ES2091865T3 - Tetraaza-compuestos macrociclicos que contienen 6 anillos, procedimiento para su preparacion y agentes farmaceuticos que los contienen. - Google Patents
Tetraaza-compuestos macrociclicos que contienen 6 anillos, procedimiento para su preparacion y agentes farmaceuticos que los contienen.Info
- Publication number
- ES2091865T3 ES2091865T3 ES91250008T ES91250008T ES2091865T3 ES 2091865 T3 ES2091865 T3 ES 2091865T3 ES 91250008 T ES91250008 T ES 91250008T ES 91250008 T ES91250008 T ES 91250008T ES 2091865 T3 ES2091865 T3 ES 2091865T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- square
- raised
- group
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 5
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 3
- -1 HYDROXY GROUP Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 2
- 150000002466 imines Chemical group 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4001655A DE4001655A1 (de) | 1990-01-18 | 1990-01-18 | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2091865T3 true ES2091865T3 (es) | 1996-11-16 |
Family
ID=6398485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91250008T Expired - Lifetime ES2091865T3 (es) | 1990-01-18 | 1991-01-16 | Tetraaza-compuestos macrociclicos que contienen 6 anillos, procedimiento para su preparacion y agentes farmaceuticos que los contienen. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0438206B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH05112567A (cg-RX-API-DMAC7.html) |
| KR (1) | KR910014377A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE141602T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU6981291A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2034242A1 (cg-RX-API-DMAC7.html) |
| DE (2) | DE4001655A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0438206T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2091865T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI94758C (cg-RX-API-DMAC7.html) |
| GR (1) | GR3020973T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUT56569A (cg-RX-API-DMAC7.html) |
| IE (1) | IE75898B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL96840A0 (cg-RX-API-DMAC7.html) |
| NO (1) | NO910191L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ236803A (cg-RX-API-DMAC7.html) |
| PT (1) | PT96505B (cg-RX-API-DMAC7.html) |
| TW (1) | TW233298B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA91389B (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| WO1994026313A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| US5480990A (en) * | 1991-12-10 | 1996-01-02 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents |
| FI933508L (fi) * | 1991-12-10 | 1993-08-31 | Dow Chemical Co | Bicyklopolyazamakrocyklokarboxylsyrakomplex, konjugat daerav, foerfarande foer deras framstaellning och anvaendning som radiofarmaceutiska medel |
| US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| MX9207166A (es) * | 1991-12-10 | 1993-07-01 | Dow Chemical Co | Acidos biciclopoliazamacrociclofosfonicos, sus complejos y conjugados, para uso como agentes de contraste, y procedimientos para su preparacion. |
| MX9207164A (es) * | 1991-12-10 | 1993-07-01 | Dow Chemical Co | Complejos de acido biciclopoliazamacrociclocarboxilico, sus conjugados, procedimientos para su preparacion y su uso como agentes de contraste. |
| WO1994026315A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals |
| US5358704A (en) * | 1993-09-30 | 1994-10-25 | Bristol-Myers Squibb | Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents |
| US5417959A (en) * | 1993-10-04 | 1995-05-23 | Mallinckrodt Medical, Inc. | Functionalized aza-crytand ligands for diagnostic imaging applications |
| DE69504220T2 (de) * | 1994-02-21 | 1999-04-29 | Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija Dionicko Drustvo | Sulfonamidodioxepane mit hypoglykämischen Eigenschaften, Methoden zu ihrer Herstellung, ihre Zwischenprodukte und Salze |
| US6207826B1 (en) | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
| AU5375896A (en) * | 1995-03-27 | 1996-10-16 | Isis Pharmaceuticals, Inc. | Nitrogenous macrocyclic compounds |
| AU719002B2 (en) * | 1996-04-19 | 2000-05-04 | Dow Chemical Company, The | Fluorescent chelates as visual tissue specific imaging agents |
| IT1291624B1 (it) * | 1997-04-18 | 1999-01-11 | Bracco Spa | Chelati complessi di metalli paramagnetici a bassa tossicita' |
| WO1998047539A1 (en) * | 1997-04-22 | 1998-10-29 | Nycomed Imaging As | Nmr image compounds |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| JP5368099B2 (ja) | 2005-10-07 | 2013-12-18 | ゲルベ | ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物 |
| EP2004642B1 (en) * | 2006-03-10 | 2017-07-26 | Nordion (Canada) Inc. | Bifunctional polyazamacrocyclic chelating agents |
| KR102231121B1 (ko) | 2013-04-26 | 2021-03-23 | 게르브 | 조영제 제형 및 이와 관련된 제조 방법 |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| ES2814555T3 (es) | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| IL321215A (en) | 2018-11-23 | 2025-07-01 | Bayer Ag | Formulation of contrast media and process of preparation thereof |
| FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| FR3091872B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| KR20230041007A (ko) | 2020-07-17 | 2023-03-23 | 게르브 | Pcta로부터 유도된 킬레이팅 리간드의 제조 방법 |
| CN114105983B (zh) * | 2021-11-09 | 2023-08-11 | 国科温州研究院(温州生物材料与工程研究所) | 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| DE3150917A1 (de) | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung" |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
| DE3417413A1 (de) | 1984-05-11 | 1985-11-14 | Dr. Karl Thomae Gmbh, 7950 Biberach | Dicarbonsaeure-monohydrazid-derivate, ihre herstellung und ihre verwendung als kopplungskomponenten |
| SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
| EP0232751B1 (en) | 1986-01-23 | 1991-09-11 | E.R. Squibb & Sons, Inc. | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
| IT1224416B (it) | 1987-12-24 | 1990-10-04 | Bracco Ind Chimica Spa | Chelanti macrociclici e loro chelati |
| DE3713842A1 (de) | 1987-04-22 | 1988-11-17 | Schering Ag | Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| DE3869251D1 (de) | 1987-07-16 | 1992-04-23 | Nycomed As | Aminopolycarbonsaeure und ihre derivate. |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
-
1990
- 1990-01-18 DE DE4001655A patent/DE4001655A1/de not_active Withdrawn
- 1990-12-31 IL IL96840A patent/IL96840A0/xx unknown
-
1991
- 1991-01-14 JP JP3002602A patent/JPH05112567A/ja active Pending
- 1991-01-16 EP EP91250008A patent/EP0438206B1/de not_active Expired - Lifetime
- 1991-01-16 ES ES91250008T patent/ES2091865T3/es not_active Expired - Lifetime
- 1991-01-16 AT AT91250008T patent/ATE141602T1/de not_active IP Right Cessation
- 1991-01-16 CA CA002034242A patent/CA2034242A1/en not_active Abandoned
- 1991-01-16 DK DK91250008.9T patent/DK0438206T3/da active
- 1991-01-16 DE DE59108091T patent/DE59108091D1/de not_active Expired - Lifetime
- 1991-01-17 NO NO91910191A patent/NO910191L/no unknown
- 1991-01-17 NZ NZ236803A patent/NZ236803A/xx unknown
- 1991-01-17 HU HU91156A patent/HUT56569A/hu unknown
- 1991-01-17 PT PT96505A patent/PT96505B/pt not_active IP Right Cessation
- 1991-01-18 IE IE16291A patent/IE75898B1/en not_active IP Right Cessation
- 1991-01-18 KR KR1019910000816A patent/KR910014377A/ko not_active Withdrawn
- 1991-01-18 ZA ZA91389A patent/ZA91389B/xx unknown
- 1991-01-18 AU AU69812/91A patent/AU6981291A/en not_active Abandoned
- 1991-01-18 FI FI910276A patent/FI94758C/fi active
- 1991-08-06 TW TW080108935A patent/TW233298B/zh active
-
1996
- 1996-09-06 GR GR960402335T patent/GR3020973T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE141602T1 (de) | 1996-09-15 |
| DK0438206T3 (cg-RX-API-DMAC7.html) | 1997-01-20 |
| KR910014377A (ko) | 1991-08-31 |
| HUT56569A (en) | 1991-09-30 |
| PT96505B (pt) | 1998-07-31 |
| DE4001655A1 (de) | 1991-07-25 |
| EP0438206A1 (de) | 1991-07-24 |
| NO910191L (no) | 1991-07-19 |
| FI910276A7 (fi) | 1991-07-19 |
| EP0438206B1 (de) | 1996-08-21 |
| IE910162A1 (en) | 1991-07-31 |
| IE75898B1 (en) | 1997-09-24 |
| CA2034242A1 (en) | 1991-07-19 |
| FI94758C (fi) | 1995-10-25 |
| TW233298B (cg-RX-API-DMAC7.html) | 1994-11-01 |
| ZA91389B (en) | 1991-10-30 |
| FI94758B (fi) | 1995-07-14 |
| GR3020973T3 (en) | 1996-12-31 |
| PT96505A (pt) | 1991-10-15 |
| JPH05112567A (ja) | 1993-05-07 |
| DE59108091D1 (de) | 1996-09-26 |
| AU6981291A (en) | 1991-08-22 |
| NZ236803A (en) | 1993-08-26 |
| NO910191D0 (no) | 1991-01-17 |
| HU910156D0 (en) | 1991-08-28 |
| IL96840A0 (en) | 1991-09-16 |
| FI910276A0 (fi) | 1991-01-18 |
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