ATE198335T1 - Cc-1065-analoge mit zwei cpi-subeinheiten - Google Patents

Cc-1065-analoge mit zwei cpi-subeinheiten

Info

Publication number
ATE198335T1
ATE198335T1 AT89308920T AT89308920T ATE198335T1 AT E198335 T1 ATE198335 T1 AT E198335T1 AT 89308920 T AT89308920 T AT 89308920T AT 89308920 T AT89308920 T AT 89308920T AT E198335 T1 ATE198335 T1 AT E198335T1
Authority
AT
Austria
Prior art keywords
pct
formula
date mar
compounds
cpi
Prior art date
Application number
AT89308920T
Other languages
German (de)
English (en)
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE198335T1 publication Critical patent/ATE198335T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Amplifiers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Artificial Filaments (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Television Receiver Circuits (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Stereophonic System (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Television Systems (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT89308920T 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten ATE198335T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (1)

Publication Number Publication Date
ATE198335T1 true ATE198335T1 (de) 2001-01-15

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89308920T ATE198335T1 (de) 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten

Country Status (14)

Country Link
US (1) US5541339A (https=)
JP (1) JP3380237B2 (https=)
KR (1) KR0137959B1 (https=)
AT (1) ATE198335T1 (https=)
AU (1) AU632288B2 (https=)
CA (1) CA1340215C (https=)
DE (1) DE68929275T2 (https=)
DK (1) DK175458B1 (https=)
FI (1) FI103668B1 (https=)
GR (1) GR3035589T3 (https=)
LV (1) LV12806B (https=)
NO (1) NO303498B1 (https=)
TW (1) TW217383B (https=)
WO (1) WO1990002746A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563475B1 (en) * 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
AU2002311919B8 (en) 2001-05-11 2007-03-22 Ludwig Institute For Cancer Research Ltd Specific binding proteins and uses thereof
JP2005509003A (ja) 2001-11-09 2005-04-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼインヒビターとして有用なベンゾイミダゾール化合物
AU2003257094A1 (en) * 2002-08-08 2004-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
WO2004035571A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
EP1641759B1 (en) * 2003-07-07 2014-03-12 Merck Patent GmbH Malonamide derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
CN101287728A (zh) * 2005-08-17 2008-10-15 先灵公司 新的高亲和力噻吩基和呋喃基激酶配体
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
ES2647317T3 (es) 2008-11-03 2017-12-20 Syntarga B.V. Análogos de CC-1065 y sus conjugados
PT3056203T (pt) 2010-04-21 2018-02-15 Syntarga Bv Conjugados de análogos de cc-1065 e ligantes bifuncionais
US20150265641A1 (en) 2012-10-22 2015-09-24 Arnold Glazier Methods for the Effective Treatment of Metastatic Cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
RU2680404C2 (ru) 2014-01-10 2019-02-21 Синтон Байофармасьютикалс Б. В. Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
SG11201605437YA (en) * 2014-01-27 2016-08-30 Pfizer Bifunctional cytotoxic agents
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
US10870706B2 (en) * 2015-03-20 2020-12-22 Pfizer Inc. Bifunctional cytotoxic agents containing the CTI pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
DE3750612T2 (de) * 1986-12-19 1995-03-02 Upjohn Co Cc-1065 analoge.

Also Published As

Publication number Publication date
AU632288B2 (en) 1992-12-24
NO910958L (no) 1991-05-10
LV12806B (lv) 2002-05-20
DK41791D0 (da) 1991-03-08
JPH04500664A (ja) 1992-02-06
KR0137959B1 (ko) 1998-05-15
FI911193A0 (fi) 1991-03-11
DK175458B1 (da) 2004-11-01
US5541339A (en) 1996-07-30
DE68929275T2 (de) 2001-05-23
GR3035589T3 (en) 2001-06-29
WO1990002746A1 (en) 1990-03-22
JP3380237B2 (ja) 2003-02-24
NO910958D0 (no) 1991-03-11
FI103668B (fi) 1999-08-13
TW217383B (https=) 1993-12-11
DE68929275D1 (de) 2001-02-01
CA1340215C (en) 1998-12-15
NO303498B1 (no) 1998-07-20
FI103668B1 (fi) 1999-08-13
LV12806A (en) 2002-03-20
AU4192289A (en) 1990-04-02
DK41791A (da) 1991-03-08
KR900701801A (ko) 1990-12-04

Similar Documents

Publication Publication Date Title
ATE198335T1 (de) Cc-1065-analoge mit zwei cpi-subeinheiten
PT653439E (pt) Oligonucleotidos e sua aplicacao
BR9814374B1 (pt) "urÉias heterocÍclicas substituÍdas e composiÇÕes compreendendo as mesmas"
ES2087056T3 (es) 2-pirimidinaminas sustituidas en las posiciones 4, 5 y 6.
TR200002616T2 (tr) Simetrik ve simetrik olmayan sübstitüe edilmiş difenil üreler kullanılarak raf kinazın inhibe edilmesi
ES2184077T3 (es) Nuevas fenantridinas sustituidas en la posicion 6.
PT1086096E (pt) Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
DE3774286D1 (de) (2,2-bis(aminomethyl)-1,3-propandiol-n,n')platin-komplexe.
TR23462A (tr) Karbamat ve tiyokarbamat olabilen aromatik bilesiklerle hasaratin bueyuemesini ayarlayin bilesikleri ihtiva eden zararlilari kontrol altina almaya mahsus bilesimler
ATE63111T1 (de) Substituierte oximether, ihre verwendung als bioregulatoren zur senkung des endogenen ethylenspiegels in pflanzen.
ES2153814T3 (es) Analogos de cc-1065 que tienen dos subunidades cpi.
ITMI920955A1 (it) Idrogeli di tipo polietereammidoamminico come materiali eparinizzabili
ATE51001T1 (de) Koordinationsverbindungen von platin.
ATE195055T1 (de) Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
DK24687D0 (da) 3-alkoxyflavonderivater samt antiviralt virksomme terapeutiske midler indeholdende disse
DE3768322D1 (de) Substituierte alkynische thiocyanate, sie enthaltende biozide zusammensetzungen und deren verwendung.
DK0713485T3 (da) Thiocarbamoylforbindelser som mikrobicider
DE3854273D1 (de) 1,2-Di(4-isobutylphenyl)ethan, ihre Herstellung und ihre Verwendung als Zwischenprodukt.
ATE87314T1 (de) Platin-arzneimittel.
ATE45147T1 (de) Azidobenzazepine.
ATE82980T1 (de) (gem-heterocyclodimethanamin-n,n')platin komplexe.
ATE175349T1 (de) Verwendung von etofibrat und pharmazeutische zusammensetzungen, enthaltend etofibrat, zur behandlung der diabetischen angio- und retinopathie
DE69909010D1 (de) Verwendung von procyanidolischen Oligomeren oder Anthocyanosiden als Anti-Urease Wirkstoffe
DE69109328D1 (de) Mischung von Dispersionsfarbstoffen.
BG91292A (bg) Пиридинсулфонилкарбамиди и приложението им като хербициди

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee