ES2042609T3 - Diaminoditioles sustituidos con esteres y sus complejos radiomarcados. - Google Patents
Diaminoditioles sustituidos con esteres y sus complejos radiomarcados.Info
- Publication number
- ES2042609T3 ES2042609T3 ES88102252T ES88102252T ES2042609T3 ES 2042609 T3 ES2042609 T3 ES 2042609T3 ES 88102252 T ES88102252 T ES 88102252T ES 88102252 T ES88102252 T ES 88102252T ES 2042609 T3 ES2042609 T3 ES 2042609T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- sterile
- carbon atoms
- diaminedithiols
- diaminoditiols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/29—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
RADIOFARMACOS QUE CONSTAN ESENCIALMENTE DE UN COMPLEJO DE UN RADIONUCLIDO LIPOFILO NEUTRO DE CARGA DE UN LIGANTE DE DIAMINDITIOL QUE TIENE DE 1 A 4 GRUPOS ESTER DE FORMULA -A-COOR DONDE A ES ALQUILENO LINEAL O RAMIFICADO DE 0 A 10 ATOMOS DE CARBONO. SON UTILES PARA RADIOGRAFIAR PERFUSION CEREBRAL EN PRIMATES. TAMBIEN SE PRESENTAN DIAMINDITIOLES ESTERUSTITUIDOS EN FORMA ESTERIL FARMACOLOGICAMENTE ACEPTABLES Y CONJUNTOS DE AMINDITIOLES Y AGENTES REDUCTORES ESTERILES NO PIROGENOS PARA REDUCIR RADIONUCLIDOS PRESELECCIONADOS, UN RADIONUCLIDO RECOMENDADO ES TECNECIO-99 M. REFERENCIA CRUZADA A SOLICITUDES RELACIONADAS CON LA PRESENTE. ESTA SOLICITUD ES UNA CONTINUACION EN PARTE DE LA SOLICITUD PENDIENTE NO. DE SERIE 016.982 REGISTRADA AL 18 DE FEBRERO DE 1987.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1698287A | 1987-02-18 | 1987-02-18 | |
US07/143,561 US5279811A (en) | 1987-02-18 | 1988-01-26 | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2042609T3 true ES2042609T3 (es) | 1993-12-16 |
Family
ID=26689304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88102252T Expired - Lifetime ES2042609T3 (es) | 1987-02-18 | 1988-02-17 | Diaminoditioles sustituidos con esteres y sus complejos radiomarcados. |
Country Status (18)
Country | Link |
---|---|
US (2) | US5279811A (es) |
EP (1) | EP0279417B1 (es) |
JP (1) | JPH0764802B2 (es) |
KR (1) | KR910006978B1 (es) |
AT (1) | ATE76401T1 (es) |
AU (1) | AU614276B2 (es) |
CA (1) | CA1271195A (es) |
DE (2) | DE19475010I2 (es) |
DK (1) | DK175089B1 (es) |
ES (1) | ES2042609T3 (es) |
GR (1) | GR3004986T3 (es) |
HK (1) | HK66292A (es) |
IE (1) | IE61254B1 (es) |
IL (1) | IL85445A (es) |
NL (1) | NL940008I2 (es) |
NZ (1) | NZ223552A (es) |
PT (1) | PT86787B (es) |
SG (1) | SG71192G (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5279811A (en) * | 1987-02-18 | 1994-01-18 | The Du Pont Merck Pharmaceutical Company | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
US5071965A (en) * | 1988-07-19 | 1991-12-10 | Mallinckrodt Medical, Inc. | Novel tc-99m complexes |
US4925650A (en) * | 1988-11-16 | 1990-05-15 | Mallinckrodt, Inc. | Technetium -99m complex for examining the renal function |
DE69023616T2 (de) * | 1989-06-16 | 1996-04-18 | Neorx Corp | Radionukleid-chelatverbindungen zur radiomarkierung von proteinen. |
FR2664166A1 (fr) * | 1990-07-04 | 1992-01-10 | Cis Bio Int | Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques. |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US7238340B1 (en) | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5192655A (en) * | 1991-07-05 | 1993-03-09 | E. I. Du Pont De Nemours And Company | Silver halide elements with improved speed and low fog |
FR2679452B1 (fr) * | 1991-07-22 | 1993-11-12 | Cis Bio International | Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation. |
DE4128183C1 (en) * | 1991-08-24 | 1993-01-14 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | New technetium complexes and corresp. complexing agents - useful for measurement of cerebral perfusion, diagnosis of Alzheimer's disease or epilepsy and localisation of tumours |
EP0542216A1 (de) * | 1991-11-13 | 1993-05-19 | Hoechst Aktiengesellschaft | Diaminomercapto (thio)ether als Komplexbildner für in der Nuklearmedizin einsetzbare Nuklide, Verfahren zur Herstellung der Komplexe, sowie Markierungskits, enthaltend diese Komplexe |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5807535A (en) * | 1992-07-31 | 1998-09-15 | Australian Nuclear Science & Technology Organisation | Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents |
US5688485A (en) * | 1992-12-31 | 1997-11-18 | The Dupont Merck Pharmaceutical Company | Radiolabelled complexes of ester-substituted diaminethiols |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
US5690904A (en) * | 1993-07-12 | 1997-11-25 | Amersham International Plc | Diagnostic radiopharmaceutical compounds (That) |
US5968477A (en) * | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
CA2190727C (en) * | 1994-05-19 | 2006-07-18 | Sudhakar Kasina | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging |
IL115099A (en) * | 1994-10-14 | 1999-04-11 | Upjohn Co | Lyophilizate of phospholipid complex of water insoluble camptothecins |
EP0779628A3 (en) * | 1995-12-11 | 1997-07-09 | Institut National des Radioéléments, Nationaal Instituut voor Radio-elementen | Method of stabilizing an aqueous solution of 99Mo molybdate |
US5961952A (en) * | 1996-01-24 | 1999-10-05 | Dupont Pharmaceuticals Company | 99m Tc-tertiary-butyl isonitrile as breast tumor imaging agents |
US6005083A (en) | 1997-03-28 | 1999-12-21 | Neorx Corporation | Bridged aromatic substituted amine ligands with donor atoms |
DE19741694C2 (de) * | 1997-09-18 | 2002-10-31 | Schering Ag | Verwendung von Komplexen, deren Ligand ein Bis-Amin-Oxim-Derivat oder ein N¶2¶S¶2¶-Derivat und deren Zentralatom ein Radionuklid ist |
US6436365B2 (en) * | 1997-09-23 | 2002-08-20 | Schering Aktiengesellschaft | Process for therapeutic treatment of proliferative diseases |
AU4067899A (en) * | 1998-02-06 | 1999-08-30 | Trustees Of The University Of Pennsylvania, The | Stereoselective tc-99m ligands |
US6692724B1 (en) * | 1999-10-25 | 2004-02-17 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
EP1286704B1 (en) * | 2000-06-02 | 2014-07-23 | Board of Regents, The University of Texas System | ETHYLENEDICYSTEINE (EC)-glucose analog CONJUGATES |
US7311893B2 (en) * | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
EP1389090A2 (en) * | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Diagnostic imaging compositions, their methods of synthesis and use |
US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
BR0316046A (pt) * | 2002-11-07 | 2005-09-13 | Univ Texas | Conjugados de fármaco e etilenodicisteìna (ec), composições e métodos para imageamento de doença especìfica de tecido |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
US7414137B2 (en) | 2006-03-23 | 2008-08-19 | Inspire Pharmaceuticals, Inc. | Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones |
WO2007111020A1 (ja) | 2006-03-24 | 2007-10-04 | Fujifilm Ri Pharma Co., Ltd. | 局所脳血流診断用放射性医薬品製造用組成物 |
US8758723B2 (en) | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
KR100891197B1 (ko) * | 2008-09-29 | 2009-04-02 | 설상준 | 쌀 세척기 |
WO2015200187A1 (en) * | 2014-06-27 | 2015-12-30 | Reiley Pharmaceuticals, Inc. | Conjugates derived from non-steroidal anti-inflammatory drugs and methods of use thereof in imaging |
WO2016111834A1 (en) | 2015-01-09 | 2016-07-14 | Reiley Pharmaceuticals, Inc. | Cox-2-targeting, platinum-containing conjugates and their use in the treatment of tumors and cancers |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB742996A (en) * | 1953-01-19 | 1956-01-04 | Dow Chemical Co | Di-sulfhydryl alkylene diamine polycarboxylic acids and salts thereof |
US2810753A (en) * | 1954-05-24 | 1957-10-22 | Dow Chemical Co | Metal ion chelating agents |
US4284619A (en) * | 1978-11-29 | 1981-08-18 | Medi-Physics, Inc. | Esters useful as brain imaging agents |
US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
US4571430A (en) * | 1982-11-08 | 1986-02-18 | Medi-Physics, Inc. | Homocysteine and homocysteinamide derivatives |
US4434151A (en) * | 1982-11-08 | 1984-02-28 | Medi-Physics, Inc. | Bifunctional chelating agents |
US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
US4638051A (en) * | 1984-04-30 | 1987-01-20 | The Johns Hopkins University | Brain imaging radiopharmaceuticals |
US4963688A (en) * | 1984-07-19 | 1990-10-16 | University Of Florida | Compounds for site-enhanced delivery of radionuclides and uses thereof |
US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
EP0200211A1 (en) * | 1985-05-01 | 1986-11-05 | The Research Foundation Of State University Of New York | Diagnostic radiopharmaceutical compounds |
EP0232751B1 (en) * | 1986-01-23 | 1991-09-11 | E.R. Squibb & Sons, Inc. | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
US4693688A (en) * | 1986-07-14 | 1987-09-15 | Amp Incorporated | Grounding connector |
US5279811A (en) * | 1987-02-18 | 1994-01-18 | The Du Pont Merck Pharmaceutical Company | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
US5037631A (en) * | 1990-10-29 | 1991-08-06 | Mallinckrodt Medical, Inc. | Technetium-99M complex for examinating the renal function |
-
1988
- 1988-01-26 US US07/143,561 patent/US5279811A/en not_active Expired - Lifetime
- 1988-02-16 AU AU11748/88A patent/AU614276B2/en not_active Expired
- 1988-02-17 ES ES88102252T patent/ES2042609T3/es not_active Expired - Lifetime
- 1988-02-17 NZ NZ223552A patent/NZ223552A/en unknown
- 1988-02-17 DK DK198800816A patent/DK175089B1/da not_active IP Right Cessation
- 1988-02-17 DE DE1994175010 patent/DE19475010I2/de active Active
- 1988-02-17 KR KR1019880001657A patent/KR910006978B1/ko not_active IP Right Cessation
- 1988-02-17 EP EP88102252A patent/EP0279417B1/en not_active Expired - Lifetime
- 1988-02-17 IE IE43188A patent/IE61254B1/en not_active IP Right Cessation
- 1988-02-17 DE DE88102252T patent/DE3871173D1/de not_active Expired - Lifetime
- 1988-02-17 IL IL8544588A patent/IL85445A/en not_active IP Right Cessation
- 1988-02-17 AT AT88102252T patent/ATE76401T1/de not_active IP Right Cessation
- 1988-02-18 JP JP63034137A patent/JPH0764802B2/ja not_active Expired - Lifetime
- 1988-02-18 CA CA000559230A patent/CA1271195A/en not_active Expired - Lifetime
- 1988-02-18 PT PT86787A patent/PT86787B/pt not_active IP Right Cessation
-
1992
- 1992-06-18 GR GR920401321T patent/GR3004986T3/el unknown
- 1992-07-08 SG SG711/92A patent/SG71192G/en unknown
- 1992-09-03 HK HK662/92A patent/HK66292A/xx not_active IP Right Cessation
-
1993
- 1993-10-20 US US08/139,894 patent/US5431900A/en not_active Expired - Lifetime
-
1994
- 1994-05-31 NL NL940008C patent/NL940008I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0279417A3 (en) | 1989-07-26 |
PT86787A (pt) | 1989-02-28 |
IL85445A (en) | 1994-01-25 |
EP0279417A2 (en) | 1988-08-24 |
US5279811A (en) | 1994-01-18 |
AU1174888A (en) | 1988-09-01 |
GR3004986T3 (es) | 1993-04-28 |
DK81688A (da) | 1988-08-19 |
JPS63295549A (ja) | 1988-12-01 |
SG71192G (en) | 1992-09-04 |
NL940008I1 (nl) | 1994-07-18 |
DE19475010I2 (de) | 2001-07-19 |
IL85445A0 (en) | 1988-07-31 |
EP0279417B1 (en) | 1992-05-20 |
DK175089B1 (da) | 2004-05-24 |
DE3871173D1 (es) | 1992-06-25 |
IE880431L (en) | 1988-08-18 |
PT86787B (pt) | 1995-03-01 |
DK81688D0 (da) | 1988-02-17 |
KR910006978B1 (ko) | 1991-09-14 |
HK66292A (en) | 1992-09-11 |
IE61254B1 (en) | 1994-10-19 |
JPH0764802B2 (ja) | 1995-07-12 |
KR880009917A (ko) | 1988-10-05 |
AU614276B2 (en) | 1991-08-29 |
CA1271195A (en) | 1990-07-03 |
NZ223552A (en) | 1990-04-26 |
ATE76401T1 (de) | 1992-06-15 |
NL940008I2 (nl) | 1999-07-01 |
US5431900A (en) | 1995-07-11 |
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