ATE165365T1 - Neue 19-nor steroide, die an der 11-beta stelle an eine thiokohlenstoffgruppe gebunden sind, ein verfahren zu ihrer herstellung und zwischenprodukte dazu - Google Patents
Neue 19-nor steroide, die an der 11-beta stelle an eine thiokohlenstoffgruppe gebunden sind, ein verfahren zu ihrer herstellung und zwischenprodukte dazuInfo
- Publication number
- ATE165365T1 ATE165365T1 AT93902339T AT93902339T ATE165365T1 AT E165365 T1 ATE165365 T1 AT E165365T1 AT 93902339 T AT93902339 T AT 93902339T AT 93902339 T AT93902339 T AT 93902339T AT E165365 T1 ATE165365 T1 AT E165365T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- bonded
- hydrogen
- steroids
- new
- Prior art date
Links
- VVUQRXPUVKXAIO-XFUVECHXSA-N 19-nor-5-androstenediol Chemical compound C1[C@@H](O)CC[C@@H]2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC=C21 VVUQRXPUVKXAIO-XFUVECHXSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- KCNKJCHARANTIP-SNAWJCMRSA-N allyl-{4-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-but-2-enyl}-methyl-amine Chemical compound C=1OC2=CC(OC/C=C/CN(CC=C)C)=CC=C2C=1C1=CC=C(Br)C=C1 KCNKJCHARANTIP-SNAWJCMRSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000732 arylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000005638 hydrazono group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002345 steroid group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9115856A FR2685332A1 (fr) | 1991-12-20 | 1991-12-20 | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE165365T1 true ATE165365T1 (de) | 1998-05-15 |
Family
ID=9420274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93902339T ATE165365T1 (de) | 1991-12-20 | 1992-12-17 | Neue 19-nor steroide, die an der 11-beta stelle an eine thiokohlenstoffgruppe gebunden sind, ein verfahren zu ihrer herstellung und zwischenprodukte dazu |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6281204B1 (enExample) |
| EP (1) | EP0623140B1 (enExample) |
| JP (1) | JP3445271B2 (enExample) |
| KR (1) | KR100278465B1 (enExample) |
| CN (1) | CN1036718C (enExample) |
| AT (1) | ATE165365T1 (enExample) |
| AU (1) | AU666916B2 (enExample) |
| CA (1) | CA2124339C (enExample) |
| DE (1) | DE69225243T2 (enExample) |
| DK (1) | DK0623140T3 (enExample) |
| ES (1) | ES2115754T3 (enExample) |
| FI (1) | FI114866B (enExample) |
| FR (1) | FR2685332A1 (enExample) |
| HU (1) | HU221482B (enExample) |
| IL (1) | IL104105A (enExample) |
| MX (1) | MX9207421A (enExample) |
| NZ (1) | NZ246624A (enExample) |
| RU (1) | RU2111213C1 (enExample) |
| WO (1) | WO1993013123A1 (enExample) |
| ZA (1) | ZA929859B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2685332A1 (fr) * | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
| FR2706454B1 (fr) * | 1993-06-17 | 1995-09-15 | Roussel Uclaf | Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant. |
| DE19510862A1 (de) * | 1995-03-16 | 1996-09-19 | Schering Ag | Verwendung von Antiestrogenen zur männlichen Fertilitätskontrolle |
| DE19526146A1 (de) * | 1995-07-07 | 1997-01-09 | Schering Ag | Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| DE19724187A1 (de) * | 1997-06-02 | 1998-12-03 | Schering Ag | 11beta-Arylsubstituierte 14,17-Ethanoestratriene, Verfahren zur Herstellung dieser Verbindungen, sowie ihre Verwendung zur Herstellung von Arzneimitteln |
| HUP9802054A3 (en) * | 1997-10-14 | 2001-02-28 | Bayer Ag | Process for producing 4,4,5,5,5-pentafluor-1-pentanol |
| US6548491B2 (en) | 1997-12-24 | 2003-04-15 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6503896B1 (en) | 1997-12-24 | 2003-01-07 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6054446A (en) * | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| DE19826213A1 (de) * | 1998-06-09 | 1999-12-16 | Schering Ag | Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| FR2780060B1 (fr) * | 1998-06-23 | 2000-08-04 | Hoechst Marion Roussel Inc | Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant |
| DE69902684T2 (de) * | 1998-11-20 | 2003-04-24 | Akzo Nobel N.V., Arnheim/Arnhem | Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11 |
| DE19929715A1 (de) | 1999-06-24 | 2000-12-28 | Schering Ag | 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| WO2001040805A1 (en) * | 1999-11-30 | 2001-06-07 | Akzo Nobel N.V. | Steroid compounds for steroid receptor binding assays |
| WO2005090379A1 (en) * | 2004-03-17 | 2005-09-29 | The Central Science Laboratory, 'csl' | Compounds and sensor for detecion of polycyclic aromatic hydrocarbons |
| EP1623713A1 (en) * | 2004-07-09 | 2006-02-08 | Proskelia SAS | Cominations of pure anti-estrogen with aromatase inhibitors |
| EP1630167A1 (en) * | 2004-07-09 | 2006-03-01 | Proskelia SAS | Polymorphs of 19-Nor steroid derivatives |
| CN100420681C (zh) * | 2005-04-29 | 2008-09-24 | 上海奥锐特国际贸易有限公司 | 多烯紫杉醇三水物的制备方法 |
| DE102008061722A1 (de) | 2008-12-12 | 2010-06-17 | Saltigo Gmbh | Verfahren zur Herstellung von Perfluoralkyl- oder Perfluoralkoxyalkanolen |
| ME03351B (me) | 2014-01-29 | 2019-10-20 | Umecrine Cognition Ab | Steroidno jedinjenje za upotrebu u lečenju hepatične encefalopatije |
| AR103384A1 (es) | 2015-01-12 | 2017-05-03 | Umecrine Cognition Ab | 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA |
| US10278977B2 (en) | 2016-06-06 | 2019-05-07 | Umecrine Cognition Ab | Methods for treating hypersomnolence |
| CN110117217B (zh) * | 2018-12-19 | 2021-09-28 | 浙江普洛家园药业有限公司 | 1-溴代甲基-2,3,5,6-四氟-4-(三氟甲基)苯的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2528434B1 (fr) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
| FR2643638B1 (fr) * | 1989-02-24 | 1991-06-14 | Roussel Uclaf | Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| EP0471612B1 (fr) * | 1990-08-14 | 1998-01-28 | Roussel Uclaf | Nouveaux 19-Nor stéroides ayant en position 11béta une chaíne carbonée comportant une fonction amide, leur préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant |
| FR2685332A1 (fr) * | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
-
1991
- 1991-12-20 FR FR9115856A patent/FR2685332A1/fr active Granted
-
1992
- 1992-12-15 IL IL104105A patent/IL104105A/xx not_active IP Right Cessation
- 1992-12-17 AT AT93902339T patent/ATE165365T1/de not_active IP Right Cessation
- 1992-12-17 DE DE69225243T patent/DE69225243T2/de not_active Expired - Fee Related
- 1992-12-17 JP JP51147893A patent/JP3445271B2/ja not_active Expired - Fee Related
- 1992-12-17 WO PCT/FR1992/001193 patent/WO1993013123A1/fr not_active Ceased
- 1992-12-17 AU AU33570/93A patent/AU666916B2/en not_active Ceased
- 1992-12-17 HU HU9402134A patent/HU221482B/hu not_active IP Right Cessation
- 1992-12-17 RU RU94031162/04A patent/RU2111213C1/ru not_active IP Right Cessation
- 1992-12-17 US US08/244,735 patent/US6281204B1/en not_active Expired - Fee Related
- 1992-12-17 KR KR1019940702134A patent/KR100278465B1/ko not_active Expired - Fee Related
- 1992-12-17 NZ NZ246624A patent/NZ246624A/en unknown
- 1992-12-17 CA CA002124339A patent/CA2124339C/fr not_active Expired - Fee Related
- 1992-12-17 EP EP93902339A patent/EP0623140B1/fr not_active Expired - Lifetime
- 1992-12-17 DK DK93902339T patent/DK0623140T3/da active
- 1992-12-17 ES ES93902339T patent/ES2115754T3/es not_active Expired - Lifetime
- 1992-12-18 ZA ZA929859A patent/ZA929859B/xx unknown
- 1992-12-18 MX MX9207421A patent/MX9207421A/es not_active IP Right Cessation
- 1992-12-19 CN CN92115248A patent/CN1036718C/zh not_active Expired - Fee Related
-
1994
- 1994-06-17 FI FI942944A patent/FI114866B/fi not_active IP Right Cessation
-
2001
- 2001-06-26 US US09/891,433 patent/US6596885B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ246624A (en) | 1995-12-21 |
| US6596885B2 (en) | 2003-07-22 |
| CN1036718C (zh) | 1997-12-17 |
| CA2124339C (fr) | 2005-02-15 |
| JP3445271B2 (ja) | 2003-09-08 |
| AU666916B2 (en) | 1996-02-29 |
| HUT68068A (en) | 1995-05-29 |
| HU9402134D0 (en) | 1994-09-28 |
| FR2685332A1 (fr) | 1993-06-25 |
| JPH07502281A (ja) | 1995-03-09 |
| FI942944L (fi) | 1994-06-17 |
| HU221482B (en) | 2002-10-28 |
| ES2115754T3 (es) | 1998-07-01 |
| EP0623140B1 (fr) | 1998-04-22 |
| IL104105A0 (en) | 1993-05-13 |
| FI114866B (fi) | 2005-01-14 |
| KR100278465B1 (ko) | 2001-02-01 |
| IL104105A (en) | 1997-07-13 |
| AU3357093A (en) | 1993-07-28 |
| RU2111213C1 (ru) | 1998-05-20 |
| RU94031162A (ru) | 1996-04-20 |
| EP0623140A1 (fr) | 1994-11-09 |
| DE69225243T2 (de) | 1998-10-29 |
| MX9207421A (es) | 1993-07-01 |
| FR2685332B1 (enExample) | 1995-06-02 |
| ZA929859B (en) | 1993-12-20 |
| FI942944A0 (fi) | 1994-06-17 |
| DK0623140T3 (da) | 1999-02-15 |
| US20020072624A1 (en) | 2002-06-13 |
| CN1075722A (zh) | 1993-09-01 |
| US6281204B1 (en) | 2001-08-28 |
| CA2124339A1 (fr) | 1993-07-08 |
| WO1993013123A1 (fr) | 1993-07-08 |
| DE69225243D1 (de) | 1998-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |