ATE148230T1 - Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat - Google Patents

Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat

Info

Publication number
ATE148230T1
ATE148230T1 AT90311771T AT90311771T ATE148230T1 AT E148230 T1 ATE148230 T1 AT E148230T1 AT 90311771 T AT90311771 T AT 90311771T AT 90311771 T AT90311771 T AT 90311771T AT E148230 T1 ATE148230 T1 AT E148230T1
Authority
AT
Austria
Prior art keywords
endotoxin
chromogenic substrate
determination method
amoebocyte lysate
limulus amoebocyte
Prior art date
Application number
AT90311771T
Other languages
German (de)
English (en)
Inventor
Ronald N Berzofsky
Original Assignee
Biowhittaker Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23698313&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE148230(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biowhittaker Inc filed Critical Biowhittaker Inc
Application granted granted Critical
Publication of ATE148230T1 publication Critical patent/ATE148230T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT90311771T 1989-10-30 1990-10-26 Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat ATE148230T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42830089A 1989-10-30 1989-10-30

Publications (1)

Publication Number Publication Date
ATE148230T1 true ATE148230T1 (de) 1997-02-15

Family

ID=23698313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311771T ATE148230T1 (de) 1989-10-30 1990-10-26 Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat

Country Status (10)

Country Link
US (1) US5310657A (enExample)
EP (1) EP0426395B1 (enExample)
JP (1) JP2955345B2 (enExample)
AT (1) ATE148230T1 (enExample)
AU (1) AU644109B2 (enExample)
CA (1) CA2028789C (enExample)
DE (1) DE69029785T2 (enExample)
DK (1) DK0426395T3 (enExample)
ES (1) ES2098256T3 (enExample)
GR (1) GR3023298T3 (enExample)

Families Citing this family (35)

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EP0549102B1 (en) * 1991-12-25 1996-07-03 Maruha Corporation Beta-glucans detection reagents and methods of detecting beta-glucans
JP3242733B2 (ja) * 1993-02-26 2001-12-25 生化学工業株式会社 エンドトキシン特異的測定剤
US6270982B1 (en) 1997-10-09 2001-08-07 Charles River Laboratories Methods and compositions for the detection of bacterial endotoxins
JP4235279B2 (ja) * 1998-04-10 2009-03-11 生化学工業株式会社 新規酵素反応測定法
AU2003225254A1 (en) * 2002-04-30 2003-11-17 Biowhittaker Technologies, Inc. Automated sequential injection analysis systems for the determination of trace endotoxin levels
ATE427068T1 (de) * 2002-12-20 2009-04-15 Charlotte Mecklenburg Hospital Wegwerf-handvorrichtung zum auffangen von ausgeatmetem atemkondensat
US7828741B2 (en) * 2002-12-20 2010-11-09 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
US7547285B2 (en) * 2003-02-14 2009-06-16 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate
DE602004024769D1 (de) * 2003-03-17 2010-02-04 Charles River Lab Inc Methoden und zusammensetzungen für den nachweis mikrobieller verunreinigungen
WO2004094987A2 (en) * 2003-04-18 2004-11-04 Associates Of Cape Cod, Inc. Kit for detecting endotoxin in aqueous solutions
US20050048655A1 (en) * 2003-04-18 2005-03-03 Novitsky Thomas J. Kit for detecting endotoxin
US20050124013A1 (en) * 2003-11-07 2005-06-09 Cambrex Bio Science Walkersville, Inc. On-line apparatus and method for determining endotoxin levels
JP2008522640A (ja) 2004-12-02 2008-07-03 チャールズ リバー ラボラトリーズ， インコーポレイテッド グラム陽性菌夾雑物の検出および／または定量化のための方法ならびに組成物
US7479375B2 (en) 2005-01-13 2009-01-20 Charles River Laboratories, Inc. Method for classifying a microorganism in a biological sample
US20090208995A1 (en) * 2006-07-07 2009-08-20 Seikagaku Corporation Pro-clotting enzyme, and method for detection of endotoxin or (1-3)-beta-d-glucan using the same
US20080124248A1 (en) * 2006-11-29 2008-05-29 Edward Andrew Sobek Endotoxins and glucans quantification in indoor air
US20090286692A1 (en) * 2008-04-15 2009-11-19 Wainwright Norman R Cartridge and Method for Sample Analysis
JP5489680B2 (ja) * 2009-12-02 2014-05-14 興和株式会社 生物由来の生理活性物質の測定方法、それを実行するためのプログラム及び、生物由来の生理活性物質の測定装置
CN102348984B (zh) 2009-03-13 2014-04-02 兴和株式会社 来自生物的生理活性物质的测定方法以及测定装置
CA2766288C (en) 2009-06-26 2020-05-05 Charles River Laboratories, Inc. Heat-treated limulus amebocyte lysates
GB2477752A (en) * 2010-02-11 2011-08-17 Arab Biotechnology Company Detection of bacteria
CU24073B1 (es) 2011-12-27 2015-01-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem COMPOSICIÓN A PARTIR DE EXTRACTO DE HEMOCITOS DE LANGOSTA PARA LA DETECCIÓN DE LIPOPOLISACÁRIDOS, PEPTIDOGLICANOS Y 1,3-ß-D-GLUCANOS
US20130078665A1 (en) * 2012-07-18 2013-03-28 Deepika Bodapati Test strip, a test kit and a method for detection of endotoxin in food
JP6319590B2 (ja) 2012-10-08 2018-05-09 ゼネラル・エレクトリック・カンパニイ マイクロ流体素子を用いるｌａｌ反応性物質試験方法及び装置
US10309947B2 (en) 2013-02-27 2019-06-04 Trace-Ability, Inc. System and method for radiosynthesis, quality control and dose dispensing
US10895563B2 (en) 2014-02-26 2021-01-19 Trace-Ability, Inc. Palette-based systems for analyte characterization
US11002717B2 (en) 2014-02-26 2021-05-11 Trace-Ability, Inc. Systems and methods for characterizing radioactive analytes
WO2018026941A1 (en) * 2016-08-03 2018-02-08 Lonza Walkersville, Inc. Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen
CN110192110B (zh) * 2017-01-11 2023-01-10 隆萨沃克斯维尔股份有限公司 无凝固蛋白原的澄清的鲎阿米巴样细胞裂解物
US20190001330A1 (en) 2017-06-28 2019-01-03 Lonza Walkersville, Inc. Cartridge for endotoxin detection
US11892397B2 (en) * 2017-10-17 2024-02-06 Board Of Regents, The University Of Texas System Endotoxin testing assay and method of same
CN109387637A (zh) * 2018-10-12 2019-02-26 四川升和药业股份有限公司 丹参注射液细菌内毒素检测方法
CN111077307B (zh) * 2018-10-21 2022-08-23 厦门鲎试剂生物科技股份有限公司 一种用革兰氏阴性细菌感染快速检测脓毒病的新方法
US12158471B2 (en) 2022-02-11 2024-12-03 Charles River Laboratories, Inc. Recombinant amebocyte lysate and uses thereof
KR20260021702A (ko) 2023-06-05 2026-02-13 찰스리버레보레토리스,인코포레이티드 재조합 아메보사이트 응고 인자 및 그의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5415797A (en) * 1977-06-14 1979-02-05 Seikagaku Kogyo Co Ltd Detection and measurement of toxin in cells
US4322217A (en) * 1980-06-27 1982-03-30 Mallinckrodt, Inc. Process for preparing Limulus lysate
US4406832A (en) * 1981-09-03 1983-09-27 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
DE3439761A1 (de) * 1984-10-31 1986-05-07 Klaus-Peter 6800 Mannheim Becker Verfahren zur bestimmung von endotoxinkonzentrationen

Also Published As

Publication number Publication date
US5310657A (en) 1994-05-10
ES2098256T3 (es) 1997-05-01
GR3023298T3 (en) 1997-07-30
JPH03220456A (ja) 1991-09-27
CA2028789A1 (en) 1991-05-01
EP0426395A1 (en) 1991-05-08
DE69029785T2 (de) 1997-05-28
AU6555690A (en) 1991-05-02
DK0426395T3 (enExample) 1997-03-03
DE69029785D1 (de) 1997-03-06
CA2028789C (en) 2001-02-06
AU644109B2 (en) 1993-12-02
JP2955345B2 (ja) 1999-10-04
EP0426395B1 (en) 1997-01-22

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Legal Events

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UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time