ATE141602T1 - 6-ring enthaltende makrocyclische tetraaza- verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel - Google Patents

6-ring enthaltende makrocyclische tetraaza- verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Info

Publication number
ATE141602T1
ATE141602T1 AT91250008T AT91250008T ATE141602T1 AT E141602 T1 ATE141602 T1 AT E141602T1 AT 91250008 T AT91250008 T AT 91250008T AT 91250008 T AT91250008 T AT 91250008T AT E141602 T1 ATE141602 T1 AT E141602T1
Authority
AT
Austria
Prior art keywords
denotes
group
hydrogen atom
figures
represent
Prior art date
Application number
AT91250008T
Other languages
German (de)
English (en)
Inventor
Heinz Dr Gries
Bernd Dr Raduechel
Johannes Dr Platzek
Hanns-Joachim Dr Weinmann
Wolf-Ruediger Press
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE141602T1 publication Critical patent/ATE141602T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
AT91250008T 1990-01-18 1991-01-16 6-ring enthaltende makrocyclische tetraaza- verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel ATE141602T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4001655A DE4001655A1 (de) 1990-01-18 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
ATE141602T1 true ATE141602T1 (de) 1996-09-15

Family

ID=6398485

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91250008T ATE141602T1 (de) 1990-01-18 1991-01-16 6-ring enthaltende makrocyclische tetraaza- verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Country Status (19)

Country Link
EP (1) EP0438206B1 (cg-RX-API-DMAC7.html)
JP (1) JPH05112567A (cg-RX-API-DMAC7.html)
KR (1) KR910014377A (cg-RX-API-DMAC7.html)
AT (1) ATE141602T1 (cg-RX-API-DMAC7.html)
AU (1) AU6981291A (cg-RX-API-DMAC7.html)
CA (1) CA2034242A1 (cg-RX-API-DMAC7.html)
DE (2) DE4001655A1 (cg-RX-API-DMAC7.html)
DK (1) DK0438206T3 (cg-RX-API-DMAC7.html)
ES (1) ES2091865T3 (cg-RX-API-DMAC7.html)
FI (1) FI94758C (cg-RX-API-DMAC7.html)
GR (1) GR3020973T3 (cg-RX-API-DMAC7.html)
HU (1) HUT56569A (cg-RX-API-DMAC7.html)
IE (1) IE75898B1 (cg-RX-API-DMAC7.html)
IL (1) IL96840A0 (cg-RX-API-DMAC7.html)
NO (1) NO910191L (cg-RX-API-DMAC7.html)
NZ (1) NZ236803A (cg-RX-API-DMAC7.html)
PT (1) PT96505B (cg-RX-API-DMAC7.html)
TW (1) TW233298B (cg-RX-API-DMAC7.html)
ZA (1) ZA91389B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
FI933508L (fi) * 1991-12-10 1993-08-31 Dow Chemical Co Bicyklopolyazamakrocyklokarboxylsyrakomplex, konjugat daerav, foerfarande foer deras framstaellning och anvaendning som radiofarmaceutiska medel
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
MX9207166A (es) * 1991-12-10 1993-07-01 Dow Chemical Co Acidos biciclopoliazamacrociclofosfonicos, sus complejos y conjugados, para uso como agentes de contraste, y procedimientos para su preparacion.
MX9207164A (es) * 1991-12-10 1993-07-01 Dow Chemical Co Complejos de acido biciclopoliazamacrociclocarboxilico, sus conjugados, procedimientos para su preparacion y su uso como agentes de contraste.
WO1994026315A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
DE69504220T2 (de) * 1994-02-21 1999-04-29 Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija Dionicko Drustvo Sulfonamidodioxepane mit hypoglykämischen Eigenschaften, Methoden zu ihrer Herstellung, ihre Zwischenprodukte und Salze
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
AU5375896A (en) * 1995-03-27 1996-10-16 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
AU719002B2 (en) * 1996-04-19 2000-05-04 Dow Chemical Company, The Fluorescent chelates as visual tissue specific imaging agents
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
WO1998047539A1 (en) * 1997-04-22 1998-10-29 Nycomed Imaging As Nmr image compounds
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
JP5368099B2 (ja) 2005-10-07 2013-12-18 ゲルベ ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物
EP2004642B1 (en) * 2006-03-10 2017-07-26 Nordion (Canada) Inc. Bifunctional polyazamacrocyclic chelating agents
KR102231121B1 (ko) 2013-04-26 2021-03-23 게르브 조영제 제형 및 이와 관련된 제조 방법
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
IL321215A (en) 2018-11-23 2025-07-01 Bayer Ag Formulation of contrast media and process of preparation thereof
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
KR20230041007A (ko) 2020-07-17 2023-03-23 게르브 Pcta로부터 유도된 킬레이팅 리간드의 제조 방법
CN114105983B (zh) * 2021-11-09 2023-08-11 国科温州研究院(温州生物材料与工程研究所) 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036945A (en) 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
DE3150917A1 (de) 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
DE3417413A1 (de) 1984-05-11 1985-11-14 Dr. Karl Thomae Gmbh, 7950 Biberach Dicarbonsaeure-monohydrazid-derivate, ihre herstellung und ihre verwendung als kopplungskomponenten
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
EP0232751B1 (en) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
IT1224416B (it) 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
DE3713842A1 (de) 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
DE3869251D1 (de) 1987-07-16 1992-04-23 Nycomed As Aminopolycarbonsaeure und ihre derivate.
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
DK0438206T3 (cg-RX-API-DMAC7.html) 1997-01-20
KR910014377A (ko) 1991-08-31
HUT56569A (en) 1991-09-30
PT96505B (pt) 1998-07-31
DE4001655A1 (de) 1991-07-25
EP0438206A1 (de) 1991-07-24
NO910191L (no) 1991-07-19
FI910276A7 (fi) 1991-07-19
EP0438206B1 (de) 1996-08-21
IE910162A1 (en) 1991-07-31
IE75898B1 (en) 1997-09-24
ES2091865T3 (es) 1996-11-16
CA2034242A1 (en) 1991-07-19
FI94758C (fi) 1995-10-25
TW233298B (cg-RX-API-DMAC7.html) 1994-11-01
ZA91389B (en) 1991-10-30
FI94758B (fi) 1995-07-14
GR3020973T3 (en) 1996-12-31
PT96505A (pt) 1991-10-15
JPH05112567A (ja) 1993-05-07
DE59108091D1 (de) 1996-09-26
AU6981291A (en) 1991-08-22
NZ236803A (en) 1993-08-26
NO910191D0 (no) 1991-01-17
HU910156D0 (en) 1991-08-28
IL96840A0 (en) 1991-09-16
FI910276A0 (fi) 1991-01-18

Similar Documents

Publication Publication Date Title
ATE141602T1 (de) 6-ring enthaltende makrocyclische tetraaza- verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
ATE118775T1 (de) 5- oder 6-ring-enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel.
DE59108930D1 (de) Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ATE80869T1 (de) Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel.
ATE175201T1 (de) Mono-n-substituierte 1,4,7,10- tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
ATE108179T1 (de) Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung.
FR2669336B1 (fr) Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE59203704D1 (de) Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung.
DE69837346D1 (de) Anilidderivate, deren herstellung und verwendung
DE3854280D1 (de) Neue cyclische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung.
DE59308940D1 (de) Cyclische Iminoderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE58909444D1 (de) 13,17-Propionsäure- und Propionsäurederivat-substituierte Porphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel.
DE69305276D1 (de) Arylglycinamidderivate, Verfahren zur deren Herstellung und deren Verwendung zur Therapie der Dysurie
ATE290524T1 (de) Aromatische aminderivate, verfahren zu ihrer herstellung und mittel, die diese enthalten
DE69006116D1 (de) Peptid-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
ATE173260T1 (de) 1,7-anellierte 3-(piperazino-alkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE172976T1 (de) 3-aminochroman-spiroderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE69625795D1 (de) Thiazolidinedionderivate mit antidiabetischen, hypolipidämischen und antihypertensiven Eigenschaften, Verfahren zu deren Herstellung und pharmazeutischen Zusammenstellungen, die sie enthalten
ATE195521T1 (de) Indolizinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ATE144510T1 (de) N-(isochinolein-5-yl)-sulfonyl azazykloalkane, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE3851579D1 (de) Cyclische Aminothioacetalamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
AP9901566A0 (en) Novel erythromycin derivatives, method of preparation and application as medicines.
ATE140216T1 (de) (cyclohexyl)alkenderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee