ATE42469T1 - Bisamide-bisthiol-verbindungen nuetzlich zur herstellung von technetium enthaltenden radiodiagnostischen mitteln fuer die niere. - Google Patents

Bisamide-bisthiol-verbindungen nuetzlich zur herstellung von technetium enthaltenden radiodiagnostischen mitteln fuer die niere.

Info

Publication number
ATE42469T1
ATE42469T1 AT84109831T AT84109831T ATE42469T1 AT E42469 T1 ATE42469 T1 AT E42469T1 AT 84109831 T AT84109831 T AT 84109831T AT 84109831 T AT84109831 T AT 84109831T AT E42469 T1 ATE42469 T1 AT E42469T1
Authority
AT
Austria
Prior art keywords
kidney
bisamide
technetium
preparation
compounds useful
Prior art date
Application number
AT84109831T
Other languages
English (en)
Inventor
Alan Davison
David Brenner
John Lister-James
Alun G Jones
Original Assignee
Massachusetts Inst Technology
Harvard College
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Harvard College, Childrens Medical Center filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE42469T1 publication Critical patent/ATE42469T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
AT84109831T 1983-08-19 1984-08-17 Bisamide-bisthiol-verbindungen nuetzlich zur herstellung von technetium enthaltenden radiodiagnostischen mitteln fuer die niere. ATE42469T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/524,888 US4673562A (en) 1983-08-19 1983-08-19 Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
EP84109831A EP0135160B1 (de) 1983-08-19 1984-08-17 Bisamide-Bisthiol-Verbindungen nützlich zur Herstellung von Technetium enthaltenden radiodiagnostischen Mitteln für die Niere

Publications (1)

Publication Number Publication Date
ATE42469T1 true ATE42469T1 (de) 1989-05-15

Family

ID=24091061

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84109831T ATE42469T1 (de) 1983-08-19 1984-08-17 Bisamide-bisthiol-verbindungen nuetzlich zur herstellung von technetium enthaltenden radiodiagnostischen mitteln fuer die niere.

Country Status (8)

Country Link
US (1) US4673562A (de)
EP (1) EP0135160B1 (de)
JP (1) JPS60120850A (de)
AT (1) ATE42469T1 (de)
CA (1) CA1268596A (de)
DE (1) DE3477884D1 (de)
DK (1) DK395484A (de)
GR (1) GR80069B (de)

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Also Published As

Publication number Publication date
CA1268596A (en) 1990-05-01
EP0135160B1 (de) 1989-04-26
GR80069B (en) 1984-12-19
US4673562A (en) 1987-06-16
JPS60120850A (ja) 1985-06-28
EP0135160A3 (en) 1985-05-22
DK395484A (da) 1985-02-20
EP0135160A2 (de) 1985-03-27
DE3477884D1 (en) 1989-06-01
DK395484D0 (da) 1984-08-17

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