JPS5728083A - 4-position ether derivative of deoxydiacetyl-fluorouridine - Google Patents
4-position ether derivative of deoxydiacetyl-fluorouridineInfo
- Publication number
- JPS5728083A JPS5728083A JP10295680A JP10295680A JPS5728083A JP S5728083 A JPS5728083 A JP S5728083A JP 10295680 A JP10295680 A JP 10295680A JP 10295680 A JP10295680 A JP 10295680A JP S5728083 A JPS5728083 A JP S5728083A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouridine
- equivalent
- deoxydiacetyl
- ether derivative
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound shown by the formula [R is (substituted) benzyl, 1WtC alkyl].
EXAMPLE: O4-Methyl-2'-deoxy-3',5'-di-O-acetyl-5-fluorouridine.
USE: An antitumor agent.
PROCESS: (A) Preferably one equivalent 2'-deoxy-3'-5'-di-O-acetyl-5-fluorourdine is reacted with (B) 1W3 equivalent silver compound, e.g., silver oxide, etc. and (C) 1W7 equivalent halide (preferably, iodide, bromide) shown by the formula RX (X is halogen) is an organic solvent, preferably acetone, etc. at room temperature W the reflux temperature of the solvent for 30min W 3 days.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10295680A JPS5728083A (en) | 1980-07-25 | 1980-07-25 | 4-position ether derivative of deoxydiacetyl-fluorouridine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10295680A JPS5728083A (en) | 1980-07-25 | 1980-07-25 | 4-position ether derivative of deoxydiacetyl-fluorouridine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5728083A true JPS5728083A (en) | 1982-02-15 |
JPS6312477B2 JPS6312477B2 (en) | 1988-03-18 |
Family
ID=14341246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10295680A Granted JPS5728083A (en) | 1980-07-25 | 1980-07-25 | 4-position ether derivative of deoxydiacetyl-fluorouridine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5728083A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62119612U (en) * | 1986-01-21 | 1987-07-29 | ||
JPS62119611U (en) * | 1986-01-21 | 1987-07-29 | ||
WO1995018138A1 (en) * | 1993-12-24 | 1995-07-06 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug |
-
1980
- 1980-07-25 JP JP10295680A patent/JPS5728083A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62119612U (en) * | 1986-01-21 | 1987-07-29 | ||
JPS62119611U (en) * | 1986-01-21 | 1987-07-29 | ||
JPH0519770Y2 (en) * | 1986-01-21 | 1993-05-25 | ||
JPH0519769Y2 (en) * | 1986-01-21 | 1993-05-25 | ||
WO1995018138A1 (en) * | 1993-12-24 | 1995-07-06 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug |
US5869464A (en) * | 1993-12-24 | 1999-02-09 | Taiho Pharmaceutical Co. Ltd. | 2'-Deoxy-5-fluorouridine derivatives, a process for their preparation, antitumor agents containing same and methods for using said agents |
Also Published As
Publication number | Publication date |
---|---|
JPS6312477B2 (en) | 1988-03-18 |
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