DE69021618D1 - Antagonisten von exzitatorischen Aminosäuren. - Google Patents
Antagonisten von exzitatorischen Aminosäuren.Info
- Publication number
- DE69021618D1 DE69021618D1 DE69021618T DE69021618T DE69021618D1 DE 69021618 D1 DE69021618 D1 DE 69021618D1 DE 69021618 T DE69021618 T DE 69021618T DE 69021618 T DE69021618 T DE 69021618T DE 69021618 D1 DE69021618 D1 DE 69021618D1
- Authority
- DE
- Germany
- Prior art keywords
- amino acid
- excitatory amino
- acid antagonists
- antagonists
- excitatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/342,498 US4960786A (en) | 1989-04-24 | 1989-04-24 | Excitatory amino acid antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69021618D1 true DE69021618D1 (de) | 1995-09-21 |
DE69021618T2 DE69021618T2 (de) | 1996-01-18 |
Family
ID=23342092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69021618T Expired - Fee Related DE69021618T2 (de) | 1989-04-24 | 1990-04-23 | Antagonisten von exzitatorischen Aminosäuren. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4960786A (de) |
EP (1) | EP0394905B1 (de) |
JP (1) | JPH02295924A (de) |
KR (1) | KR0164434B1 (de) |
AT (1) | ATE126436T1 (de) |
AU (1) | AU625998B2 (de) |
DE (1) | DE69021618T2 (de) |
DK (1) | DK0394905T3 (de) |
ES (1) | ES2078257T3 (de) |
GR (1) | GR3017792T3 (de) |
IE (1) | IE66722B1 (de) |
PH (1) | PH26924A (de) |
ZA (1) | ZA902928B (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT93943A (pt) * | 1989-05-05 | 1991-02-08 | Searle & Co | Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc |
US5051442A (en) * | 1990-04-25 | 1991-09-24 | Merrell Dow Pharmaceuticals Inc. | 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof |
JP3058688B2 (ja) * | 1990-07-16 | 2000-07-04 | メレルダウファーマスーティカルズ インコーポレイテッド | 興奮性アミノ酸拮抗剤 |
US5189054A (en) * | 1990-11-02 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | 3-amidoindolyl derivatives and pharmaceutical compositions thereof |
US5284862A (en) * | 1991-03-18 | 1994-02-08 | Warner-Lambert Company | Derivatives of 2-carboxyindoles having pharmaceutical activity |
US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
US5318985A (en) * | 1991-12-20 | 1994-06-07 | Merrell Dow Pharmaceuticals Inc. | Potentiation of NMDA antagonists |
GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
US5464843A (en) * | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
GB9304500D0 (en) * | 1993-03-05 | 1993-04-21 | Glaxo Spa | Heterocyclic compounds |
GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
TW280819B (de) * | 1993-11-17 | 1996-07-11 | Sumitomo Pharma | |
GB9523999D0 (en) * | 1995-11-23 | 1996-01-24 | Lilly Co Eli | Indolyl neuropeptide y receptor antagonists |
JP4603667B2 (ja) * | 2000-09-18 | 2010-12-22 | Juki株式会社 | 根巻きボタン付けミシン |
WO2003039540A2 (en) * | 2001-11-09 | 2003-05-15 | Sepracor Inc. | D-amino acid oxidase inhibitors for learning and memory |
SE0302035D0 (sv) * | 2003-07-09 | 2003-07-09 | Biolipox Ab | New compound |
CZ2006427A3 (cs) | 2003-12-29 | 2006-11-15 | Sepracor Inc. | Pyrrolové a pyrazolové inhibitory DAAO |
JP2008502672A (ja) * | 2004-06-18 | 2008-01-31 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
CA2570363A1 (en) * | 2004-06-18 | 2005-12-29 | Biolipox Ab | Indoles useful in the treatment of inflammation |
US20080188473A1 (en) * | 2004-06-18 | 2008-08-07 | Kristofer Olofsson | Indoles Useful in the Treatment of Inflammation |
JP2008527031A (ja) * | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なピロロピリジン誘導体 |
EA200701504A1 (ru) * | 2005-01-19 | 2008-02-28 | Биолипокс Аб | Индолы, пригодные для лечения воспалений |
WO2006077367A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflamation |
JP2008527032A (ja) * | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なチエノピロール |
US20090042949A1 (en) * | 2005-01-19 | 2009-02-12 | Benjamin Pelcman | Indoles Useful in the Treatment of Inflammation |
US20080249091A1 (en) * | 2005-01-19 | 2008-10-09 | Benjamin Pelcman | Indoles Useful in the Treatment of Inflammation |
US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
US7884124B2 (en) * | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
EP2567698B1 (de) | 2011-09-07 | 2014-02-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | GPR-17-Agonisten und Screening-Assay |
EP3427729A1 (de) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3544563A (en) * | 1966-03-15 | 1970-12-01 | Sumitomo Chemical Co | Certain 3-indolyl-lower-alkanoic acid derivatives |
US3578669A (en) * | 1969-09-16 | 1971-05-11 | Sterling Drug Inc | 1-((2 - substituted - 3 - indolyl) - lower-alkanoyl) - cycloalkyl - lower-alkylpiperidines and 1 - ((2 - hydroxymethyl-3 - indolyl)-lower-alkayl)-cycloalkyl-lower-alkylpiperidines |
AT352708B (de) * | 1976-10-04 | 1979-10-10 | Frantsits Werner J Dipl Ing | Verfahren zur herstellung neuer indolderivate |
IT1206078B (it) * | 1987-06-03 | 1989-04-14 | Polifarma Spa | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico |
-
1989
- 1989-04-24 US US07/342,498 patent/US4960786A/en not_active Expired - Fee Related
-
1990
- 1990-04-18 ZA ZA902928A patent/ZA902928B/xx unknown
- 1990-04-20 AU AU53780/90A patent/AU625998B2/en not_active Ceased
- 1990-04-20 JP JP2103199A patent/JPH02295924A/ja active Pending
- 1990-04-21 KR KR1019900005614A patent/KR0164434B1/ko not_active IP Right Cessation
- 1990-04-23 EP EP90107633A patent/EP0394905B1/de not_active Expired - Lifetime
- 1990-04-23 AT AT90107633T patent/ATE126436T1/de not_active IP Right Cessation
- 1990-04-23 IE IE143790A patent/IE66722B1/en not_active IP Right Cessation
- 1990-04-23 DE DE69021618T patent/DE69021618T2/de not_active Expired - Fee Related
- 1990-04-23 DK DK90107633.1T patent/DK0394905T3/da active
- 1990-04-23 ES ES90107633T patent/ES2078257T3/es not_active Expired - Lifetime
- 1990-04-24 PH PH40411A patent/PH26924A/en unknown
-
1995
- 1995-10-18 GR GR950402895T patent/GR3017792T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH02295924A (ja) | 1990-12-06 |
AU5378090A (en) | 1990-10-25 |
IE901437L (en) | 1990-10-24 |
EP0394905A3 (de) | 1992-01-22 |
ZA902928B (en) | 1991-02-27 |
US4960786A (en) | 1990-10-02 |
EP0394905B1 (de) | 1995-08-16 |
AU625998B2 (en) | 1992-07-23 |
EP0394905A2 (de) | 1990-10-31 |
GR3017792T3 (en) | 1996-01-31 |
KR0164434B1 (ko) | 1999-01-15 |
PH26924A (en) | 1992-12-03 |
IE66722B1 (en) | 1996-01-24 |
DE69021618T2 (de) | 1996-01-18 |
KR900015729A (ko) | 1990-11-10 |
ATE126436T1 (de) | 1995-09-15 |
DK0394905T3 (da) | 1995-09-18 |
ES2078257T3 (es) | 1995-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69021618D1 (de) | Antagonisten von exzitatorischen Aminosäuren. | |
DE69021530D1 (de) | Neue Derivate von A-nor-3-Carboxysteroiden. | |
IL94915A0 (en) | Substituted quinazolinones and pharmaceutical compositions containing them | |
FI914065A (fi) | Serotonin-5ht1a-agonister. | |
DK0807633T3 (da) | Hidtil ukendte 2,3-disubstituerede-(5,6)-heteroarylkondenserede pyrimidin-4-oner | |
DE69013750D1 (de) | Antagonisten von excitatorischen Aminosäuren. | |
NO930035D0 (no) | Eksitatoriske aminosyreantagonister | |
FI882358A0 (fi) | Cykliska antikoagulationspeptider. | |
PT87537A (pt) | Process for the preparation of cyclic anticoagulant peptides | |
DE68916850D1 (de) | Antikoagulierende Peptid-Alkohole. | |
ATE130009T1 (de) | Antitumor-aminosäuren und peptid-derivate von 1,4-bis((aminoalkyl und hydroxyaminoalkyl)amino>5,8- dihydroxyanthraquinonen. | |
ATE116974T1 (de) | 5- piperazinylalkyl-1,5-benzothiazepinone verwendbar als calciumantagonisten. | |
DK614489A (da) | Peptidderivater | |
ATE84303T1 (de) | Cysteinderivate. | |
FI97388B (fi) | Menetelmä heterosyklisten NMDA-antagonistien valmistamiseksi | |
ATE98478T1 (de) | Calcitonin enthaltende pharmazeutische zusammensetzungen. | |
ATE84794T1 (de) | Aminosaeure-derivate als antihypertensive. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |