ATE197608T1 - Signalsequenzen für die secretion heterologer proteine von hefe - Google Patents
Signalsequenzen für die secretion heterologer proteine von hefeInfo
- Publication number
- ATE197608T1 ATE197608T1 AT94119437T AT94119437T ATE197608T1 AT E197608 T1 ATE197608 T1 AT E197608T1 AT 94119437 T AT94119437 T AT 94119437T AT 94119437 T AT94119437 T AT 94119437T AT E197608 T1 ATE197608 T1 AT E197608T1
- Authority
- AT
- Austria
- Prior art keywords
- secretion
- proteins
- heterologue
- yeast
- signal sequences
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01007—Inulinase (3.2.1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR930027269 | 1993-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE197608T1 true ATE197608T1 (de) | 2000-12-15 |
Family
ID=19370595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94119437T ATE197608T1 (de) | 1993-12-10 | 1994-12-08 | Signalsequenzen für die secretion heterologer proteine von hefe |
Country Status (5)
Country | Link |
---|---|
US (1) | US5712113A (de) |
EP (1) | EP0662515B1 (de) |
JP (1) | JP2799348B2 (de) |
AT (1) | ATE197608T1 (de) |
DE (1) | DE69426289T2 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919654A (en) * | 1995-02-03 | 1999-07-06 | Asahi Glass Company Ltd. | Secretion signal gene and expression vector containing it |
JP2005524684A (ja) * | 2002-04-22 | 2005-08-18 | ザ プロクター アンド ギャンブル カンパニー | 陽イオン性グアー誘導体を含有するシャンプー |
US20070172446A1 (en) | 2003-05-16 | 2007-07-26 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
DE10342794A1 (de) * | 2003-09-16 | 2005-04-21 | Basf Ag | Sekretion von Proteinen aus Hefen |
DK2275556T3 (da) | 2004-01-17 | 2013-07-08 | Korea Res Inst Of Bioscience | Hurtig fremgangsmåde til screening af translationsfusionspartnere til fremstilling af rekombinante proteiner og translationsfusionpartnere screenet derfra |
JP2008513356A (ja) * | 2004-08-09 | 2008-05-01 | アリオス バイオファーマ インク. | 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法 |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
WO2006082251A2 (de) | 2005-02-07 | 2006-08-10 | Basf Aktiengesellschaft | Neue hydrophobinfusionsproteine, deren herstellung und verwendung |
BRPI0607594A2 (pt) | 2005-03-31 | 2010-04-06 | Basf Ag | compósito multi-camadas ou substrato revestido, processo para a preparação dos mesmos, e, uso de hidrofobinas |
EP1869138B1 (de) | 2005-04-01 | 2009-11-25 | Basf Se | Bohrspülung enthaltend hydrophobin |
WO2006103252A2 (de) | 2005-04-01 | 2006-10-05 | Basf Aktiengesellschaft | Verwendung von hydrophobin als phasen-stabilisator |
DE102005027139A1 (de) | 2005-06-10 | 2006-12-28 | Basf Ag | Neue Cystein-verarmte Hydrophobinfusionsproteine, deren Herstellung und Verwendung |
DE102005048720A1 (de) | 2005-10-12 | 2007-04-19 | Basf Ag | Verwendung von Proteinen als Antischaum-Komponente in Kraftstoffen |
JP5354559B2 (ja) * | 2005-11-24 | 2013-11-27 | 独立行政法人産業技術総合研究所 | 高効率分泌シグナルペプチド及びそれらを利用したタンパク質発現系 |
ES2374320T3 (es) | 2006-08-15 | 2012-02-15 | Basf Se | Procedimiento para la producción de preparaciones de hidrofobina secas de flujo libre. |
JP5769142B2 (ja) * | 2007-09-04 | 2015-08-26 | 独立行政法人酒類総合研究所 | ピヒア属酵母において異種タンパク質を高分泌させる方法 |
KR101387693B1 (ko) * | 2008-12-04 | 2014-04-21 | 한국생명공학연구원 | 고분비성 단백질의 스크리닝 및 재조합 단백질의 생산을 위한 융합 파트너로서 그의 용도 |
WO2012060666A2 (ko) | 2010-11-04 | 2012-05-10 | 한국생명공학연구원 | 효모에서 인체 상피세포 성장인자를 대량 생산하는 방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588684A (en) * | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
US5081019A (en) * | 1985-01-10 | 1992-01-14 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lipocortin-like polypeptides |
IT1196484B (it) * | 1986-07-11 | 1988-11-16 | Sclavo Spa | Vettore ad espressione e secrezione in lieviti,utile per la preparazione di proteine eterologhe |
WO1991005051A1 (en) * | 1989-09-28 | 1991-04-18 | Leningradsky Gosudarstvenny Universitet | Method of obtaining human-interleukin-2 polypeptide in yeast cells |
WO1994013821A1 (en) * | 1992-12-11 | 1994-06-23 | Quest International B.V. | The use of the kluyveromyces marxianus inulinase gene promoter for protein production |
-
1994
- 1994-12-08 EP EP94119437A patent/EP0662515B1/de not_active Expired - Lifetime
- 1994-12-08 AT AT94119437T patent/ATE197608T1/de not_active IP Right Cessation
- 1994-12-08 DE DE69426289T patent/DE69426289T2/de not_active Expired - Fee Related
- 1994-12-09 JP JP6331663A patent/JP2799348B2/ja not_active Expired - Fee Related
- 1994-12-12 US US08/353,751 patent/US5712113A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69426289D1 (de) | 2000-12-21 |
US5712113A (en) | 1998-01-27 |
EP0662515B1 (de) | 2000-11-15 |
JPH0847393A (ja) | 1996-02-20 |
DE69426289T2 (de) | 2001-04-12 |
EP0662515A1 (de) | 1995-07-12 |
JP2799348B2 (ja) | 1998-09-17 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |