DK0655065T3 - - Google Patents
Info
- Publication number
- DK0655065T3 DK0655065T3 DK93919994.9T DK93919994T DK0655065T3 DK 0655065 T3 DK0655065 T3 DK 0655065T3 DK 93919994 T DK93919994 T DK 93919994T DK 0655065 T3 DK0655065 T3 DK 0655065T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxyrapamycin
- formula
- compound
- deoxo
- immunosuppressive
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93012492A | 1992-08-13 | 1992-08-13 | |
| US08/009,605 US5256790A (en) | 1992-08-13 | 1993-01-27 | 27-hydroxyrapamycin and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0655065T3 true DK0655065T3 (enFirst) | 1997-02-24 |
Family
ID=26679675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93919994.9T DK0655065T3 (enFirst) | 1992-08-13 | 1993-08-12 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0655065B1 (enFirst) |
| JP (1) | JPH08501084A (enFirst) |
| AT (1) | ATE146179T1 (enFirst) |
| AU (1) | AU5007193A (enFirst) |
| CA (1) | CA2142288A1 (enFirst) |
| DE (1) | DE69306585T2 (enFirst) |
| DK (1) | DK0655065T3 (enFirst) |
| ES (1) | ES2096941T3 (enFirst) |
| GR (1) | GR3022730T3 (enFirst) |
| HU (1) | HU221499B (enFirst) |
| MX (1) | MX9304868A (enFirst) |
| WO (1) | WO1994004540A1 (enFirst) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| EP0729471A1 (en) * | 1993-11-19 | 1996-09-04 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| DE69624921T2 (de) | 1995-06-09 | 2003-09-11 | Novartis Ag, Basel | Rapamycinderivate |
| IL147803A0 (en) | 1999-08-24 | 2002-08-14 | Ariad Gene Therapeutics Inc | 28-epirapalogs |
| US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| EP1478648B1 (en) | 2002-02-01 | 2014-04-30 | ARIAD Pharmaceuticals, Inc. | Phosphorus-containing compounds and uses thereof |
| WO2004060346A2 (en) | 2002-12-30 | 2004-07-22 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| CA2669415A1 (en) | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Solid dosage form comprising ap23573 |
| EP2245165A4 (en) | 2008-01-11 | 2011-06-01 | Massachusetts Eye & Ear Infirm | TRANSGENIC CONDITIONAL STOP DIMERICABLE CASPASE ANIMALS |
| CN105283553B (zh) | 2013-06-11 | 2021-06-25 | 克隆技术实验室有限公司 | 蛋白质富集的微泡及其制备和使用方法 |
| PL3788049T3 (pl) | 2018-05-01 | 2023-06-19 | Revolution Medicines, Inc. | Połączone z C40, C28 i C32 analogi rapamycyny jako inhibitory mTOR |
| EP3788050B1 (en) | 2018-05-01 | 2024-08-28 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
| AU2022253019A1 (en) * | 2021-04-09 | 2023-11-16 | Revolution Medicines, Inc. | Synthesis of rapamycin analog compounds |
| EP4531859A4 (en) | 2022-05-25 | 2026-05-27 | Revolution Medicines Inc | CANCER TREATMENT METHODS USING AN MTOR INHIBITOR |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
-
1993
- 1993-08-11 MX MX9304868A patent/MX9304868A/es not_active IP Right Cessation
- 1993-08-12 CA CA002142288A patent/CA2142288A1/en not_active Abandoned
- 1993-08-12 JP JP6506398A patent/JPH08501084A/ja active Pending
- 1993-08-12 AT AT93919994T patent/ATE146179T1/de not_active IP Right Cessation
- 1993-08-12 DE DE69306585T patent/DE69306585T2/de not_active Expired - Fee Related
- 1993-08-12 AU AU50071/93A patent/AU5007193A/en not_active Abandoned
- 1993-08-12 DK DK93919994.9T patent/DK0655065T3/da active
- 1993-08-12 HU HU9500432A patent/HU221499B/hu not_active IP Right Cessation
- 1993-08-12 ES ES93919994T patent/ES2096941T3/es not_active Expired - Lifetime
- 1993-08-12 EP EP93919994A patent/EP0655065B1/en not_active Expired - Lifetime
- 1993-08-12 WO PCT/US1993/007581 patent/WO1994004540A1/en not_active Ceased
-
1997
- 1997-03-03 GR GR970400422T patent/GR3022730T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3022730T3 (en) | 1997-06-30 |
| DE69306585D1 (de) | 1997-01-23 |
| ATE146179T1 (de) | 1996-12-15 |
| WO1994004540A1 (en) | 1994-03-03 |
| AU5007193A (en) | 1994-03-15 |
| HU221499B (en) | 2002-10-28 |
| JPH08501084A (ja) | 1996-02-06 |
| CA2142288A1 (en) | 1994-03-03 |
| HUT71614A (en) | 1996-01-29 |
| HU9500432D0 (en) | 1995-04-28 |
| ES2096941T3 (es) | 1997-03-16 |
| MX9304868A (es) | 1994-05-31 |
| EP0655065A1 (en) | 1995-05-31 |
| EP0655065B1 (en) | 1996-12-11 |
| DE69306585T2 (de) | 1997-04-17 |
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