ATE119194T1 - Lebendes gewebeäquivalent. - Google Patents

Lebendes gewebeäquivalent.

Info

Publication number
ATE119194T1
ATE119194T1 AT90309942T AT90309942T ATE119194T1 AT E119194 T1 ATE119194 T1 AT E119194T1 AT 90309942 T AT90309942 T AT 90309942T AT 90309942 T AT90309942 T AT 90309942T AT E119194 T1 ATE119194 T1 AT E119194T1
Authority
AT
Austria
Prior art keywords
living tissue
tissue equivalent
tissue equivalents
present
provides
Prior art date
Application number
AT90309942T
Other languages
English (en)
Inventor
Paul Kemp
Eugene Bell
David T Kagan
Valerie Mason
John Cavallaro
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Application granted granted Critical
Publication of ATE119194T1 publication Critical patent/ATE119194T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698Skin equivalents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60Materials for use in artificial skin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02Membranes; Filters
    • C12M25/04Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/09Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323Adult fibroblasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT90309942T 1989-09-15 1990-09-11 Lebendes gewebeäquivalent. ATE119194T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40805289A 1989-09-15 1989-09-15

Publications (1)

Publication Number Publication Date
ATE119194T1 true ATE119194T1 (de) 1995-03-15

Family

ID=23614662

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90309942T ATE119194T1 (de) 1989-09-15 1990-09-11 Lebendes gewebeäquivalent.

Country Status (12)

Country Link
US (1) US5536656A (de)
EP (1) EP0418035B1 (de)
JP (1) JPH03151977A (de)
KR (1) KR940001379B1 (de)
AT (1) ATE119194T1 (de)
AU (1) AU6215690A (de)
CA (2) CA2298856C (de)
DE (1) DE69017324T2 (de)
DK (1) DK0418035T3 (de)
ES (1) ES2071778T3 (de)
IE (1) IE903340A1 (de)
IL (1) IL95429A (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888720A (en) * 1992-10-27 1999-03-30 Yissum Research And Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
GB9306449D0 (en) * 1993-03-29 1993-05-19 Nat Heart Research Fund Tissue equivalents
EP1217101B8 (de) 1994-04-29 2006-02-01 Boston Scientific Scimed, Inc. Stent mit Kollagen
US5665114A (en) * 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
US20020086423A1 (en) * 1997-09-09 2002-07-04 Toshiaki Takezawa Hydrogel thin film containing extracellular matrix components
AU3077299A (en) 1998-03-11 1999-09-27 University Of Southern California Method of promoting production of living tissue equivalents
US6129757A (en) * 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
JP2002530069A (ja) * 1998-11-19 2002-09-17 オルガノジェネシス インク. 生物工学的組織構築物およびそれを生成および使用する方法
US7001746B1 (en) 1999-01-29 2006-02-21 Artecel Sciences, Inc. Methods and compositions for the differentiation of human preadipocytes into adipocytes
US6479072B1 (en) * 1999-02-11 2002-11-12 The General Hospital Corporation Microfabricated membranes and matrices
US6197061B1 (en) * 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
DE60036385T2 (de) 1999-06-21 2008-06-26 The General Hospital Corp., Boston Zellkultursysteme und verfahren für einrichtungen zur organunterstützung
WO2001014527A1 (en) * 1999-08-23 2001-03-01 Organogenesis Inc. Skin care compositions and treatments
US7582292B2 (en) 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
EP1918366A1 (de) 2000-02-26 2008-05-07 Artecel, Inc. Pluripotente Stammzellen aus Bindegewebszellen aus dem Fettgewebe und Verwendungen dafür
DE60132429T2 (de) 2000-02-26 2009-01-08 Artecel, Inc. Pluripotente aus von fettgewebe stammenden stromazellen erzeugte stammzellen und deren verwendung
ATE308610T1 (de) 2000-05-31 2005-11-15 Fraunhofer Ges Forschung Dreidimensionales hautmodell
WO2001092476A2 (de) * 2000-05-31 2001-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. In vitro-gewebetestsystem
US7144729B2 (en) 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
EP1832300A3 (de) * 2000-09-18 2008-02-27 Organogenesis Inc. Verfahren zur Behandlung eines Patienten unter Verwendung eines kultivierten Bindegewebekonstrukts
US7597712B2 (en) 2000-09-18 2009-10-06 Organogenesis, Inc. Method for treating a patient using a cultured connective tissue construct
US7041868B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
JP4317366B2 (ja) * 2001-03-02 2009-08-19 ストラタテック コーポレーション 改良代用皮膚およびその使用法
US6974697B2 (en) * 2001-03-02 2005-12-13 Stratech Corporation Skin substitutes with improved barrier function
US20030211793A1 (en) * 2001-03-05 2003-11-13 Eugene Bell Injectable bio-compatible material and methods of use
US7282362B2 (en) 2001-06-14 2007-10-16 Millipore Corporation Tray with protrusions
EP1435980A4 (de) * 2001-09-15 2006-06-07 Univ California Stratifiziertes knorpelgewebe und verfahren zu seiner hestellung
US20030165473A1 (en) * 2001-11-09 2003-09-04 Rush-Presbyterian-St. Luke's Medical Center Engineered intervertebral disc tissue
WO2003072128A2 (en) * 2002-02-22 2003-09-04 Ebi, L.P. Methods and compositions for treating bone or cartilage defects
US7741116B2 (en) 2002-03-06 2010-06-22 University Of Cincinnati Surgical device for skin therapy or testing
NZ536205A (en) * 2002-04-30 2008-04-30 Stratatech Corp Keratinocytes expressing exogenous angiogenic growth factors
US7229820B2 (en) * 2002-06-13 2007-06-12 Wilson Wolf Manufacturing Corporation Apparatus and method for culturing and preserving tissue constructs
AU2003254298A1 (en) 2002-08-02 2004-02-23 Stratatech Corporation Species specific dna detection
EP2481287B1 (de) 2003-08-01 2016-07-20 Stratatech Corporation Exogene Polypeptide exprimierende Äquivalente menschlicher Haut
FR2881434B1 (fr) * 2005-02-02 2007-05-11 Coletica Sa Dispositif de support de culture de cellules
JP4993752B2 (ja) 2005-03-01 2012-08-08 ストラタテック コーポレーション 外因性ポリペプチドを発現するヒト皮膚同等物
AU2006227752B2 (en) 2005-03-17 2010-10-21 Stratatech Corporation Skin substitutes with improved purity
FR2889808B1 (fr) 2005-08-17 2011-07-22 Oreal Utilisation de l'acide 8-hexadecene-1,16-dicarboxylique comme agent de soin destine a favoriser la cohesion de la couche cornee
WO2007103865A2 (en) * 2006-03-03 2007-09-13 Organogenesis, Inc. Oral tissue regeneration and repair
FR2903702B1 (fr) * 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
US20090068250A1 (en) 2007-09-07 2009-03-12 Philippe Gravagna Bioresorbable and biocompatible compounds for surgical use
US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
JP5719172B2 (ja) 2007-11-14 2015-05-13 ストラタテック コーポレーション 臨床用途のための器官培養された皮膚同等物の冷蔵保管方法
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
WO2009128076A2 (en) 2008-04-18 2009-10-22 Collplant Ltd. Methods of generating and using procollagen
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
JP5669741B2 (ja) * 2008-10-22 2015-02-12 リジーンメッド インコーポレイテッド 培養システム
PT2352472T (pt) * 2008-11-04 2017-04-11 Stratatech Corp Equivalentes de pele secos e irradiados prontos a utilizar
WO2010111278A1 (en) * 2009-03-23 2010-09-30 The Texas A&M University System Compositions of mesenchymal stem cells to regenerate bone
US20100330046A1 (en) 2009-05-21 2010-12-30 Stratatech Corporation Human skin substitutes expressing il-12
US9321988B2 (en) * 2009-06-18 2016-04-26 Illinois Tool Works Inc. Gas and liquid tissue culture interface
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
ES2750303T3 (es) 2010-04-05 2020-03-25 Emd Millipore Corp Membranas poliméricas con propiedades de permeabilidad similares a la piel humana y usos de las mismas
FR2967163A1 (fr) 2010-11-05 2012-05-11 Centre Nat Rech Scient Procede in vitro ou ex vivo pour la maintenance en survie et la generation ou reconstruction d'un epiderme
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
AU2012313984B2 (en) 2011-09-30 2016-02-11 Covidien Lp Reversible stiffening of light weight mesh
EP2760431A1 (de) 2011-09-30 2014-08-06 Sofradim Production Mehrschichtige implantate zur verabreichung therapeutischer wirkstoffe
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
PL226837B1 (pl) 2012-08-24 2017-09-29 Celther Polska Spółka Z Ograniczoną Odpowiedzialnością Aktywna warstwa polimerowa utworzona zpochodnych chityny zwłaszcza doopatrunku oraz jejzastosowanie
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
US10159555B2 (en) 2012-09-28 2018-12-25 Sofradim Production Packaging for a hernia repair device
USD692160S1 (en) * 2012-10-26 2013-10-22 Paragonix Technologies, Inc. Tissue suspension adaptor
PT2967836T (pt) 2013-03-13 2019-01-21 Stratatech Corp Criopreservação de substitutos de pele humana viáveis
CA2910328C (en) 2013-05-03 2019-10-22 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Skin substitutes and methods for hair follicle neogenesis
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
EP3137594B1 (de) 2014-04-30 2018-03-28 Fondazione Istituto Italiano di Tecnologia Verfahren zur herstellung eines vollständig endogenen genmanipulierten gewebe und damit hergestelltes gewebe
EP3000489B1 (de) 2014-09-24 2017-04-05 Sofradim Production Verfahren zur Herstellung einer Antihaft-Sperrschicht
EP3000432B1 (de) 2014-09-29 2022-05-04 Sofradim Production Textilbasierte Prothese für die Behandlung von Leistenbruch
EP3000433B1 (de) 2014-09-29 2022-09-21 Sofradim Production Vorrichtung zur Einführung einer Prothese zur Hernie-Behandlung in einen Einschnitt und flexible textile Prothese
EP3029189B1 (de) 2014-12-05 2021-08-11 Sofradim Production Prothetisches poröses Netz, sein Herstellungsverfahren und Hernienprothese
EP3059255B1 (de) 2015-02-17 2020-05-13 Sofradim Production Verfahren zur Herstellung einer Matrix auf Chitosanbasis mit faseroptischem Verstärkungselement
EP3085337B1 (de) 2015-04-24 2022-09-14 Sofradim Production Prothese zur unterstützung einer bruststruktur
ES2676072T3 (es) 2015-06-19 2018-07-16 Sofradim Production Prótesis sintética que comprende un tejido de punto y una película no porosa y método para formarla
EP3195830B1 (de) 2016-01-25 2020-11-18 Sofradim Production Prothese zur hernienreparatur
FR3054449B1 (fr) 2016-07-29 2018-08-31 L'oreal Equivalent de peau a compartiments dermiques juxtaposes distincts
EP3312325B1 (de) 2016-10-21 2021-09-22 Sofradim Production Verfahren zur herstellung eines netzes mit einem daran befestigten nahtmaterial mit widerhaken und dadurch erhaltenes netz
EP3398554B1 (de) 2017-05-02 2025-06-25 Sofradim Production Prothese zur leistenbruch reparatur
WO2018220137A1 (en) * 2017-05-31 2018-12-06 ETH Zürich Assembly for the production of tissue implants
FR3071512B1 (fr) 2017-09-28 2022-02-25 Oreal Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations
EP3653171B1 (de) 2018-11-16 2024-08-21 Sofradim Production Implantate zur weichgewebereparatur
US12064330B2 (en) 2020-04-28 2024-08-20 Covidien Lp Implantable prothesis for minimally invasive hernia repair
FR3111904B1 (fr) 2020-06-30 2022-10-21 Oreal Bioencre pour bioimpression d’un modèle de jonction dermo-épidermique invaginée
US12435312B2 (en) 2022-02-28 2025-10-07 Brown University Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model
LU502391B1 (en) 2022-06-28 2024-01-09 Univerza V Mariboru A complex in vitro model of human skin, a process for preparation and use thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2677646A (en) * 1952-03-22 1954-05-04 Lovell Chemical Company Unit for bacterial analysis
US2761813A (en) * 1953-01-21 1956-09-04 Goetz Alexander Means and method of producing and controlling cultures of microorganisms
GB1594389A (en) * 1977-06-03 1981-07-30 Max Planck Gesellschaft Dressing material for wounds
DE2967509D1 (en) * 1978-12-26 1985-10-10 Massachusetts Inst Technology Skin-equivalent
US4290911A (en) * 1979-02-07 1981-09-22 Fmc Corporation Agarose composition, aqueous gel and method of making same
SE7908454L (sv) * 1979-10-11 1981-04-12 Pharmacia Fine Chemicals Ab Medium for isoelektrisk fokusering
US4539716A (en) * 1981-03-19 1985-09-10 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4546500A (en) * 1981-05-08 1985-10-15 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4598045A (en) * 1982-08-25 1986-07-01 Hana Biologics, Inc. Triphasic mycoplasmatales detection method
US4734372A (en) * 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
US4578354A (en) * 1983-05-09 1986-03-25 Pfizer Inc. Immobilization of catalytically active microorganisms in agar gel fibers
EP0164583B1 (de) * 1984-05-11 1991-09-25 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Verfahren zur Herstellung eines Behälters aus syntetischem Harz
US4604346A (en) * 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
JPS6225974A (ja) * 1985-07-25 1987-02-03 Asahi Chem Ind Co Ltd コラ−ゲンよりなるゲル状組成物
US5026649A (en) * 1986-03-20 1991-06-25 Costar Corporation Apparatus for growing tissue cultures in vitro
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5037656A (en) * 1986-12-04 1991-08-06 Millipore Corporation Porous membrane having hydrophilic and cell growth promotions surface and process
FR2612938B1 (fr) * 1987-03-26 1989-06-23 Cird Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
US4835102A (en) * 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
US4837379A (en) * 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
US4996154A (en) * 1989-05-04 1991-02-26 Millipore Corporation Method for growing cellular tissue
US4912057A (en) * 1989-06-13 1990-03-27 Cancer Diagnostics, Inc. Cell chamber for chemotaxis assay

Also Published As

Publication number Publication date
AU6215690A (en) 1991-08-01
US5536656A (en) 1996-07-16
DK0418035T3 (da) 1995-07-10
CA2023968C (en) 2000-05-02
ES2071778T3 (es) 1995-07-01
DE69017324T2 (de) 1995-08-03
IL95429A0 (en) 1991-06-30
KR910005893A (ko) 1991-04-27
JPH0553505B2 (de) 1993-08-10
KR940001379B1 (ko) 1994-02-21
EP0418035A1 (de) 1991-03-20
IE903340A1 (en) 1991-04-10
DE69017324D1 (de) 1995-04-06
CA2298856A1 (en) 1991-03-16
CA2298856C (en) 2004-11-16
IL95429A (en) 1997-09-30
EP0418035B1 (de) 1995-03-01
JPH03151977A (ja) 1991-06-28
CA2023968A1 (en) 1991-03-16

Similar Documents

Publication Publication Date Title
ATE119194T1 (de) Lebendes gewebeäquivalent.
DK0457430T3 (da) Kollagenkonstruktioner
DE69130018D1 (de) Vorrichtung zur biopsie von weichem gewebe
DE69117227D1 (de) Apparat zur Präparation von Gewebeproben zur histologischen Untersuchung
ATA223394A (de) Einrichtung zur optischen untersuchung von human-haut sowie derselben zugeordnete auswertungs-einrichtung
DE69631738D1 (de) Medizinische implantierbare Vorrichtung für elektrochemische Messungen von Bluteigenschaften
NO890496D0 (no) Fremgangsmaate og anordning for ikke-inntrengende akustisk undersoekelse av elastisiteten til mykt, biologisk vev.
ES506351A0 (es) Procedimiento y aparato de cirugia anastomotica
DE3854540D1 (de) Behandlungsapparat und Verfahren.
DE69019886D1 (de) Katheter und Instrumentarium zur extrakorporalen Zirkulation.
DE69005840D1 (de) Analytisches Element zur Untersuchung des gesamten Blutes.
FI874419A7 (fi) Laitteisto ja menetelmä kohteen ominaisuuksien tutkimiseen.
DK94990A (da) Fremgangsmaade samt apparat til indtraengningsfri maaling af mindst en mekanisk egenskab for bloede biologiske vaev
DK331688D0 (da) Apparat til undersoegelse af leverfunktionen
DE69015372D1 (de) Protein-testverfahren.
DE68907688D1 (de) Verfahren und vorrichtung zur optischen untersuchung von loetstellen.
NO904873D0 (no) Fremgangsmaate og anordning for behandling av sinkslig.
NO903338L (no) Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
DE3855783D1 (de) Gerät zur Analyse von partiellen molekularen Strukturen
DE3872790D1 (de) Geraet zur untersuchung von reissverschlusselementen.
GR3005231T3 (de)
DE68924481D1 (de) Vorrichtung zur Untersuchung der Röntgenstrahlung.
DE3883878D1 (de) Behandlungsapparat und Verfahren.
ITTO910481A1 (it) Apparecchio e procedimento per la verifica della solidita' di un oggetto.
NO900544D0 (no) Fremgangsmaate og apparat for forbedring av ben-heling.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee