ATE171445T1 - Perhydroisoindolderivate als substanz p antagonisten - Google Patents
Perhydroisoindolderivate als substanz p antagonistenInfo
- Publication number
- ATE171445T1 ATE171445T1 AT94923755T AT94923755T ATE171445T1 AT E171445 T1 ATE171445 T1 AT E171445T1 AT 94923755 T AT94923755 T AT 94923755T AT 94923755 T AT94923755 T AT 94923755T AT E171445 T1 ATE171445 T1 AT E171445T1
- Authority
- AT
- Austria
- Prior art keywords
- antagonists
- substance
- pct
- derivatives
- perhydroisoindole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9309400A FR2709752B1 (fr) | 1993-07-30 | 1993-07-30 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR9311946A FR2710913B1 (fr) | 1993-10-07 | 1993-10-07 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE171445T1 true ATE171445T1 (de) | 1998-10-15 |
Family
ID=26230522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94923755T ATE171445T1 (de) | 1993-07-30 | 1994-07-28 | Perhydroisoindolderivate als substanz p antagonisten |
Country Status (19)
Country | Link |
---|---|
US (1) | US5624950A (de) |
EP (1) | EP0711280B1 (de) |
JP (1) | JPH09500893A (de) |
KR (1) | KR960703858A (de) |
AT (1) | ATE171445T1 (de) |
AU (1) | AU7386594A (de) |
CA (1) | CA2168233A1 (de) |
CZ (1) | CZ26396A3 (de) |
DE (1) | DE69413542T2 (de) |
DK (1) | DK0711280T3 (de) |
ES (1) | ES2123149T3 (de) |
FI (1) | FI960399A0 (de) |
HU (1) | HUT75304A (de) |
IL (1) | IL110494A0 (de) |
NO (1) | NO960365D0 (de) |
PL (1) | PL312739A1 (de) |
SK (1) | SK13096A3 (de) |
TW (1) | TW365603B (de) |
WO (1) | WO1995004040A1 (de) |
Families Citing this family (48)
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---|---|---|---|---|
FR2727411B1 (fr) * | 1994-11-30 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
DE19738339C2 (de) * | 1997-09-02 | 2000-08-31 | Siemens Ag | Verfahren zum benutzergesteuerten Abbauen von drahtlosen Telekommunikationsverbindungen in drahtlosen Telekommunikationssystemen, insbesondere DECT-Systemen |
US6061833A (en) * | 1998-12-17 | 2000-05-16 | Wdc Holdings, Inc. | Protective glove with improved wrist strap |
AU1201101A (en) | 1999-10-15 | 2001-04-30 | Du Pont Pharmaceuticals Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
US6784200B2 (en) | 2000-10-13 | 2004-08-31 | Bristol-Myers Squibb Pharma Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
ZA200701232B (en) | 2004-07-15 | 2008-08-27 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
US7956050B2 (en) | 2005-07-15 | 2011-06-07 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
EP1940842B1 (de) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylierte spiropiperidinderivate als modulatoren des melanocortin-4-rezeptors |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US7265247B1 (en) | 2006-07-28 | 2007-09-04 | Im&T Research, Inc. | Substituted phenylsulfur trifluoride and other like fluorinating agents |
EP2698157B1 (de) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Verfahren zur Behandlung von Fettsäure-Synthese-Hemmern |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP2109608B1 (de) | 2007-01-10 | 2011-03-23 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Amidsubstituierte indazole als poly-(adp-ribose)-polymerase (parp)-hemmer |
KR20140061493A (ko) | 2007-03-23 | 2014-05-21 | 우베 인더스트리즈 리미티드 | 아릴설퍼 펜타플루오라이드의 제조공정 |
US8399720B2 (en) | 2007-03-23 | 2013-03-19 | Ube Industries, Ltd. | Methods for producing fluorinated phenylsulfur pentafluorides |
AU2008233662B2 (en) | 2007-04-02 | 2012-08-23 | Msd K.K. | Indoledione derivative |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US8030516B2 (en) | 2007-10-19 | 2011-10-04 | Ube Industries, Ltd. | Methods for producing perfluoroalkanedi(sulfonyl chloride) |
CN102014631A (zh) | 2008-03-03 | 2011-04-13 | 泰格尔医药科技公司 | 酪氨酸激酶抑制剂 |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
EP2334661B1 (de) | 2008-09-22 | 2017-08-30 | Ube Industries, Ltd. | Verfahren zur herstellung aromatischer poly(pentafluorsulfanyl)-verbindungen |
US8203003B2 (en) | 2009-01-09 | 2012-06-19 | Ube Industries, Ltd. | 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods |
EP2413932A4 (de) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | Hemmer der akt-aktivität |
WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用 |
CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
EP2488028B1 (de) | 2009-10-14 | 2020-08-19 | Merck Sharp & Dohme Corp. | Substituierte piperidine zur erhöhung der p53-aktivität und ihre verwendung |
WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
CN103068980B (zh) | 2010-08-02 | 2017-04-05 | 瑟纳治疗公司 | 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制 |
KR102072631B1 (ko) | 2010-08-17 | 2020-02-03 | 시르나 쎄러퓨틱스 인코퍼레이티드 | 짧은 간섭 핵산 (siNA)을 사용한 B형 간염 바이러스 (HBV) 유전자 발현의 RNA 간섭 매개 억제 |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
EP3766975A1 (de) | 2010-10-29 | 2021-01-20 | Sirna Therapeutics, Inc. | Rna-interferenz-vermittelte inhibition von genexpression unter verwendung kurzer interferierender nukleinsäure (sina) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US20140046059A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Process for the preparation of morpholino sulfonyl indole derivatives |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
WO2014052563A2 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
ES2651347T3 (es) | 2012-11-28 | 2018-01-25 | Merck Sharp & Dohme Corp. | Composiciones y métodos para el tratamiento del cáncer |
CA2895504A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2654726B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
FR2676442B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2676443B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole et leur preparation. |
FR2689889B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, et leur preparation. |
FR2689888B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
-
1994
- 1994-07-21 TW TW083106682A patent/TW365603B/zh active
- 1994-07-28 WO PCT/FR1994/000952 patent/WO1995004040A1/fr active IP Right Grant
- 1994-07-28 IL IL11049494A patent/IL110494A0/xx unknown
- 1994-07-28 ES ES94923755T patent/ES2123149T3/es not_active Expired - Lifetime
- 1994-07-28 CA CA002168233A patent/CA2168233A1/fr not_active Abandoned
- 1994-07-28 KR KR1019960700531A patent/KR960703858A/ko not_active Application Discontinuation
- 1994-07-28 JP JP7505618A patent/JPH09500893A/ja active Pending
- 1994-07-28 DK DK94923755T patent/DK0711280T3/da active
- 1994-07-28 AT AT94923755T patent/ATE171445T1/de not_active IP Right Cessation
- 1994-07-28 US US08/586,708 patent/US5624950A/en not_active Expired - Fee Related
- 1994-07-28 PL PL94312739A patent/PL312739A1/xx unknown
- 1994-07-28 SK SK130-96A patent/SK13096A3/sk unknown
- 1994-07-28 EP EP94923755A patent/EP0711280B1/de not_active Expired - Lifetime
- 1994-07-28 CZ CZ96263A patent/CZ26396A3/cs unknown
- 1994-07-28 HU HU9503986A patent/HUT75304A/hu unknown
- 1994-07-28 DE DE69413542T patent/DE69413542T2/de not_active Expired - Fee Related
- 1994-07-28 AU AU73865/94A patent/AU7386594A/en not_active Abandoned
-
1996
- 1996-01-29 NO NO960365A patent/NO960365D0/no unknown
- 1996-01-29 FI FI960399A patent/FI960399A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
EP0711280A1 (de) | 1996-05-15 |
NO960365L (no) | 1996-01-29 |
HU9503986D0 (en) | 1996-03-28 |
DK0711280T3 (da) | 1999-06-14 |
DE69413542T2 (de) | 1999-03-25 |
HUT75304A (en) | 1997-05-28 |
KR960703858A (ko) | 1996-08-31 |
AU7386594A (en) | 1995-02-28 |
DE69413542D1 (de) | 1998-10-29 |
PL312739A1 (en) | 1996-05-13 |
IL110494A0 (en) | 1994-10-21 |
FI960399A (fi) | 1996-01-29 |
WO1995004040A1 (fr) | 1995-02-09 |
JPH09500893A (ja) | 1997-01-28 |
FI960399A0 (fi) | 1996-01-29 |
CZ26396A3 (en) | 1996-05-15 |
ES2123149T3 (es) | 1999-01-01 |
CA2168233A1 (fr) | 1995-02-09 |
SK13096A3 (en) | 1996-09-04 |
US5624950A (en) | 1997-04-29 |
TW365603B (en) | 1999-08-01 |
NO960365D0 (no) | 1996-01-29 |
EP0711280B1 (de) | 1998-09-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |