ATE205213T1 - Pentacyclische verbindungen - Google Patents
Pentacyclische verbindungenInfo
- Publication number
- ATE205213T1 ATE205213T1 AT96912252T AT96912252T ATE205213T1 AT E205213 T1 ATE205213 T1 AT E205213T1 AT 96912252 T AT96912252 T AT 96912252T AT 96912252 T AT96912252 T AT 96912252T AT E205213 T1 ATE205213 T1 AT E205213T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- alkynyl
- alkyl
- alkenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000004579 taxol derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10629595 | 1995-04-28 | ||
| PCT/JP1996/001145 WO1996033998A1 (en) | 1995-04-28 | 1996-04-25 | Pentacyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE205213T1 true ATE205213T1 (de) | 2001-09-15 |
Family
ID=14430058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96912252T ATE205213T1 (de) | 1995-04-28 | 1996-04-25 | Pentacyclische verbindungen |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US6075140A (de) |
| EP (1) | EP0826688B1 (de) |
| KR (1) | KR100380875B1 (de) |
| CN (1) | CN1094940C (de) |
| AT (1) | ATE205213T1 (de) |
| BR (1) | BR9608040B1 (de) |
| CA (1) | CA2219675C (de) |
| DE (1) | DE69615016T2 (de) |
| DK (1) | DK0826688T3 (de) |
| EA (1) | EA000701B1 (de) |
| ES (1) | ES2164241T3 (de) |
| NO (1) | NO321942B1 (de) |
| PT (1) | PT826688E (de) |
| TW (1) | TW480262B (de) |
| WO (1) | WO1996033998A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| PT826688E (pt) | 1995-04-28 | 2002-02-28 | Daiichi Seiyaku Co | Composto pentaciclico |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| EP1147226B1 (de) * | 1999-01-27 | 2013-01-23 | Folim G. Halaka | Materialien und verfahren zur reinigung von polyelektrolyten |
| AU774787B2 (en) * | 1999-10-15 | 2004-07-08 | Daiichi Sankyo Company, Limited | Pentacyclic taxane compounds |
| US6677456B2 (en) | 1999-10-15 | 2004-01-13 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic taxan compound |
| CN1266129C (zh) * | 2000-01-19 | 2006-07-26 | 卡地拉健康护理有限公司 | 具有降血脂和降低血中胆固醇活性的新化合物、其制备方法和含有它们的药物组合物 |
| US6362217B2 (en) * | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
| US6987123B2 (en) | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
| RU2284328C2 (ru) * | 2001-11-29 | 2006-09-27 | Дайити Фармасьютикал Ко., Лтд. | Кристаллы производных таксана и способ их получения |
| US6787659B2 (en) * | 2001-12-11 | 2004-09-07 | Barr Laboratories, Inc. | Process for the production of oxandrolone |
| AU2003202026A1 (en) | 2002-01-16 | 2003-09-02 | Dynal Biotech Asa | Method for isolating nucleic acids and protein from a single sample |
| KR101186475B1 (ko) | 2004-04-30 | 2012-09-27 | 다이이찌 세이야꾸 가부시기가이샤 | 펜타사이클릭 탁산의 제조방법 |
| WO2007049575A1 (ja) * | 2005-10-25 | 2007-05-03 | Daiichi Sankyo Company, Limited | アゼチジン環構造を有するタキサン化合物 |
| CN100516067C (zh) * | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
| US8697892B2 (en) | 2010-06-30 | 2014-04-15 | Gfv, Llc | Taxane compounds, compositions and methods |
| US8785669B2 (en) | 2010-06-30 | 2014-07-22 | Gfv, Llc | Taxane compounds, compositions and methods |
| CN103354757A (zh) | 2011-01-31 | 2013-10-16 | 卡迪拉保健有限公司 | 脂肪代谢障碍的治疗 |
| EP2988736A1 (de) | 2013-04-22 | 2016-03-02 | Cadila Healthcare Limited | Neuartige zusammensetzung für nicht alkoholbedingte fettlebererkrankung (nafld) |
| US20160107989A1 (en) | 2013-05-30 | 2016-04-21 | Cadila Healthcare Limited | A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities |
| TW201636015A (zh) | 2013-07-05 | 2016-10-16 | 卡地拉保健有限公司 | 協同性組成物 |
| IN2013MU02470A (de) | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
| IN2013MU02905A (de) | 2013-09-06 | 2015-07-03 | Cadila Healthcare Ltd | |
| US10385017B2 (en) | 2015-10-14 | 2019-08-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
| WO2018104916A1 (en) | 2016-12-09 | 2018-06-14 | Cadila Healthcare Limited | Treatment for primary biliary cholangitis |
| CN107188895B (zh) * | 2017-04-17 | 2020-03-13 | 上海大学 | C-13和c-14位结构改造的紫杉醇类化合物及其制备方法 |
| CN108530400B (zh) * | 2018-05-28 | 2022-07-12 | 上海大学 | C-2位和c-4位修饰的1-去氧紫杉烷类化合物及其制备方法 |
| CN110105368B (zh) * | 2019-05-09 | 2022-01-07 | 上海大学 | 去氧紫杉烷类似物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5481010A (en) * | 1991-07-16 | 1996-01-02 | Centre National De La Recherche Scientifique | 7-deacetoxy beccatine IV derivative and preparation and use thereof |
| US5284864A (en) * | 1991-09-23 | 1994-02-08 | Florida State University | Butenyl substituted taxanes and pharmaceutical compositions containing them |
| JPH07505887A (ja) * | 1992-04-17 | 1995-06-29 | アボツト・ラボラトリーズ | タキソール誘導体 |
| EP0577083B1 (de) * | 1992-07-01 | 2003-12-10 | Bristol-Myers Squibb Company | 7,8-Zyklopropataxanen mit antitumor Wirkung |
| JP3208517B2 (ja) * | 1992-07-01 | 2001-09-17 | ブリストル−マイヤーズ スクイブ カンパニー | 7,8−シクロプロパタキサン類 |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| DE69434190T2 (de) * | 1993-03-22 | 2005-05-25 | Florida State University, Tallahassee | Pharmazeutische Zusammenstellungen enthaltende eine furyl oder thienyl substituierte Seitenkette |
| US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| FR2711370B1 (fr) * | 1993-10-18 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2723094A1 (fr) * | 1994-07-26 | 1996-02-02 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| PT826688E (pt) * | 1995-04-28 | 2002-02-28 | Daiichi Seiyaku Co | Composto pentaciclico |
| US5780653A (en) * | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
-
1996
- 1996-04-25 PT PT96912252T patent/PT826688E/pt unknown
- 1996-04-25 AT AT96912252T patent/ATE205213T1/de active
- 1996-04-25 TW TW085104983A patent/TW480262B/zh not_active IP Right Cessation
- 1996-04-25 BR BRPI9608040-0A patent/BR9608040B1/pt not_active IP Right Cessation
- 1996-04-25 US US08/945,276 patent/US6075140A/en not_active Expired - Lifetime
- 1996-04-25 KR KR1019970707705A patent/KR100380875B1/ko not_active Expired - Fee Related
- 1996-04-25 CN CN96194915A patent/CN1094940C/zh not_active Expired - Fee Related
- 1996-04-25 DK DK96912252T patent/DK0826688T3/da active
- 1996-04-25 WO PCT/JP1996/001145 patent/WO1996033998A1/ja not_active Ceased
- 1996-04-25 CA CA002219675A patent/CA2219675C/en not_active Expired - Fee Related
- 1996-04-25 ES ES96912252T patent/ES2164241T3/es not_active Expired - Lifetime
- 1996-04-25 EP EP96912252A patent/EP0826688B1/de not_active Expired - Lifetime
- 1996-04-25 EA EA199700351A patent/EA000701B1/ru not_active IP Right Cessation
- 1996-04-25 DE DE69615016T patent/DE69615016T2/de not_active Expired - Lifetime
-
1997
- 1997-10-24 NO NO19974912A patent/NO321942B1/no not_active IP Right Cessation
-
2000
- 2000-02-25 US US09/513,852 patent/US6211363B1/en not_active Expired - Lifetime
-
2001
- 2001-01-16 US US09/759,378 patent/US6545151B2/en not_active Expired - Lifetime
-
2002
- 2002-04-22 US US10/126,653 patent/US6646123B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2219675C (en) | 2009-08-18 |
| US20030162971A1 (en) | 2003-08-28 |
| KR19990008180A (ko) | 1999-01-25 |
| US6646123B2 (en) | 2003-11-11 |
| PT826688E (pt) | 2002-02-28 |
| HK1008529A1 (en) | 1999-07-16 |
| US6075140A (en) | 2000-06-13 |
| EA199700351A1 (ru) | 1998-04-30 |
| US6211363B1 (en) | 2001-04-03 |
| NO974912L (no) | 1997-12-29 |
| US20010041796A1 (en) | 2001-11-15 |
| TW480262B (en) | 2002-03-21 |
| BR9608040A (pt) | 1999-01-12 |
| DK0826688T3 (da) | 2001-10-22 |
| EP0826688A1 (de) | 1998-03-04 |
| CN1094940C (zh) | 2002-11-27 |
| NO974912D0 (no) | 1997-10-24 |
| WO1996033998A1 (en) | 1996-10-31 |
| CA2219675A1 (en) | 1996-10-31 |
| KR100380875B1 (ko) | 2003-10-10 |
| BR9608040B1 (pt) | 2010-02-23 |
| EP0826688B1 (de) | 2001-09-05 |
| US6545151B2 (en) | 2003-04-08 |
| DE69615016D1 (de) | 2001-10-11 |
| AU704198B2 (en) | 1999-04-15 |
| AU5514596A (en) | 1996-11-18 |
| ES2164241T3 (es) | 2002-02-16 |
| DE69615016T2 (de) | 2002-05-02 |
| NO321942B1 (no) | 2006-07-24 |
| EA000701B1 (ru) | 2000-02-28 |
| EP0826688A4 (de) | 1998-05-13 |
| CN1188477A (zh) | 1998-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |