ATE45143T1 - Radiodiagnostische mittel. - Google Patents

Radiodiagnostische mittel.

Info

Publication number
ATE45143T1
ATE45143T1 AT86303131T AT86303131T ATE45143T1 AT E45143 T1 ATE45143 T1 AT E45143T1 AT 86303131 T AT86303131 T AT 86303131T AT 86303131 T AT86303131 T AT 86303131T AT E45143 T1 ATE45143 T1 AT E45143T1
Authority
AT
Austria
Prior art keywords
radiodiagnostic
media
ligand
bisthiol
bisamide
Prior art date
Application number
AT86303131T
Other languages
English (en)
Inventor
Alun G Jones
John Lister-James
Alan Davison
Original Assignee
Harvard College
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Massachusetts Inst Technology filed Critical Harvard College
Application granted granted Critical
Publication of ATE45143T1 publication Critical patent/ATE45143T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT86303131T 1985-04-26 1986-04-25 Radiodiagnostische mittel. ATE45143T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/727,582 US4746505A (en) 1985-04-26 1985-04-26 Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
EP86303131A EP0200492B1 (de) 1985-04-26 1986-04-25 Radiodiagnostische Mittel

Publications (1)

Publication Number Publication Date
ATE45143T1 true ATE45143T1 (de) 1989-08-15

Family

ID=24923217

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86303131T ATE45143T1 (de) 1985-04-26 1986-04-25 Radiodiagnostische mittel.

Country Status (6)

Country Link
US (1) US4746505A (de)
EP (1) EP0200492B1 (de)
JP (1) JPS6256A (de)
AT (1) ATE45143T1 (de)
CA (1) CA1273950A (de)
DE (1) DE3664767D1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4795626A (en) * 1985-05-10 1989-01-03 University Of Cincinnati 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
US5187264A (en) * 1986-05-28 1993-02-16 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US5021556A (en) * 1987-07-22 1991-06-04 Neorx Corporation Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
US5202451A (en) * 1988-02-17 1993-04-13 Neorx Corporation Anchimeric radiometal chelating compounds
US5057301A (en) * 1988-04-06 1991-10-15 Neorx Corporation Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
EP0381713B1 (de) * 1988-04-29 1994-01-19 Mallinckrodt, Inc. Diaminedithiol-chelatierungsmittel für radioarzneimittel
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
GB8902362D0 (en) * 1989-02-03 1989-03-22 Amersham Int Plc Cationic complexes of technetium-99m
FR2655339B2 (fr) * 1989-04-19 1992-04-10 Medgenix Group Sa Composes et complexes utiles notamment en imagerie medicale.
DE122005000028I2 (de) * 1989-10-30 2007-08-16 Rotop Pharmaka Ag Kit (nichtradioaktive Vorstufe) zur Herstellung einer enantiomeren Form des Nierenfunktionsdiagnostikums Technetium-99m-Mercaptoacetyltriglycin (99m-Tc-MAG-3) und Verfahren zur Herstellung des Kits
ATE101596T1 (de) * 1989-12-12 1994-03-15 Amersham Int Plc Phenyldiaminodithiolderivate.
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
DE4107571A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Amid-chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
EP0542216A1 (de) * 1991-11-13 1993-05-19 Hoechst Aktiengesellschaft Diaminomercapto (thio)ether als Komplexbildner für in der Nuklearmedizin einsetzbare Nuklide, Verfahren zur Herstellung der Komplexe, sowie Markierungskits, enthaltend diese Komplexe
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
CA2129033A1 (en) * 1992-02-05 1993-08-19 Leon Lyle Radiolabelled peptide compounds
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5690904A (en) * 1993-07-12 1997-11-25 Amersham International Plc Diagnostic radiopharmaceutical compounds (That)
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
DE19536780A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNY für radioaktive Isotope
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US6171576B1 (en) 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
DE69636881T2 (de) * 1995-12-01 2007-09-20 Molecular Insight Pharmaceuticals, Inc., Cambridge Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung
US5693308A (en) * 1996-02-21 1997-12-02 Mallinckrodt Medical, Inc. Magnetic resonance blood pool agents bound to human serum albumin
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6437103B1 (en) 1999-04-14 2002-08-20 Biostream Inc. Fatty acid analogs for diagnosis of coronary artery disease
CA2285516C (en) 1999-05-12 2010-12-07 President And Fellows Of Harvard College Dopamine transporter imaging agents
US6379650B1 (en) 2001-03-19 2002-04-30 Wesley Scott Ashton Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging
DE20120708U1 (de) 2001-10-09 2002-08-01 Meltzer Peter C Tropan-Analoga zur Inhibierung des Monoamin-Transports
JP4951798B2 (ja) * 2002-04-01 2012-06-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 側基脂肪酸撮像剤
DE10316965B4 (de) * 2003-04-12 2005-04-28 Rossendorf Forschzent Technetiummarkierte Fettsäuren und deren Verwendung für die Myokarddiagnostik sowie Verfahren zur Herstellung der technetiummarkierten Fettsäuren
EP1722762A2 (de) * 2004-03-02 2006-11-22 Massachusetts Institute of Technology Nanozellen-arzneiabgabesystem
US20070053845A1 (en) * 2004-03-02 2007-03-08 Shiladitya Sengupta Nanocell drug delivery system
US20090110633A1 (en) * 2005-03-14 2009-04-30 Shiladitya Sengupta Nanocells for Diagnosis and Treatment of Diseases and Disorders
JP2007079857A (ja) * 2005-09-13 2007-03-29 Canon Inc サーバー装置、クライアント装置及びそれらの制御方法、コンピュータプログラム、記憶媒体
US20110236308A1 (en) * 2006-04-19 2011-09-29 The General Hospital Corporation Aryl Bidentate Isonitriles and Their Uses
EP2440584A4 (de) * 2009-06-13 2015-09-23 Harvard College Zusammensetzungen und verfahren zur bildgebung von geweben, organen und tumoren

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3165552A (en) * 1959-12-11 1965-01-12 Eastman Kodak Co Internal amide, nonpolymeric thioether sensitizers for photographic emulsions
US3742032A (en) * 1971-04-23 1973-06-26 Goodrich Co B F N,n{40 -alkylene-bis{8 {62 -(alkyl-carboxyalkylthio)propionamides{9
US3868383A (en) * 1973-04-23 1975-02-25 Lilly Co Eli Process for preparing 5-({60 -cyanobenzylidene) oxazolidine-2, 4-diones
JPS51131832A (en) * 1975-04-21 1976-11-16 Minnesota Mining & Mfg Process for manufacturing complex of tcc99m and dimercaptoaliphatic compound
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
FR2549051B1 (fr) * 1983-06-22 1986-05-16 Centre Nat Rech Scient Nouveaux agents radioprotecteurs ayant une structure amino-thioalkyle et procede pour leur preparation
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
FR2556721B1 (fr) * 1983-12-14 1986-05-16 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals

Also Published As

Publication number Publication date
JPS6256A (ja) 1987-01-06
DE3664767D1 (de) 1989-09-07
EP0200492A1 (de) 1986-11-05
EP0200492B1 (de) 1989-08-02
US4746505A (en) 1988-05-24
CA1273950A (en) 1990-09-11

Similar Documents

Publication Publication Date Title
ATE45143T1 (de) Radiodiagnostische mittel.
ATE42469T1 (de) Bisamide-bisthiol-verbindungen nuetzlich zur herstellung von technetium enthaltenden radiodiagnostischen mitteln fuer die niere.
DK172154B1 (da) Isonitrilkompleks omfattende et radionuclid, middel til anvendelse ved mærkning, afbildning eller detektering og indeholdende et sådant kompleks, kit til fremstilling af et sådant kompleks, og fremgangsmåde til mærkning af en celle eller et liposom in vitro
IE810892L (en) Liphophilic complexes of 99m tc
ES2042609T3 (es) Diaminoditioles sustituidos con esteres y sus complejos radiomarcados.
JPH0233019B2 (de)
JPS542343A (en) Radioactive diagnostic agent labelled with tecnetium 99m and production thereof
GB1510664A (en) Bone-seeking technetium-99m imidodiphosphonate complex
Yamamura et al. Technetium-99m-labeled medium-chain fatty acid analogues metabolized by β-oxidation: radiopharmaceutical for assessing liver function
US4917879A (en) 99MTC(III) myocardial imaging agents that are effective in humans
GB1469075A (en) Method of tagging vehicular substances with 99mm technetium
ES8304912A1 (es) Procedimiento para la preparacion de un acido graso marcado con yodo radioactivo.
JP2690018B2 (ja) グルコサミン誘導体よりなる放射性診断剤
US5002754A (en) Technetium (III/II) imaging agents
IT8148488A0 (it) Procedimento per ottenere preparati di tossoplasmi per la diagnosi del la tossoplasmosi e preparati cosi'ottenuti
US4946668A (en) Tumor imaging with technetium labelled glucarate
US4617184A (en) 99m Tc-1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane complex for skeleton scanning
CA1310652C (en) Tc-99_ mononuclide complex compound
Okada et al. Tellurium-labeled fatty-acid analogs: Relationship of heteroatom position to myocardial kinetics
Nogawa et al. Synthesis of 186 Re-DMSA and its biodistributions in mice
Mansur et al. Renal elimination of some 99mTc-labelled cysteamine derivatives
Mercer Synthesis and evaluation of radiolabelled 5-halo-1-(2'-fluoro-2'-deoxy-[beta]-D-ribofuranosyl)-uracil analogs as non-invasive tumor diagnostic radiopharmaceuticals
BE766354A (fr) Preparation d'esters d'acides organophosphoreux
KR910002469A (ko) 간.담도계 진단용 ^99mTC 표지 방사성의 약품의 제조방법
RU95110078A (ru) Способ получения препарата с технецием 99м

Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee