ATE17940T1 - Verfahren zur extemporierten herstellung einer mit radioaktivem jod markierten injizierbaren fettsaeure und herstellung von in der ausfuehrung dieses verfahrens brauchbaren jodierten derivaten. - Google Patents

Verfahren zur extemporierten herstellung einer mit radioaktivem jod markierten injizierbaren fettsaeure und herstellung von in der ausfuehrung dieses verfahrens brauchbaren jodierten derivaten.

Info

Publication number
ATE17940T1
ATE17940T1 AT82401192T AT82401192T ATE17940T1 AT E17940 T1 ATE17940 T1 AT E17940T1 AT 82401192 T AT82401192 T AT 82401192T AT 82401192 T AT82401192 T AT 82401192T AT E17940 T1 ATE17940 T1 AT E17940T1
Authority
AT
Austria
Prior art keywords
preparation
fatty acid
radioactive iodine
performance
derivatives useful
Prior art date
Application number
AT82401192T
Other languages
German (de)
English (en)
Inventor
Andre Bardy
Michel Comet
Sabine Coornaert
Jean-Paul Mathieu
Francoise Riche
Michel Vidal
Original Assignee
Commissariat Energie Atomique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique filed Critical Commissariat Energie Atomique
Application granted granted Critical
Publication of ATE17940T1 publication Critical patent/ATE17940T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0402Organic compounds carboxylic acid carriers, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/042Acyclic alcohols with carbon-to-carbon triple bonds with only one triple bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19Acids containing three or more carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
AT82401192T 1981-07-02 1982-06-28 Verfahren zur extemporierten herstellung einer mit radioaktivem jod markierten injizierbaren fettsaeure und herstellung von in der ausfuehrung dieses verfahrens brauchbaren jodierten derivaten. ATE17940T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8113039A FR2508902B1 (fr) 1981-07-02 1981-07-02 Procede de preparation extemporanee d'un acide gras injectable, marque a l'iode radioactif et preparation de derives iodes utilisables pour la mise en oeuvre de ce procede
EP82401192A EP0069648B1 (fr) 1981-07-02 1982-06-28 Procédé de préparation extemporanée d'un acide gras injectable, marqué à l'iode radioactif et préparation de dérivés iodes utilisables pour la mise en oeuvre de ce procédé

Publications (1)

Publication Number Publication Date
ATE17940T1 true ATE17940T1 (de) 1986-02-15

Family

ID=9260121

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82401192T ATE17940T1 (de) 1981-07-02 1982-06-28 Verfahren zur extemporierten herstellung einer mit radioaktivem jod markierten injizierbaren fettsaeure und herstellung von in der ausfuehrung dieses verfahrens brauchbaren jodierten derivaten.

Country Status (9)

Country Link
US (1) US4476106A (fr)
EP (1) EP0069648B1 (fr)
JP (1) JPS5859926A (fr)
AT (1) ATE17940T1 (fr)
CA (1) CA1198737A (fr)
DK (1) DK293082A (fr)
ES (1) ES513640A0 (fr)
FR (1) FR2508902B1 (fr)
NO (1) NO162612C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010010666A1 (de) * 2010-03-01 2011-09-01 Sven Reske Diagnose und Therapie von Krebserkrankungen mittels Fettsäuren

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2947500C2 (de) * 1979-11-24 1984-05-10 Dutschka, Klaus, 4300 Essen Radiojodierte ω -Phenylfettsäuren, ihre Herstellung und deren Verwendung zur szintigraphischen Untersuchung des Herzmuskels und der Leber
US4649039A (en) * 1984-07-03 1987-03-10 E. I. Du Pont De Nemours And Company Radiolabeling of methionine-containing proteins and peptides
US4764358A (en) * 1985-04-30 1988-08-16 The United States Of America As Represented By The United States Department Of Energy Radiolabeled dimethyl branched long chain fatty acid for heart imaging
JP2715240B2 (ja) * 1993-05-18 1998-02-18 株式会社第一ラジオアイソトープ研究所 放射性ヨウ素標識脂肪酸−シクロデキストリン複合体およびこれを含有するイメージング剤
FR2726765B1 (fr) * 1994-11-14 1996-12-20 Cis Bio Int Compositions radiopharmaceutiques comprenant un complexe d'inclusion d'une cyclodextrine et d'un acide gras radiohalogene
WO1997019705A1 (fr) * 1995-12-01 1997-06-05 Elmaleh David R Stereo-isomeres d'analogues d'acides gras pour imagerie diagnostique
EP1384706A1 (fr) * 2002-07-24 2004-01-28 Degussa AG Procédé de monoalkylation de groupes de méthylènes comportant des liaisons C-H acides
CN113087623A (zh) * 2021-04-13 2021-07-09 苏州昊帆生物股份有限公司 一种8-溴辛酸乙酯的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2810696C3 (de) * 1978-03-11 1982-02-25 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur Gewinnung von ω-↑123↑J-Hexadecansäure oder ω↑123↑J-Heptadecansäure und deren Verwendung als Radiopharmaka
DE2828623C2 (de) * 1978-06-29 1983-11-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung
DE2914089C2 (de) * 1979-04-07 1982-02-11 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur Herstellung von ω-↑123↑J-markierten Fettsäuren
DE2947500C2 (de) * 1979-11-24 1984-05-10 Dutschka, Klaus, 4300 Essen Radiojodierte ω -Phenylfettsäuren, ihre Herstellung und deren Verwendung zur szintigraphischen Untersuchung des Herzmuskels und der Leber
DE3127239A1 (de) * 1981-07-10 1983-01-20 Hoechst Ag, 6000 Frankfurt Quartaere n-alkyl-n,n',n'-polyoxyalkyl-(alpha),(omega)-diaminoalkylenfettsaeureester, verfahren zu deren herstellung und deren verwendung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010010666A1 (de) * 2010-03-01 2011-09-01 Sven Reske Diagnose und Therapie von Krebserkrankungen mittels Fettsäuren

Also Published As

Publication number Publication date
EP0069648A1 (fr) 1983-01-12
DK293082A (da) 1983-01-03
ES8304912A1 (es) 1983-03-16
NO822147L (no) 1983-01-03
US4476106A (en) 1984-10-09
FR2508902A1 (fr) 1983-01-07
NO162612C (no) 1990-01-24
JPH0365333B2 (fr) 1991-10-11
CA1198737A (fr) 1985-12-31
JPS5859926A (ja) 1983-04-09
FR2508902B1 (fr) 1985-09-06
ES513640A0 (es) 1983-03-16
NO162612B (no) 1989-10-16
EP0069648B1 (fr) 1986-02-12

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Legal Events

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EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee