ES8801316A1 - Un procedimiento para preparar un material peptidico que tiene actividad humoral timica - Google Patents

Un procedimiento para preparar un material peptidico que tiene actividad humoral timica

Info

Publication number
ES8801316A1
ES8801316A1 ES557738A ES557738A ES8801316A1 ES 8801316 A1 ES8801316 A1 ES 8801316A1 ES 557738 A ES557738 A ES 557738A ES 557738 A ES557738 A ES 557738A ES 8801316 A1 ES8801316 A1 ES 8801316A1
Authority
ES
Spain
Prior art keywords
leu
pro
novel
phe
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557738A
Other languages
English (en)
Other versions
ES557738A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of ES557738A0 publication Critical patent/ES557738A0/es
Publication of ES8801316A1 publication Critical patent/ES8801316A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/065—Thymic humoral factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO PEPTIDICO QUE CONTIENE AL MENOS UN PEPTIDO CON UNA SECUENCIA DE AMINOACIDOS LEU-GLU-ASP-GLY-PRO-LYS-PHE-LEU. COMPRENDE LA REACCION DE COPULACION DE UN AMINOACIDO N-PROTEGIDO, QUE HA DE FORMAR EL RESIDUO TERMINAL DE CARBOXILO DEL PEPTIDO, CON UN POLIMERO; INTRODUCCION DEL SIGUIENTE RESIDUO AMINOACIDO EN LA SECUENCIA POR SEPARACION DEL GRUPO PROTECTOR DE NITROGENO; REACCION DEL PRODUCTO FORMADO CON EL AMINOACIDO N-PROTEGIDO; REPETICION DE LAS DOS ULTIMAS ETAPAS HASTA COMPLETAR LA SECUENCIA DESEADA; DESCOPULACION DE LA SECUENCIA DE PEPTIDO DEL POLIMERO, Y SEPARACION DEL GRUPO N-PROTECTOR FINAL. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD HUMORAL TIMICA.
ES557738A 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica Expired ES8801316A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/741,753 US4621135A (en) 1983-12-08 1985-06-06 Novel THF compositions

Publications (2)

Publication Number Publication Date
ES557738A0 ES557738A0 (es) 1987-12-16
ES8801316A1 true ES8801316A1 (es) 1987-12-16

Family

ID=24982034

Family Applications (6)

Application Number Title Priority Date Filing Date
ES555737A Expired ES8801322A1 (es) 1985-06-06 1986-06-05 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557738A Expired ES8801316A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557736A Expired ES8801315A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557739A Expired ES8801317A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557737A Expired ES8801307A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557740A Expired ES8801308A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES555737A Expired ES8801322A1 (es) 1985-06-06 1986-06-05 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES557736A Expired ES8801315A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557739A Expired ES8801317A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557737A Expired ES8801307A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
ES557740A Expired ES8801308A1 (es) 1985-06-06 1987-09-16 Un procedimiento para preparar un material peptidico que tiene actividad humoral timica

Country Status (16)

Country Link
US (1) US4621135A (es)
EP (1) EP0204328B1 (es)
JP (2) JPS6248698A (es)
KR (1) KR900003095B1 (es)
AT (1) ATE110389T1 (es)
AU (1) AU569193B2 (es)
CA (1) CA1270597A (es)
CZ (1) CZ419491A3 (es)
DE (2) DE204328T1 (es)
DK (1) DK262986A (es)
ES (6) ES8801322A1 (es)
HK (1) HK195495A (es)
IL (1) IL78951A (es)
NZ (1) NZ216316A (es)
SK (1) SK419491A3 (es)
ZA (1) ZA863848B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807830A (en) * 1987-12-30 1998-09-15 Cytoven J.V. Method for treatment of purulent inflammatory diseases
US5728680A (en) 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
US5811399A (en) * 1988-12-14 1998-09-22 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
US5770576A (en) * 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
US6100380A (en) * 1991-10-28 2000-08-08 Cytran, Inc. Immunomodulating peptides and methods of use
US6066622A (en) * 1991-10-28 2000-05-23 Cytran, Inc. Immunomodulating peptides and methods of use
IL106214A (en) * 1993-07-01 1998-12-06 Yeda Res & Dev Thf-gamma2 analogs and pharmaceutical compositions comprising them
MX339762B (es) * 2011-09-28 2016-05-27 Univ Autonoma Del Estado De Morelos Metalopeptidos inmunomoduladores (immp) y composiciones que los contienen.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4881838A (es) * 1972-02-15 1973-11-01
US4002602A (en) * 1974-03-11 1977-01-11 Gideon Goldstein Ubiquitous immunopoietic polypeptide (UBIP) and methods
NL7502830A (nl) * 1974-03-25 1975-09-29 Jean Francois Bach En Dr Jean Werkwijze voor het isoleren van een polypeptide hormoon.
IL47645A (en) * 1975-07-04 1980-10-26 Yeda Res & Dev Substantially pure and uniform thymic hormone thf,its preparation and pharmaceutical compositions containing it
DE2732587A1 (de) * 1976-09-22 1978-03-23 Bach Jean Francois Polypeptid mit thymischer wirksamkeit
US4079127A (en) * 1976-10-28 1978-03-14 Board Of Regents Of The University Of Texas Thymosin alpha 1
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
SE448605B (sv) * 1980-10-27 1987-03-09 Vtoroi Mo G Med I Imen Terapeutiskt preparat for reglering av t-immunsystemet och forfarande for framstellning derav
US4374828A (en) * 1980-11-17 1983-02-22 Board Of Reagents, The University Of Texas System Biologically active thymones from the thymus
IT1148005B (it) * 1981-04-09 1986-11-26 Leonida Grippa Tripeptide nelle sue sei combinazioni amminoacide alania fenilalanina e leucina in particolare fenil-alanina-alanina-leucina (p-a-l) aventela proprieta' di esaltare l'immunita' antivirale ed antitumorale
US4505898A (en) * 1982-04-21 1985-03-19 Marks Robert E Derivatives of acetylsalicylic acid and substituted phenylacetic acids and compositions containing them

Also Published As

Publication number Publication date
KR900003095B1 (ko) 1990-05-07
ES555737A0 (es) 1987-12-16
JPH0422919B2 (es) 1992-04-20
DE3650035T2 (de) 1995-03-23
ES8801307A1 (es) 1987-12-16
ZA863848B (en) 1987-12-30
DE3650035D1 (de) 1994-09-29
IL78951A (en) 1990-11-05
ES557738A0 (es) 1987-12-16
ES557740A0 (es) 1987-12-16
DE204328T1 (de) 1987-11-05
EP0204328A3 (en) 1988-07-27
SK419491A3 (en) 1995-07-11
JPH01156997A (ja) 1989-06-20
ATE110389T1 (de) 1994-09-15
EP0204328B1 (en) 1994-08-24
ES557739A0 (es) 1988-01-01
DK262986D0 (da) 1986-06-04
JPH0210160B2 (es) 1990-03-06
KR870000357A (ko) 1987-02-18
US4621135A (en) 1986-11-04
ES557737A0 (es) 1987-12-16
AU5833686A (en) 1987-01-08
IL78951A0 (en) 1986-09-30
ES557736A0 (es) 1987-12-16
DK262986A (da) 1986-12-07
ES8801317A1 (es) 1988-01-01
ES8801308A1 (es) 1987-12-16
CZ419491A3 (en) 1993-03-17
HK195495A (en) 1996-01-05
EP0204328A2 (en) 1986-12-10
CA1270597A (en) 1990-06-19
NZ216316A (en) 1991-11-26
AU569193B2 (en) 1988-01-21
ES8801315A1 (es) 1987-12-16
JPS6248698A (ja) 1987-03-03
ES8801322A1 (es) 1987-12-16

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