ATE127124T1 - 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. - Google Patents

2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden.

Info

Publication number
ATE127124T1
ATE127124T1 AT91915632T AT91915632T ATE127124T1 AT E127124 T1 ATE127124 T1 AT E127124T1 AT 91915632 T AT91915632 T AT 91915632T AT 91915632 T AT91915632 T AT 91915632T AT E127124 T1 ATE127124 T1 AT E127124T1
Authority
AT
Austria
Prior art keywords
formula
image
compound
under conditions
conditions effective
Prior art date
Application number
AT91915632T
Other languages
English (en)
Inventor
Victor E Marquez
John S Driscoll
Ronald J Wysocki Jr
Maqbool A Siddiqui
Original Assignee
Us Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Commerce filed Critical Us Commerce
Application granted granted Critical
Publication of ATE127124T1 publication Critical patent/ATE127124T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
AT91915632T 1990-07-23 1991-07-19 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden. ATE127124T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/556,713 US5817799A (en) 1990-07-23 1990-07-23 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides

Publications (1)

Publication Number Publication Date
ATE127124T1 true ATE127124T1 (de) 1995-09-15

Family

ID=24222534

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915632T ATE127124T1 (de) 1990-07-23 1991-07-19 2'-fluorofuranosylderivate und verfahren zur herstellung von 2'-fluoropyrimidin- und 2'- fluoropurin-nucleosiden.

Country Status (10)

Country Link
US (2) US5817799A (de)
EP (1) EP0540686B1 (de)
JP (2) JPH0714956B2 (de)
AT (1) ATE127124T1 (de)
CA (1) CA2087425C (de)
DE (1) DE69112628T2 (de)
DK (1) DK0540686T3 (de)
ES (1) ES2080332T3 (de)
GR (1) GR3017571T3 (de)
WO (1) WO1992001700A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG94686A1 (en) * 1992-06-22 2003-03-18 Lilly Co Eli Stereoselective gylcosylation process
EP0577304B1 (de) * 1992-06-22 1997-03-05 Eli Lilly And Company Verfahren zur Stereoselektivanionglycosylierung
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
AT400953B (de) 1994-08-25 1996-05-28 Joern Saischek Pentofuranosid-derivate, deren herstellung und verwendung
ATE344271T1 (de) * 1998-02-25 2006-11-15 Univ Emory 2'-fluoronukleoside
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
US6949522B2 (en) 2001-06-22 2005-09-27 Pharmasset, Inc. β-2′- or 3′-halonucleosides
EP1937825B1 (de) * 2005-09-26 2016-12-21 Gilead Pharmasset LLC Modifizierte 4'-nukleoside als antivirusmittel
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US4908440A (en) * 1987-11-12 1990-03-13 Bristol Myers Company 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
FI105556B (fi) * 1991-09-30 2000-09-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof

Also Published As

Publication number Publication date
JPH06501927A (ja) 1994-03-03
AU8403991A (en) 1992-02-18
DE69112628D1 (de) 1995-10-05
EP0540686B1 (de) 1995-08-30
WO1992001700A1 (en) 1992-02-06
EP0540686A1 (de) 1993-05-12
DK0540686T3 (da) 1995-12-27
US5336764A (en) 1994-08-09
JPH0714956B2 (ja) 1995-02-22
EP0540686A4 (en) 1993-05-26
DE69112628T2 (de) 1996-04-04
CA2087425C (en) 1998-08-04
JP2770162B2 (ja) 1998-06-25
ES2080332T3 (es) 1996-02-01
GR3017571T3 (en) 1995-12-31
JPH08333382A (ja) 1996-12-17
AU641545B2 (en) 1993-09-23
US5817799A (en) 1998-10-06
CA2087425A1 (en) 1992-01-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee