ATE136906T1 - Antikörperantagonisten gegen humanes interleukin- 4 - Google Patents

Antikörperantagonisten gegen humanes interleukin- 4

Info

Publication number
ATE136906T1
ATE136906T1 AT91902038T AT91902038T ATE136906T1 AT E136906 T1 ATE136906 T1 AT E136906T1 AT 91902038 T AT91902038 T AT 91902038T AT 91902038 T AT91902038 T AT 91902038T AT E136906 T1 ATE136906 T1 AT E136906T1
Authority
AT
Austria
Prior art keywords
binding
antagonists
receptors
against human
antibodies
Prior art date
Application number
AT91902038T
Other languages
German (de)
English (en)
Inventor
Lata Ramanathan
Gail F Seelig
Paul P Trotta
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE136906T1 publication Critical patent/ATE136906T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT91902038T 1989-12-20 1990-12-18 Antikörperantagonisten gegen humanes interleukin- 4 ATE136906T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45357089A 1989-12-20 1989-12-20

Publications (1)

Publication Number Publication Date
ATE136906T1 true ATE136906T1 (de) 1996-05-15

Family

ID=23801108

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91902038T ATE136906T1 (de) 1989-12-20 1990-12-18 Antikörperantagonisten gegen humanes interleukin- 4

Country Status (26)

Country Link
US (1) US6358509B1 (https=)
EP (1) EP0506826B1 (https=)
JP (1) JPH0730116B2 (https=)
KR (1) KR960016862B1 (https=)
AT (1) ATE136906T1 (https=)
AU (1) AU639754B2 (https=)
CA (1) CA2071908C (https=)
CZ (1) CZ283050B6 (https=)
DE (1) DE69026627T2 (https=)
DK (1) DK0506826T3 (https=)
ES (1) ES2085983T3 (https=)
FI (1) FI104180B1 (https=)
GR (1) GR3020325T3 (https=)
HU (1) HU215245B (https=)
IE (1) IE74708B1 (https=)
IL (1) IL96714A0 (https=)
MX (1) MX9203401A (https=)
MY (1) MY106507A (https=)
NO (1) NO922457D0 (https=)
NZ (1) NZ236511A (https=)
OA (1) OA09704A (https=)
PT (1) PT96230B (https=)
SK (1) SK635290A3 (https=)
TW (1) TW221675B (https=)
WO (1) WO1991009059A1 (https=)
ZA (1) ZA9010190B (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714146A (en) * 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
ZA946765B (en) 1993-09-02 1996-02-15 Dartmouth College Methods of prolonged suppression of humoral immunity
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
WO1995007301A1 (en) * 1993-09-07 1995-03-16 Smithkline Beecham Corporation Recombinant il4 antibodies useful in treatment of il4 mediated disorders
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
IL126714A (en) * 1997-02-28 2010-12-30 Enzo Therapeutics Inc Use of cells, organs or components thereof for the preparation of a pharmaceutical composition for establishing selective immune downregulation
US7553487B2 (en) 1998-12-14 2009-06-30 Genetics Institute, Llc Method and compositions for treating asthma
MXPA01006006A (es) 1998-12-14 2004-08-12 Genetics Inst Cadena receptora de citocina.
DE60135170D1 (de) * 2000-04-06 2008-09-18 Fujifilm Corp Farbstoffkomplex und optisches Informationsaufzeichnungsmedium
DK2990420T3 (en) 2000-05-26 2017-04-03 Immunex Corp USE OF INTERLEUKIN-4 RECEPTOR ANTIBODIES AND COMPOSITIONS THEREOF
AU2001273413A1 (en) * 2000-07-12 2002-01-21 Immunex Corporation Method for treating cancer using an interleukin- 4 antagonist
US20030170258A1 (en) * 2001-05-09 2003-09-11 Enzo Therapeutics, Inc. Novel processes implementing selective immune down regulation (SIDR)
FR2838444B1 (fr) * 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
AU2003251633A1 (en) * 2002-07-01 2004-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Il-21 as a regulator of immunoglobin production
US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
WO2004096849A2 (en) * 2003-04-25 2004-11-11 University Of Manitoba Peptide-based cytokine/chemokine vaccines against allergy
BRPI0416603A (pt) 2003-11-07 2007-01-30 Immunex Corp anticorpo que se liga ao receptor interleucina-4 (il-4) humano
PL3718564T3 (pl) 2003-12-23 2024-03-18 Genentech, Inc. Nowe przeciwciała anty-IL 13 i ich zastosowania
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
PE20060560A1 (es) * 2004-08-03 2006-06-27 Novartis Ag Anticuerpos de interleucina-4 humana
RU2382049C2 (ru) * 2004-08-03 2010-02-20 Новартис Аг ЧЕЛОВЕЧЕСКИЕ МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА К ЧЕЛОВЕЧЕСКОМУ ИНТЕРЛЕЙКИНУ-4 (hIL-4)
NZ592943A (en) * 2008-11-17 2012-09-28 Uinv Kobenhavns Il-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases
KR101860963B1 (ko) 2010-04-23 2018-05-24 제넨테크, 인크. 이종다량체 단백질의 생산
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
RU2018108836A (ru) 2011-02-04 2019-03-14 Дженентек, Инк. ВАРИАНТЫ Fc И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
JP2016522168A (ja) * 2013-04-05 2016-07-28 ジェネンテック， インコーポレイテッド 抗ｉｌ−４抗体及び二重特異性抗体及びその使用
CN120904322A (zh) 2013-09-13 2025-11-07 豪夫迈·罗氏有限公司 包含纯化的重组多肽的方法和组合物
RU2016107435A (ru) 2013-09-13 2017-10-18 Дженентек, Инк. Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты
BR122021009041B1 (pt) 2014-05-06 2022-11-29 Genentech, Inc Métodos para a preparação de uma proteína heteromultimérica
RU2758092C1 (ru) * 2018-02-01 2021-10-26 Бэйцзин Кавин Текнолоджи Шеа-Холдинг Ко., Лтд. АНТИТЕЛО К IL-4Rα И ЕГО ПРИМЕНЕНИЕ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL80678A (en) * 1985-11-19 1999-05-09 Schering Biotech Corp Human interleukin-4
US5013824A (en) * 1985-11-19 1991-05-07 Schering Corporation Human interleukin-4 peptides and conjugates thereof
US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
ZA872781B (en) 1986-05-19 1987-10-05 Immunology Ventures B-cell stimulating factor
DE68908431T2 (de) * 1988-02-02 1993-12-23 Schering Biotech Corp Methode zur Verminderung der Immunglobulin-E-Reaktion.

Also Published As

Publication number Publication date
ZA9010190B (en) 1991-08-28
ES2085983T3 (es) 1996-06-16
MY106507A (en) 1995-06-30
HU215245B (hu) 1998-11-30
NO922457L (no) 1992-06-19
SK279933B6 (sk) 1999-06-11
IE74708B1 (en) 1997-07-30
HU9202073D0 (en) 1992-09-28
CA2071908A1 (en) 1991-06-21
HUT64568A (en) 1994-01-28
FI922847A0 (fi) 1992-06-18
NZ236511A (en) 1993-02-25
GR3020325T3 (en) 1996-09-30
FI104180B (fi) 1999-11-30
MX9203401A (es) 1992-07-01
DE69026627D1 (de) 1996-05-23
PT96230B (pt) 1998-06-30
AU639754B2 (en) 1993-08-05
JPH04506359A (ja) 1992-11-05
FI104180B1 (fi) 1999-11-30
TW221675B (https=) 1994-03-11
CZ283050B6 (cs) 1997-12-17
CZ635290A3 (en) 1997-08-13
FI922847L (fi) 1992-06-18
CA2071908C (en) 2002-04-30
NO922457D0 (no) 1992-06-19
EP0506826B1 (en) 1996-04-17
IL96714A0 (en) 1991-09-16
JPH0730116B2 (ja) 1995-04-05
OA09704A (en) 1993-08-30
EP0506826A1 (en) 1992-10-07
IE904589A1 (en) 1991-07-03
SK635290A3 (en) 1999-06-11
AU7176291A (en) 1991-07-18
KR960016862B1 (ko) 1996-12-23
DK0506826T3 (da) 1996-05-13
US6358509B1 (en) 2002-03-19
WO1991009059A1 (en) 1991-06-27
DE69026627T2 (de) 1996-08-22
KR920703642A (ko) 1992-12-18
PT96230A (pt) 1991-10-15

Similar Documents

Publication Publication Date Title
ATE136906T1 (de) Antikörperantagonisten gegen humanes interleukin- 4
DK0760857T5 (da) Receptor for onkostatin M
DE69232952D1 (de) Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1
ATE249476T1 (de) Cyclin d1 und seine cdna
ATE184019T1 (de) Monoklonale antikörper gegen rezeptor-induzierte bindungsstellen
DE69319662D1 (de) Monoklonale Antikörper gegen GP130-Protein
ATE144713T1 (de) Antikörper gegen menschlichen interleukin-6- rezeptor
ATE226247T1 (de) Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes
DE69939327D1 (de) Funktionelle antagonisten von hedgehog-aktivität
DK0920509T3 (da) Polypeptider, der er i stand til at danne antigenbindende strukturer med specificitet for Rhesus D-antigener, DNA, der koder herfor, samt fremgangsmåde til fremstilling heraf og anvendelse heraf
ATE132162T1 (de) Humane gammainterferonantagonisten
DE69737651D1 (de) Cortistatin: neuropeptide, zusammensetzungen und methoden
TR200102877T2 (tr) İmmünoglobulinin kendi yüksek afinite reseptörüne bağlanmasını inhibe eden antikorlara karşı anti-idiotipik antikorlar.
ATE286074T1 (de) Gegen ccr5 gerichtete antikörperkonstrukte und ihre verwendung in der behandlung von autoimmunkrankheiten
DE3867537D1 (de) Mischung von monoklonalen antikoerpern zur bestimmung der creatinkinaseaktivitaet.
DE69430313D1 (de) Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen
DE3888604D1 (de) Monoklonale Antikörper gegen Antithrombinbindende Substanz und seine Verwendungen.
DE69216408D1 (de) Charakterisierung oder bestimmung der menge von säugerzellen mittels antikörpern
ATE386119T1 (de) Vier-helix bündelprotein zsig81
ATE99333T1 (de) Immunogen und seine verwendung zur gewinnung von antikoerpern gegen haemoglobin a1c.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee