ATE146179T1 - 27 hydroxyrapamycin und derivate davon - Google Patents

27 hydroxyrapamycin und derivate davon

Info

Publication number
ATE146179T1
ATE146179T1 AT93919994T AT93919994T ATE146179T1 AT E146179 T1 ATE146179 T1 AT E146179T1 AT 93919994 T AT93919994 T AT 93919994T AT 93919994 T AT93919994 T AT 93919994T AT E146179 T1 ATE146179 T1 AT E146179T1
Authority
AT
Austria
Prior art keywords
hydroxyrapamycin
derivatives
formula
compound
deoxo
Prior art date
Application number
AT93919994T
Other languages
German (de)
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE146179T1 publication Critical patent/ATE146179T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93919994T 1992-08-13 1993-08-12 27 hydroxyrapamycin und derivate davon ATE146179T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
ATE146179T1 true ATE146179T1 (de) 1996-12-15

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93919994T ATE146179T1 (de) 1992-08-13 1993-08-12 27 hydroxyrapamycin und derivate davon

Country Status (12)

Country Link
EP (1) EP0655065B1 (enFirst)
JP (1) JPH08501084A (enFirst)
AT (1) ATE146179T1 (enFirst)
AU (1) AU5007193A (enFirst)
CA (1) CA2142288A1 (enFirst)
DE (1) DE69306585T2 (enFirst)
DK (1) DK0655065T3 (enFirst)
ES (1) ES2096941T3 (enFirst)
GR (1) GR3022730T3 (enFirst)
HU (1) HU221499B (enFirst)
MX (1) MX9304868A (enFirst)
WO (1) WO1994004540A1 (enFirst)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
EP0729471A1 (en) * 1993-11-19 1996-09-04 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
DE69624921T2 (de) 1995-06-09 2003-09-11 Novartis Ag, Basel Rapamycinderivate
IL147803A0 (en) 1999-08-24 2002-08-14 Ariad Gene Therapeutics Inc 28-epirapalogs
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EP1478648B1 (en) 2002-02-01 2014-04-30 ARIAD Pharmaceuticals, Inc. Phosphorus-containing compounds and uses thereof
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
CA2669415A1 (en) 2006-11-14 2008-05-22 Ariad Pharmaceuticals, Inc. Solid dosage form comprising ap23573
EP2245165A4 (en) 2008-01-11 2011-06-01 Massachusetts Eye & Ear Infirm TRANSGENIC CONDITIONAL STOP DIMERICABLE CASPASE ANIMALS
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
PL3788049T3 (pl) 2018-05-01 2023-06-19 Revolution Medicines, Inc. Połączone z C40, C28 i C32 analogi rapamycyny jako inhibitory mTOR
EP3788050B1 (en) 2018-05-01 2024-08-28 Revolution Medicines, Inc. C26-linked rapamycin analogs as mtor inhibitors
AU2022253019A1 (en) * 2021-04-09 2023-11-16 Revolution Medicines, Inc. Synthesis of rapamycin analog compounds
EP4531859A4 (en) 2022-05-25 2026-05-27 Revolution Medicines Inc CANCER TREATMENT METHODS USING AN MTOR INHIBITOR

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
GR3022730T3 (en) 1997-06-30
DE69306585D1 (de) 1997-01-23
WO1994004540A1 (en) 1994-03-03
AU5007193A (en) 1994-03-15
HU221499B (en) 2002-10-28
JPH08501084A (ja) 1996-02-06
CA2142288A1 (en) 1994-03-03
DK0655065T3 (enFirst) 1997-02-24
HUT71614A (en) 1996-01-29
HU9500432D0 (en) 1995-04-28
ES2096941T3 (es) 1997-03-16
MX9304868A (es) 1994-05-31
EP0655065A1 (en) 1995-05-31
EP0655065B1 (en) 1996-12-11
DE69306585T2 (de) 1997-04-17

Similar Documents

Publication Publication Date Title
DE69306585D1 (de) 27 hydroxyrapamycin und derivate davon
ES2085726T3 (es) Derivado prolinico de rapamicina, su produccion y aplicacion.
ATE119774T1 (de) Imidazopyridinderivate und ihre verwendung.
DE69319976D1 (de) 7-Substituierte-9-substituierte Glycylamido-6-Demethyl-6-Deoxytetracycline
NO932873L (no) 9-(substituerte glycyl)amido)-6- dementyl-6-deoksotetrasykliner
ATE180773T1 (de) N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptoren
BG92804A (bg) 4-бензоилизоксазолови производни
MX9300222A (es) Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion.
FI913458A0 (fi) Tioalkyltiocefalosporinderivat.
AU641686B2 (en) Benzanilides
DE69423339D1 (de) Epoxycyclohexendionderivat
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
DK377687A (da) Triazol-fungicidpraeparater
FI901277A0 (fi) 2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
DE69220222D1 (de) Neue D-Homo-17-oxa und D-Homo-17-aza-androstanderivate
ATE176242T1 (de) Uck14-verbindungen
ATE255121T1 (de) Antitumor-indolopyrolocarbazolderivat
ES2149180T3 (es) Derivado de pirazolotiazolopirimidina.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee