ATE221125T1 - Klonierte glutaminsäure-decarboxylase - Google Patents
Klonierte glutaminsäure-decarboxylaseInfo
- Publication number
- ATE221125T1 ATE221125T1 AT94927940T AT94927940T ATE221125T1 AT E221125 T1 ATE221125 T1 AT E221125T1 AT 94927940 T AT94927940 T AT 94927940T AT 94927940 T AT94927940 T AT 94927940T AT E221125 T1 ATE221125 T1 AT E221125T1
- Authority
- AT
- Austria
- Prior art keywords
- cloned
- acid decarboxylase
- glutamine acid
- glutamine
- gad
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01015—Glutamate decarboxylase (4.1.1.15)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/123,859 US5674978A (en) | 1990-09-21 | 1993-09-17 | Peptides derived from glutamic acid decarboxylase |
| PCT/US1994/009478 WO1995007992A2 (en) | 1993-09-17 | 1994-08-24 | Cloned glutamic acid decarboxylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE221125T1 true ATE221125T1 (de) | 2002-08-15 |
Family
ID=22411325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94927940T ATE221125T1 (de) | 1993-09-17 | 1994-08-24 | Klonierte glutaminsäure-decarboxylase |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US5674978A (de) |
| EP (1) | EP0719340B1 (de) |
| JP (1) | JP3133339B2 (de) |
| KR (1) | KR100367943B1 (de) |
| AT (1) | ATE221125T1 (de) |
| AU (1) | AU697058B2 (de) |
| CA (1) | CA2170523C (de) |
| DE (1) | DE69431060T2 (de) |
| DK (1) | DK0719340T3 (de) |
| ES (1) | ES2179077T3 (de) |
| WO (1) | WO1995007992A2 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2727377B2 (ja) | 1990-09-07 | 1998-03-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 糖尿病自己抗体の検出方法 |
| US5674978A (en) * | 1990-09-21 | 1997-10-07 | The Regents Of The University Of California | Peptides derived from glutamic acid decarboxylase |
| US6682906B1 (en) * | 1990-09-21 | 2004-01-27 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase |
| WO1992020811A2 (en) * | 1991-05-15 | 1992-11-26 | Zymogenetics, Inc. | Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
| DE69334246D1 (de) * | 1992-12-03 | 2008-12-24 | Univ California | Verbesserte reagentien und methoden zur diagnose und behandlung von diabetes und stiff man syndrome |
| CN1112933A (zh) * | 1994-01-20 | 1995-12-06 | 伯伦格·曼海姆有限公司 | 抗原特异性活化t淋巴细胞,其检测和用途 |
| WO1996026218A1 (en) * | 1995-02-20 | 1996-08-29 | Amrad Operations Pty. Ltd. | Immunoreactive and immunotherapeutic molecules which interact in subjects with insulin-dependent diabetes mellitus (iddm) |
| US5840307A (en) * | 1995-03-31 | 1998-11-24 | Immulogic Pharmacuetical Corp. | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation |
| US5945401A (en) * | 1995-06-23 | 1999-08-31 | Conlon; Paul J. | Peptide analogues of the 65KD isoform of human glutamic acid decarboxylase and uses thereof |
| DE19525784A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Mannheim Gmbh | Autoreaktive Peptide aus der humanen Glutamin-Decarboxylase (GAD) |
| DE19526561A1 (de) * | 1995-07-20 | 1997-01-23 | Boehringer Mannheim Gmbh | In-vivo-Diabetes-Test |
| WO1997036618A1 (en) * | 1996-04-01 | 1997-10-09 | Chugai Seiyaku Kabushiki Kaisha | Diagnostic composition for diseases accompanied by autoimmune reactions caused by 65k-glutamic acid decarboxylase |
| US7361331B2 (en) | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
| US6815174B1 (en) * | 1996-11-28 | 2004-11-09 | Edgardo Poskus | Thioredoxin-glutamate decarboxylase 65 fusion protein |
| FR2759701B1 (fr) * | 1997-02-19 | 1999-06-04 | Inst Nat Sante Rech Med | Utilisation des proteines ulip dans le diagnostic et la therapie des cancers et des syndromes neurologiques paraneoplasiques |
| JP2001520200A (ja) * | 1997-10-17 | 2001-10-30 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ウロキナーゼタイプのプラスミノーゲン活性化因子の内在化および分解を促進するための組成物および方法 |
| SE9704451D0 (sv) * | 1997-11-28 | 1997-11-28 | Diamyd Therapeutics Ab | New method and compositions for the treatment of autoimmune diseases |
| WO1999037315A1 (en) * | 1998-01-27 | 1999-07-29 | Bai Jane Pei Fan | Chemical derivatives of autoantigens and autoimmune-suppressive peptides and pharmaceutical composition containing the same |
| US6303325B1 (en) | 1998-05-29 | 2001-10-16 | Dade Behring Inc. | Method for detecting analytes |
| US6232082B1 (en) | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| EP1207895A4 (de) * | 1999-08-23 | 2002-08-28 | Virginia Mason Res Ct | Peptide und ihre analoge zur behandlung und vorbeugung von diabetes |
| US6436401B1 (en) | 1999-09-14 | 2002-08-20 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with diabetes and diabetic neuropathy comprising administration of low levels of antibodies |
| US6713058B2 (en) | 1999-09-14 | 2004-03-30 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with neuropathic conditions comprising administration of low levels of antibodies |
| EP1149914B1 (de) * | 2000-04-10 | 2008-06-18 | Labor Dr. Merk und Kollegen GmbH | Fusionsprotein zur gleichzeitigen Erkennung von humanen Autoantikörpern |
| EP1275003A2 (de) | 2000-04-19 | 2003-01-15 | Research Corporation Technologies, Inc | Diagnostisches assay für endometriose |
| US7178152B2 (en) * | 2001-03-01 | 2007-02-13 | Sony Corporation | Application programming interface for communication between audio/video file system and audio video controller |
| JP4594588B2 (ja) * | 2001-04-10 | 2010-12-08 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ | 抗体特異的プロファイルの治療的および診断的使用方法 |
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| US20050250691A1 (en) * | 2004-05-10 | 2005-11-10 | Diamyd Therapeutics Ab | Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes |
| US20050209138A1 (en) * | 2004-03-19 | 2005-09-22 | Diamyd Therapeutics Ab | Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes |
| EP1755631A2 (de) * | 2004-03-03 | 2007-02-28 | Diamyd Medical AB | Immunomodulation mittels therapeutischer verabreichung von medikamenten zur behandlung von diabetes und vorbeugung von autoimmuner diabetes |
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| US7994279B2 (en) * | 2006-04-04 | 2011-08-09 | The University Of Toledo | Altered peptide ligands of GAD65 |
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| US8114682B2 (en) * | 2006-09-27 | 2012-02-14 | Cmed Technologies Ltd. | Method for the quantitative evaluation of sex hormones in a serum sample |
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| JP5378202B2 (ja) * | 2007-03-15 | 2013-12-25 | 株式会社リバース・プロテオミクス研究所 | 脳・神経に特異的あるいは神経分化に特異的なバイオマーカー |
| JP5551448B2 (ja) | 2007-03-16 | 2014-07-16 | ジェノマティカ・インコーポレイテッド | 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法 |
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| CN105441374A (zh) * | 2009-10-13 | 2016-03-30 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
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|---|---|---|---|---|
| US4624926A (en) * | 1981-01-02 | 1986-11-25 | The Research Foundation Of State University Of New York | Novel cloning vehicles for polypeptide expression in microbial hosts |
| US4487830A (en) * | 1982-05-14 | 1984-12-11 | American Hoechst Corporation | Enzyme/immunofluorescent assay for autoantibodies |
| US4708871A (en) * | 1983-03-08 | 1987-11-24 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
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| US5762937A (en) * | 1988-12-13 | 1998-06-09 | University Of Florida Research Foundation, Inc. | Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus |
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| US5645998A (en) * | 1988-12-13 | 1997-07-08 | University Of Florida Research Foundation | Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus |
| US6001360A (en) * | 1988-12-13 | 1999-12-14 | University Of Florida | Method and compositions for early detection and treatment of insulin dependent diabetes mellitus |
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| ES2093714T3 (es) * | 1990-08-17 | 1997-01-01 | Univ Florida | Metodos y composiciones para la deteccion y el tratamiento precoces de la diabetes mellitus insulinodependiente. |
| US5512447A (en) * | 1990-09-07 | 1996-04-30 | The Regents Of The University Of California | Methods for the diagnosis and treatment of diabetes |
| US5475086A (en) * | 1990-09-21 | 1995-12-12 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase peptides |
| US5674978A (en) * | 1990-09-21 | 1997-10-07 | The Regents Of The University Of California | Peptides derived from glutamic acid decarboxylase |
| AU8864791A (en) * | 1990-10-02 | 1992-04-28 | Trigen Incorporated | Antibodies and methods for diagnosis and treatment of diabetes |
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| WO1992020811A2 (en) * | 1991-05-15 | 1992-11-26 | Zymogenetics, Inc. | Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
| AU661684B2 (en) * | 1991-06-18 | 1995-08-03 | Regents Of The University Of California, The | Cloned glutamic acid decarboxylase |
| US5200318A (en) * | 1992-05-13 | 1993-04-06 | Miles Inc. | Diagnosis of IDDM with a panel of immunoreagents |
| US5837477A (en) * | 1993-01-15 | 1998-11-17 | The United States Of America As Represented By The Department Of Health And Human Services | T cell receptor ligands and methods of using same |
| JP3908271B2 (ja) * | 1993-03-05 | 2007-04-25 | エピミューン,インコーポレイティド | Hla−a2.1結合ペプチドおよびそれらの使用 |
| US5547847A (en) * | 1993-09-07 | 1996-08-20 | University Of Washington | Diagnosis of insulin-dependent diabetes |
-
1993
- 1993-09-17 US US08/123,859 patent/US5674978A/en not_active Expired - Lifetime
-
1994
- 1994-08-24 JP JP07509191A patent/JP3133339B2/ja not_active Expired - Lifetime
- 1994-08-24 EP EP94927940A patent/EP0719340B1/de not_active Expired - Lifetime
- 1994-08-24 AT AT94927940T patent/ATE221125T1/de active
- 1994-08-24 AU AU79201/94A patent/AU697058B2/en not_active Expired
- 1994-08-24 WO PCT/US1994/009478 patent/WO1995007992A2/en not_active Ceased
- 1994-08-24 ES ES94927940T patent/ES2179077T3/es not_active Expired - Lifetime
- 1994-08-24 DK DK94927940T patent/DK0719340T3/da active
- 1994-08-24 CA CA2170523A patent/CA2170523C/en not_active Expired - Lifetime
- 1994-08-24 KR KR1019960701348A patent/KR100367943B1/ko not_active Expired - Lifetime
- 1994-08-24 DE DE69431060T patent/DE69431060T2/de not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/485,725 patent/US8926966B1/en active Active
- 1995-06-07 US US08/483,952 patent/US6011139A/en not_active Expired - Lifetime
- 1995-06-07 US US08/476,501 patent/US6455267B1/en not_active Expired - Lifetime
- 1995-09-22 US US08/484,530 patent/US5846740A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0719340A1 (de) | 1996-07-03 |
| AU697058B2 (en) | 1998-09-24 |
| EP0719340B1 (de) | 2002-07-24 |
| US6011139A (en) | 2000-01-04 |
| US8926966B1 (en) | 2015-01-06 |
| ES2179077T3 (es) | 2003-01-16 |
| WO1995007992A2 (en) | 1995-03-23 |
| DE69431060T2 (de) | 2002-11-14 |
| US5846740A (en) | 1998-12-08 |
| CA2170523A1 (en) | 1995-03-23 |
| US6455267B1 (en) | 2002-09-24 |
| JPH09503387A (ja) | 1997-04-08 |
| KR100367943B1 (ko) | 2003-06-18 |
| WO1995007992A3 (en) | 1995-06-22 |
| US5674978A (en) | 1997-10-07 |
| CA2170523C (en) | 2010-03-30 |
| DE69431060D1 (de) | 2002-08-29 |
| KR960705051A (ko) | 1996-10-09 |
| JP3133339B2 (ja) | 2001-02-05 |
| DK0719340T3 (da) | 2002-11-18 |
| AU7920194A (en) | 1995-04-03 |
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