FR3071512B1 - Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations - Google Patents

Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations Download PDF

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Publication number
FR3071512B1
FR3071512B1 FR1759026A FR1759026A FR3071512B1 FR 3071512 B1 FR3071512 B1 FR 3071512B1 FR 1759026 A FR1759026 A FR 1759026A FR 1759026 A FR1759026 A FR 1759026A FR 3071512 B1 FR3071512 B1 FR 3071512B1
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populations
sub
fibroblast
dermal fibroblasts
molecular signatures
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FR1759026A
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FR3071512A1 (fr
Inventor
Valerie Haydont
Daniel Asselineau
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LOreal SA
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LOreal SA
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Priority to FR1759026A priority Critical patent/FR3071512B1/fr
Application filed by LOreal SA filed Critical LOreal SA
Priority to PCT/EP2018/076347 priority patent/WO2019063731A1/fr
Priority to JP2020518055A priority patent/JP7399083B2/ja
Priority to CN201880063540.0A priority patent/CN111164223B/zh
Priority to EP18773228.4A priority patent/EP3688192B1/fr
Priority to US16/650,258 priority patent/US20210371925A1/en
Publication of FR3071512A1 publication Critical patent/FR3071512A1/fr
Priority to JP2021202527A priority patent/JP2022031351A/ja
Application granted granted Critical
Publication of FR3071512B1 publication Critical patent/FR3071512B1/fr
Priority to JP2023188579A priority patent/JP2024003103A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention a pour objet l'utilisation d'un produit d'expression d'au moins un gène choisi dans le groupe constitué des gènes UCP2, et FGF9 et éventuellement des gènes COL11A1 et ACAN, éventuellement en combinaison avec un produit d'expression du gène KLF9, comme marqueur pour identifier in vitro un fibroblaste dermique comme étant un fibroblaste papillaire, un fibroblaste réticulaire ou un fibroblaste de la jonction dermo-hypodermique (FJDH).
FR1759026A 2017-09-28 2017-09-28 Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations Active FR3071512B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR1759026A FR3071512B1 (fr) 2017-09-28 2017-09-28 Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations
JP2020518055A JP7399083B2 (ja) 2017-09-28 2018-09-27 真皮繊維芽細胞の３種の亜集団の分子シグネチャー及びこれらの亜集団のうちの１種を含む真皮等価物
CN201880063540.0A CN111164223B (zh) 2017-09-28 2018-09-27 真皮成纤维细胞的三个亚群的分子标签和包括这些亚群之一的真皮等同物
EP18773228.4A EP3688192B1 (fr) 2017-09-28 2018-09-27 Signatures moléculaires de trois sous-populations de fibroblastes dermiques et équivalent dermique comprenant une de ces sous-populations
PCT/EP2018/076347 WO2019063731A1 (fr) 2017-09-28 2018-09-27 Signatures moléculaires de trois sous-populations de fibroblastes dermiques et équivalent dermique comprenant une de ces sous-populations
US16/650,258 US20210371925A1 (en) 2017-09-28 2018-09-27 Molecular signatures of three sub-populations of dermal fibroblasts and dermal equivalent comprising one of these sub-populations
JP2021202527A JP2022031351A (ja) 2017-09-28 2021-12-14 真皮繊維芽細胞の３種の亜集団の分子シグネチャー及びこれらの亜集団のうちの１種を含む真皮等価物
JP2023188579A JP2024003103A (ja) 2017-09-28 2023-11-02 真皮繊維芽細胞の３種の亜集団の分子シグネチャー及びこれらの亜集団のうちの１種を含む真皮等価物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1759026A FR3071512B1 (fr) 2017-09-28 2017-09-28 Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations
FR1759026 2017-09-28

Publications (2)

Publication Number Publication Date
FR3071512A1 FR3071512A1 (fr) 2019-03-29
FR3071512B1 true FR3071512B1 (fr) 2022-02-25

Family

ID=61027846

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1759026A Active FR3071512B1 (fr) 2017-09-28 2017-09-28 Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations

Country Status (6)

Country Link
US (1) US20210371925A1 (fr)
EP (1) EP3688192B1 (fr)
JP (3) JP7399083B2 (fr)
CN (1) CN111164223B (fr)
FR (1) FR3071512B1 (fr)
WO (1) WO2019063731A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3083246B1 (fr) * 2018-06-29 2023-12-08 Oreal Modeles cellulaires et tissulaires comprenant des fibroblastes de la jonction dermo-hypodermique et ses applications
CN113215098B (zh) * 2021-06-04 2023-02-24 安徽医科大学第一附属医院 一种低成本原代小鼠脾脏网状成纤维细胞体外分离和培养方法
CN113355278A (zh) * 2021-06-29 2021-09-07 安徽医科大学第一附属医院 Ⅰ型干扰素受体基因敲除小鼠脾脏网状成纤维永生化细胞系的培养方法及应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980001350A1 (fr) 1978-12-26 1980-07-10 Massachusetts Inst Technology Substitut de peau
US4604346A (en) 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
FR2612939B1 (fr) 1987-03-26 1989-06-23 Cird Equivalent de peau
FR2612938B1 (fr) 1987-03-26 1989-06-23 Cird Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
USRE35399E (en) 1990-04-24 1996-12-10 Eisenberg; Mark Composite living skin equivalents
FR2665175B1 (fr) 1990-07-27 1993-12-31 Rosdy Martin Equivalent d'epiderme, son procede d'obtention et son utilisation.
FR2667246A1 (fr) 1990-10-02 1992-04-03 Imedex Biomateriau a base de collagene et des applications.
FR2689904B1 (fr) 1992-04-08 1994-12-16 Martin Rosdy Test de bronzage épidermique in vitro.
FR2743817B1 (fr) 1996-01-23 1998-03-13 Oreal Equivalent de peau comprenant des cellules de langerhans
JP2000508922A (ja) * 1996-04-26 2000-07-18 ケース ウエスターン リザーブ ユニバーシティ 間葉幹細胞を用いる皮膚再生
FR2903702B1 (fr) * 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
FR2940611B1 (fr) * 2008-12-30 2012-01-13 Oreal Association de monosaccharides et d'adenosine et son utilisation en cosmetique
EP2783212B1 (fr) * 2011-11-25 2016-10-05 Chanel Parfums Beauté Nouveaux marqueurs de fibroblastes réticulaires et papillaires et utilisations de ceux-ci
SG11201700095SA (en) * 2014-07-09 2017-02-27 Sanford Burnham Med Res Inst Methods and compositions to modulate hair growth

Also Published As

Publication number Publication date
EP3688192B1 (fr) 2024-05-01
JP2024003103A (ja) 2024-01-11
CN111164223A (zh) 2020-05-15
EP3688192C0 (fr) 2024-05-01
CN111164223B (zh) 2024-06-21
US20210371925A1 (en) 2021-12-02
WO2019063731A1 (fr) 2019-04-04
JP2022031351A (ja) 2022-02-18
FR3071512A1 (fr) 2019-03-29
EP3688192A1 (fr) 2020-08-05
JP2020534852A (ja) 2020-12-03
JP7399083B2 (ja) 2023-12-15

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