AT513858B1 - Neue bioaktive Polymere - Google Patents
Neue bioaktive Polymere Download PDFInfo
- Publication number
- AT513858B1 AT513858B1 ATA53/2013A AT532013A AT513858B1 AT 513858 B1 AT513858 B1 AT 513858B1 AT 532013 A AT532013 A AT 532013A AT 513858 B1 AT513858 B1 AT 513858B1
- Authority
- AT
- Austria
- Prior art keywords
- polyguanidine
- diamine
- diaminoguanidine
- salt
- derivative
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title description 24
- 230000000975 bioactive effect Effects 0.000 title description 2
- 150000004985 diamines Chemical class 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- -1 aminoguanidino Chemical group 0.000 claims abstract description 15
- 238000006068 polycondensation reaction Methods 0.000 claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 11
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 10
- JGGFDEJXWLAQKR-UHFFFAOYSA-N 1,2-diaminoguanidine Chemical compound NNC(N)=NN JGGFDEJXWLAQKR-UHFFFAOYSA-N 0.000 claims abstract description 9
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 239000011541 reaction mixture Substances 0.000 claims description 11
- 150000002357 guanidines Chemical class 0.000 claims description 9
- 150000007513 acids Chemical class 0.000 claims description 7
- 239000003139 biocide Substances 0.000 claims description 7
- 230000003115 biocidal effect Effects 0.000 claims description 6
- 239000000645 desinfectant Substances 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 230000036961 partial effect Effects 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical class [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 3
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 229920000570 polyether Polymers 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical class CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- 208000035143 Bacterial infection Diseases 0.000 claims description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical class [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical class CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 229910002651 NO3 Inorganic materials 0.000 claims description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical class [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical class [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical class [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000002141 anti-parasite Effects 0.000 claims description 2
- 239000003096 antiparasitic agent Substances 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical class [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 230000007613 environmental effect Effects 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical class I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Chemical class SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims description 2
- 238000002663 nebulization Methods 0.000 claims description 2
- 239000000575 pesticide Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical class [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Chemical class 0.000 claims description 2
- 230000006641 stabilisation Effects 0.000 claims description 2
- 238000011105 stabilization Methods 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 description 20
- 238000012360 testing method Methods 0.000 description 12
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 11
- 238000001035 drying Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 8
- 239000007795 chemical reaction product Substances 0.000 description 8
- 238000001816 cooling Methods 0.000 description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 230000035484 reaction time Effects 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- HAZRIBSLCUYMQP-UHFFFAOYSA-N 1,2-diaminoguanidine;hydron;chloride Chemical compound Cl.NN\C(N)=N/N HAZRIBSLCUYMQP-UHFFFAOYSA-N 0.000 description 5
- YOOSAIJKYCBPFW-UHFFFAOYSA-N 3-[4-(3-aminopropoxy)butoxy]propan-1-amine Chemical compound NCCCOCCCCOCCCN YOOSAIJKYCBPFW-UHFFFAOYSA-N 0.000 description 5
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 210000002889 endothelial cell Anatomy 0.000 description 4
- 210000002510 keratinocyte Anatomy 0.000 description 4
- 238000005185 salting out Methods 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 3
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 3
- 125000001841 imino group Chemical group [H]N=* 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 231100000820 toxicity test Toxicity 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 230000002924 anti-infective effect Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- IWBOPFCKHIJFMS-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl) ether Chemical compound NCCOCCOCCN IWBOPFCKHIJFMS-UHFFFAOYSA-N 0.000 description 2
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 2
- 210000003606 umbilical vein Anatomy 0.000 description 2
- FQQQSNAVVZSYMB-UHFFFAOYSA-N 1,1-diaminoguanidine Chemical compound NN(N)C(N)=N FQQQSNAVVZSYMB-UHFFFAOYSA-N 0.000 description 1
- UBDZFAGVPPMTIT-UHFFFAOYSA-N 2-aminoguanidine;hydron;chloride Chemical compound [Cl-].NC(N)=N[NH3+] UBDZFAGVPPMTIT-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 241000430519 Human rhinovirus sp. Species 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 125000005263 alkylenediamine group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000009635 antibiotic susceptibility testing Methods 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 238000002827 antifungal susceptibility testing Methods 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 208000037798 influenza B Diseases 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000028 nontoxic concentration Toxicity 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 150000004986 phenylenediamines Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- AOHJOMMDDJHIJH-UHFFFAOYSA-N propylenediamine Chemical compound CC(N)CN AOHJOMMDDJHIJH-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000186 toxicological potential Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Virology (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polyamides (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA53/2013A AT513858B1 (de) | 2013-01-25 | 2013-01-25 | Neue bioaktive Polymere |
| CA2899456A CA2899456C (en) | 2013-01-25 | 2014-01-22 | New bioactive polymers |
| US14/763,356 US9567294B2 (en) | 2013-01-25 | 2014-01-22 | Bioactive polymers |
| PCT/AT2014/050026 WO2014113835A1 (de) | 2013-01-25 | 2014-01-22 | Neue bioaktive polymere |
| BR112015017840-5A BR112015017840B1 (pt) | 2013-01-25 | 2014-01-22 | Novos polímeros bioativos |
| CN201480017636.5A CN105073835B (zh) | 2013-01-25 | 2014-01-22 | 生物活性聚合物 |
| DK14712557.9T DK2948496T3 (da) | 2013-01-25 | 2014-01-22 | Hidtil ukendte bioaktive polymerer |
| EP14712557.9A EP2948496B1 (de) | 2013-01-25 | 2014-01-22 | Neue bioaktive polymere |
| SI201431346T SI2948496T1 (sl) | 2013-01-25 | 2014-01-22 | Novi bioaktivni polimeri |
| HUE14712557A HUE045159T2 (hu) | 2013-01-25 | 2014-01-22 | Új, biológiailag aktív polimerek |
| MYPI2015702428A MY184140A (en) | 2013-01-25 | 2014-01-22 | New bioactive polymers |
| PL14712557T PL2948496T3 (pl) | 2013-01-25 | 2014-01-22 | Nowe bioaktywne polimery |
| JP2015553988A JP6302487B2 (ja) | 2013-01-25 | 2014-01-22 | 新規生物活性ポリマー |
| HRP20191642 HRP20191642T1 (hr) | 2013-01-25 | 2014-01-22 | Novi bioaktivni polimeri |
| UAA201508288A UA115581C2 (uk) | 2013-01-25 | 2014-01-22 | Біоактивні полімери |
| PT147125579T PT2948496T (pt) | 2013-01-25 | 2014-01-22 | Novos polímeros bioativos |
| EA201591381A EA031075B1 (ru) | 2013-01-25 | 2014-01-22 | Производные полигуанидина в качестве биоцидов |
| AU2014210359A AU2014210359B2 (en) | 2013-01-25 | 2014-01-22 | New bioactive polymers |
| SG11201505832SA SG11201505832SA (en) | 2013-01-25 | 2014-01-22 | New bioactive polymers |
| ES14712557T ES2753948T3 (es) | 2013-01-25 | 2014-01-22 | Nuevos polímeros bioactivos |
| ZA201505345A ZA201505345B (en) | 2013-01-25 | 2015-07-24 | New bioactive polymers |
| PH12015501655A PH12015501655B1 (en) | 2013-01-25 | 2015-07-24 | New bioactive polymers |
| CY20191100956T CY1122517T1 (el) | 2013-01-25 | 2019-09-12 | Νεα βιοδραστικα πολυμερη |
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|---|---|---|---|
| ATA53/2013A AT513858B1 (de) | 2013-01-25 | 2013-01-25 | Neue bioaktive Polymere |
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| AT513858A4 AT513858A4 (de) | 2014-08-15 |
| AT513858B1 true AT513858B1 (de) | 2014-08-15 |
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| ATA53/2013A AT513858B1 (de) | 2013-01-25 | 2013-01-25 | Neue bioaktive Polymere |
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| EP (1) | EP2948496B1 (OSRAM) |
| JP (1) | JP6302487B2 (OSRAM) |
| CN (1) | CN105073835B (OSRAM) |
| AT (1) | AT513858B1 (OSRAM) |
| AU (1) | AU2014210359B2 (OSRAM) |
| BR (1) | BR112015017840B1 (OSRAM) |
| CA (1) | CA2899456C (OSRAM) |
| CY (1) | CY1122517T1 (OSRAM) |
| DK (1) | DK2948496T3 (OSRAM) |
| EA (1) | EA031075B1 (OSRAM) |
| ES (1) | ES2753948T3 (OSRAM) |
| HR (1) | HRP20191642T1 (OSRAM) |
| HU (1) | HUE045159T2 (OSRAM) |
| MY (1) | MY184140A (OSRAM) |
| PH (1) | PH12015501655B1 (OSRAM) |
| PL (1) | PL2948496T3 (OSRAM) |
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| UA (1) | UA115581C2 (OSRAM) |
| WO (1) | WO2014113835A1 (OSRAM) |
| ZA (1) | ZA201505345B (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107099031B (zh) * | 2017-04-21 | 2019-05-14 | 石家庄学院 | 一种耐高温改性聚六亚甲基胍及其制备方法和用途 |
| CN107964795A (zh) * | 2017-12-24 | 2018-04-27 | 江苏美翔体育用品有限公司 | 一种含有pe功能性涂层的面料的加工方法 |
| EP3524055A1 (de) | 2018-02-08 | 2019-08-14 | BCSK Biocid GmbH | Antibakterielles und spermizides gleitmittel |
| AT521124A1 (de) * | 2018-03-23 | 2019-10-15 | Bcsk Biocid Gmbh | Verfahren und Zusammensetzung zur Bekämpfung von Viren der Familie Picornaviridae |
| US11548982B2 (en) * | 2019-05-16 | 2023-01-10 | Marwian GmbH | Active biocidal substances and production process thereof |
| TWI751552B (zh) * | 2020-05-11 | 2022-01-01 | 亞東學校財團法人亞東科技大學 | 染色用助劑之製造方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1095902A (en) * | 1964-04-09 | 1967-12-20 | Sterling Drug Inc | Guanidine derivatives |
| WO2001085676A1 (de) * | 2000-05-11 | 2001-11-15 | P.O.C. Oil Industry Technology Beratungsges.M.B.H | Biozide polymere auf der basis von guanidin-salzen |
| AT411060B (de) * | 2000-10-23 | 2003-09-25 | P O C Oil Industry Technology | Biozide polymere guanidinderivate auf der basis von diaminen und verfahren zur gewinnung von solchen salzen |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2325586A (en) | 1940-03-21 | 1943-08-03 | Du Pont | Polymeric guanidines and process for preparing the same |
| FR1413915A (fr) * | 1964-07-10 | 1965-10-15 | Constr Telephoniques | Perfectionnements aux systèmes de sélection pour circuits ou équipements électriques |
| US5612332A (en) * | 1984-03-19 | 1997-03-18 | Alteon Inc. | Di- and triaminoguanidines, and methods of use |
| JPS6456614A (en) * | 1987-08-27 | 1989-03-03 | Ono Pharmaceutical Co | Maillard reaction inhibitor |
| JP3554629B2 (ja) * | 1996-04-02 | 2004-08-18 | 東洋化成工業株式会社 | 安定化されたテトラゾ−ル系樹脂発泡剤 |
| AT406163B (de) | 1998-04-22 | 2000-03-27 | P O C Oil Industry Technology | Verfahren zur gewinnung eines desinfektionsmittels |
| WO2002030877A1 (fr) | 2000-09-29 | 2002-04-18 | Regionalnaya Obschestvennaya Organizatsya-Institut Ekologo-Tekhnologicheskikh Problem | Procede de production d'un desinfectant |
| CA2434693A1 (en) * | 2001-01-18 | 2002-10-17 | Genzyme Corporation | Ionene polymers and their use as antimicrobial agents |
| JP2003191606A (ja) * | 2001-12-25 | 2003-07-09 | Fuji Photo Film Co Ltd | インクジェット記録用シート |
| CN1282698C (zh) * | 2002-03-15 | 2006-11-01 | 上海塑杰科技有限公司 | 一种聚烯烃功能化母粒及其制备方法和应用 |
| AT501983B1 (de) * | 2003-02-04 | 2007-03-15 | Geopharma Produktionsgmbh | Zytostatisches arzneimittel enthaltend ein polymeres guanidinderivat |
| AT505102B1 (de) * | 2004-11-05 | 2010-05-15 | Schmidt Oskar | Biozid, insbesondere fungizid wirkendes mittel |
| RU2422137C1 (ru) | 2009-10-08 | 2011-06-27 | Виктор Вениаминович Тец | Способ получения биоцидного полигуанидина и биоцидный полигуанидин |
| CN103145981B (zh) * | 2011-12-07 | 2015-04-01 | 上海高聚生物科技有限公司 | 聚六亚甲基胍磷酸盐及其合成方法 |
-
2013
- 2013-01-25 AT ATA53/2013A patent/AT513858B1/de active
-
2014
- 2014-01-22 US US14/763,356 patent/US9567294B2/en not_active Expired - Fee Related
- 2014-01-22 WO PCT/AT2014/050026 patent/WO2014113835A1/de not_active Ceased
- 2014-01-22 CA CA2899456A patent/CA2899456C/en active Active
- 2014-01-22 DK DK14712557.9T patent/DK2948496T3/da active
- 2014-01-22 HU HUE14712557A patent/HUE045159T2/hu unknown
- 2014-01-22 HR HRP20191642 patent/HRP20191642T1/hr unknown
- 2014-01-22 EP EP14712557.9A patent/EP2948496B1/de active Active
- 2014-01-22 SG SG11201505832SA patent/SG11201505832SA/en unknown
- 2014-01-22 AU AU2014210359A patent/AU2014210359B2/en not_active Ceased
- 2014-01-22 CN CN201480017636.5A patent/CN105073835B/zh active Active
- 2014-01-22 ES ES14712557T patent/ES2753948T3/es active Active
- 2014-01-22 BR BR112015017840-5A patent/BR112015017840B1/pt active IP Right Grant
- 2014-01-22 SI SI201431346T patent/SI2948496T1/sl unknown
- 2014-01-22 PL PL14712557T patent/PL2948496T3/pl unknown
- 2014-01-22 MY MYPI2015702428A patent/MY184140A/en unknown
- 2014-01-22 EA EA201591381A patent/EA031075B1/ru unknown
- 2014-01-22 UA UAA201508288A patent/UA115581C2/uk unknown
- 2014-01-22 PT PT147125579T patent/PT2948496T/pt unknown
- 2014-01-22 JP JP2015553988A patent/JP6302487B2/ja not_active Expired - Fee Related
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2015
- 2015-07-24 PH PH12015501655A patent/PH12015501655B1/en unknown
- 2015-07-24 ZA ZA201505345A patent/ZA201505345B/en unknown
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2019
- 2019-09-12 CY CY20191100956T patent/CY1122517T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1095902A (en) * | 1964-04-09 | 1967-12-20 | Sterling Drug Inc | Guanidine derivatives |
| WO2001085676A1 (de) * | 2000-05-11 | 2001-11-15 | P.O.C. Oil Industry Technology Beratungsges.M.B.H | Biozide polymere auf der basis von guanidin-salzen |
| AT411060B (de) * | 2000-10-23 | 2003-09-25 | P O C Oil Industry Technology | Biozide polymere guanidinderivate auf der basis von diaminen und verfahren zur gewinnung von solchen salzen |
Also Published As
| Publication number | Publication date |
|---|---|
| SI2948496T1 (sl) | 2019-11-29 |
| EA201591381A1 (ru) | 2016-04-29 |
| BR112015017840A2 (pt) | 2021-06-01 |
| AU2014210359A1 (en) | 2015-08-13 |
| CN105073835B (zh) | 2017-06-20 |
| PH12015501655B1 (en) | 2020-10-09 |
| CY1122517T1 (el) | 2021-01-27 |
| DK2948496T3 (da) | 2019-09-23 |
| HRP20191642T1 (hr) | 2019-12-13 |
| CN105073835A (zh) | 2015-11-18 |
| ZA201505345B (en) | 2019-10-30 |
| EP2948496A1 (de) | 2015-12-02 |
| AU2014210359B2 (en) | 2017-08-24 |
| CA2899456C (en) | 2020-12-22 |
| MY184140A (en) | 2021-03-22 |
| JP6302487B2 (ja) | 2018-03-28 |
| ES2753948T3 (es) | 2020-04-15 |
| JP2016504474A (ja) | 2016-02-12 |
| CA2899456A1 (en) | 2014-07-31 |
| UA115581C2 (uk) | 2017-11-27 |
| AT513858A4 (de) | 2014-08-15 |
| US20150368193A1 (en) | 2015-12-24 |
| EA031075B1 (ru) | 2018-11-30 |
| PT2948496T (pt) | 2019-10-10 |
| WO2014113835A1 (de) | 2014-07-31 |
| EP2948496B1 (de) | 2019-06-12 |
| PL2948496T3 (pl) | 2020-03-31 |
| US9567294B2 (en) | 2017-02-14 |
| PH12015501655A1 (en) | 2015-10-19 |
| HUE045159T2 (hu) | 2019-12-30 |
| SG11201505832SA (en) | 2015-08-28 |
| BR112015017840B1 (pt) | 2022-03-15 |
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