ATE127124T1 - 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. - Google Patents
2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden.Info
- Publication number
- ATE127124T1 ATE127124T1 AT91915632T AT91915632T ATE127124T1 AT E127124 T1 ATE127124 T1 AT E127124T1 AT 91915632 T AT91915632 T AT 91915632T AT 91915632 T AT91915632 T AT 91915632T AT E127124 T1 ATE127124 T1 AT E127124T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- image
- compound
- under conditions
- conditions effective
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 229910015844 BCl3 Inorganic materials 0.000 abstract 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003212 purines Chemical class 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 229910000077 silane Inorganic materials 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/556,713 US5817799A (en) | 1990-07-23 | 1990-07-23 | 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE127124T1 true ATE127124T1 (de) | 1995-09-15 |
Family
ID=24222534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91915632T ATE127124T1 (de) | 1990-07-23 | 1991-07-19 | 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5817799A (de) |
| EP (1) | EP0540686B1 (de) |
| JP (2) | JPH0714956B2 (de) |
| AT (1) | ATE127124T1 (de) |
| CA (1) | CA2087425C (de) |
| DE (1) | DE69112628T2 (de) |
| DK (1) | DK0540686T3 (de) |
| ES (1) | ES2080332T3 (de) |
| GR (1) | GR3017571T3 (de) |
| WO (1) | WO1992001700A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG94686A1 (en) * | 1992-06-22 | 2003-03-18 | Lilly Co Eli | Stereoselective gylcosylation process |
| NO932286L (no) * | 1992-06-22 | 1993-12-23 | Lilly Co Eli | Stereoselektiv anion-glykosyleringsprosess |
| UA41261C2 (uk) * | 1992-06-22 | 2001-09-17 | Елі Ліллі Енд Компані | Спосіб одержання збагачених бета-аномером нуклеозидів |
| AT400953B (de) | 1994-08-25 | 1996-05-28 | Joern Saischek | Pentofuranosid-derivate, deren herstellung und verwendung |
| AU2787199A (en) * | 1998-02-25 | 1999-09-15 | Emory University | 2'-fluoronucleosides |
| US6462191B1 (en) * | 2000-07-13 | 2002-10-08 | Air Products And Chemicals, Inc. | Synthesis of 2-deoxy-2-fluoro-arabinose derivatives |
| US6949522B2 (en) | 2001-06-22 | 2005-09-27 | Pharmasset, Inc. | β-2′- or 3′-halonucleosides |
| CA2623522C (en) * | 2005-09-26 | 2015-12-08 | Pharmasset, Inc. | Modified 4'-nucleosides as antiviral agents |
| US8895531B2 (en) * | 2006-03-23 | 2014-11-25 | Rfs Pharma Llc | 2′-fluoronucleoside phosphonates as antiviral agents |
| US20090274686A1 (en) * | 2008-05-02 | 2009-11-05 | Yat Sun Or | Nucleoside phosphonate derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| US4625020A (en) * | 1983-11-18 | 1986-11-25 | Bristol-Myers Company | Nucleoside process |
| US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
| US4908440A (en) * | 1987-11-12 | 1990-03-13 | Bristol Myers Company | 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides |
| GB8816345D0 (en) * | 1988-07-08 | 1988-08-10 | Hoffmann La Roche | Purine derivatives |
| RU2085557C1 (ru) * | 1991-09-30 | 1997-07-27 | Санкио Компани Лимитед | Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения |
| US5594124A (en) * | 1992-06-22 | 1997-01-14 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof |
-
1990
- 1990-07-23 US US07/556,713 patent/US5817799A/en not_active Expired - Fee Related
-
1991
- 1991-07-19 CA CA002087425A patent/CA2087425C/en not_active Expired - Fee Related
- 1991-07-19 ES ES91915632T patent/ES2080332T3/es not_active Expired - Lifetime
- 1991-07-19 DK DK91915632.3T patent/DK0540686T3/da active
- 1991-07-19 DE DE69112628T patent/DE69112628T2/de not_active Expired - Fee Related
- 1991-07-19 WO PCT/US1991/005001 patent/WO1992001700A1/en not_active Ceased
- 1991-07-19 AT AT91915632T patent/ATE127124T1/de not_active IP Right Cessation
- 1991-07-19 JP JP3514075A patent/JPH0714956B2/ja not_active Expired - Fee Related
- 1991-07-19 EP EP91915632A patent/EP0540686B1/de not_active Expired - Lifetime
-
1992
- 1992-10-29 US US07/968,567 patent/US5336764A/en not_active Expired - Lifetime
-
1995
- 1995-09-28 GR GR950402685T patent/GR3017571T3/el unknown
-
1996
- 1996-03-08 JP JP8080564A patent/JP2770162B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2087425C (en) | 1998-08-04 |
| US5817799A (en) | 1998-10-06 |
| EP0540686B1 (de) | 1995-08-30 |
| JPH06501927A (ja) | 1994-03-03 |
| WO1992001700A1 (en) | 1992-02-06 |
| AU641545B2 (en) | 1993-09-23 |
| AU8403991A (en) | 1992-02-18 |
| CA2087425A1 (en) | 1992-01-24 |
| EP0540686A4 (en) | 1993-05-26 |
| DE69112628D1 (de) | 1995-10-05 |
| DK0540686T3 (da) | 1995-12-27 |
| JPH08333382A (ja) | 1996-12-17 |
| ES2080332T3 (es) | 1996-02-01 |
| JPH0714956B2 (ja) | 1995-02-22 |
| EP0540686A1 (de) | 1993-05-12 |
| GR3017571T3 (en) | 1995-12-31 |
| US5336764A (en) | 1994-08-09 |
| DE69112628T2 (de) | 1996-04-04 |
| JP2770162B2 (ja) | 1998-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |