ATE170188T1 - 2'-desoxy-5-fluoruridin, pharmazeutisch anwendbare salze davon, verfahren zu ihrer herstellung und antitumormedikament - Google Patents
2'-desoxy-5-fluoruridin, pharmazeutisch anwendbare salze davon, verfahren zu ihrer herstellung und antitumormedikamentInfo
- Publication number
- ATE170188T1 ATE170188T1 AT95903918T AT95903918T ATE170188T1 AT E170188 T1 ATE170188 T1 AT E170188T1 AT 95903918 T AT95903918 T AT 95903918T AT 95903918 T AT95903918 T AT 95903918T AT E170188 T1 ATE170188 T1 AT E170188T1
- Authority
- AT
- Austria
- Prior art keywords
- antitumor drug
- fluoruridine
- desoxy
- production
- pharmaceutically applicable
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 229940041181 antineoplastic drug Drugs 0.000 title abstract 2
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP05327338A JP3074341B2 (ja) | 1993-12-24 | 1993-12-24 | ２’−デオキシ−５−フルオロウリジン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE170188T1 true ATE170188T1 (de) | 1998-09-15 |
Family
ID=18198026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95903918T ATE170188T1 (de) | 1993-12-24 | 1994-12-21 | 2'-desoxy-5-fluoruridin, pharmazeutisch anwendbare salze davon, verfahren zu ihrer herstellung und antitumormedikament |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5869464A (de) |
| EP (1) | EP0686641B1 (de) |
| JP (1) | JP3074341B2 (de) |
| AT (1) | ATE170188T1 (de) |
| AU (1) | AU1370895A (de) |
| DE (1) | DE69412794T2 (de) |
| DK (1) | DK0686641T3 (de) |
| ES (1) | ES2122521T3 (de) |
| WO (1) | WO1995018138A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107936154B (zh) | 2017-12-01 | 2020-11-06 | 中国石油天然气股份有限公司 | 一种烷氧基镁催化剂载体及其制备方法和应用 |
| JP7539785B2 (ja) | 2020-03-31 | 2024-08-26 | 住友化学株式会社 | オレフィン重合用固体触媒成分 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56113797A (en) * | 1980-02-14 | 1981-09-07 | Funai Corp | 3-benzoyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
| JPS5728083A (en) * | 1980-07-25 | 1982-02-15 | Funai Corp | 4-position ether derivative of deoxydiacetyl-fluorouridine |
| JPS5750999A (en) * | 1980-09-11 | 1982-03-25 | Funai Corp | Benzyloxy derivative at 4-position of deoxyfluorouridine |
| JPS57109722A (en) * | 1980-12-26 | 1982-07-08 | Funai Corp | Antitumor agent containing deoxyfluorouridine benzyloxylated at 4-position |
| DE3263939D1 (en) * | 1981-12-09 | 1985-07-04 | Teijin Ltd | 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof |
| US4864021A (en) * | 1984-10-30 | 1989-09-05 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
| JPH0696590B2 (ja) * | 1985-04-16 | 1994-11-30 | 富山化学工業株式会社 | 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩 |
| AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
-
1993
- 1993-12-24 JP JP05327338A patent/JP3074341B2/ja not_active Expired - Fee Related
-
1994
- 1994-12-21 WO PCT/JP1994/002167 patent/WO1995018138A1/ja not_active Ceased
- 1994-12-21 DK DK95903918T patent/DK0686641T3/da active
- 1994-12-21 US US08/505,291 patent/US5869464A/en not_active Expired - Fee Related
- 1994-12-21 AT AT95903918T patent/ATE170188T1/de not_active IP Right Cessation
- 1994-12-21 AU AU13708/95A patent/AU1370895A/en not_active Abandoned
- 1994-12-21 ES ES95903918T patent/ES2122521T3/es not_active Expired - Lifetime
- 1994-12-21 EP EP95903918A patent/EP0686641B1/de not_active Expired - Lifetime
- 1994-12-21 DE DE69412794T patent/DE69412794T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5869464A (en) | 1999-02-09 |
| JPH07188277A (ja) | 1995-07-25 |
| EP0686641A4 (de) | 1996-07-10 |
| DE69412794T2 (de) | 1999-04-29 |
| DK0686641T3 (da) | 1998-11-23 |
| DE69412794D1 (de) | 1998-10-01 |
| AU1370895A (en) | 1995-07-17 |
| ES2122521T3 (es) | 1998-12-16 |
| JP3074341B2 (ja) | 2000-08-07 |
| EP0686641B1 (de) | 1998-08-26 |
| EP0686641A1 (de) | 1995-12-13 |
| WO1995018138A1 (en) | 1995-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |