CA1270597A - Thf compositions - Google Patents

Thf compositions

Info

Publication number
CA1270597A
CA1270597A CA000510940A CA510940A CA1270597A CA 1270597 A CA1270597 A CA 1270597A CA 000510940 A CA000510940 A CA 000510940A CA 510940 A CA510940 A CA 510940A CA 1270597 A CA1270597 A CA 1270597A
Authority
CA
Canada
Prior art keywords
thf
fractions
amino acid
column
gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000510940A
Other languages
English (en)
French (fr)
Inventor
Nathan Trainin
Yigal Burstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of CA1270597A publication Critical patent/CA1270597A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/065—Thymic humoral factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000510940A 1985-06-06 1986-06-05 Thf compositions Expired - Fee Related CA1270597A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US741,753 1985-06-06
US06/741,753 US4621135A (en) 1983-12-08 1985-06-06 Novel THF compositions

Publications (1)

Publication Number Publication Date
CA1270597A true CA1270597A (en) 1990-06-19

Family

ID=24982034

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000510940A Expired - Fee Related CA1270597A (en) 1985-06-06 1986-06-05 Thf compositions

Country Status (16)

Country Link
US (1) US4621135A (es)
EP (1) EP0204328B1 (es)
JP (2) JPS6248698A (es)
KR (1) KR900003095B1 (es)
AT (1) ATE110389T1 (es)
AU (1) AU569193B2 (es)
CA (1) CA1270597A (es)
CZ (1) CZ419491A3 (es)
DE (2) DE204328T1 (es)
DK (1) DK262986A (es)
ES (6) ES8801322A1 (es)
HK (1) HK195495A (es)
IL (1) IL78951A (es)
NZ (1) NZ216316A (es)
SK (1) SK419491A3 (es)
ZA (1) ZA863848B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728680A (en) 1987-12-30 1998-03-17 Cytoven J.V. Methods for normalizing numbers of lymphocytes
US5807830A (en) * 1987-12-30 1998-09-15 Cytoven J.V. Method for treatment of purulent inflammatory diseases
US5811399A (en) * 1988-12-14 1998-09-22 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
US5770576A (en) * 1989-08-30 1998-06-23 Cytran, Inc. Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
US6066622A (en) * 1991-10-28 2000-05-23 Cytran, Inc. Immunomodulating peptides and methods of use
US6100380A (en) * 1991-10-28 2000-08-08 Cytran, Inc. Immunomodulating peptides and methods of use
IL106214A (en) * 1993-07-01 1998-12-06 Yeda Res & Dev Thf-gamma2 analogs and pharmaceutical compositions comprising them
MX339762B (es) 2011-09-28 2016-05-27 Univ Autonoma Del Estado De Morelos Metalopeptidos inmunomoduladores (immp) y composiciones que los contienen.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4881838A (es) * 1972-02-15 1973-11-01
US4002602A (en) * 1974-03-11 1977-01-11 Gideon Goldstein Ubiquitous immunopoietic polypeptide (UBIP) and methods
NL7502830A (nl) * 1974-03-25 1975-09-29 Jean Francois Bach En Dr Jean Werkwijze voor het isoleren van een polypeptide hormoon.
IL47645A (en) * 1975-07-04 1980-10-26 Yeda Res & Dev Substantially pure and uniform thymic hormone thf,its preparation and pharmaceutical compositions containing it
DE2732587A1 (de) * 1976-09-22 1978-03-23 Bach Jean Francois Polypeptid mit thymischer wirksamkeit
US4079127A (en) * 1976-10-28 1978-03-14 Board Of Regents Of The University Of Texas Thymosin alpha 1
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
SE448605B (sv) * 1980-10-27 1987-03-09 Vtoroi Mo G Med I Imen Terapeutiskt preparat for reglering av t-immunsystemet och forfarande for framstellning derav
US4374828A (en) * 1980-11-17 1983-02-22 Board Of Reagents, The University Of Texas System Biologically active thymones from the thymus
IT1148005B (it) * 1981-04-09 1986-11-26 Leonida Grippa Tripeptide nelle sue sei combinazioni amminoacide alania fenilalanina e leucina in particolare fenil-alanina-alanina-leucina (p-a-l) aventela proprieta' di esaltare l'immunita' antivirale ed antitumorale
US4505898A (en) * 1982-04-21 1985-03-19 Marks Robert E Derivatives of acetylsalicylic acid and substituted phenylacetic acids and compositions containing them

Also Published As

Publication number Publication date
JPH0422919B2 (es) 1992-04-20
DE204328T1 (de) 1987-11-05
EP0204328A3 (en) 1988-07-27
JPS6248698A (ja) 1987-03-03
ES8801307A1 (es) 1987-12-16
ES557736A0 (es) 1987-12-16
DK262986A (da) 1986-12-07
JPH01156997A (ja) 1989-06-20
HK195495A (en) 1996-01-05
JPH0210160B2 (es) 1990-03-06
ES8801308A1 (es) 1987-12-16
AU569193B2 (en) 1988-01-21
IL78951A (en) 1990-11-05
ES8801315A1 (es) 1987-12-16
DE3650035T2 (de) 1995-03-23
NZ216316A (en) 1991-11-26
ES8801322A1 (es) 1987-12-16
AU5833686A (en) 1987-01-08
ZA863848B (en) 1987-12-30
ES557737A0 (es) 1987-12-16
ES555737A0 (es) 1987-12-16
ES8801316A1 (es) 1987-12-16
DK262986D0 (da) 1986-06-04
ATE110389T1 (de) 1994-09-15
ES557740A0 (es) 1987-12-16
SK419491A3 (en) 1995-07-11
ES557739A0 (es) 1988-01-01
IL78951A0 (en) 1986-09-30
KR870000357A (ko) 1987-02-18
ES8801317A1 (es) 1988-01-01
CZ419491A3 (en) 1993-03-17
ES557738A0 (es) 1987-12-16
EP0204328B1 (en) 1994-08-24
EP0204328A2 (en) 1986-12-10
DE3650035D1 (de) 1994-09-29
US4621135A (en) 1986-11-04
KR900003095B1 (ko) 1990-05-07

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