ATA167676A - Verfahren zur herstellung von neuen imidazo(1,5 -a) (1,4)diazepinverbindungen, ihren salzen und optisch aktiven formen - Google Patents

Verfahren zur herstellung von neuen imidazo(1,5 -a) (1,4)diazepinverbindungen, ihren salzen und optisch aktiven formen

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Publication number
ATA167676A
ATA167676A AT167676A AT167676A ATA167676A AT A167676 A ATA167676 A AT A167676A AT 167676 A AT167676 A AT 167676A AT 167676 A AT167676 A AT 167676A AT A167676 A ATA167676 A AT A167676A
Authority
AT
Austria
Prior art keywords
salts
optically active
active forms
producing new
diazepine compounds
Prior art date
Application number
AT167676A
Other languages
English (en)
Other versions
AT361486B (de
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to AT761079A priority Critical patent/AT395154B/de
Priority to AT760979A priority patent/AT395153B/de
Priority to AT760879A priority patent/AT395152B/de
Priority to AT761179A priority patent/AT395155B/de
Publication of ATA167676A publication Critical patent/ATA167676A/de
Application granted granted Critical
Publication of AT361486B publication Critical patent/AT361486B/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/101,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT167676A 1975-08-07 1976-03-08 Verfahren zur herstellung von neuen imidazo(1,5 -a) (1,4)diazepinverbindungen, ihren salzen und optisch aktiven formen AT361486B (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT761079A AT395154B (de) 1975-08-07 1979-11-30 Verfahren zur herstellung von neuen imidazo(1,5-a)(1,4)diazepinverbindungen
AT760979A AT395153B (de) 1975-08-07 1979-11-30 Verfahren zur herstellung von neuen imidazo(1,5-a)(1,4)diazepinverbindungen
AT760879A AT395152B (de) 1975-08-07 1979-11-30 Verfahren zur herstellung von neuen imidazo (1,5-a)(1,4)diazepinverbindungen
AT761179A AT395155B (de) 1975-08-07 1979-11-30 Verfahren zur herstellung von neuen imidazo(1,5-a)(1,4)diazepinverbindungen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60272075A 1975-08-07 1975-08-07
US60269175A 1975-08-07 1975-08-07
US66366076A 1976-03-04 1976-03-04
US05/766,637 US4076939A (en) 1975-08-07 1977-02-08 2-(4-Substituted-1,2,5-thiadiazole-3-yloxy)-acetaldehydes

Publications (2)

Publication Number Publication Date
ATA167676A true ATA167676A (de) 1980-08-15
AT361486B AT361486B (de) 1981-03-10

Family

ID=27505060

Family Applications (1)

Application Number Title Priority Date Filing Date
AT167676A AT361486B (de) 1975-08-07 1976-03-08 Verfahren zur herstellung von neuen imidazo(1,5 -a) (1,4)diazepinverbindungen, ihren salzen und optisch aktiven formen

Country Status (12)

Country Link
US (2) US4076939A (de)
AT (1) AT361486B (de)
AU (1) AU509371B2 (de)
BE (1) BE839364A (de)
CA (1) CA1076572A (de)
CH (4) CH630381A5 (de)
DE (1) DE2609486A1 (de)
FR (2) FR2342735A1 (de)
GB (6) GB1549835A (de)
LU (1) LU74512A1 (de)
NL (1) NL7602469A (de)
SE (1) SE422580B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125726A (en) * 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
US4226768A (en) * 1979-05-29 1980-10-07 Hoffmann-La Roche Inc. Process for the preparation of imidazobenzodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4508725A (en) * 1982-12-22 1985-04-02 American Hospital Supply Corporation Esters of 3-(3-substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazole derivatives
ZA845757B (en) * 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
US4555521A (en) * 1983-11-16 1985-11-26 Fmc Corporation Nematicidal 3-substituted-4-phenyl-1,2,5-thiadiazoles
CA2184802C (en) * 1995-10-10 2007-07-31 Karl-Heinz Bender Process for manufacture of imidazo benzodiazepine derivatives
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US6512114B1 (en) * 1999-06-30 2003-01-28 Abbott Laboratories Process for the preparation of Midazolam
US6262260B1 (en) 2000-03-23 2001-07-17 Abbott Laboratories Process for the preparation of midazolam
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657237A (en) * 1968-05-22 1972-04-18 Frosst & Co Charles E Process for making 1 2 5-thiadiazoles in the sinister configuration
US3655663A (en) * 1969-04-21 1972-04-11 Burton K Wasson 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles
US3619370A (en) * 1969-04-21 1971-11-09 Frosst & Co Charles E Microbial reduction of thiadiazoles
JPS4932874B1 (de) * 1970-12-11 1974-09-03
US3917627A (en) * 1971-08-04 1975-11-04 Upjohn Co 6-Substituted 4H-imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines and process for their production
US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US3927016A (en) * 1971-08-04 1975-12-16 Upjohn Co 6-Substituted 4H-imidazo (1,2-a) (1,4)-benzodiazepine-1-carboxaldehydes and processes for their production
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
FR2183716A1 (en) * 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
CA1005443A (en) * 1972-06-22 1977-02-15 Michio Nakanishi Thienodiazepine compounds
US3770762A (en) * 1972-08-29 1973-11-06 Parke Davis & Co Diazepine compounds and methods for their production
US3823157A (en) * 1972-12-15 1974-07-09 Wald H De Pyrazolodiazepine compounds and methods for their production
US3910946A (en) * 1974-09-12 1975-10-07 Upjohn Co 4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines

Also Published As

Publication number Publication date
DE2609486A1 (de) 1977-05-12
GB1549836A (en) 1979-08-08
US4076939A (en) 1978-02-28
GB1549832A (en) 1979-08-08
LU74512A1 (de) 1977-09-27
DE2609486C2 (de) 1988-11-03
FR2342735A1 (fr) 1977-09-30
GB1549834A (en) 1979-08-08
CH630381A5 (de) 1982-06-15
SE7603085L (sv) 1977-02-08
NL7602469A (nl) 1977-02-09
CA1076572A (en) 1980-04-29
AU509371B2 (en) 1980-05-08
FR2342736A1 (fr) 1977-09-30
FR2342735B1 (de) 1981-12-31
GB1549835A (en) 1979-08-08
SE422580B (sv) 1982-03-15
US4145550A (en) 1979-03-20
BE839364A (fr) 1976-09-09
CH631177A5 (de) 1982-07-30
CH632511A5 (de) 1982-10-15
GB1549833A (en) 1979-08-08
FR2342736B1 (de) 1979-03-09
CH631985A5 (de) 1982-09-15
GB1549831A (en) 1979-08-08
AT361486B (de) 1981-03-10
AU1176576A (en) 1977-09-15

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