EP0204775A4 - Inhibiteur aux amino-acides et aux peptides de l'elastase leucocytique humaine. - Google Patents

Inhibiteur aux amino-acides et aux peptides de l'elastase leucocytique humaine.

Info

Publication number
EP0204775A4
EP0204775A4 EP19860900028 EP86900028A EP0204775A4 EP 0204775 A4 EP0204775 A4 EP 0204775A4 EP 19860900028 EP19860900028 EP 19860900028 EP 86900028 A EP86900028 A EP 86900028A EP 0204775 A4 EP0204775 A4 EP 0204775A4
Authority
EP
European Patent Office
Prior art keywords
amino acid
peptide inhibitors
leucocytic elastase
human leucocytic
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19860900028
Other languages
German (de)
English (en)
Other versions
EP0204775A1 (fr
Inventor
Bela Ternai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
La Trobe University
Australia Commercial Research and Development Ltd
Original Assignee
La Trobe University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by La Trobe University filed Critical La Trobe University
Publication of EP0204775A1 publication Critical patent/EP0204775A1/fr
Publication of EP0204775A4 publication Critical patent/EP0204775A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP19860900028 1984-12-14 1985-12-13 Inhibiteur aux amino-acides et aux peptides de l'elastase leucocytique humaine. Withdrawn EP0204775A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPG857484 1984-12-14
AU8574/84 1984-12-14

Publications (2)

Publication Number Publication Date
EP0204775A1 EP0204775A1 (fr) 1986-12-17
EP0204775A4 true EP0204775A4 (fr) 1989-10-04

Family

ID=3770882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19860900028 Withdrawn EP0204775A4 (fr) 1984-12-14 1985-12-13 Inhibiteur aux amino-acides et aux peptides de l'elastase leucocytique humaine.

Country Status (5)

Country Link
EP (1) EP0204775A4 (fr)
JP (1) JPS62501147A (fr)
AU (1) AU583578B2 (fr)
NZ (1) NZ214543A (fr)
WO (1) WO1986003746A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217319A (en) * 1988-04-19 1989-10-25 Synpharm Ltd Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi
WO1990005141A1 (fr) * 1988-11-10 1990-05-17 Australian Commercial Research & Development Limited Amino acide et peptide inhibiteurs de l'elastase leucocytaire humaine et de la collagenase
MX9301789A (es) * 1992-04-03 1993-10-01 Iaf Biochem Int Nuevos oligopeptidos lipofilicos con actividad inmunomoduladora.
FR2719584B1 (fr) * 1994-05-09 1996-06-07 Oreal Nouveaux dérivés de la sérine, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2728593A1 (de) * 1976-06-25 1978-01-05 Hoffmann La Roche Dipeptide
US4242329A (en) * 1978-07-18 1980-12-30 Ab Kabi Bradykinin-inhibiting tripeptide derivatives
FR2510990A1 (fr) * 1981-08-07 1983-02-11 Spofa Vereinigte Pharma Werke Alcoylamides de carboxyalcanoylpeptides
EP0195212A2 (fr) * 1985-02-04 1986-09-24 Merrell Dow Pharmaceuticals Inc. Inhibiteurs peptidases

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH490338A (de) * 1967-04-13 1970-05-15 Ciba Geigy Verfahren zur Herstellung von ACTH-wirksamen Peptiden mit verlängerter Wirkung
FR1591598A (fr) * 1967-07-31 1970-05-04
US3574747A (en) * 1968-03-29 1971-04-13 Norwich Pharma Co Amides of diaminoacids
US3862928A (en) * 1969-07-09 1975-01-28 Akzona Inc Psychopharmacological hexa-peptides containing a d-phenylalanyl residue
CH552567A (de) * 1970-10-30 1974-08-15 Hoffmann La Roche Verfahren zur herstellung von phenylalaninderivaten.
NL175293C (nl) * 1972-02-08 1984-10-16 Akzo Nv Werkwijze ter bereiding of vervaardiging van een farmaceutisch preparaat met psychofarmacologische werking, alsmede werkwijze voor het bereiden van een van vasopressine afgeleid peptide.
BE795788A (nl) * 1972-02-22 1973-08-22 Akzo Nv Werkwijze ter bereiding van peptiden en peptide-derivaten en de toepassing hiervan
NL175988C (nl) * 1972-05-24 1985-02-01 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat dat afgeleid is van een de aminozuren 4-10 omvattend, fragment van adrenocorticotroop hormoon als actief bestanddeel bevat, alsmede een werkwijze ter bereiding van deze peptiden.
NL175618C (nl) * 1972-07-15 1984-12-03 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat bevat, alsmede een werkwijze ter bereiding van dergelijke peptiden.
CA1103239A (fr) * 1976-03-23 1981-06-16 Charles E. Frohman Produit et procede pour traiter la schirophrenie
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
US4231782A (en) * 1978-11-03 1980-11-04 Monsanto Company N-Carbobenzoxy-N-phosphonomethylglycine thioesters
US4335111A (en) * 1978-12-22 1982-06-15 Agence National De Valorisation De La Recherche (Anvar) Compounds associating peptidyl of aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds
HU180925B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
DE2938420A1 (de) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung
FR2533209B1 (fr) * 1982-09-22 1985-11-08 Centre Nat Rech Scient Lipopeptides, leur obtention et leur application comme emulsifiants
EP0136879A3 (fr) * 1983-09-30 1987-01-07 Yamanouchi Pharmaceutical Co., Ltd. Dérivés d'acides gras et procédés de leur préparation
JPH0510569A (ja) * 1991-07-05 1993-01-19 Kubota Corp 空調装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2728593A1 (de) * 1976-06-25 1978-01-05 Hoffmann La Roche Dipeptide
US4242329A (en) * 1978-07-18 1980-12-30 Ab Kabi Bradykinin-inhibiting tripeptide derivatives
FR2510990A1 (fr) * 1981-08-07 1983-02-11 Spofa Vereinigte Pharma Werke Alcoylamides de carboxyalcanoylpeptides
EP0195212A2 (fr) * 1985-02-04 1986-09-24 Merrell Dow Pharmaceuticals Inc. Inhibiteurs peptidases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 101, no. 21, 19th November 1984, page 333, abstract no. 186798y, Columbus, Ohio, US; L. ROBERT et al.: "Bifunctional inhibitors as potential agents against elastolysis", & BIOCHEM. SOC. TRANS. 1984, 12(5), 876-7 *
CHEMICAL ABSTRACTS, vol. 84, no. 1, 5th January 1976, page 461, abstract no. 5386z, Columbus, Ohio, US; & JP-A-75 10 569 (TAISHO PHARMACEUTICAL CO., LTD) 22-04-1975 *
CHEMICAL ABSTRACTS, vol. 86, no. 3, 17th January 1977, page 452, abstract no. 16925s, Columbus, Ohio, US; U. BEITLER et al.: "Interaction between asymmetric solutes and solvents. Diamides derived from L-valine as stationary phases in gas-liquid partition chromatography", & J. CHROMATOGR. 1976, 123(1), 149-66 *
See also references of WO8603746A1 *

Also Published As

Publication number Publication date
WO1986003746A1 (fr) 1986-07-03
EP0204775A1 (fr) 1986-12-17
AU5208386A (en) 1986-07-22
NZ214543A (en) 1990-03-27
AU583578B2 (en) 1989-05-04
JPS62501147A (ja) 1987-05-07

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19860726

AK Designated contracting states

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Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: LA TROBE UNIVERSITY

Owner name: AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMI

A4 Supplementary search report drawn up and despatched

Effective date: 19891004

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMIT

17Q First examination report despatched

Effective date: 19910620

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19921229

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TERNAI, BELA