ATE157090T1 - Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren - Google Patents

Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren

Info

Publication number
ATE157090T1
ATE157090T1 AT94905595T AT94905595T ATE157090T1 AT E157090 T1 ATE157090 T1 AT E157090T1 AT 94905595 T AT94905595 T AT 94905595T AT 94905595 T AT94905595 T AT 94905595T AT E157090 T1 ATE157090 T1 AT E157090T1
Authority
AT
Austria
Prior art keywords
superoxide dismutase
manganeous
complexes
catalysts
nitrogen
Prior art date
Application number
AT94905595T
Other languages
English (en)
Inventor
Karl William Aston
Patrick James Lennon
Anil Shrikrishna Modak
William Lojda Neumann
Dennis Patrick Riley
Randy Herman Weiss
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ATE157090T1 publication Critical patent/ATE157090T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
AT94905595T 1993-01-14 1994-01-05 Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren ATE157090T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/004,444 US6204259B1 (en) 1993-01-14 1993-01-14 Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (1)

Publication Number Publication Date
ATE157090T1 true ATE157090T1 (de) 1997-09-15

Family

ID=21710837

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94905595T ATE157090T1 (de) 1993-01-14 1994-01-05 Mangan-komplexe von stickstoff-enthaltenden macrozyklischen liganden und ihre verwendung als superoxiddismutase katalysatoren

Country Status (11)

Country Link
US (1) US6204259B1 (de)
EP (1) EP0679155B1 (de)
JP (1) JPH08505622A (de)
AT (1) ATE157090T1 (de)
AU (1) AU5964894A (de)
CA (1) CA2151262A1 (de)
DE (1) DE69405086T2 (de)
DK (1) DK0679155T3 (de)
ES (1) ES2107184T3 (de)
GR (1) GR3025447T3 (de)
WO (1) WO1994015925A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492349B1 (en) * 1993-03-31 2002-12-10 Nutramax Laboratories, Inc. Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
CN1152880A (zh) * 1994-04-22 1997-06-25 孟山都公司 使用含氮大环配拉体的金属络合物的诊断图像分析的方法
BR9507643A (pt) * 1994-05-13 1997-09-23 Monsanto Co Métodos de uso para catalisadores de decomposição de peroxinitrito composições farmacéuticas para os mesmos
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
AU5928396A (en) * 1995-06-07 1996-12-30 Monsanto Company Process for preparing substituted polyazamacrocycles
BR9610241A (pt) * 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
CZ39898A3 (cs) * 1995-08-17 1998-07-15 Monsanto Company Biokonjugáty manganových komplexů makrocyklických ligandů obsahujících dusík účinné jako katalyzátory dismutace superoxidu
GB9613182D0 (en) * 1996-06-24 1996-08-28 Nycomed Imaging As Method
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
CA2309154C (en) 1997-11-03 2010-02-16 Duke University Substituted porphyrins
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
US6429197B1 (en) * 1998-10-08 2002-08-06 Bionebraska, Inc. Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
ES2254142T3 (es) * 1999-01-25 2006-06-16 National Jewish Medical And Research Center Porfirinas sustituidas y su uso terapeutico.
AU5048400A (en) 1999-05-27 2000-12-18 Monsanto Company Biomaterials modified with superoxide dismutase mimics
GB9930422D0 (en) * 1999-12-22 2000-02-16 Unilever Plc Bleach catalysts
FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
CA2395165C (en) 2000-10-20 2012-05-22 Mario Ehlers Treatment of hibernating myocardium and diabetic cardiomyopathy with a glp-1 peptide
ES2330728T3 (es) * 2001-01-19 2009-12-15 National Jewish Health Medicamento para proteccion en radioterapia.
EP1439842A4 (de) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Oxidantienfänger zur behandlung von diabetes oder zur verwendung bei der transplantation oder induktion von immuntoleranz
JP2006501163A (ja) * 2002-06-07 2006-01-12 デューク・ユニバーシティー 置換ポルフィリン
US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
KR100648618B1 (ko) * 2003-11-19 2006-11-23 주식회사 웰스킨 활성 산소 억제제
EP1740094A4 (de) * 2004-03-29 2008-09-03 Inotek Pharmaceuticals Corp Pyridyl-substituierte porphyrin-verbindungen und anwendungsverfahren dafür
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
KR100724586B1 (ko) 2005-12-09 2007-06-04 세종대학교산학협력단 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
ES2725023T3 (es) 2006-10-12 2019-09-18 Galera Labs Llc Métodos para el tratamiento de la mucositis oral
CA2724550C (en) 2008-05-22 2017-01-03 Kereos, Inc. Combination antitumor therapy
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
CN103906756B (zh) 2011-09-26 2020-03-03 加莱拉实验室有限责任公司 用于治疗疾病的方法
AU2012364227B2 (en) 2012-01-05 2017-12-07 Egetis Therapeutics Ab Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment
EP3334744B1 (de) 2015-08-11 2020-04-22 Galera Labs, LLC Makrocyclische pentaaza-ring-komplexe mit oraler bioverfügbarkeit
IL269915B (en) 2017-04-13 2022-09-01 Galera Labs Llc Cancer immunotherapy combined with a macrocyclic ring pentase complex
WO2019152661A1 (en) 2018-01-31 2019-08-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001212A (en) 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
US3930867A (en) 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
JPS61226751A (ja) 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5223538A (en) 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
US5227405A (en) * 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
FR2614020B1 (fr) 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US5096724A (en) 1988-06-03 1992-03-17 Aquanautics Corporation Methods, compositions, and systems for ligand extraction
WO1990007261A2 (en) 1988-12-22 1990-07-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
FR2644785B1 (fr) 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
CA2032559C (en) 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
ATE164164T1 (de) * 1991-07-19 1998-04-15 Monsanto Co Mangan-komplexe mit stickstoff enthaltenden makrozyklischen liganden, wirksam als superoxiddismutasekatalysatoren.

Also Published As

Publication number Publication date
ES2107184T3 (es) 1997-11-16
GR3025447T3 (en) 1998-02-27
DK0679155T3 (da) 1997-12-29
CA2151262A1 (en) 1994-07-21
DE69405086T2 (de) 1998-03-26
EP0679155B1 (de) 1997-08-20
AU5964894A (en) 1994-08-15
WO1994015925A1 (en) 1994-07-21
DE69405086D1 (de) 1997-09-25
US6204259B1 (en) 2001-03-20
EP0679155A1 (de) 1995-11-02
JPH08505622A (ja) 1996-06-18

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