ATE164164T1 - Mangan-komplexe mit stickstoff enthaltenden makrozyklischen liganden, wirksam als superoxiddismutasekatalysatoren. - Google Patents
Mangan-komplexe mit stickstoff enthaltenden makrozyklischen liganden, wirksam als superoxiddismutasekatalysatoren.Info
- Publication number
- ATE164164T1 ATE164164T1 AT92915849T AT92915849T ATE164164T1 AT E164164 T1 ATE164164 T1 AT E164164T1 AT 92915849 T AT92915849 T AT 92915849T AT 92915849 T AT92915849 T AT 92915849T AT E164164 T1 ATE164164 T1 AT E164164T1
- Authority
- AT
- Austria
- Prior art keywords
- superoxide dismutase
- manganeous
- complexes
- catalysts
- nitrogen
- Prior art date
Links
- 102000019197 Superoxide Dismutase Human genes 0.000 title abstract 3
- 108010012715 Superoxide dismutase Proteins 0.000 title abstract 3
- 239000003054 catalyst Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000037906 ischaemic injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73285391A | 1991-07-19 | 1991-07-19 | |
| US82986592A | 1992-02-03 | 1992-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE164164T1 true ATE164164T1 (de) | 1998-04-15 |
Family
ID=27112468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92915849T ATE164164T1 (de) | 1991-07-19 | 1992-07-02 | Mangan-komplexe mit stickstoff enthaltenden makrozyklischen liganden, wirksam als superoxiddismutasekatalysatoren. |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0598753B1 (de) |
| JP (1) | JP3155552B2 (de) |
| KR (1) | KR0145953B1 (de) |
| AT (1) | ATE164164T1 (de) |
| AU (1) | AU661023B2 (de) |
| DE (1) | DE69224839T2 (de) |
| ES (1) | ES2113952T3 (de) |
| IE (1) | IE922211A1 (de) |
| IL (1) | IL102408A0 (de) |
| NZ (2) | NZ272364A (de) |
| WO (1) | WO1993002090A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US6204259B1 (en) * | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US5994339A (en) * | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| US5747026A (en) * | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
| WO1995028968A1 (en) * | 1994-04-22 | 1995-11-02 | Monsanto Company | Diagnostic image analysis with metal complexes |
| HUT76327A (en) * | 1994-05-13 | 1997-08-28 | Monsanto Co | Pharmaceutical compositions catalyzing decomposition of peroxy-nitrite |
| US6245758B1 (en) | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
| WO1996009053A1 (en) * | 1994-09-20 | 1996-03-28 | Duke University | Oxidoreductase activity of manganic porphyrins |
| US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| JPH11507621A (ja) * | 1995-06-07 | 1999-07-06 | モンサント カンパニー | 置換ポリアザ大環状化合物の製造法 |
| EP0844889A1 (de) * | 1995-08-17 | 1998-06-03 | Monsanto Company | Diagnostische bildanalyseverfahrenunter verwendung von metallkomplexen von stickstoff-enthaltenden makrozyklischen liganden |
| CA2229799A1 (en) * | 1995-08-17 | 1997-02-27 | Monsanto Company | Bioconjugates of manganese complexes and their application as catalysts |
| EP0846003A1 (de) | 1995-08-17 | 1998-06-10 | Monsanto Company | Verfahren zur diagnostischen bildanalyse unter verwendung von biokonjugaten von metallkomplexen von stickstoffhaltigen makrocyclischen liganden |
| EP0888115A1 (de) * | 1996-03-13 | 1999-01-07 | Monsanto Company | Eisenkomplexe mit stickstoffhaltigen makrocyclischen liganden, die als katalysatoren für die superoxid-dismutation wirken |
| BR9708179A (pt) * | 1996-03-13 | 1999-07-27 | Monsanto Co | Bioconjugados de complexos de manganês ou ferro de ligantes macrociclicos contendo nitrogênio eficazes como catalizadores para desmutar superoxidos |
| DK0932402T3 (da) | 1996-10-15 | 2004-11-08 | Searle Llc | Metode til anvendelse af cyclooxygenase-2-inhibitorer ved behandling og forebyggelse af neoplasi |
| US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| US6180620B1 (en) | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
| EP1045851B1 (de) | 1997-11-03 | 2003-04-23 | Duke University | Substituierte porphyrinen |
| JP4648542B2 (ja) | 1998-04-24 | 2011-03-09 | デューク ユニバーシティ | 置換ポルフィリン |
| ES2385486T3 (es) | 1999-01-25 | 2012-07-25 | National Jewish Health | Porfirinas sustituidas y su uso terapéutico |
| EP1577313B1 (de) * | 1999-05-27 | 2008-01-09 | Monsanto Company | Biomaterialien, modifiziert mit Superoxid-Dismutase Imitatoren |
| CA2374472A1 (en) | 1999-05-27 | 2000-12-07 | Monsanto Company | Biomaterials modified with superoxide dismutase mimics |
| US6448239B1 (en) | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
| DE60233317D1 (de) | 2001-01-19 | 2009-09-24 | Nat Jewish Med & Res Center | Medikament zum schutz in der radiotherapie |
| WO2002058686A2 (en) * | 2001-01-26 | 2002-08-01 | Metaphore Pharmaceuticals, Inc. | Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes |
| EP1439842A4 (de) | 2001-06-01 | 2009-09-02 | Nat Jewish Med & Res Center | Oxidantienfänger zur behandlung von diabetes oder zur verwendung bei der transplantation oder induktion von immuntoleranz |
| EP1513537A4 (de) | 2002-06-07 | 2006-09-06 | Univ Duke | Substituierte porphyrine |
| WO2005095408A1 (ja) * | 2004-03-30 | 2005-10-13 | Nagoya Institute Of Technology | ケージ状配位子を有する多核金属錯体 |
| US8232267B2 (en) | 2006-10-06 | 2012-07-31 | The Trustees Of Princeton University | Porphyrin catalysts and methods of use thereof |
| EP3527079A1 (de) | 2006-10-12 | 2019-08-21 | Galera Labs, LLC | Verfahren zur behandlung oraler mukositis |
| WO2008054298A1 (en) * | 2006-11-03 | 2008-05-08 | Magnus Sendel | Method of producing a device and a device produced according to said method |
| KR101646066B1 (ko) | 2008-05-23 | 2016-08-05 | 내셔날 쥬이쉬 헬스 | 알킬화 종으로의 노출과 관련된 상해를 치료하는 방법 |
| CA2849456C (en) | 2011-09-26 | 2021-12-07 | Galera Therapeutics, Llc | Methods for treatment of diseases |
| AU2016306568B2 (en) * | 2015-08-11 | 2021-01-07 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
| JP7166634B2 (ja) | 2016-09-01 | 2022-11-08 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | ペンタアザ大環状環複合体およびアスコルビン酸化合物による組み合わせ癌療法 |
| US11246950B2 (en) | 2017-04-13 | 2022-02-15 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223538A (en) * | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
| FR2614020B1 (fr) * | 1987-04-14 | 1989-07-28 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands. |
| US4952289A (en) * | 1988-05-09 | 1990-08-28 | Aquanautics Corporation | Macrocyclic amine complexes for ligand extraction and generation |
| GB9024208D0 (en) * | 1990-11-07 | 1990-12-19 | Salutar Inc | Compounds |
-
1992
- 1992-07-02 KR KR98701831A patent/KR0145953B1/ko active
- 1992-07-02 WO PCT/US1992/005805 patent/WO1993002090A1/en active IP Right Grant
- 1992-07-02 DE DE69224839T patent/DE69224839T2/de not_active Expired - Fee Related
- 1992-07-02 AT AT92915849T patent/ATE164164T1/de not_active IP Right Cessation
- 1992-07-02 JP JP50287293A patent/JP3155552B2/ja not_active Expired - Fee Related
- 1992-07-02 AU AU23383/92A patent/AU661023B2/en not_active Ceased
- 1992-07-02 EP EP92915849A patent/EP0598753B1/de not_active Expired - Lifetime
- 1992-07-02 EP EP92870097A patent/EP0524161A1/de active Pending
- 1992-07-02 ES ES92915849T patent/ES2113952T3/es not_active Expired - Lifetime
- 1992-07-03 IL IL102408A patent/IL102408A0/xx unknown
- 1992-07-07 IE IE221192A patent/IE922211A1/en not_active IP Right Cessation
- 1992-07-13 NZ NZ272364A patent/NZ272364A/en not_active IP Right Cessation
- 1992-07-13 NZ NZ243530A patent/NZ243530A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2338392A (en) | 1993-02-23 |
| NZ243530A (en) | 1997-08-22 |
| EP0598753B1 (de) | 1998-03-18 |
| KR0145953B1 (ko) | 1998-08-17 |
| IL102408A0 (en) | 1993-01-14 |
| JPH06509566A (ja) | 1994-10-27 |
| JP3155552B2 (ja) | 2001-04-09 |
| EP0598753A1 (de) | 1994-06-01 |
| WO1993002090A1 (en) | 1993-02-04 |
| AU661023B2 (en) | 1995-07-13 |
| NZ272364A (en) | 1996-02-27 |
| DE69224839D1 (de) | 1998-04-23 |
| DE69224839T2 (de) | 1998-10-08 |
| EP0524161A1 (de) | 1993-01-20 |
| IE922211A1 (en) | 1993-01-27 |
| ES2113952T3 (es) | 1998-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |