NO984165L - Jernkomplekser av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismuterende superoksider - Google Patents
Jernkomplekser av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismuterende superoksiderInfo
- Publication number
- NO984165L NO984165L NO984165A NO984165A NO984165L NO 984165 L NO984165 L NO 984165L NO 984165 A NO984165 A NO 984165A NO 984165 A NO984165 A NO 984165A NO 984165 L NO984165 L NO 984165L
- Authority
- NO
- Norway
- Prior art keywords
- dismutating
- superoxides
- catalysts
- nitrogen
- iron complexes
- Prior art date
Links
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 title 1
- 239000003054 catalyst Substances 0.000 title 1
- 150000002505 iron Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 102000019197 Superoxide Dismutase Human genes 0.000 abstract 2
- 108010012715 Superoxide dismutase Proteins 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000037906 ischaemic injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Farmasøytiske sammensetninger av etterligninger av superoksid dismutase (SOD) med lav molekylvekt representert ved formel (I), hvori R, R1, R^ R',, R2, R'2) Rj, R'3, R«, R'.». R5, R'5> Ri, R'6) R7, R'7) R8, R'g, R* og R'9, og X, Y, Z og n er som definert heri, nyttig som terapeutiske midler for inflammatoriske sykdomstilstander og forstyrrelser, iskemisk/reperfusjonsskade, slag, atherosklerose, inflammatorisk tarmsykdom og alle andre tilstander med oksidant-indusert vevsskade.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61471096A | 1996-03-13 | 1996-03-13 | |
| PCT/US1997/003348 WO1997033588A1 (en) | 1996-03-13 | 1997-03-11 | Iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO984165D0 NO984165D0 (no) | 1998-09-10 |
| NO984165L true NO984165L (no) | 1998-11-10 |
Family
ID=24462404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO984165A NO984165L (no) | 1996-03-13 | 1998-09-10 | Jernkomplekser av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismuterende superoksider |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0888115A1 (no) |
| JP (1) | JP2000507929A (no) |
| KR (1) | KR19990087783A (no) |
| AU (1) | AU2065697A (no) |
| BR (1) | BR9707978A (no) |
| CA (1) | CA2248964A1 (no) |
| CZ (1) | CZ277698A3 (no) |
| IL (1) | IL125993A0 (no) |
| NO (1) | NO984165L (no) |
| WO (1) | WO1997033588A1 (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2385486T3 (es) | 1999-01-25 | 2012-07-25 | National Jewish Health | Porfirinas sustituidas y su uso terapéutico |
| CA2374472A1 (en) | 1999-05-27 | 2000-12-07 | Monsanto Company | Biomaterials modified with superoxide dismutase mimics |
| DE60235955D1 (de) * | 2001-01-05 | 2010-05-27 | Metaphore Pharmaceuticals Inc | Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen |
| WO2002058686A2 (en) * | 2001-01-26 | 2002-08-01 | Metaphore Pharmaceuticals, Inc. | Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes |
| EP1439842A4 (en) | 2001-06-01 | 2009-09-02 | Nat Jewish Med & Res Center | OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE |
| WO2008055953A2 (en) | 2006-11-08 | 2008-05-15 | Sidec Technologies Ab | Iterated variational regularization combined with componentwise regularization |
| KR101646066B1 (ko) | 2008-05-23 | 2016-08-05 | 내셔날 쥬이쉬 헬스 | 알킬화 종으로의 노출과 관련된 상해를 치료하는 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0145953B1 (ko) * | 1991-07-19 | 1998-08-17 | 제임스 클리프튼 보올딩 | 슈퍼옥사이드의 불균화촉매로서 효과적인 질소를 포함하는 마크로사이클 릭리간드의 망간착물 |
| WO1995028968A1 (en) * | 1994-04-22 | 1995-11-02 | Monsanto Company | Diagnostic image analysis with metal complexes |
| US6525041B1 (en) * | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
-
1997
- 1997-03-11 EP EP97908848A patent/EP0888115A1/en not_active Withdrawn
- 1997-03-11 CZ CZ982776A patent/CZ277698A3/cs unknown
- 1997-03-11 KR KR1019980707264A patent/KR19990087783A/ko not_active Application Discontinuation
- 1997-03-11 IL IL12599397A patent/IL125993A0/xx unknown
- 1997-03-11 WO PCT/US1997/003348 patent/WO1997033588A1/en not_active Application Discontinuation
- 1997-03-11 AU AU20656/97A patent/AU2065697A/en not_active Abandoned
- 1997-03-11 JP JP9532095A patent/JP2000507929A/ja active Pending
- 1997-03-11 CA CA002248964A patent/CA2248964A1/en not_active Abandoned
- 1997-03-11 BR BR9707978A patent/BR9707978A/pt not_active Application Discontinuation
-
1998
- 1998-09-10 NO NO984165A patent/NO984165L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9707978A (pt) | 1999-07-27 |
| CA2248964A1 (en) | 1997-09-18 |
| CZ277698A3 (cs) | 1999-02-17 |
| JP2000507929A (ja) | 2000-06-27 |
| IL125993A0 (en) | 1999-04-11 |
| KR19990087783A (ko) | 1999-12-27 |
| NO984165D0 (no) | 1998-09-10 |
| EP0888115A1 (en) | 1999-01-07 |
| AU2065697A (en) | 1997-10-01 |
| WO1997033588A1 (en) | 1997-09-18 |
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