ATE197040T1 - Serotonin 5ht1a und 5ht1d agonisten - Google Patents
Serotonin 5ht1a und 5ht1d agonistenInfo
- Publication number
- ATE197040T1 ATE197040T1 AT91114456T AT91114456T ATE197040T1 AT E197040 T1 ATE197040 T1 AT E197040T1 AT 91114456 T AT91114456 T AT 91114456T AT 91114456 T AT91114456 T AT 91114456T AT E197040 T1 ATE197040 T1 AT E197040T1
- Authority
- AT
- Austria
- Prior art keywords
- serotonin 5ht1a
- agonists
- 5ht1d
- serotonin
- 5ht1a
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57471090A | 1990-08-29 | 1990-08-29 | |
US07/735,700 US5189179A (en) | 1990-08-29 | 1991-07-30 | Serotonin 5ht1a agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE197040T1 true ATE197040T1 (de) | 2000-11-15 |
Family
ID=27076473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91114456T ATE197040T1 (de) | 1990-08-29 | 1991-08-28 | Serotonin 5ht1a und 5ht1d agonisten |
Country Status (21)
Country | Link |
---|---|
US (3) | US5189179A (de) |
EP (1) | EP0478954B1 (de) |
JP (1) | JPH04270264A (de) |
KR (1) | KR920004345A (de) |
CN (1) | CN1030766C (de) |
AT (1) | ATE197040T1 (de) |
AU (1) | AU641535B2 (de) |
CA (1) | CA2049803A1 (de) |
DE (1) | DE69132450T2 (de) |
DK (1) | DK0478954T3 (de) |
ES (1) | ES2153346T3 (de) |
FI (1) | FI914065A (de) |
GR (1) | GR3035062T3 (de) |
HU (1) | HU208955B (de) |
IE (1) | IE913036A1 (de) |
IL (1) | IL99306A (de) |
NO (1) | NO175430C (de) |
NZ (1) | NZ239521A (de) |
PH (1) | PH30242A (de) |
PT (1) | PT98800B (de) |
TW (1) | TW200457B (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5189179A (en) * | 1990-08-29 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | Serotonin 5ht1a agonists |
US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
USRE38506E1 (en) | 1991-10-04 | 2004-04-20 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US6406859B1 (en) | 1992-01-08 | 2002-06-18 | Synaptic Pharmaceutical Corporation | DNA encoding a 5-HT 1F receptor and uses thereof |
GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
GB9304632D0 (en) * | 1993-03-06 | 1993-04-21 | Wyeth John & Brother Ltd | Amide derivatives |
FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
US5478572A (en) * | 1994-09-06 | 1995-12-26 | Bristol-Myers Squibb Co. | Gepirone dosage form |
EP0894085B1 (de) | 1996-03-29 | 2005-08-17 | Pfizer Inc. | Benkyl(idene)-lactam-derivate, deren herstellung und verwendung als selektive (ant)agonisten von 5-ht1a- und/oder 5-ht1d rezeptoren |
US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US8022095B2 (en) * | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
US6121307A (en) * | 1998-04-08 | 2000-09-19 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
CA2327360A1 (en) * | 1998-04-08 | 1999-10-14 | Richard Eric Mewshaw | Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression (5-ht1 receptor antagonists) |
AU3479299A (en) * | 1998-04-08 | 1999-10-25 | American Home Products Corporation | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
CA2327359A1 (en) * | 1998-04-08 | 1999-10-14 | Wyeth | N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents) |
US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
US7588029B2 (en) * | 2000-03-21 | 2009-09-15 | Fisher & Paykel Healthcare Limited | Humidified gases delivery apparatus |
AU2002325712C1 (en) | 2001-08-30 | 2008-07-31 | Stem Cell Therapeutics Inc. | Differentiation of neural stem cells and therapeutic use theeof |
AR036401A1 (es) * | 2001-09-14 | 2004-09-08 | Stem Cell Therapeutics Inc | Incremento de la cantidad de celulas madre neuronales inducido por prolactina. |
US20030054551A1 (en) * | 2001-09-18 | 2003-03-20 | Stem Cell Therapeutics Inc. | Effect of growth hormone and IGF-1 on neural stem cells |
EP1546198A1 (de) * | 2002-07-31 | 2005-06-29 | Stem Cell Therapeutics Inc. | Verfahren zur verbesserung der proliferation, der differenzierung und des berlebens von neuralen stammzellen unter verwendung von pituitary adenylate cyclase activating polypeptide (pacap) |
ATE546134T1 (de) * | 2002-12-26 | 2012-03-15 | Pozen Inc | Mehrschichtige dosierformen enthaltend naproxen und triptane |
KR20060015641A (ko) * | 2003-06-06 | 2006-02-17 | 글락소 그룹 리미티드 | 트립탄 및 nsaid를 포함하는 조성물 |
WO2005018541A2 (en) * | 2003-07-11 | 2005-03-03 | Pharmacia Corporation | Cox-2 inhibitor and serotonin modulator for treating cns damage |
US20070111932A1 (en) * | 2003-07-31 | 2007-05-17 | Stem Cell Therapeutics Inc. | Method of enhancing and/or inducing neuronal migration using erythropoietin |
EP1660079A2 (de) * | 2003-08-22 | 2006-05-31 | Pharmacia Corporation | Zusammensetzungen aus einem cyclooxygenase-2 selektiven hemmer und einem serotonin-modulierenden mittel zur behandlung von neoplasien |
CN1325673C (zh) * | 2003-12-30 | 2007-07-11 | 上海交通大学 | 利用废旧紫铜生产无氧铜的装置 |
US7846898B2 (en) * | 2004-02-13 | 2010-12-07 | Stem Cell Therapeutics Corp. | Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis |
MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
JP2008545650A (ja) | 2005-05-20 | 2008-12-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | スルファミド誘導体の製造方法 |
JP2009509943A (ja) | 2005-09-27 | 2009-03-12 | ステム セル セラピューティクス コーポレイション | プロラクチンにより制御される乏突起膠細胞前駆体細胞の増殖 |
US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
US8497298B2 (en) | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
US8492431B2 (en) | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
US20070191474A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine |
AU2007229301B2 (en) * | 2006-03-17 | 2013-08-01 | Stem Cell Therapeutics Corp. | Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents |
TW200812573A (en) | 2006-05-19 | 2008-03-16 | Janssen Pharmaceutica Nv | Co-therapy for the treatment of epilepsy and related disorders |
MX2011000090A (es) | 2008-06-23 | 2011-03-02 | Janssen Pharmaceutica Nv | Forma cristalina de (2s)-(-)-n-(6-cloro-2,3-dihidro-benzo[1,4]diox in-2-ilmetil)sulfamida. |
US8815939B2 (en) | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
CN111116451A (zh) * | 2020-01-16 | 2020-05-08 | 宁波大学 | 一种多取代色胺基苯甲酰胺类化合物及其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2725386A (en) * | 1953-02-13 | 1955-11-29 | Fond Emanuele Paterno | 2-(1, 4-benzodioxan) methyl derivatives of amino-lower fatty acid amides and preparation thereof |
FR2463765A1 (fr) * | 1979-08-17 | 1981-02-27 | Clin Midy | Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire |
US4684739A (en) * | 1980-12-15 | 1987-08-04 | Mitsubishi Chemical Industries Limited | Alkylenedioxybenzene derivatives and acid addition salts thereof |
US4614807A (en) * | 1984-10-04 | 1986-09-30 | Eli Lilly And Company | 6,7-dihalomelatonins |
ATE65084T1 (de) * | 1986-06-26 | 1991-07-15 | Ciba Geigy Ag | Hydrierte 1-benzooxacycloalkylpyridincarbons|ureverbindungen. |
DE3642497A1 (de) * | 1986-12-12 | 1988-06-23 | Hoechst Ag | Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte |
US4956382A (en) * | 1987-02-07 | 1990-09-11 | Pfizer Inc. | Sulfonamide anti-arrhythmic agents |
US5189179A (en) * | 1990-08-29 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | Serotonin 5ht1a agonists |
US5120758A (en) * | 1991-02-08 | 1992-06-09 | Ciba-Geigy Corporation | Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors |
-
1991
- 1991-07-30 US US07/735,700 patent/US5189179A/en not_active Expired - Fee Related
- 1991-08-23 AU AU82664/91A patent/AU641535B2/en not_active Ceased
- 1991-08-23 CA CA002049803A patent/CA2049803A1/en not_active Abandoned
- 1991-08-23 NZ NZ239521A patent/NZ239521A/xx unknown
- 1991-08-26 IL IL9930691A patent/IL99306A/en unknown
- 1991-08-27 KR KR1019910014843A patent/KR920004345A/ko not_active Application Discontinuation
- 1991-08-28 ES ES91114456T patent/ES2153346T3/es not_active Expired - Lifetime
- 1991-08-28 EP EP91114456A patent/EP0478954B1/de not_active Expired - Lifetime
- 1991-08-28 DK DK91114456T patent/DK0478954T3/da active
- 1991-08-28 PT PT98800A patent/PT98800B/pt not_active IP Right Cessation
- 1991-08-28 IE IE303691A patent/IE913036A1/en not_active Application Discontinuation
- 1991-08-28 FI FI914065A patent/FI914065A/fi not_active Application Discontinuation
- 1991-08-28 HU HU912810A patent/HU208955B/hu not_active IP Right Cessation
- 1991-08-28 NO NO913384A patent/NO175430C/no unknown
- 1991-08-28 AT AT91114456T patent/ATE197040T1/de not_active IP Right Cessation
- 1991-08-28 DE DE69132450T patent/DE69132450T2/de not_active Expired - Fee Related
- 1991-08-29 TW TW080106873A patent/TW200457B/zh active
- 1991-08-29 PH PH43017A patent/PH30242A/en unknown
- 1991-08-29 CN CN91108614A patent/CN1030766C/zh not_active Expired - Fee Related
- 1991-08-29 JP JP3242328A patent/JPH04270264A/ja active Pending
-
1992
- 1992-10-16 US US07/962,434 patent/US5387604A/en not_active Expired - Fee Related
-
1994
- 1994-10-07 US US08/319,916 patent/US5559143A/en not_active Expired - Fee Related
-
2000
- 2000-12-13 GR GR20000402750T patent/GR3035062T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PH30242A (en) | 1997-02-05 |
AU8266491A (en) | 1992-03-05 |
CA2049803A1 (en) | 1992-03-01 |
AU641535B2 (en) | 1993-09-23 |
US5387604A (en) | 1995-02-07 |
CN1030766C (zh) | 1996-01-24 |
EP0478954B1 (de) | 2000-10-18 |
GR3035062T3 (en) | 2001-03-30 |
FI914065A0 (fi) | 1991-08-28 |
FI914065A (fi) | 1992-03-01 |
KR920004345A (ko) | 1992-03-27 |
NO913384L (no) | 1992-03-02 |
US5189179A (en) | 1993-02-23 |
EP0478954A1 (de) | 1992-04-08 |
TW200457B (de) | 1993-02-21 |
IE913036A1 (en) | 1992-03-11 |
DE69132450D1 (de) | 2000-11-23 |
NO913384D0 (no) | 1991-08-28 |
HUT59092A (en) | 1992-04-28 |
NO175430C (no) | 1994-10-12 |
PT98800B (pt) | 1999-01-29 |
IL99306A0 (en) | 1992-07-15 |
IL99306A (en) | 1995-03-30 |
CN1059717A (zh) | 1992-03-25 |
PT98800A (pt) | 1992-08-31 |
NO175430B (no) | 1994-07-04 |
US5559143A (en) | 1996-09-24 |
JPH04270264A (ja) | 1992-09-25 |
DK0478954T3 (da) | 2001-01-08 |
DE69132450T2 (de) | 2001-05-03 |
NZ239521A (en) | 1993-07-27 |
ES2153346T3 (es) | 2001-03-01 |
HU208955B (en) | 1994-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |