JPS5750999A - Benzyloxy derivative at 4-position of deoxyfluorouridine - Google Patents

Benzyloxy derivative at 4-position of deoxyfluorouridine

Info

Publication number
JPS5750999A
JPS5750999A JP12677580A JP12677580A JPS5750999A JP S5750999 A JPS5750999 A JP S5750999A JP 12677580 A JP12677580 A JP 12677580A JP 12677580 A JP12677580 A JP 12677580A JP S5750999 A JPS5750999 A JP S5750999A
Authority
JP
Japan
Prior art keywords
benzyl
compound
formula
deoxyfluorouridine
fluorouridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12677580A
Other languages
Japanese (ja)
Other versions
JPS632278B2 (en
Inventor
Setsuo Fujii
Bonpei Yasui
Satoshi Fukumori
Tomohisa Miyamoto
Mitsuru Hirohashi
Masatoshi Shiga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUNAI CORP
Funai Yakuhin Kogyo Kk
Funai Pharmaceutical Industries Ltd
Original Assignee
FUNAI CORP
Funai Yakuhin Kogyo Kk
Funai Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUNAI CORP, Funai Yakuhin Kogyo Kk, Funai Pharmaceutical Industries Ltd filed Critical FUNAI CORP
Priority to JP12677580A priority Critical patent/JPS5750999A/en
Publication of JPS5750999A publication Critical patent/JPS5750999A/en
Publication of JPS632278B2 publication Critical patent/JPS632278B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula I (R is H, halogen, or 1W4C alkyl; n is 3 or 4).
EXAMPLE: 4-O-Benzyl-2'-deoxy-3',5'-O-n-hexanoyl-5-fluorouridine.
USE: A drug, e.g., antitumor agent.
PROCESS: For example, a 2'-deoxy-3',5'-di-O-alkanoyl-5-fluorouridine shown by the formula II is reacted with a silver compound, e.g., silver carbonate, etc. and a benzyl compound (preferably benzyl iodide, bromide, chloride) shown by the formula III (hal is halogen) in an equivalent ratio of preferably 1:1W4:1W5, and, if necessary, in the presence of an organic solvent, e.g., acetone, etc., preferably in the shield of light.
COPYRIGHT: (C)1982,JPO&Japio
JP12677580A 1980-09-11 1980-09-11 Benzyloxy derivative at 4-position of deoxyfluorouridine Granted JPS5750999A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12677580A JPS5750999A (en) 1980-09-11 1980-09-11 Benzyloxy derivative at 4-position of deoxyfluorouridine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12677580A JPS5750999A (en) 1980-09-11 1980-09-11 Benzyloxy derivative at 4-position of deoxyfluorouridine

Publications (2)

Publication Number Publication Date
JPS5750999A true JPS5750999A (en) 1982-03-25
JPS632278B2 JPS632278B2 (en) 1988-01-18

Family

ID=14943617

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12677580A Granted JPS5750999A (en) 1980-09-11 1980-09-11 Benzyloxy derivative at 4-position of deoxyfluorouridine

Country Status (1)

Country Link
JP (1) JPS5750999A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018138A1 (en) * 1993-12-24 1995-07-06 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018138A1 (en) * 1993-12-24 1995-07-06 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug
US5869464A (en) * 1993-12-24 1999-02-09 Taiho Pharmaceutical Co. Ltd. 2'-Deoxy-5-fluorouridine derivatives, a process for their preparation, antitumor agents containing same and methods for using said agents

Also Published As

Publication number Publication date
JPS632278B2 (en) 1988-01-18

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