ES2107184T3 - Complejos de manganeso de ligandos macrociclicos que contienen nitrogeno efectivos como catalizadores para la dismutacion del superoxido. - Google Patents

Complejos de manganeso de ligandos macrociclicos que contienen nitrogeno efectivos como catalizadores para la dismutacion del superoxido.

Info

Publication number
ES2107184T3
ES2107184T3 ES94905595T ES94905595T ES2107184T3 ES 2107184 T3 ES2107184 T3 ES 2107184T3 ES 94905595 T ES94905595 T ES 94905595T ES 94905595 T ES94905595 T ES 94905595T ES 2107184 T3 ES2107184 T3 ES 2107184T3
Authority
ES
Spain
Prior art keywords
sub
superoxide
dismutation
catalysts
containing nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94905595T
Other languages
English (en)
Inventor
Karl William Aston
Patrick James Lennon
Anil Shrikrishna Modak
William Lojda Neumann
Dennis Patrick Riley
Randy Herman Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2107184T3 publication Critical patent/ES2107184T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)

Abstract

LA PRESENTE INVENCION ESTA DIRIGIDA A IMITADORES DE BAJO PESO MOLECULAR DE DISMUTASA DE SUPEROXIDO (SOD) REPRESENTADOS POR LA FORMULA (I), EN DONDE R, R'', R{SUB, 1}, R''{SUB, 1}, R{SUB, 2}, R''{SUB, 2}, R{SUB, 3}, R''{SUB, 3}, R{SUB, 4}, R''{SUB, 4}, R{SUB, 5}, R''{SUB, 5}, R{SUB, 6}, R''{SUB, 6}, R{SUB, 7}, R''{SUB, 7}, R{SUB, 8}, R''{SUB, 8}, R{SUB, 9}, R''{SUB, 9}, R{SUB, 10} Y R''{SUB, 10}, X, Y, Z Y N SON COMO SE DEFINE AQUI, UTILES COMO AGENTES TERAPEUTICOS PARA ESTADOS DE ENFERMEDAD Y DESORDENES INFLAMATORIOS, LESIONES ISQUEMICAS/REPERFUSION, INFARTO DE MIOCARDIO, APOPLEJIA, ATEROESCLEROSIS, Y EL RESTO DE CONDICIONES DE DAÑO O LESION EN EL TEJIDO INDUCIDOS POR OXIDANTE.
ES94905595T 1993-01-14 1994-01-05 Complejos de manganeso de ligandos macrociclicos que contienen nitrogeno efectivos como catalizadores para la dismutacion del superoxido. Expired - Lifetime ES2107184T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/004,444 US6204259B1 (en) 1993-01-14 1993-01-14 Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (1)

Publication Number Publication Date
ES2107184T3 true ES2107184T3 (es) 1997-11-16

Family

ID=21710837

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94905595T Expired - Lifetime ES2107184T3 (es) 1993-01-14 1994-01-05 Complejos de manganeso de ligandos macrociclicos que contienen nitrogeno efectivos como catalizadores para la dismutacion del superoxido.

Country Status (11)

Country Link
US (1) US6204259B1 (es)
EP (1) EP0679155B1 (es)
JP (1) JPH08505622A (es)
AT (1) ATE157090T1 (es)
AU (1) AU5964894A (es)
CA (1) CA2151262A1 (es)
DE (1) DE69405086T2 (es)
DK (1) DK0679155T3 (es)
ES (1) ES2107184T3 (es)
GR (1) GR3025447T3 (es)
WO (1) WO1994015925A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492349B1 (en) * 1993-03-31 2002-12-10 Nutramax Laboratories, Inc. Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
JPH10500401A (ja) * 1994-04-22 1998-01-13 モンサント カンパニー 金属錯体を用いる診断画像解析法
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
NZ285648A (en) * 1994-05-13 1999-08-30 Monsanto Co Use of a metal complex as a metal peroxynitrite decomposition catalyst to treat diseases which are affected by accelerated decomposition of peroxynitrite
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JPH11507621A (ja) * 1995-06-07 1999-07-06 モンサント カンパニー 置換ポリアザ大環状化合物の製造法
EP0846003A1 (en) * 1995-08-17 1998-06-10 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
IL123040A0 (en) * 1995-08-17 1998-09-24 Monsanto Co Manganese complexes pharmaceutical compositions containg them and their use
GB9613182D0 (en) * 1996-06-24 1996-08-28 Nycomed Imaging As Method
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
CA2309154C (en) 1997-11-03 2010-02-16 Duke University Substituted porphyrins
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
US6429197B1 (en) * 1998-10-08 2002-08-06 Bionebraska, Inc. Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
EP1616869B1 (en) 1999-01-25 2012-04-04 National Jewish Health Substituted porphyrins and their therapeutic use
DE60018925T2 (de) 1999-05-27 2006-04-13 Pharmacia Corp.(N.D.Ges.D.Staates Delaware) Biomaterialien, modifiziert mit superoxid-dismutase imitatoren
GB9930422D0 (en) 1999-12-22 2000-02-16 Unilever Plc Bleach catalysts
FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
DE60142351D1 (de) 2000-10-20 2010-07-22 Amylin Pharmaceuticals Inc Behandlung von hypoaktivem myokard und diabetischer herzmyopathie mit einem glp-1 peptid
CA2436245C (en) 2001-01-19 2013-04-23 National Jewish Medical And Research Center Medicament for protection in radiotherapy
EP1439842A4 (en) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
US7485721B2 (en) * 2002-06-07 2009-02-03 Duke University Substituted porphyrins
US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
KR100648618B1 (ko) * 2003-11-19 2006-11-23 주식회사 웰스킨 활성 산소 억제제
KR20060135922A (ko) * 2004-03-29 2006-12-29 이노텍 파마슈티컬스 코포레이션 피리딜 치환된 포르피린 화합물 및 이의 사용 방법
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
KR100724586B1 (ko) 2005-12-09 2007-06-04 세종대학교산학협력단 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
DK2056675T3 (en) 2006-10-12 2019-04-23 Galera Labs Llc Methods for treating oral mucositis
ES2530462T3 (es) 2008-05-22 2015-03-03 Galera Therapeutics Llc Combinación terapia antitumoral
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
US9149483B2 (en) 2011-09-26 2015-10-06 Galera Labs, Llc Methods for treatment of diseases
WO2013102806A1 (en) 2012-01-05 2013-07-11 Pledpharma Ab Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment
CN108350009B (zh) 2015-08-11 2021-07-09 加莱拉实验室有限责任公司 具有口服生物利用率的五氮杂大环状环络合物
IL269915B (en) 2017-04-13 2022-09-01 Galera Labs Llc Cancer immunotherapy combined with a macrocyclic ring pentase complex
CA3090129A1 (en) 2018-01-31 2019-08-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001212A (en) 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
US3930867A (en) 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
JPS61226751A (ja) 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5223538A (en) 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
US5227405A (en) * 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
FR2614020B1 (fr) 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US5096724A (en) 1988-06-03 1992-03-17 Aquanautics Corporation Methods, compositions, and systems for ligand extraction
WO1990007261A2 (en) 1988-12-22 1990-07-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
FR2644785B1 (fr) 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
CA2032559C (en) 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
EP0598753B1 (en) * 1991-07-19 1998-03-18 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Also Published As

Publication number Publication date
DE69405086T2 (de) 1998-03-26
ATE157090T1 (de) 1997-09-15
GR3025447T3 (en) 1998-02-27
WO1994015925A1 (en) 1994-07-21
AU5964894A (en) 1994-08-15
US6204259B1 (en) 2001-03-20
CA2151262A1 (en) 1994-07-21
JPH08505622A (ja) 1996-06-18
EP0679155B1 (en) 1997-08-20
EP0679155A1 (en) 1995-11-02
DE69405086D1 (de) 1997-09-25
DK0679155T3 (da) 1997-12-29

Similar Documents

Publication Publication Date Title
ES2107184T3 (es) Complejos de manganeso de ligandos macrociclicos que contienen nitrogeno efectivos como catalizadores para la dismutacion del superoxido.
ES2113952T3 (es) Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos.
DK1212323T3 (da) Substituerede pyridino-pentaazamakrocykluskomplekser med superoxid-dismutaseaktivitet
CA2224060A1 (en) Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
ES2161220T3 (es) 9-((glicil sustituido)amido)-6-desmetil-6-desoxitetraciclinas como agentes antibioticos.
ATE121939T1 (de) Ascorbinsäure-tocopheryl-phosphatdiester zur hemmung der maillard-reaktion.
DE69321525T2 (de) Morphinan-derivate und medizinische verwendung
ATE123651T1 (de) Topische zusammensetzungen enthaltend lycd und sonstige topisch aktive mittel.
DE10075004I2 (de) N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte daf}r.
DE60324155D1 (de) Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen
ATE364605T1 (de) 3-aryloxy und 3-heteroaryloxy substituierte benzo(b) thiophene als therapeutische wirkstoffe mit pi3k aktivität
ES2111025T3 (es) Piridinilamino-1h-indoles, 1h-indazoles, 2h-indazoles, benzo(b)tiofenos y 1,2-benzoisotiazoles sustituidos, un procedimiento para su preparacion y su utilizacion como medicamentos.
ATE95978T1 (de) Stabilisierte antimikrobielle mittel, thermoplastische zusammensetzungen, welche sie enthalten und damit hergestellte erzeugnisse.
ATE141605T1 (de) Thienotriazoldiazepinverbindungen und deren pharmazeutische anwendungen
ES2078922T3 (es) Derivados de cicloheteroetanoantraceno dihetero nitrogenados utiles como agentes antipsicoticos.
WO1997006824A3 (en) Bioconjugates of manganese complexes and their application as catalysts
NO984164L (no) Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid
DE3776220D1 (de) Kondensierte imidazoheterocyclische verbindungen.
IL92867A0 (en) N-pyridinyl-9h-carbazol-9-amines,a process for their preparation and their use as medicaments
NO984165L (no) Jernkomplekser av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismuterende superoksider
ES2066147T3 (es) Derivados de la 1,4-dihidro-4-oxo-3-quinolina como agentes antibacterianos en mamiferos selectivamente toxicos.
TH42381A (th) สารผสมสำหรับใช้ในการดูแลรักษาเฉพาะตัว

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 679155

Country of ref document: ES