NO960365L - Perhydroisoindolderivater som substans-P-antagonister - Google Patents
Perhydroisoindolderivater som substans-P-antagonisterInfo
- Publication number
- NO960365L NO960365L NO960365A NO960365A NO960365L NO 960365 L NO960365 L NO 960365L NO 960365 A NO960365 A NO 960365A NO 960365 A NO960365 A NO 960365A NO 960365 L NO960365 L NO 960365L
- Authority
- NO
- Norway
- Prior art keywords
- antagonists
- substance
- pct
- derivatives
- perhydroisoindole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Perhydrolsolndolderlvater med den generelle formel (I). der R1 er eventuelt substituert fenyl, cykloheksadlenyl, naftyl, Indenyl eller eventuelt substituert heterocyklyl, R2 er H, halogen, CB. alkyl, amlnoalkyl, alkylamlnoalkyl. dlalkylamlnoalkyl. alkyloksy. alkyltlo, acyloksy, karboksy, eventuelt substituert alkyloksykarbonyl, benzyloksykarbonyl, amlno eller acylamlno, Ra er en fenylrest som eventuelt er substituert l 2-stllllng med Cj- til C2-alkyl eller -alkyloksy eller med et fluoratan, eller dlsubstltuert med trlfluonnetyl og *6 PS R*6 er Ilke eller forskjellige og den ene betyr H eller CH eller alkyl og den andre H eller alkyl, og R« er (H, eller også R4 er F, hvis symbolene RS og R*5 er H eller alkyl, eller også R4 samnen med RS danner en binding, og R$ er H eller alkyl, hydroksy eller hydroksyalkyl, og av symbolene R er en H. alkyl. hydroksy eller hydroksyalkyl og den andre er H, alkyl, fenyl eller hydroksyalkyl, l Isenere former med strukturen (la) eller deres blandinger, eventuelt deres salter hvis de eksisterer. ¿ J! ..¿_¿ Forblndelsenes fremstilling beskrives. N~"~C~~CH K j 2 De nye forbindelser Ifølge oppfinnelsen er spesielt Interessante som substans P- antagonlster.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9309400A FR2709752B1 (fr) | 1993-07-30 | 1993-07-30 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR9311946A FR2710913B1 (fr) | 1993-10-07 | 1993-10-07 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| PCT/FR1994/000952 WO1995004040A1 (fr) | 1993-07-30 | 1994-07-28 | Derives de perhydroisoindole comme antagonistes de la substance p |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO960365L true NO960365L (no) | 1996-01-29 |
| NO960365D0 NO960365D0 (no) | 1996-01-29 |
Family
ID=26230522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960365A NO960365D0 (no) | 1993-07-30 | 1996-01-29 | Perhydroisoindolderivater som substans-P-antagonister |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5624950A (no) |
| EP (1) | EP0711280B1 (no) |
| JP (1) | JPH09500893A (no) |
| KR (1) | KR960703858A (no) |
| AT (1) | ATE171445T1 (no) |
| AU (1) | AU7386594A (no) |
| CA (1) | CA2168233A1 (no) |
| CZ (1) | CZ26396A3 (no) |
| DE (1) | DE69413542T2 (no) |
| DK (1) | DK0711280T3 (no) |
| ES (1) | ES2123149T3 (no) |
| FI (1) | FI960399A (no) |
| HU (1) | HUT75304A (no) |
| IL (1) | IL110494A0 (no) |
| NO (1) | NO960365D0 (no) |
| PL (1) | PL312739A1 (no) |
| SK (1) | SK13096A3 (no) |
| TW (1) | TW365603B (no) |
| WO (1) | WO1995004040A1 (no) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2727411B1 (fr) * | 1994-11-30 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE19738339C2 (de) * | 1997-09-02 | 2000-08-31 | Siemens Ag | Verfahren zum benutzergesteuerten Abbauen von drahtlosen Telekommunikationsverbindungen in drahtlosen Telekommunikationssystemen, insbesondere DECT-Systemen |
| US6061833A (en) * | 1998-12-17 | 2000-05-16 | Wdc Holdings, Inc. | Protective glove with improved wrist strap |
| US6784200B2 (en) | 2000-10-13 | 2004-08-31 | Bristol-Myers Squibb Pharma Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
| AU1201101A (en) | 1999-10-15 | 2001-04-30 | Du Pont Pharmaceuticals Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
| KR101412339B1 (ko) | 2004-07-15 | 2014-06-25 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를차단하기 위한 용도 |
| US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
| KR20080044840A (ko) | 2005-07-15 | 2008-05-21 | 에이엠알 테크놀로지, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도 |
| CN101277960A (zh) | 2005-09-29 | 2008-10-01 | 默克公司 | 作为黑皮质素-4受体调节剂的酰化螺哌啶衍生物 |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US7265247B1 (en) | 2006-07-28 | 2007-09-04 | Im&T Research, Inc. | Substituted phenylsulfur trifluoride and other like fluorinating agents |
| CA2664113C (en) | 2006-09-22 | 2013-05-28 | Merck & Co., Inc. | Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| PL2805945T3 (pl) | 2007-01-10 | 2019-09-30 | Msd Italia S.R.L. | Indazole podstawione grupą amidową jako inhibitory polimerazy poli(adp-rybozy) - (parp) |
| CN101663268B (zh) | 2007-03-23 | 2014-12-24 | 宇部兴产株式会社 | 一种制备芳基硫五氟化物的方法 |
| US8399720B2 (en) | 2007-03-23 | 2013-03-19 | Ube Industries, Ltd. | Methods for producing fluorinated phenylsulfur pentafluorides |
| US8106086B2 (en) | 2007-04-02 | 2012-01-31 | Msd K.K. | Indoledione derivative |
| WO2009002495A1 (en) | 2007-06-27 | 2008-12-31 | Merck & Co., Inc. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| US8030516B2 (en) | 2007-10-19 | 2011-10-04 | Ube Industries, Ltd. | Methods for producing perfluoroalkanedi(sulfonyl chloride) |
| US8598184B2 (en) | 2008-03-03 | 2013-12-03 | Tiger Pharmatech | Protein kinase inhibitors |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| JP5574280B2 (ja) | 2008-09-22 | 2014-08-20 | 宇部興産株式会社 | ポリ（ペンタフルオロスルファニル）芳香族化合物の製造方法 |
| US8203003B2 (en) | 2009-01-09 | 2012-06-19 | Ube Industries, Ltd. | 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
| ES2528404T3 (es) | 2009-05-12 | 2015-02-10 | Bristol-Myers Squibb Company | Formas cristalinas de (S)-7-([1,2,4]triazol[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y sus usos |
| CN102595902B (zh) | 2009-05-12 | 2015-04-29 | 阿尔巴尼分子研究公司 | 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途 |
| UA109417C2 (uk) | 2009-10-14 | 2015-08-25 | Мерк Шарп Енд Доме Корп. | ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ |
| US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
| US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
| EP4079856A1 (en) | 2010-08-17 | 2022-10-26 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
| EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
| US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
| US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
| WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| CA2833009A1 (en) | 2011-04-21 | 2012-10-26 | Merck Sharp & Dohme Corp. | Insulin-like growth factor-1 receptor inhibitors |
| US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| WO2013165816A2 (en) | 2012-05-02 | 2013-11-07 | Merck Sharp & Dohme Corp. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| MX2015004041A (es) | 2012-09-28 | 2015-07-06 | Merck Sharp & Dohme | Compuestos novedosos que son inhibidores de erk. |
| CA2892361A1 (en) | 2012-11-28 | 2014-06-05 | Merck Sharp & Dohme Corp. | Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels |
| RU2690663C2 (ru) | 2012-12-20 | 2019-06-05 | Мерк Шарп И Доум Корп. | Замещенные имидазопиридины в качестве ингибиторов hdm2 |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2654726B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
| FR2676443B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole et leur preparation. |
| FR2676442B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2689888B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2689889B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, et leur preparation. |
-
1994
- 1994-07-21 TW TW083106682A patent/TW365603B/zh active
- 1994-07-28 IL IL11049494A patent/IL110494A0/xx unknown
- 1994-07-28 PL PL94312739A patent/PL312739A1/xx unknown
- 1994-07-28 HU HU9503986A patent/HUT75304A/hu unknown
- 1994-07-28 DE DE69413542T patent/DE69413542T2/de not_active Expired - Fee Related
- 1994-07-28 AT AT94923755T patent/ATE171445T1/de not_active IP Right Cessation
- 1994-07-28 SK SK130-96A patent/SK13096A3/sk unknown
- 1994-07-28 AU AU73865/94A patent/AU7386594A/en not_active Abandoned
- 1994-07-28 ES ES94923755T patent/ES2123149T3/es not_active Expired - Lifetime
- 1994-07-28 CZ CZ96263A patent/CZ26396A3/cs unknown
- 1994-07-28 EP EP94923755A patent/EP0711280B1/fr not_active Expired - Lifetime
- 1994-07-28 US US08/586,708 patent/US5624950A/en not_active Expired - Fee Related
- 1994-07-28 WO PCT/FR1994/000952 patent/WO1995004040A1/fr active IP Right Grant
- 1994-07-28 DK DK94923755T patent/DK0711280T3/da active
- 1994-07-28 JP JP7505618A patent/JPH09500893A/ja active Pending
- 1994-07-28 KR KR1019960700531A patent/KR960703858A/ko not_active Application Discontinuation
- 1994-07-28 CA CA002168233A patent/CA2168233A1/fr not_active Abandoned
-
1996
- 1996-01-29 FI FI960399A patent/FI960399A/fi unknown
- 1996-01-29 NO NO960365A patent/NO960365D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9503986D0 (en) | 1996-03-28 |
| DE69413542T2 (de) | 1999-03-25 |
| WO1995004040A1 (fr) | 1995-02-09 |
| KR960703858A (ko) | 1996-08-31 |
| US5624950A (en) | 1997-04-29 |
| FI960399A0 (fi) | 1996-01-29 |
| ES2123149T3 (es) | 1999-01-01 |
| EP0711280A1 (fr) | 1996-05-15 |
| DE69413542D1 (de) | 1998-10-29 |
| SK13096A3 (en) | 1996-09-04 |
| IL110494A0 (en) | 1994-10-21 |
| FI960399A (fi) | 1996-01-29 |
| TW365603B (en) | 1999-08-01 |
| JPH09500893A (ja) | 1997-01-28 |
| CZ26396A3 (en) | 1996-05-15 |
| EP0711280B1 (fr) | 1998-09-23 |
| PL312739A1 (en) | 1996-05-13 |
| HUT75304A (en) | 1997-05-28 |
| ATE171445T1 (de) | 1998-10-15 |
| DK0711280T3 (da) | 1999-06-14 |
| AU7386594A (en) | 1995-02-28 |
| CA2168233A1 (fr) | 1995-02-09 |
| NO960365D0 (no) | 1996-01-29 |
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