ATE161879T1 - Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer - Google Patents

Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer

Info

Publication number
ATE161879T1
ATE161879T1 AT89913054T AT89913054T ATE161879T1 AT E161879 T1 ATE161879 T1 AT E161879T1 AT 89913054 T AT89913054 T AT 89913054T AT 89913054 T AT89913054 T AT 89913054T AT E161879 T1 ATE161879 T1 AT E161879T1
Authority
AT
Austria
Prior art keywords
strands
polymer produced
synthetic protein
protein polymer
functional synthetic
Prior art date
Application number
AT89913054T
Other languages
English (en)
Inventor
Joseph Cappello
Franco A Ferrari
Original Assignee
Protein Polymer Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Polymer Tech Inc filed Critical Protein Polymer Tech Inc
Application granted granted Critical
Publication of ATE161879T1 publication Critical patent/ATE161879T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT89913054T 1988-11-09 1989-11-07 Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer ATE161879T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26942988A 1988-11-09 1988-11-09

Publications (1)

Publication Number Publication Date
ATE161879T1 true ATE161879T1 (de) 1998-01-15

Family

ID=23027205

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89913054T ATE161879T1 (de) 1988-11-09 1989-11-07 Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer

Country Status (10)

Country Link
EP (1) EP0406357B1 (de)
JP (1) JP3338441B2 (de)
KR (1) KR0176966B1 (de)
AT (1) ATE161879T1 (de)
AU (1) AU630643B2 (de)
DE (1) DE68928532T2 (de)
DK (1) DK163690A (de)
FI (1) FI101706B1 (de)
NO (1) NO178625C (de)
WO (1) WO1990005177A1 (de)

Families Citing this family (48)

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US5496712A (en) * 1990-11-06 1996-03-05 Protein Polymer High molecular weight collagen-like protein polymers
US5830713A (en) * 1986-11-04 1998-11-03 Protein Polymer Technologies, Inc. Methods for preparing synthetic repetitive DNA
US5773249A (en) * 1986-11-04 1998-06-30 Protein Polymer Technologies, Inc. High molecular weight collagen-like protein polymers
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
EP0559725B1 (de) * 1990-11-28 1999-06-23 E.I. Du Pont De Nemours And Company Strukturproteine durch künstliche gene
US5171505A (en) * 1990-11-28 1992-12-15 E. I. Du Pont De Nemours And Company Process for spinning polypeptide fibers
JP2745351B2 (ja) * 1991-02-14 1998-04-28 富士写真フイルム株式会社 ペプチド誘導体及びその用途
DE69228254T2 (de) * 1991-11-12 1999-08-19 Du Pont Kollagenartige polypeptide
AU675056B2 (en) * 1991-11-12 1997-01-23 Protein Polymer Technologies, Inc. High molecular weight collagen-like protein polymers
FR2685347A1 (fr) * 1991-12-23 1993-06-25 Univ Pasteur Procede biotechnologique d'obtention et de production microbienne d'oligomeres peptidiques comme substituts de la gelatine.
US5773577A (en) * 1994-03-03 1998-06-30 Protein Polymer Technologies Products comprising substrates capable of enzymatic cross-linking
US5760004A (en) * 1994-11-21 1998-06-02 Protein Polymer Technologies, Inc. Chemical modification of repetitive polymers to enhance water solubility
US5710252A (en) * 1995-02-03 1998-01-20 Eastman Kodak Company Method for recombinant yeast expression and isolation of water-soluble collagen-type polypeptides
US5670616A (en) * 1995-02-03 1997-09-23 Eastman Kodak Company Collagen-like polypeptides and biopolymers and nucleic acids encoding same
FR2738841B1 (fr) * 1995-09-15 1997-11-21 Centre Nat Rech Scient Procede de polymerisation de sequences d'acides nucleiques et ses applications
US5969106A (en) * 1996-08-07 1999-10-19 The Hospital For Sick Children Self-aligning peptides modeled on human elastin and other fibrous proteins
US6489446B1 (en) 1996-08-07 2002-12-03 Hsc Research And Development Limited Partnership Self-aligning peptides modeled on human elastin and other fibrous proteins
WO1998043686A1 (en) * 1997-04-03 1998-10-08 California Institute Of Technology Enzyme-mediated modification of fibrin for tissue engineering
GB9718463D0 (en) * 1997-08-29 1997-11-05 Dynal As Biomolecules
NL1007908C2 (nl) * 1997-12-24 1999-06-25 Fuji Photo Film Bv Zilverhalide-emulsies met recombinant collageen die geschikt zijn voor fotografische toediening alsmede de bereiding daarvan.
US6150081A (en) 1997-12-24 2000-11-21 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
US7241730B2 (en) 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
WO2002094856A2 (en) 2001-05-24 2002-11-28 Neuronz Limited Gpe analogs and peptidomimetics
US7714020B2 (en) 2001-05-24 2010-05-11 Neuren Pharmaceuticals Limited Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate
US7605177B2 (en) 2001-05-24 2009-10-20 Neuren Pharmaceuticals Limited Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
JP4504624B2 (ja) * 2002-01-17 2010-07-14 三洋化成工業株式会社 細胞接着性ペプチド含有基材
JP4705319B2 (ja) * 2002-07-19 2011-06-22 三洋化成工業株式会社 創傷被覆材
JP4510512B2 (ja) * 2003-05-21 2010-07-28 三洋化成工業株式会社 細胞接着性ポリペプチド
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
CN101405384B (zh) 2006-03-17 2013-12-04 三洋化成工业株式会社 细胞培养用载体以及制造方法和应用
US8192760B2 (en) * 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
EP2112998B1 (de) * 2007-02-21 2012-04-18 FUJIFILM Manufacturing Europe B.V. Rgd-haltige rekombinante gelatine
MX2009011005A (es) 2007-04-13 2009-11-02 Kuros Biosurgery Ag Sellador polimerico para tejido.
WO2008133196A1 (ja) * 2007-04-19 2008-11-06 Fujifilm Corporation 再生医療用材料
JP2010526582A (ja) 2007-05-10 2010-08-05 エラスティン・スペシャルティーズ，インコーポレイテッド 関節の再構成、修復およびクッションのための合成ペプチド材料
WO2009083544A2 (en) 2007-12-28 2009-07-09 Kuros Biosurgery Ag Pdgf fusion proteins incorporated into fibrin foams
WO2012060351A1 (ja) 2010-11-04 2012-05-10 三洋化成工業株式会社 生体組織用細胞接着性材料
WO2012111438A1 (ja) 2011-02-18 2012-08-23 国立大学法人京都大学 組織再生用材料、これを含むタンパク質水溶液及びこれをゲル化させる方法
WO2012123028A1 (en) 2011-03-16 2012-09-20 Kuros Biosurgery Ag Pharmaceutical formulation for use in spinal fusion
US9403897B2 (en) 2011-10-12 2016-08-02 Sanyo Chemical Industries, Ltd. Proteinaceous protease inhibitor and protein solution and detergent composition containing it
JP6077316B2 (ja) * 2012-02-02 2017-02-08 三洋化成工業株式会社 組織再生用材料及び組織再生用タンパク質溶液
WO2014129541A1 (ja) 2013-02-22 2014-08-28 三洋化成工業株式会社 創傷治癒剤
EP3811983B1 (de) 2018-06-12 2023-10-25 Kyoto University Zusammensetzung für zelltransplantation und verfahren zur transplantation von zellen
CN112789063B (zh) 2018-10-05 2022-10-25 国立大学法人广岛大学 半月板再生用材料
CN113943345B (zh) * 2021-10-14 2023-05-26 国科温州研究院(温州生物材料与工程研究所) 一种肝素中和肽、肝素中和剂及其应用

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US4187852A (en) * 1976-07-09 1980-02-12 The University Of Alabama Synthetic elastomeric insoluble cross-linked polypentapeptide
US4474851A (en) * 1981-10-02 1984-10-02 The University Of Alabama In Birmingham Elastomeric composite material comprising a polypeptide
US4589882A (en) * 1983-09-19 1986-05-20 Urry Dan W Enzymatically crosslinked bioelastomers
JPS60229592A (ja) * 1984-04-27 1985-11-14 Mitsubishi Electric Corp 符号化伝送方式文字放送受信装置
GB2162190A (en) * 1984-07-06 1986-01-29 Pa Consulting Services Improvements in or relating to production of silk
AU612340B2 (en) * 1986-11-04 1991-07-11 Protein Polymers Technologies, Inc. Construction of synthetic dna and its use in large polypeptide synthesis

Also Published As

Publication number Publication date
NO903025L (no) 1990-09-04
KR900702026A (ko) 1990-12-05
DE68928532T2 (de) 1998-05-28
EP0406357A1 (de) 1991-01-09
NO903025D0 (no) 1990-07-06
AU630643B2 (en) 1992-11-05
FI101706B (fi) 1998-08-14
FI101706B1 (fi) 1998-08-14
FI903201A0 (fi) 1990-06-26
NO178625C (no) 1996-05-02
NO178625B (no) 1996-01-22
AU4642589A (en) 1990-05-28
DK163690A (da) 1990-09-07
JP3338441B2 (ja) 2002-10-28
DE68928532D1 (de) 1998-02-12
WO1990005177A1 (en) 1990-05-17
KR0176966B1 (ko) 1999-04-01
EP0406357B1 (de) 1998-01-07
DK163690D0 (da) 1990-07-06
EP0406357A4 (en) 1992-04-15
JPH03502935A (ja) 1991-07-04

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Legal Events

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REN Ceased due to non-payment of the annual fee