DK0679155T3 - Mangankomplekser af nitrogenholdige, makrocykliske ligander effektive som katalysatorer til at dismutere superoxid - Google Patents

Mangankomplekser af nitrogenholdige, makrocykliske ligander effektive som katalysatorer til at dismutere superoxid

Info

Publication number
DK0679155T3
DK0679155T3 DK94905595.8T DK94905595T DK0679155T3 DK 0679155 T3 DK0679155 T3 DK 0679155T3 DK 94905595 T DK94905595 T DK 94905595T DK 0679155 T3 DK0679155 T3 DK 0679155T3
Authority
DK
Denmark
Prior art keywords
superoxide
dismantling
catalysts
nitrogen
manganese complexes
Prior art date
Application number
DK94905595.8T
Other languages
Danish (da)
English (en)
Inventor
Karl William Aston
Dennis Patrick Riley
Patrick James Lennon
Anil Shrikrishna Modak
William Lojda Neumann
Randy Herman Weiss
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DK0679155T3 publication Critical patent/DK0679155T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
DK94905595.8T 1993-01-14 1994-01-05 Mangankomplekser af nitrogenholdige, makrocykliske ligander effektive som katalysatorer til at dismutere superoxid DK0679155T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/004,444 US6204259B1 (en) 1993-01-14 1993-01-14 Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (1)

Publication Number Publication Date
DK0679155T3 true DK0679155T3 (da) 1997-12-29

Family

ID=21710837

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94905595.8T DK0679155T3 (da) 1993-01-14 1994-01-05 Mangankomplekser af nitrogenholdige, makrocykliske ligander effektive som katalysatorer til at dismutere superoxid

Country Status (11)

Country Link
US (1) US6204259B1 (es)
EP (1) EP0679155B1 (es)
JP (1) JPH08505622A (es)
AT (1) ATE157090T1 (es)
AU (1) AU5964894A (es)
CA (1) CA2151262A1 (es)
DE (1) DE69405086T2 (es)
DK (1) DK0679155T3 (es)
ES (1) ES2107184T3 (es)
GR (1) GR3025447T3 (es)
WO (1) WO1994015925A1 (es)

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CA2229799A1 (en) * 1995-08-17 1997-02-27 Monsanto Company Bioconjugates of manganese complexes and their application as catalysts
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US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
EP1045851B1 (en) 1997-11-03 2003-04-23 Duke University Substituted porphyrins
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
US6429197B1 (en) * 1998-10-08 2002-08-06 Bionebraska, Inc. Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
US6284725B1 (en) * 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
ES2385486T3 (es) 1999-01-25 2012-07-25 National Jewish Health Porfirinas sustituidas y su uso terapéutico
CA2374472A1 (en) 1999-05-27 2000-12-07 Monsanto Company Biomaterials modified with superoxide dismutase mimics
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FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
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MXPA02006118A (es) 2000-10-20 2004-08-23 Amylin Pharmaceuticals Inc Tratamiento de la invernacion del miocardio y cardiopatia diabetica con un peptido glp-1.
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US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
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EA010834B1 (ru) * 2004-03-29 2008-12-30 Инотек Фармасьютикалз Корпорейшн Пиридилзамещённые порфириновые соединения и способы их применения
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
KR100724586B1 (ko) 2005-12-09 2007-06-04 세종대학교산학협력단 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
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KR101646066B1 (ko) 2008-05-23 2016-08-05 내셔날 쥬이쉬 헬스 알킬화 종으로의 노출과 관련된 상해를 치료하는 방법
CA2849456C (en) 2011-09-26 2021-12-07 Galera Therapeutics, Llc Methods for treatment of diseases
WO2013102806A1 (en) 2012-01-05 2013-07-11 Pledpharma Ab Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment
AU2016306568B2 (en) * 2015-08-11 2021-01-07 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US11246950B2 (en) 2017-04-13 2022-02-15 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
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Also Published As

Publication number Publication date
AU5964894A (en) 1994-08-15
GR3025447T3 (en) 1998-02-27
ATE157090T1 (de) 1997-09-15
DE69405086D1 (de) 1997-09-25
JPH08505622A (ja) 1996-06-18
WO1994015925A1 (en) 1994-07-21
US6204259B1 (en) 2001-03-20
DE69405086T2 (de) 1998-03-26
ES2107184T3 (es) 1997-11-16
EP0679155A1 (en) 1995-11-02
CA2151262A1 (en) 1994-07-21
EP0679155B1 (en) 1997-08-20

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