JPS5735571A - 5-fluorouracil derivative and its preparation - Google Patents

5-fluorouracil derivative and its preparation

Info

Publication number
JPS5735571A
JPS5735571A JP10906180A JP10906180A JPS5735571A JP S5735571 A JPS5735571 A JP S5735571A JP 10906180 A JP10906180 A JP 10906180A JP 10906180 A JP10906180 A JP 10906180A JP S5735571 A JPS5735571 A JP S5735571A
Authority
JP
Japan
Prior art keywords
preparation
formula
fluorouracil
compound
fluorouracil derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10906180A
Other languages
Japanese (ja)
Inventor
Takeshi Tomiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kotobuki Seiyaku Co Ltd
Original Assignee
Kotobuki Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kotobuki Seiyaku Co Ltd filed Critical Kotobuki Seiyaku Co Ltd
Priority to JP10906180A priority Critical patent/JPS5735571A/en
Publication of JPS5735571A publication Critical patent/JPS5735571A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (A is CO or CH2; R is H, CH3, Cl).
EXAMPLE: 1-(p-Chlorophenylthioisobutyryl)5-fluorouracil.
USE: Antitumor agent.
PREPARATION: 5-Fluorouracil, after silylated according to the Hilbert-Johnson method, is made to react with a compound of formula II (X is halogen) in an inert solvent at room temperature or under heating to produce the compound of formula I. An acid acceptor is not always necessary, however, a proper base may be used, when needed.
COPYRIGHT: (C)1982,JPO&Japio
JP10906180A 1980-08-08 1980-08-08 5-fluorouracil derivative and its preparation Pending JPS5735571A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10906180A JPS5735571A (en) 1980-08-08 1980-08-08 5-fluorouracil derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10906180A JPS5735571A (en) 1980-08-08 1980-08-08 5-fluorouracil derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5735571A true JPS5735571A (en) 1982-02-26

Family

ID=14500601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10906180A Pending JPS5735571A (en) 1980-08-08 1980-08-08 5-fluorouracil derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5735571A (en)

Similar Documents

Publication Publication Date Title
JPS52118484A (en) Benzoguanamine derivatives
JPS5735571A (en) 5-fluorouracil derivative and its preparation
JPS5271444A (en) Synthesis of phenyl-onn-azoxycyanides
JPS5344587A (en) Novel urazol derivatives and herbicide containing the same
JPS5254084A (en) Manufacture of 2-gamma-glutamylamino-4-hexynic acid and/or 2-gamma-glutamylamino- 3-hydroxy-4-hexynic acid
JPS5283652A (en) Benzanthrone derivatives
JPS5239674A (en) Imidazole derivatives and agricultural bactericides therefrom
JPS5321186A (en) Penicillanic acid derivatives and their preparation
JPS52125146A (en) Arylacetylenesulfonamide derivatives and method of preparing the same
JPS5276434A (en) Dungicides for nonmedical use and method of making the same
JPS5285169A (en) Novel allantoin-n-acetylglutamine-aluminum molecular complex and its p reparation
JPS5293771A (en) Benzotriazoles
JPS5353638A (en) Alpha-acetyl cinnamic acid ester derivatives, their preparation and theirherbicides containing the same
JPS52134634A (en) 3,10-dialkoxy-4-halogeno-13-cyanotriphenodioxazines
JPS536424A (en) Thiophosphoroamide compounds and insecticide-miticide containing the same
JPS5328183A (en) 1-carbamoyl-5-fluorouracil derivatives and thier preparation
JPS52102280A (en) 5,7,8-trimethyltocotrienol-nicotinic acid esters and preparation there of
JPS52100457A (en) 5-hydroxy-4-homoisotwistane and method of making same
JPS52105177A (en) 2-substituted methyl-thiochroman derivatives
JPS543065A (en) Imidazole derivatives and insecticide-miticide containing the same
JPS52106868A (en) Tetrathiafulvalene-dicarboxylic acid and method of making the same
JPS5295661A (en) 5-alkoxy-4-oxazolealkanoic acid derivatives
JPS5312892A (en) Novel 1,n6-etheno-2-substituted-adenosine-3,5-cyclic phosphoric acid and its preparation
JPS5242884A (en) Preparation of 2,3,6-trimethyl hydroquinone-1-nicotinic acid esters
JPS52131590A (en) Bis-trimethoxybenzylpiperazino-alkanes