AU5208386A - Amino acid and peptide inhibitors of human leucocytic elastase - Google Patents

Amino acid and peptide inhibitors of human leucocytic elastase

Info

Publication number
AU5208386A
AU5208386A AU52083/86A AU5208386A AU5208386A AU 5208386 A AU5208386 A AU 5208386A AU 52083/86 A AU52083/86 A AU 52083/86A AU 5208386 A AU5208386 A AU 5208386A AU 5208386 A AU5208386 A AU 5208386A
Authority
AU
Australia
Prior art keywords
amino acid
peptide inhibitors
leucocytic elastase
human leucocytic
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU52083/86A
Other versions
AU583578B2 (en
Inventor
Bela Ternai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Australia Commercial Research and Development Ltd
Original Assignee
La Trobe University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by La Trobe University filed Critical La Trobe University
Publication of AU5208386A publication Critical patent/AU5208386A/en
Application granted granted Critical
Publication of AU583578B2 publication Critical patent/AU583578B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU52083/86A 1984-12-14 1985-12-13 Amino acid and peptide inhibitors of human leucocytic elastase Ceased AU583578B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPG8574 1984-12-14
AUPG857484 1984-12-14

Publications (2)

Publication Number Publication Date
AU5208386A true AU5208386A (en) 1986-07-22
AU583578B2 AU583578B2 (en) 1989-05-04

Family

ID=3770882

Family Applications (1)

Application Number Title Priority Date Filing Date
AU52083/86A Ceased AU583578B2 (en) 1984-12-14 1985-12-13 Amino acid and peptide inhibitors of human leucocytic elastase

Country Status (5)

Country Link
EP (1) EP0204775A4 (en)
JP (1) JPS62501147A (en)
AU (1) AU583578B2 (en)
NZ (1) NZ214543A (en)
WO (1) WO1986003746A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010348A1 (en) * 1988-04-19 1989-11-02 Synpharm Ltd Fatty amino acids, and homo- and hetero-oligomers and conjugates thereof
WO1990005141A1 (en) * 1988-11-10 1990-05-17 Australian Commercial Research & Development Limited Amino acid and peptide inhibitors of human leukocytic elastase and collagenase

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9301789A (en) * 1992-04-03 1993-10-01 Iaf Biochem Int NEW LIPOPHILIC OLIGOPEPTIDES WITH IMMUNOMODULATING ACTIVITY.
FR2719584B1 (en) * 1994-05-09 1996-06-07 Oreal New serine derivatives, their preparation and their use in cosmetic or dermatological compositions.

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH490338A (en) * 1967-04-13 1970-05-15 Ciba Geigy Process for the production of ACTH-active peptides with extended action
FR1591598A (en) * 1967-07-31 1970-05-04
US3574747A (en) * 1968-03-29 1971-04-13 Norwich Pharma Co Amides of diaminoacids
US3862928A (en) * 1969-07-09 1975-01-28 Akzona Inc Psychopharmacological hexa-peptides containing a d-phenylalanyl residue
CH552567A (en) * 1970-10-30 1974-08-15 Hoffmann La Roche PROCESS FOR PRODUCING PHENYLALANINE DERIVATIVES.
NL175293C (en) * 1972-02-08 1984-10-16 Akzo Nv METHOD FOR PREPARING OR MANUFACTURING A PHARMACEUTICAL PREPARATION WITH A PSYCHOPHARMACOLOGICAL ACTION, AND A METHOD FOR PREPARING A VASOPRESSIN DERIVED PEPTIDE.
BE795788A (en) * 1972-02-22 1973-08-22 Akzo Nv PROCESS FOR THE PREPARATION OF PEPTIDES AND PEPTIDE DERIVATIVES AND THEIR USE
NL175988C (en) * 1972-05-24 1985-02-01 Akzo Nv PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH A PSYCHOPHARMACOLOGICAL EFFECT, THAT A PEPTIDE OR PEPTIDE DERIVATIVE DERIVED FROM AN AMINO ACIDS 4-10, FRAGMENT OF ADRENOCORTICOTROP HORMONE, AS AN PROPERTY, AND ITS PROPERTY, PROPERTY, AND ITS PROPERTY.
NL175618C (en) * 1972-07-15 1984-12-03 Akzo Nv PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH A PSYCHOPHARMACOLOGICAL ACTION CONTAINING A PEPTIDE OR PEPTIDE DERIVATIVE AND A PROCESS FOR THE PREPARATION OF SUCH PEPTIDES.
CA1103239A (en) * 1976-03-23 1981-06-16 Charles E. Frohman Product and process for treating schizophrenia
US4187216A (en) * 1976-06-25 1980-02-05 Hoffmann-La Roche Inc. Dipeptide derivatives
FR2442241A2 (en) * 1978-03-20 1980-06-20 Anvar NOVEL ESTER COMPOUNDS OF MURAMYL-PEPTIDE, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, IN PARTICULAR IN THE FORM OF LIPOSOMES
DE2964956D1 (en) * 1978-07-18 1983-04-07 Kabi Ab Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them
US4231782A (en) * 1978-11-03 1980-11-04 Monsanto Company N-Carbobenzoxy-N-phosphonomethylglycine thioesters
US4335111A (en) * 1978-12-22 1982-06-15 Agence National De Valorisation De La Recherche (Anvar) Compounds associating peptidyl of aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds
HU180925B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem
NL8005121A (en) * 1979-09-20 1981-03-24 Erba Farmitalia ORGANICALLY ACTIVE PEPTIDES.
DE2938420A1 (en) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt NEW PEPTIDES AND METHOD FOR THEIR PRODUCTION
CS226907B1 (en) * 1981-08-07 1984-04-16 Kasafirek Evzen Alkylamides of carboxyalkanoylpeptides
FR2533209B1 (en) * 1982-09-22 1985-11-08 Centre Nat Rech Scient LIPOPEPTIDES, THEIR OBTAINMENT AND THEIR APPLICATION AS EMULSIFIERS
EP0136879A3 (en) * 1983-09-30 1987-01-07 Yamanouchi Pharmaceutical Co., Ltd. Fatty acid derivatives and processes of producing them
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
JPH0510569A (en) * 1991-07-05 1993-01-19 Kubota Corp Air conditioner

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010348A1 (en) * 1988-04-19 1989-11-02 Synpharm Ltd Fatty amino acids, and homo- and hetero-oligomers and conjugates thereof
WO1990005141A1 (en) * 1988-11-10 1990-05-17 Australian Commercial Research & Development Limited Amino acid and peptide inhibitors of human leukocytic elastase and collagenase

Also Published As

Publication number Publication date
AU583578B2 (en) 1989-05-04
NZ214543A (en) 1990-03-27
JPS62501147A (en) 1987-05-07
EP0204775A1 (en) 1986-12-17
EP0204775A4 (en) 1989-10-04
WO1986003746A1 (en) 1986-07-03

Similar Documents

Publication Publication Date Title
IL77748A (en) Amino acid and peptide derivatives as peptidase inhibitors
PL252807A1 (en) Physiologically active human peptide and method of obtaining it
EP0785276A4 (en) Modification of peptide and protein
AU556832B2 (en) Chromogenic amino acid esters and peptide esters
US5656608B1 (en) Amino acid compositions and methods of treatment using same
AU5684594A (en) Novel human amyloid protein precursor homologue and kunitz-type inhibitors
ES541775A0 (en) ESTERS OF AMINO ACIDS AND CHROMOGEN PEPTIDES
AU4077193A (en) Alpha-aminoboronic acid peptides and their use as elastase inhibitors
IL84268A (en) Amino-cyclohexyl-hydroxyalkanoic acid peptide derivatives and pharmaceutical compositions containing them
AU5770786A (en) Human anti-inflammatory phospholipase inhibitor protein
AU6428890A (en) Therapeutic peptides and proteins
AU590738B2 (en) Novel growth hormone-releasing peptides and method of treating mammals therewith
AU4062185A (en) Aseptic addition of dipeptide of l-phenylalanine and l-aspartic acid
NZ227669A (en) Amino acid glycerides and pharmaceutical compositions thereof
AU4327285A (en) Human atrial natriuretic peptide and gene encoding same
NZ215282A (en) Peptide amino alcohol, renin and acid protease inhibitors, preparation and pharmaceutical composition
AU5208386A (en) Amino acid and peptide inhibitors of human leucocytic elastase
AU6643690A (en) Polypeptide inhibitors of gamma interferon
NZ213628A (en) Amino alcohol derivatives and preparation thereof
AU6518486A (en) Peptides and compositions
GB2161166B (en) Radiolabeling of methionine containing proteins and peptides
AU3193089A (en) Prepromotilin and motilin-associated peptide (map)
JPS6455181A (en) Artificial protein having particular amino acid composition and method for preparation thereof
AU4588189A (en) Imidazole-containing peptide and preparation thereof
AU7831887A (en) Pharmaceutical composition of a short, glycine and tyrosine containing peptide