-31
AU747203B2 (en) 2002-05-09
NO312722B1 (no) 2002-06-24
EP0967207A1 (de) 1999-12-29
ES2183492T3 (es) 2003-03-16
DK0967207T3 (da) 2003-01-20
DE69902851D1 (de) 2002-10-17
NO993122L (no) 1999-12-27
HU9902199D0 (en) 1999-08-30

Similar Documents

Publication Publication Date Title
ATE185807T1 (de) Thiazolylbenzofuranderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten
MX9306831A (es) Nuevos compuestos heterociclicos.
ATE144503T1 (de) Thiazolidin-2,4-dionderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE223904T1 (de) Nitronderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE129503T1 (de) Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien.
DE69021472T2 (de) Pyrazolderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellung.
DE69010232T2 (de) 2-(1-Piperazinyl)-4-phenylcycloalkanpyridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten.
KR860004894A (ko) 벤조옥사졸- 및 벤조티아졸아민 유도체의 제조방법
ATE128975T1 (de) Harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente.
ATE117304T1 (de) Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
KR970704444A (ko) 트리아진 유도체 및 의약(triazine derivative and medicine)
ATE240306T1 (de) Benzothiadiazinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
PT83725B (pt) Processo para preparacao de novos derivados da 3-oxadiol-beta-carbolina e 3-carboxilato-beta-carbolina e de composicoes farmaceuticas que os contem
PT99502A (pt) Processo para a preparacao de novos derivados de imidazol
ATE41659T1 (de) Benzothiazepinderivate, verfahren zur herstellung und pharmazeutische zusammensetzungen.
ATE23715T1 (de) Neue 1-acetonyl-2-(phenylimino)-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung.
ATE281452T1 (de) 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE69024154T2 (de) Pyrimidoindolderivate und Verfahren zu ihrer Herstellung
ATE28457T1 (de) (5-(2-aminomethyl-imidazol-1-yl)-1,3-dialkyl-1h pyrazol-4-yl)(aryl)methanone und verfahren zu deren herstellung.
ATE117682T1 (de) Substituierte benzothiazolinone, ihre herstellung und sie enthaltende pharmazeutische zusammenstellungen.
DE3860117D1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0967207

Country of ref document: EP

REN Ceased due to non-payment of the annual fee