EP0204775A4 - Amino acid and peptide inhibitors of human leucocytic elastase. - Google Patents

Amino acid and peptide inhibitors of human leucocytic elastase.

Info

Publication number
EP0204775A4
EP0204775A4 EP19860900028 EP86900028A EP0204775A4 EP 0204775 A4 EP0204775 A4 EP 0204775A4 EP 19860900028 EP19860900028 EP 19860900028 EP 86900028 A EP86900028 A EP 86900028A EP 0204775 A4 EP0204775 A4 EP 0204775A4
Authority
EP
European Patent Office
Prior art keywords
amino acid
peptide inhibitors
leucocytic elastase
human leucocytic
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19860900028
Other languages
German (de)
French (fr)
Other versions
EP0204775A1 (en
Inventor
Bela Ternai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
La Trobe University
Australia Commercial Research and Development Ltd
Original Assignee
La Trobe University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by La Trobe University filed Critical La Trobe University
Publication of EP0204775A1 publication Critical patent/EP0204775A1/en
Publication of EP0204775A4 publication Critical patent/EP0204775A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP19860900028 1984-12-14 1985-12-13 Amino acid and peptide inhibitors of human leucocytic elastase. Withdrawn EP0204775A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU8574/84 1984-12-14
AUPG857484 1984-12-14

Publications (2)

Publication Number Publication Date
EP0204775A1 EP0204775A1 (en) 1986-12-17
EP0204775A4 true EP0204775A4 (en) 1989-10-04

Family

ID=3770882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19860900028 Withdrawn EP0204775A4 (en) 1984-12-14 1985-12-13 Amino acid and peptide inhibitors of human leucocytic elastase.

Country Status (5)

Country Link
EP (1) EP0204775A4 (en)
JP (1) JPS62501147A (en)
AU (1) AU583578B2 (en)
NZ (1) NZ214543A (en)
WO (1) WO1986003746A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217319A (en) * 1988-04-19 1989-10-25 Synpharm Ltd Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi
WO1990005141A1 (en) * 1988-11-10 1990-05-17 Australian Commercial Research & Development Limited Amino acid and peptide inhibitors of human leukocytic elastase and collagenase
MX9301789A (en) * 1992-04-03 1993-10-01 Iaf Biochem Int NEW LIPOPHILIC OLIGOPEPTIDES WITH IMMUNOMODULATING ACTIVITY.
FR2719584B1 (en) * 1994-05-09 1996-06-07 Oreal New serine derivatives, their preparation and their use in cosmetic or dermatological compositions.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2728593A1 (en) * 1976-06-25 1978-01-05 Hoffmann La Roche DIPEPTIDES
US4242329A (en) * 1978-07-18 1980-12-30 Ab Kabi Bradykinin-inhibiting tripeptide derivatives
FR2510990A1 (en) * 1981-08-07 1983-02-11 Spofa Vereinigte Pharma Werke ALKYLAMIDES OF CARBOXYALCANOYLPEPTIDES
EP0195212A2 (en) * 1985-02-04 1986-09-24 Merrell Dow Pharmaceuticals Inc. Novel peptidase inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH490338A (en) * 1967-04-13 1970-05-15 Ciba Geigy Process for the production of ACTH-active peptides with extended action
FR1591598A (en) * 1967-07-31 1970-05-04
US3574747A (en) * 1968-03-29 1971-04-13 Norwich Pharma Co Amides of diaminoacids
US3862928A (en) * 1969-07-09 1975-01-28 Akzona Inc Psychopharmacological hexa-peptides containing a d-phenylalanyl residue
CH552567A (en) * 1970-10-30 1974-08-15 Hoffmann La Roche PROCESS FOR PRODUCING PHENYLALANINE DERIVATIVES.
NL175293C (en) * 1972-02-08 1984-10-16 Akzo Nv METHOD FOR PREPARING OR MANUFACTURING A PHARMACEUTICAL PREPARATION WITH A PSYCHOPHARMACOLOGICAL ACTION, AND A METHOD FOR PREPARING A VASOPRESSIN DERIVED PEPTIDE.
BE795788A (en) * 1972-02-22 1973-08-22 Akzo Nv PROCESS FOR THE PREPARATION OF PEPTIDES AND PEPTIDE DERIVATIVES AND THEIR USE
NL175988C (en) * 1972-05-24 1985-02-01 Akzo Nv PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH A PSYCHOPHARMACOLOGICAL EFFECT, THAT A PEPTIDE OR PEPTIDE DERIVATIVE DERIVED FROM AN AMINO ACIDS 4-10, FRAGMENT OF ADRENOCORTICOTROP HORMONE, AS AN PROPERTY, AND ITS PROPERTY, PROPERTY, AND ITS PROPERTY.
NL175618C (en) * 1972-07-15 1984-12-03 Akzo Nv PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH A PSYCHOPHARMACOLOGICAL ACTION CONTAINING A PEPTIDE OR PEPTIDE DERIVATIVE AND A PROCESS FOR THE PREPARATION OF SUCH PEPTIDES.
AU510679B2 (en) * 1976-03-23 1980-07-10 Stateof Michigan Polypeptides for treating schizophrenia
FR2442241A2 (en) * 1978-03-20 1980-06-20 Anvar NOVEL ESTER COMPOUNDS OF MURAMYL-PEPTIDE, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, IN PARTICULAR IN THE FORM OF LIPOSOMES
US4231782A (en) * 1978-11-03 1980-11-04 Monsanto Company N-Carbobenzoxy-N-phosphonomethylglycine thioesters
DE2965017D1 (en) * 1978-12-22 1983-04-14 Anvar New compounds associating peptidyl or aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds
HU180925B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem
NL8005121A (en) * 1979-09-20 1981-03-24 Erba Farmitalia ORGANICALLY ACTIVE PEPTIDES.
DE2938420A1 (en) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt NEW PEPTIDES AND METHOD FOR THEIR PRODUCTION
FR2533209B1 (en) * 1982-09-22 1985-11-08 Centre Nat Rech Scient LIPOPEPTIDES, THEIR OBTAINMENT AND THEIR APPLICATION AS EMULSIFIERS
EP0136879A3 (en) * 1983-09-30 1987-01-07 Yamanouchi Pharmaceutical Co., Ltd. Fatty acid derivatives and processes of producing them
JPH0510569A (en) * 1991-07-05 1993-01-19 Kubota Corp Air conditioner

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2728593A1 (en) * 1976-06-25 1978-01-05 Hoffmann La Roche DIPEPTIDES
US4242329A (en) * 1978-07-18 1980-12-30 Ab Kabi Bradykinin-inhibiting tripeptide derivatives
FR2510990A1 (en) * 1981-08-07 1983-02-11 Spofa Vereinigte Pharma Werke ALKYLAMIDES OF CARBOXYALCANOYLPEPTIDES
EP0195212A2 (en) * 1985-02-04 1986-09-24 Merrell Dow Pharmaceuticals Inc. Novel peptidase inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 101, no. 21, 19th November 1984, page 333, abstract no. 186798y, Columbus, Ohio, US; L. ROBERT et al.: "Bifunctional inhibitors as potential agents against elastolysis", & BIOCHEM. SOC. TRANS. 1984, 12(5), 876-7 *
CHEMICAL ABSTRACTS, vol. 84, no. 1, 5th January 1976, page 461, abstract no. 5386z, Columbus, Ohio, US; & JP-A-75 10 569 (TAISHO PHARMACEUTICAL CO., LTD) 22-04-1975 *
CHEMICAL ABSTRACTS, vol. 86, no. 3, 17th January 1977, page 452, abstract no. 16925s, Columbus, Ohio, US; U. BEITLER et al.: "Interaction between asymmetric solutes and solvents. Diamides derived from L-valine as stationary phases in gas-liquid partition chromatography", & J. CHROMATOGR. 1976, 123(1), 149-66 *
See also references of WO8603746A1 *

Also Published As

Publication number Publication date
JPS62501147A (en) 1987-05-07
WO1986003746A1 (en) 1986-07-03
NZ214543A (en) 1990-03-27
AU583578B2 (en) 1989-05-04
AU5208386A (en) 1986-07-22
EP0204775A1 (en) 1986-12-17

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19860726

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: LA TROBE UNIVERSITY

Owner name: AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMI

A4 Supplementary search report drawn up and despatched

Effective date: 19891004

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMIT

17Q First examination report despatched

Effective date: 19910620

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19921229

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TERNAI, BELA